Virology Journal,
Journal Year:
2023,
Volume and Issue:
20(1)
Published: May 15, 2023
Coronavirus
Disease
2019
(COVID-19)
is
a
worldwide
pandemic
challenge
spreading
enormously
within
few
months.
COVID-19
characterized
by
the
over-activation
of
immune
system
causing
cytokine
storm.
Insulin-like
growth
factor-1
(IGF-1)
pathway
can
regulate
response
via
interaction
with
various
implicated
cytokines.
Heart-type
fatty
acid-binding
protein
(H-FABP)
has
been
shown
to
promote
inflammation.
Given
fact
that
coronavirus
infections
induce
cytokines
secretion
leading
inflammatory
lung
injury,
it
suggested
H-FABP
levels
are
affected
severity.
Moreover,
endotrophin
(ETP),
cleavage
product
collagen
VI,
may
be
an
indicator
overactive
repair
process
and
fibrosis,
considering
viral
infection
predispose
or
exacerbate
existing
respiratory
conditions,
including
pulmonary
fibrosis.
This
study
aims
assess
prognostic
capacity
circulating
IGF-1,
HFABP,
ETP,
for
severity
progression
in
Egyptian
patients.The
cohort
included
107
RNA-positive
patients
equivalent
number
control
individuals
no
clinical
signs
infection.
Clinical
assessments
profiling
CBC;
serum
iron;
liver
kidney
functions;
markers.
Circulating
IGF-1;
H-FABP,
ETP
were
estimated
using
corresponding
ELISA
kits.No
statistical
difference
body
mass
index
was
detected
between
healthy
groups,
while
mean
age
infected
significantly
higher
(P
=
0.0162)
than
control.
Patients
generally
showed
elevated
markers
CRP
ESR
concomitant
ferritin;
D
dimer
procalcitonin
levels,
besides
characteristic
lymphopenia
hypoxemia
also
frequent.
Logistic
regression
analysis
revealed
oxygen
saturation;
predict
<
0.001
each).
Both
IGF-1
as
well
O2
saturation
remarkable
potentials
terms
large
AUC
values,
high
sensitivity/specificity
wide
confidence
interval.
The
calculated
threshold
prognosis
25.5
ng/mL;
19.5
ng/mL,
94.5,
%
respectively.
thresholds
positive
negative
value
ranges
79-91%
72-97%;
respectively,
66-95%,
83-94%
sensitivity,
specificity;
respectively.The
cut-off
values
represent
promising
non-invasive
tool
would
facilitate
risk
stratification
patients,
morbidity/mortality
associated
progressive
Journal of Engineering and Applied Science,
Journal Year:
2022,
Volume and Issue:
69(1)
Published: Sept. 30, 2022
Abstract
The
long
stay
at
home
during
the
COVID-19
pandemic
implied
that
most
people
had
to
perform
all
their
daily
activities
home.
That
raised
need
for
special
features
related
health,
safety,
and
well-being
of
residents.
This
study
aimed
explore
essential
design
measure
perception
importance
by
Cairenes
(Egypt)
construction
industry
experts
further
implementation
in
future
as
part
buyers’
preferences
house
quality
features.
employed
an
exploratory
survey,
identifying
eight
features,
followed
a
quantitative
questionnaire
each
feature
among
stakeholders.
results
showed
indicators
were
certain
degree
importance.
It
was
found
availability
natural
ventilation
light
private
outdoor
space,
such
terrace
with
good-looking
view
or
garden,
least
one
bedroom
enclosed
bathroom
isolation
needs.
In
contrast,
extra
storage
space
food
supplies,
well
indoor
family
entertainment
reported
important.
Epidemiology and Infection,
Journal Year:
2023,
Volume and Issue:
151
Published: Jan. 1, 2023
Data
on
coronavirus
disease
2019
(COVID-19)
prevalence
in
the
Democratic
Republic
of
Congo
are
scarce.
We
conducted
a
cross-sectional
study
to
determine
seroprevalence
antibodies
against
anti-severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
slum
Kadutu,
city
Bukavu,
between
June
and
September
2021.
The
survey
participants
were
all
unvaccinated
SARS-CoV-2.
crude
rate
was
adjusted
known
characteristics
assay.
Participants
aged
15-49
years
old
made
up
80%
population
enrolled
(n
=
507;
319
women
188
men).
overall
rates
for
COVID-19
59.7%
(95%
CI
55.4-63.9%)
84.0%
76.2-92.4%),
respectively.
This
indicates
widespread
dissemination
SARS-CoV-2
these
communities.
symptoms
either
absent
or
mild
more
than
half
with
none
required
hospitalisation.
These
results
suggest
that
spread
did
not
appear
be
associated
severe
settlements
many
cases
went
unreported
densely
populated
locations.
relevance
vaccination
communities
should
thoroughly
investigated.
