Ferulic acid restores mitochondrial dynamics and autophagy via AMPK signaling pathway in a palmitate-induced hepatocyte model of metabolic syndrome DOI Creative Commons
Yitong Li,

Weiyang Zhao,

Ali Tahir Sair

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 16, 2024

Mitochondrial dysfunction, characterized by elevated oxidative stress, impaired energy balance, and dysregulated mitochondrial dynamics, is a hallmark of metabolic syndrome (MetS) its comorbidities. Ferulic acid (FA), principal phenolic compound found in whole grains, has demonstrated potential ameliorating stress preserving homeostasis. However, the influence FA on health within context MetS remains unexplored. Moreover, impact autophagy, which essential for maintaining homeostasis integrity, not fully understood. Here, we aimed to study mechanisms action regulating autophagy using palmitate-treated HepG2 hepatocytes as cell model. We that improved restoring redox balance optimizing including biogenesis fusion/fission ratio. Additionally, was shown recover activate AMPK-related signaling. Our results provide new insights into therapeutic mitochondria-targeting agent prevention treatment MetS.

Language: Английский

Programmed cell death and lipid metabolism of macrophages in NAFLD DOI Creative Commons
Zhun Xiao, Minghao Liu,

Fangming Yang

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 18, 2023

Non-alcoholic fatty liver disease (NAFLD) has now become the leading chronic worldwide with lifestyle changes. This may lead to NAFLD becoming cause of end-stage in future. To date, there are still no effective therapeutic drugs for NAFLD. An in-depth exploration pathogenesis can help provide a basis new agents or strategies. As most important immune cells liver, macrophages play an role occurrence and development inflammation expected targets treatment. Programmed cell death (PCD) plays regulatory phenotypic transformation, is also certain connection between different types PCD. However, how PCD regulates macrophage polarization not been systematically elucidated. Based on lipid metabolic reprogramming polarization, alter phenotype by regulating metabolism. We reviewed effects changes their metabolism, as well relationship metabolism macrophages. Furthermore, interactions potential targeting explored.

Language: Английский

Citations

19
Effect of natural polysaccharides on alcoholic liver disease: A review DOI
Siyu Li, Xin Zhou, Ruhai Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 251, P. 126317 - 126317

Published: Aug. 16, 2023

Language: Английский

Citations

19
Tiaogan Jiejiu Tongluo Formula attenuated alcohol-induced chronic liver injury by regulating lipid metabolism in rats DOI Open Access
Chunqiu Fang, Jingzhou Zhang, Jiajun Han

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 317, P. 116838 - 116838

Published: June 22, 2023

Language: Английский

Citations

17
Xiaozhi formula attenuates non-alcoholic fatty liver disease by regulating lipid metabolism via activation of AMPK and PPAR pathways DOI Creative Commons

Liping You,

Tao Wang, Wenxuan Li

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 329, P. 118165 - 118165

Published: April 7, 2024

Xiaozhi formula (XZF) is a practical Chinese herbal for the treatment of non-alcoholic fatty liver disease (NAFLD), which possesses an authorized patent certificate issued by State Intellectual Property Office China (ZL202211392355.0). However, underlying mechanism XZF treats NAFLD remains unclear.

Language: Английский

Citations

7
Polygala fallax Hemsl polysaccharides alleviated alcoholic fatty liver disease by modifying lipid metabolism via AMPK DOI

Rui Lv,

Houkang Cao, Mingli Zhong

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135565 - 135565

Published: Sept. 1, 2024

Language: Английский

Citations

6
From Kinases to Diseases: Investigating the Role of AMPK in Human Pathologies DOI Open Access
Verónica Rey, Isaac Tamargo‐Gómez

Kinases and Phosphatases, Journal Year: 2023, Volume and Issue: 1(3), P. 181 - 205

Published: Aug. 1, 2023

Adenosine Monophosphate-Activated Protein Kinase (AMPK) is the major conserved regulator of cellular metabolism in eukaryotic cells, from yeast to mammals. Given its pivotal role, it not surprising that alterations function may contribute pathogenesis numerous human diseases. Indeed, AMPK has become a promising therapeutic target for several pathologies. In this context, significant efforts have been dedicated discovering new pharmacological agents capable activating based on next-generation sequencing (NGS) technology and personalized medicine. Thanks computational methodologies high-throughput screening, identification small molecules compounds with potential directly activate or modulate intricate signaling network viable. However, most widely used drug patients still metformin, which shown results treatment various diseases, such as type II diabetes, atherosclerosis, Alzheimer’s disease, Huntington’s types cancer. review, we present comprehensive analysis involvement pathology, emphasizing target.

