Brain-based Sex Differences in Depression: A Systematic Review of Neuroimaging Studies

Brain Imaging and Behavior, Journal Year: 2023, Volume and Issue: 17(5), P. 541 - 569

Published: April 14, 2023

Language: Английский

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Shared network‐level functional alterations across substance use disorders: A multi‐level kernel density meta‐analysis of resting‐state functional connectivity studies

Addiction Biology, Journal Year: 2022, Volume and Issue: 27(4)

Published: June 21, 2022

Abstract An increasing number of neuroimaging studies indicate functional alterations in cortico‐striatal loops individuals with substance use disorders (SUD). Dysregulations these circuits may contribute to drug‐seeking and drug‐consuming behaviour by impeding inhibitory control, habit formation, reward processing. Despite evidence network‐level changes SUD, a shared pattern within between spatially distributed brain networks has not been systematically investigated. The present meta‐analytic investigation aims at identifying common resting‐state connectivity patterns across different including stimulant, heroin, alcohol, cannabis, nicotine use. To this aim, seed‐based whole‐brain maps for were extracted subjected multi‐level kernel density analysis identify dysfunctional SUD compared healthy controls. In addition, an exploratory examined substance‐specific effects as well the influence drug status on main findings. Our findings hypoconnectivity limbic, salience, frontoparietal default mode network additionally exhibited complex hypo‐ hyperconnectivity studies. observed disrupted associate deficient control mechanisms that are thought excessive craving automatic drug‐related failure cessation. identified network‐based represent potential treatment targets neuromodulation, example, real‐time magnetic resonance imaging (fMRI) neurofeedback. Such interventions can evaluate behavioural relevance neural circuits.

Language: Английский

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Transdiagnostic alterations in neural emotion regulation circuits – neural substrates of cognitive reappraisal in patients with depression and post-traumatic stress disorder

BMC Psychiatry, Journal Year: 2022, Volume and Issue: 22(1)

Published: March 8, 2022

Impaired cognitive reappraisal, associated with the social functioning and well-being of patients affected by mood or anxiety disorders, is characterized distinct neural activation patterns across clinical populations. To date, studies dedicated to identifying common profiles need be clarified. The aim present study was investigate transdiagnostic differences commonalities in brain during reappraisal-mediated downregulation emotions.

Language: Английский

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fNIRS neurofeedback facilitates emotion regulation: Exploring individual differences over the ventrolateral prefrontal cortex

NeuroImage, Journal Year: 2025, Volume and Issue: 308, P. 121079 - 121079

Published: Feb. 8, 2025

The ventrolateral prefrontal cortex (VLPFC) plays a pivotal role in emotion regulation, yet the effectiveness of neurofeedback (NF) training targeting VLPFC remains uncertain, suggesting significant individual differences outcomes. In this study, we aimed to clarify these by enrolling 90 participants, randomly assigned either an experimental group or sham (n = 48/42). Participants underwent VLPFC-NF over eight sessions across two consecutive days, while those received random signals from functional near-infrared spectroscopy (fNIRS). To investigate variability, participants were further categorized as high low-efficacy groups based on their efficiency, determined regression slope activity sessions. Our results revealed reduction negative emotions and increased during regulation high-efficacy group, compared both group. Importantly, benefit reflected decreased negativity ratings, was predicted NF efficiency. Furthermore, enhancement fully mediated relationship between efficiency benefits. with higher exhibited greater engagement leading superior emotional Additionally, linked habitual use reappraisal strategies daily life. This study provides novel causal evidence that can effectively enhance highlighting importance findings suggest offers promising personalized intervention strategy for improving potential applications treating disorders. research underscores approaches, offering new avenues tailored therapeutic interventions future.

Language: Английский

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Altered neural activities during emotion regulation in depression: a meta-analysis

Journal of Psychiatry and Neuroscience, Journal Year: 2024, Volume and Issue: 49(5), P. E334 - E344

Published: Oct. 25, 2024

Background

Deficient neural activities during emotion regulation have been reported in depression. We sought to conduct a meta-analysis provide comprehensive description of these alterations use strategies among patients with depression, including major depressive disorder (MDD) and bipolar (BD).

Methods

identified neuroimaging studies abnormal extracted the peak coordinates effect sizes differences brain activity between healthy controls. Using seed-based d mapping, we conducted voxel-wise meta-analyses activation pattern 2 groups across conditions involving those where was not needed.

Results

included 33 reporting 34 data sets, 23 MDD (571 people 578 matched controls) 11 BD (358 369 controls). Overall, compared controls, depression showed hyperactivity insula postcentral gyrus, hypoactivity prefrontal part inferior, middle, superior frontal middle temporal supplementary motor area. In subgroup analyses, from focused on decreasing negative emotions or using emotional strategy reappraisal specific cerebellar peduncles.

Limitations

Given limited BD, were unable detect common distinct abnormalities BD. did any meta-regression analyses because information.