Viruses,
Journal Year:
2022,
Volume and Issue:
14(9), P. 1878 - 1878
Published: Aug. 25, 2022
COVID-19
was
first
diagnosed
in
Egypt
on
14
February
2020.
By
the
end
of
November
2021,
over
333,840
cases
and
18,832
deaths
had
been
reported.
As
part
national
genomic
surveillance,
1027
SARS-CoV-2
near
whole-genomes
were
generated
published
by
July
2021.
Here
we
describe
epidemiology
this
period
using
a
subset
976
high-quality
Egyptian
genomes
analyzed
together
with
representative
set
global
sequences
within
phylogenetic
framework.
A
single
lineage,
C.36,
introduced
early
pandemic
responsible
for
most
Egypt.
Furthermore,
to
remain
dominant
face
mounting
immunity
from
previous
infections
vaccinations,
lineage
acquired
several
mutations
known
confer
an
adaptive
advantage.
These
results
highlight
value
continuous
surveillance
regions
where
VOCs
are
not
predominant
need
enforcement
public
health
measures
prevent
expansion
existing
lineages.
International Journal of Environmental Research and Public Health,
Journal Year:
2022,
Volume and Issue:
19(17), P. 10832 - 10832
Published: Aug. 31, 2022
Insufficient
physical
activity
is
considered
a
strong
risk
factor
associated
with
non-communicable
diseases.
This
study
aimed
to
assess
the
impact
of
COVID-19
on
(in)activity
behavior
in
10
Arab
countries
before
and
during
lockdown.
A
cross-sectional
using
validated
online
survey
was
launched
originally
38
different
countries.
The
Eastern
Mediterranean
regional
data
related
Arabic
that
participated
were
selected
for
analysis
this
study.
total
12,433
participants
included
analysis.
mean
age
30.3
(SD,
11.7)
years.
Descriptive
regression
analyses
conducted
examine
associations
between
levels
participants’
sociodemographic
characteristics,
watching
TV,
screen
time,
computer
usage.
Physical
decreased
significantly
Participants’
country
origin,
gender,
education
lockdown
(p
<
0.050).
Older
age,
computers
had
negative
effect
Strategies
improve
minimize
sedentary
should
be
implemented,
as
well
reduce
unhealthy
inactive
especially
times
crisis.
Further
research
influence
lack
overall
health
status,
disease
recommended.
Transportation Letters,
Journal Year:
2023,
Volume and Issue:
16(3), P. 291 - 305
Published: March 8, 2023
ABSTRACTABSTRACTThis
study
aims
to
identify
the
impacts
of
COVID-19
pandemic
on
school
trips
using
a
survey
1120
students
and
their
households
in
Cairo,
Egypt.
We
found
that
students'
age,
distance
school,
type
(public
or
private)
influence
mode
used
majority
parents
would
prefer
wait
for
one
month
more
after
lockdown
before
sending
children
has
significant
impact
parents'
evaluation
various
schooling
options.
Based
responses
different
scenarios,
we
predicted
original
vehicle-kilometers-traveled
increase
by
17%
34%,
with
most
expected
modal
shift
occurring
from
large
occupancy
vehicles
smaller
vehicles.
This
was
attributed
to;
father's
occupation
education
level,
waiting
time
send
expecting
reduced
class
capacity.
KEYWORDS:
COVID-19school
tripsstudents’
travel
behaviormode
choiceEgypt
AcknowledgmentsThis
supported
German
Federal
Ministry
Education
Research,
Bundesministerium
für
Bildung
und
Forschung
(bmbf),
project
FuturTrans:
Indo-German
Collaborative
Research
Center
Intelligent
Transportation
Systems.
Gemeinsames
Indisch-Deutsches
Forschungszentrum
Intelligente
Verkehrssysteme
DAAD
Project
number
57474280
Verkehr-SuTra:
Technologies
Sustainable
Transportation,
within
Programme:
A
New
Passage
India
—
Deutsch-Indische
Hochschulkooperationen
ab
2019.Disclosure
statementNo
potential
conflict
interest
reported
author(s).AbbreviationVKT:
Vehicle-Kilometers-Traveled;
WHO:World
Health
Organization;
EFA:Explanatory
Factor
Analysis;
ICLV:
Integrated
Choice
Latent
Models;
PT:
Public
Transportation;
PAX:
Passenger;
PCE:
Passenger
Car
Equivalent.Data
availability
statementThe
data
is
available
collaborations
further
research
projects;
please
get
touch
corresponding
author
review
request.
The
contains
individual
information
cannot
be
publicly
shared.
BMC Medical Genomics,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: Dec. 2, 2024
The
vitamin
D
binding
protein
(DBP)
plays
a
critical
role
in
both
innate
and
adaptive
immune
systems,
participating
several
clinical
conditions,
including
coronavirus
disease
2019
infection
severity,
mortality
rate.
study
aimed
to
investigate
the
correlation
between
rs7041
rs4588
polymorphisms
DBP
gene
Coronavirus
Disease-2019
(COVID-19)
severity
mortality,
patients
of
Suez
Canal
University
Hospitals
Ismailia,
Egypt.
