Evaluation of circulating insulin-like growth factor-1, heart-type fatty acid-binding protein, and endotrophin levels as prognostic markers of COVID-19 infection severity DOI Creative Commons
Amal Ahmed Mohamed,

Aya A. Nour,

Noha M. Mosbah

et al.

Virology Journal, Journal Year: 2023, Volume and Issue: 20(1)

Published: May 15, 2023

Coronavirus Disease 2019 (COVID-19) is a worldwide pandemic challenge spreading enormously within few months. COVID-19 characterized by the over-activation of immune system causing cytokine storm. Insulin-like growth factor-1 (IGF-1) pathway can regulate response via interaction with various implicated cytokines. Heart-type fatty acid-binding protein (H-FABP) has been shown to promote inflammation. Given fact that coronavirus infections induce cytokines secretion leading inflammatory lung injury, it suggested H-FABP levels are affected severity. Moreover, endotrophin (ETP), cleavage product collagen VI, may be an indicator overactive repair process and fibrosis, considering viral infection predispose or exacerbate existing respiratory conditions, including pulmonary fibrosis. This study aims assess prognostic capacity circulating IGF-1, HFABP, ETP, for severity progression in Egyptian patients.The cohort included 107 RNA-positive patients equivalent number control individuals no clinical signs infection. Clinical assessments profiling CBC; serum iron; liver kidney functions; markers. Circulating IGF-1; H-FABP, ETP were estimated using corresponding ELISA kits.No statistical difference body mass index was detected between healthy groups, while mean age infected significantly higher (P = 0.0162) than control. Patients generally showed elevated markers CRP ESR concomitant ferritin; D dimer procalcitonin levels, besides characteristic lymphopenia hypoxemia also frequent. Logistic regression analysis revealed oxygen saturation; predict < 0.001 each). Both IGF-1 as well O2 saturation remarkable potentials terms large AUC values, high sensitivity/specificity wide confidence interval. The calculated threshold prognosis 25.5 ng/mL; 19.5 ng/mL, 94.5, % respectively. thresholds positive negative value ranges 79-91% 72-97%; respectively, 66-95%, 83-94% sensitivity, specificity; respectively.The cut-off values represent promising non-invasive tool would facilitate risk stratification patients, morbidity/mortality associated progressive

Language: Английский

Home design features post-COVID-19 DOI Creative Commons
Nancy H. Alhadedy, Hisham S. Gabr

Journal of Engineering and Applied Science, Journal Year: 2022, Volume and Issue: 69(1)

Published: Sept. 30, 2022

Abstract The long stay at home during the COVID-19 pandemic implied that most people had to perform all their daily activities home. That raised need for special features related health, safety, and well-being of residents. This study aimed explore essential design measure perception importance by Cairenes (Egypt) construction industry experts further implementation in future as part buyers’ preferences house quality features. employed an exploratory survey, identifying eight features, followed a quantitative questionnaire each feature among stakeholders. results showed indicators were certain degree importance. It was found availability natural ventilation light private outdoor space, such terrace with good-looking view or garden, least one bedroom enclosed bathroom isolation needs. In contrast, extra storage space food supplies, well indoor family entertainment reported important.

Language: Английский

Citations

11

Seroprevalence of COVID-19 infection in a densely populated district in the eastern Democratic Republic of Congo DOI Creative Commons
Léonid M. Irenge,

Homer M. Bulakali,

Arthur Irenge Akonkwa

et al.