Language: Английский

Citations

15
Effect of Isoquercitrin on Free Fatty Acid-Induced Lipid Accumulation in HepG2 Cells DOI Creative Commons
Sou Hyun Kim, Chawon Yun, Doyoung Kwon

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(3), P. 1476 - 1476

Published: Feb. 3, 2023

Liver metabolic disorders and oxidative stress are crucial factors in the development of nonalcoholic fatty liver disease (NAFLD); however, treatment strategies to combat NAFLD remain poorly established, presenting an important challenge that needs be addressed. Herein, we aimed examine effect isoquercitrin on lipid accumulation induced by exogenous free acids (FFA) using HepG2 cells elucidate underlying molecular mechanism. The were exposed 0.5 mM FFA induce intracellular accumulation, followed co-treatment with confirm potential inhibitory FFA-induced production. alone exhibited compromised endoplasmic reticulum (ER) stress, enhanced expression proteins genes involved synthesis; decreased these molecules a dose-dependent manner. Furthermore, could activate AMP-activated protein kinase (AMPK), key regulatory hepatic acid oxidation, suppressing new production phosphorylating acetyl-CoA carboxylase (ACC) inhibiting sterol element-binding transcription factor 1 (SREBP-1)/fatty synthase (FAS) signals. Overall, findings suggest can employed as therapeutic agent improve via regulation metabolism targeting AMPK/ACC SREBP1/FAS pathways.

Language: Английский

Citations

14
SGLT2 inhibitors and AMPK: The road to cellular housekeeping? DOI
Naser Safaie, Shahab Masoumi, Shaban Alizadeh

et al.

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(1)

Published: Jan. 1, 2024

Abstract Sodium‐glucose co‐transporter‐2 (SGLT2) inhibitors, known as Gliflozins, are a class of Glucose‐lowering drugs in adults with type 2 diabetes (T2D) that induce glucosuria by blocking SGLT2 co‐transporters the proximal tubules. Several lines evidence suggest inhibitors regulate multiple mechanisms associated regulation varying cellular pathways. The 5′‐adenosine monophosphate‐activated protein kinase (AMPK) pathway plays an important role metabolic homeostasis influencing processes. Recently, it has been shown can affect AMPK differing physiological and pathological ways, resulting kidney, intestinal, cardiovascular, liver protective effects. Additionally, they have therapeutic effects on nonalcoholic fatty disease mellitus‐associated complications. In this review, we summarize results studies AMPK‐associated different organelle functions.

Language: Английский

Citations

5
Exploring the Therapeutic Potential of Royal Jelly in Metabolic Disorders and Gastrointestinal Diseases DOI Open Access
Hesham R. El‐Seedi, Suzy Munir Salama, Aida A. Abd El‐Wahed

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(3), P. 393 - 393

Published: Jan. 29, 2024

Metabolic disorders, encompassing diabetes mellitus, cardiovascular diseases, gastrointestinal etc., pose a substantial global health threat, with rising morbidity and mortality rates. Addressing these disorders is crucial, as conventional drugs often come high costs adverse effects. This review explores the potential of royal jelly (RJ), natural bee product rich in bioactive components, an alternative strategy for managing metabolic diseases. RJ exhibits diverse therapeutic properties, including antimicrobial, estrogen-like, anti-inflammatory, hypotensive, anticancer, antioxidant review’s focus on investigating how its components impact conditions like disease, illnesses. Evidence suggests that serves complementary treatment various issues, notably demonstrating cholesterol- glucose-lowering effects diabetic rats. Specific RJ-derived metabolites, such 10-hydroxy-2-decenoic acid (10-HDA), also known “Queen acid,” show promise reducing insulin resistance hyperglycemia. Recent research highlights RJ’s role modulating immune responses, enhancing anti-inflammatory cytokines, suppressing key inflammatory mediators. Despite promising findings, further needed to comprehensively understand mechanisms underlying

Language: Английский

Citations

5
Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease—Clinical and Pre-Clinical Overview and Systematic Review of the Literature DOI Open Access
Florentina Ioniţă‐Radu, Cristina Patoni,

Andreea Simona Nancoff

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4201 - 4201

Published: April 10, 2024

Non-alcoholic fatty liver disease (NAFLD) is the predominant cause of chronic conditions, and its progression marked by evolution to non-alcoholic steatosis, steatohepatitis, cirrhosis related potential occurrence hepatocellular carcinoma. In our systematic review, we searched two databases, Medline (via Pubmed Central) Scopus, from inception 5 February 2024, included 73 types research (nine clinical studies 64 pre-clinical studies) 2854 published papers. Our extensive highlights impact Berberine on NAFLD pathophysiology mechanisms, such as Adenosine Monophosphate-Activated Protein Kinase (AMPK), gut dysbiosis, peroxisome proliferator-activated receptor (PPAR), Sirtuins, inflammasome. Studies involving human subjects showed a measurable reduction fat in addition improved profiles serum lipids hepatic enzymes. While current drugs for treatment are either scarce or still development launch phases, presents promising profile. However, improvements formulation necessary enhance bioavailability this natural substance.

Language: Английский

Citations

5