A
case-control
enrolled
220
individuals;
140
COVID-19
80
healthy
controls.
Serum
25(OH)
levels
were
determined
by
enzyme-linked
immunosorbent
assay
(ELISA),
genotyped
using
polymerase
chain
reaction-restriction
fragment
length
polymorphism
(PCR-RFLP).
found
that
groups
had
deficiency,
which
was
considerably
lower
group
compared
Among
patients,
there
significant
difference
according
indicating
can
be
used
as
predictors
severity.
Negative
correlations
genetic
variants
CA
genotype
TT
prevalence
(p
=
0.006
0.009
respectively)
proved.
No
all
>
0.05).
Positive
TG
0.029
0.031
respectively).
deficiency
increased
COVID-19.
correlated
with
mortality.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2022,
Volume and Issue:
unknown
Published: Jan. 5, 2022
Abstract
COVID-19
was
first
diagnosed
in
Egypt
on
14
February
2020.
By
the
end
of
November
2021,
over
333,840
cases
and
18,832
deaths
had
been
reported.
As
part
national
genomic
surveillance,
1,027
SARS-CoV-2
near
whole-genomes
generated
published
by
May
2021.
Here
we
describe
epidemiology
this
period
using
a
subset
976
high-quality
Egyptian
genomes
analysed
together
with
representative
set
global
sequences
within
phylogenetic
framework.
We
show
that
single
lineage,
C.36,
introduced
early
pandemic
responsible
for
most
Egypt.
Furthermore,
to
remain
dominant
face
mounting
immunity
from
previous
infection
vaccination,
lineage
evolved
into
various
sub-lineages
acquiring
several
mutations
known
confer
adaptive
advantage
pathogenic
properties.
These
results
highlight
value
continuous
surveillance
regions
where
VOCs
are
not
predominant
enforcement
public
health
measures
prevent
expansion
existing
lineages.
Behavioral Sciences,
Journal Year:
2024,
Volume and Issue:
14(5), P. 351 - 351
Published: April 23, 2024
Background:
In
2020,
healthcare
providers
were
expected
to
provide
care
individuals
with
coronavirus
disease
2019
(COVID-19),
putting
them
at
risk
of
acquiring
COVID-19.
The
possibility
poorly
understood
infectious
diseases
while
providing
may
have
an
impact
on
the
mental
health
providers.
We
conducted
a
study
explore
effects
COVID-19
Methods:
Between
April
and
August
2021,
we
in-depth
interviews
60
in
unit
(IDU)
other
units
hospital
(non-IDU).
completed
online
self-administered
survey
form
demographic
data
(age,
sex,
average
income,
known
contact
patient).
used
semi-structured
interview
guides
understand
providers’
lived
experiences
stress,
anxiety,
depression,
their
associated
factors.
transcribed
verbatim
coded
analyzed
transcripts
derive
thematic
concepts
related
experiences.
Results:
had
median
age
37
years
[IQR
20.0–58.0],
56.7%
female,
30.0%
nurses,
18.3%
medical
doctors,
11.7%
laboratory
technologists.
reported
increased
stress
during
pandemic,
attributed
high
demand
for
patient
care,
changes
social
life,
fear
infection.
They
also
anxiety
depression
as
result
limited
knowledge
beginning
pandemic
perception
that
“COVID-19
resulted
death”.
Testing
positive
COVID-19,
exposure
risks,
death
patients
colleagues
reportedly
affected
health.
Additionally,
support
through
debriefing
meetings,
peer-to-peer
support,
psychological
counseling,
privacy
confidentiality
concerns.
Conclusions:
Healthcare
faced
issues
such
taking
patients.
An
effective
response
requires
institutional
practices
address
context-specific
challenges
confidentiality.
Vaccines,
Journal Year:
2024,
Volume and Issue:
12(5), P. 514 - 514
Published: May 9, 2024
Coronavirus
disease
2019
(COVID-19)
is
a
highly
contagious
zoonotic
respiratory
with
many
similarities
to
influenza.
Effective
vaccines
are
available
for
both;
however,
rapid
viral
evolution
and
waning
immunity
make
them
virtually
impossible
eradicate
vaccines.
Thus,
the
practical
goal
of
vaccination
reduce
incidence
serious
illnesses
death.
Three
years
after
introduction
COVID-19
vaccines,
optimal
strategy
in
endemic
period
remains
elusive,
health
authorities
worldwide
have
begun
adopt
various
approaches.
Herein,
we
propose
based
on
data
until
early
2024
discuss
aspects
that
require
further
clarification
better
decision
making.
Drawing
from
comparisons
between
influenza
strategies,
our
proposed
prioritizes
high-risk
groups,
emphasizes
seasonal
administration
aligned
campaigns,
advocates
co-administration
increase
coverage.