Conclusion

this meta-analysis, regions associated experience cognitive control relative These findings could help indicate target for future interventions aimed at increasing capacity

Language: Английский

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TMS-EEG signatures of facilitated cognitive reappraisal in emotion regulation by left ventrolateral prefrontal cortex stimulation

Neuropsychologia, Journal Year: 2023, Volume and Issue: 184, P. 108560 - 108560

Published: April 5, 2023

Language: Английский

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Electro-Acupuncture Effects Measured by Functional Magnetic Resonance Imaging—A Systematic Review of Randomized Clinical Trials

Healthcare, Journal Year: 2023, Volume and Issue: 12(1), P. 2 - 2

Published: Dec. 19, 2023

Electro-acupuncture, an innovative adaptation of traditional acupuncture, combines electrical stimulation with acupuncture needles to enhance therapeutic effects. While is widely used, its biological mechanisms remain incompletely understood. Recent research has explored the neurophysiological aspects particularly through functional magnetic resonance imaging (fMRI) investigate effects on brain activity. In this systematic review, we conducted extensive search for randomized clinical trials examining electro-acupuncture measured by fMRI. We employed strict eligibility criteria, quality assessment, and data extraction. Five studies met our inclusion criteria were analyzed. The selected investigated in various medical conditions, including carpal tunnel syndrome, fibromyalgia, Crohn's disease, irritable bowel obesity. Notably, was found modulate activity connectivity regions associated pain perception, emotional regulation, cognitive processing. These findings align holistic approach Chinese medicine, emphasizing interconnectedness body mind. at both local distal sites showed improvements, suggesting distinct neuroplasticity mechanisms. somatosensory correlated reduced severity, enhanced connectivity, increased gamma-aminobutyric acid levels. For influenced homeostatic afferent processing network, potentially mitigating gut inflammation. Electro-acupuncture syndrome led decreased anterior cingulate cortex, offering relief, while obesity impacted dietary inhibition regulation. This review provides evidence that can positively impact a range possibly modulating connectivity. reviewed generally good, further larger sample sizes longer-term assessments needed better understand optimize protocols specific health conditions. limited number emphasizes need broader investigations promising field. protocol registered PROSPERO (CRD42023465866).

Language: Английский

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Different Roles of the Left and Right Ventrolateral Prefrontal Cortex in Cognitive Reappraisal: An Online Transcranial Magnetic Stimulation Study

Frontiers in Human Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: June 10, 2022

The ventrolateral prefrontal cortex (VLPFC) plays a pivotal role in cognitive reappraisal. Previous studies suggested functional asymmetry of the bilateral VLPFC, but evidence is still insufficient during In this study, we conducted an online single-pulse transcranial magnetic stimulation (spTMS) to investigate causal and distinct roles left right VLPFC Participants were instructed reappraise (down-regulate) or attend pictures depicting social exclusion scenarios while spTMS was applied over participants’ brains. results showed that either would increase reappraisal difficulty. Meanwhile, outcome (measured by self-reported negative feelings) significantly deteriorated when (but not left) temporally interrupted spTMS, verbal fluency oral reporting strategy reduced spTMS. Taken together, these findings provide for involvement with roles: responsible linguistic especially semantic process generating selecting appraisals according goal emotion regulation, critical inhibiting inappropriate emotions thoughts generated effective scenarios. These deepen our understanding neurocognitive mechanism regulation.

Language: Английский

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Frontostriatal circuitry as a target for fMRI-based neurofeedback interventions: A systematic review

Frontiers in Human Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Aug. 24, 2022

Dysregulated frontostriatal circuitries are viewed as a common target for the treatment of aberrant behaviors in various psychiatric and neurological disorders. Accordingly, experimental neurofeedback paradigms have been applied to modify circuitry. The human circuitry is topographically functionally organized into "limbic," "associative," "motor" subsystems underlying variety affective, cognitive, motor functions. We conducted systematic review literature regarding functional magnetic resonance imaging-based studies that targeted brain activations within Seventy-nine published were included our survey. assessed efficacy these terms imaging findings intervention well behavioral clinical outcomes. Furthermore, we evaluated whether targets could be assigned identifiable subsystems. majority functions focused on anterior cingulate cortex, dorsolateral prefrontal supplementary area. Only few (

Language: Английский

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Individual brain regulation as learned via neurofeedback is related to affective changes in adolescents with autism spectrum disorder

Child and Adolescent Psychiatry and Mental Health, Journal Year: 2023, Volume and Issue: 17(1)

Published: Jan. 12, 2023

Emotions often play a role in neurofeedback (NF) regulation strategies. However, investigations of the relationship between induced neuronal changes and improvements affective domains are scarce electroencephalography-based studies. Thus, we extended findings first study on slow cortical potential (SCP) NF autism spectrum disorder (ASD) by linking to whole-brain activity during rest regulation. Forty-one male adolescents with ASD were scanned twice at using functional magnetic resonance imaging. Between scans, half underwent training, whereas other received treatment as usual. Furthermore, parents reported their child's characteristics each measurement. The group had alternatingly produce negative positive SCP shifts training was additionally imaging while applying developed No significant group-by-time interactions or resting-state measures found. found increases resting anterior cingulate cortex right inferior temporal gyrus well over both groups. Activation corresponding differentiation these regions correlated improvements. A further correlation for Rolandic operculum activation shifts. There no correlations respective achieved training. did not lead superior functioning compared might be related individual strategies patterns indicated level. Trial registration This clinical trial registered drks.de (DRKS00012339) 20th April, 2017.

Language: Английский

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