Epidemiology and Infection, Journal Year: 2023, Volume and Issue: 151

Published: Jan. 1, 2023

Data on coronavirus disease 2019 (COVID-19) prevalence in the Democratic Republic of Congo are scarce. We conducted a cross-sectional study to determine seroprevalence antibodies against anti-severe acute respiratory syndrome 2 (SARS-CoV-2) slum Kadutu, city Bukavu, between June and September 2021. The survey participants were all unvaccinated SARS-CoV-2. crude rate was adjusted known characteristics assay. Participants aged 15-49 years old made up 80% population enrolled (n = 507; 319 women 188 men). overall rates for COVID-19 59.7% (95% CI 55.4-63.9%) 84.0% 76.2-92.4%), respectively. This indicates widespread dissemination SARS-CoV-2 these communities. symptoms either absent or mild more than half with none required hospitalisation. These results suggest that spread did not appear be associated severe settlements many cases went unreported densely populated locations. relevance vaccination communities should thoroughly investigated.

Language: Английский

Citations

6

SARS-CoV-2 Genetic Diversity and Lineage Dynamics in Egypt during the First 18 Months of the Pandemic DOI Creative Commons
Wael H. Roshdy, Mohamed K. Khalifa, James Emmanuel San

et al.

Viruses, Journal Year: 2022, Volume and Issue: 14(9), P. 1878 - 1878

Published: Aug. 25, 2022

COVID-19 was first diagnosed in Egypt on 14 February 2020. By the end of November 2021, over 333,840 cases and 18,832 deaths had been reported. As part national genomic surveillance, 1027 SARS-CoV-2 near whole-genomes were generated published by July 2021. Here we describe epidemiology this period using a subset 976 high-quality Egyptian genomes analyzed together with representative set global sequences within phylogenetic framework. A single lineage, C.36, introduced early pandemic responsible for most Egypt. Furthermore, to remain dominant face mounting immunity from previous infections vaccinations, lineage acquired several mutations known confer an adaptive advantage. These results highlight value continuous surveillance regions where VOCs are not predominant need enforcement public health measures prevent expansion existing lineages.

Language: Английский

Citations

9

The Impact of COVID-19 on Physical (In)Activity Behavior in 10 Arab Countries DOI Open Access
Haleama Al Sabbah, Zainab Taha, Radwan Qasrawi

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(17), P. 10832 - 10832

Published: Aug. 31, 2022

Insufficient physical activity is considered a strong risk factor associated with non-communicable diseases. This study aimed to assess the impact of COVID-19 on (in)activity behavior in 10 Arab countries before and during lockdown. A cross-sectional using validated online survey was launched originally 38 different countries. The Eastern Mediterranean regional data related Arabic that participated were selected for analysis this study. total 12,433 participants included analysis. mean age 30.3 (SD, 11.7) years. Descriptive regression analyses conducted examine associations between levels participants’ sociodemographic characteristics, watching TV, screen time, computer usage. Physical decreased significantly Participants’ country origin, gender, education lockdown (p < 0.050). Older age, computers had negative effect Strategies improve minimize sedentary should be implemented, as well reduce unhealthy inactive especially times crisis. Further research influence lack overall health status, disease recommended.

Language: Английский

Citations

8

Exploring COVID-19 pandemic potential impacts on students’ school travel behavior DOI
Mohamed Abouelela, Mohamed Samir, Constantinos Antoniou

et al.

Transportation Letters, Journal Year: 2023, Volume and Issue: 16(3), P. 291 - 305

Published: March 8, 2023

ABSTRACTABSTRACTThis study aims to identify the impacts of COVID-19 pandemic on school trips using a survey 1120 students and their households in Cairo, Egypt. We found that students' age, distance school, type (public or private) influence mode used majority parents would prefer wait for one month more after lockdown before sending children has significant impact parents' evaluation various schooling options. Based responses different scenarios, we predicted original vehicle-kilometers-traveled increase by 17% 34%, with most expected modal shift occurring from large occupancy vehicles smaller vehicles. This was attributed to; father's occupation education level, waiting time send expecting reduced class capacity. KEYWORDS: COVID-19school tripsstudents’ travel behaviormode choiceEgypt AcknowledgmentsThis supported German Federal Ministry Education Research, Bundesministerium für Bildung und Forschung (bmbf), project FuturTrans: Indo-German Collaborative Research Center Intelligent Transportation Systems. Gemeinsames Indisch-Deutsches Forschungszentrum Intelligente Verkehrssysteme DAAD Project number 57474280 Verkehr-SuTra: Technologies Sustainable Transportation, within Programme: A New Passage India — Deutsch-Indische Hochschulkooperationen ab 2019.Disclosure statementNo potential conflict interest reported author(s).AbbreviationVKT: Vehicle-Kilometers-Traveled; WHO:World Health Organization; EFA:Explanatory Factor Analysis; ICLV: Integrated Choice Latent Models; PT: Public Transportation; PAX: Passenger; PCE: Passenger Car Equivalent.Data availability statementThe data is available collaborations further research projects; please get touch corresponding author review request. The contains individual information cannot be publicly shared.

Language: Английский

Citations

4

Correlation between rs7041 and rs4588 polymorphisms in vitamin D binding protein gene and COVID-19-related severity and mortality DOI Creative Commons
Ehab Hamed,

Shaymaa Abdelraheem Abdelhady,

Shimaa A. Al-Touny

et al.

BMC Medical Genomics, Journal Year: 2024, Volume and Issue: 17(1)

Published: Dec. 2, 2024

The vitamin D binding protein (DBP) plays a critical role in both innate and adaptive immune systems, participating several clinical conditions, including coronavirus disease 2019 infection severity, mortality rate. study aimed to investigate the correlation between rs7041 rs4588 polymorphisms DBP gene Coronavirus Disease-2019 (COVID-19) severity mortality, patients of Suez Canal University Hospitals Ismailia, Egypt. A case-control enrolled 220 individuals; 140 COVID-19 80 healthy controls. Serum 25(OH) levels were determined by enzyme-linked immunosorbent assay (ELISA), genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). found that groups had deficiency, which was considerably lower group compared Among patients, there significant difference according indicating can be used as predictors severity. Negative correlations genetic variants CA genotype TT prevalence (p = 0.006 0.009 respectively) proved. No all > 0.05). Positive TG 0.029 0.031 respectively). deficiency increased COVID-19. correlated with mortality.

Language: Английский

Citations

1

SARS-CoV-2 Genetic diversity and lineage dynamics of in Egypt DOI Open Access
Wael H. Roshdy, Mohamed K. Khalifa, James Emmanuel San

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Jan. 5, 2022

Abstract COVID-19 was first diagnosed in Egypt on 14 February 2020. By the end of November 2021, over 333,840 cases and 18,832 deaths had been reported. As part national genomic surveillance, 1,027 SARS-CoV-2 near whole-genomes generated published by May 2021. Here we describe epidemiology this period using a subset 976 high-quality Egyptian genomes analysed together with representative set global sequences within phylogenetic framework. We show that single lineage, C.36, introduced early pandemic responsible for most Egypt. Furthermore, to remain dominant face mounting immunity from previous infection vaccination, lineage evolved into various sub-lineages acquiring several mutations known confer adaptive advantage pathogenic properties. These results highlight value continuous surveillance regions where VOCs are not predominant enforcement public health measures prevent expansion existing lineages.

Language: Английский

Citations

7

The Effects of the COVID-19 Pandemic on Healthcare Providers’ Mental Health: Experiences at Kenyatta National Hospital, Kenya DOI Creative Commons
Vallery Ogello, Nicholas Thuo,

Phelix Okello

et al.

Behavioral Sciences, Journal Year: 2024, Volume and Issue: 14(5), P. 351 - 351

Published: April 23, 2024

Background: In 2020, healthcare providers were expected to provide care individuals with coronavirus disease 2019 (COVID-19), putting them at risk of acquiring COVID-19. The possibility poorly understood infectious diseases while providing may have an impact on the mental health providers. We conducted a study explore effects COVID-19 Methods: Between April and August 2021, we in-depth interviews 60 in unit (IDU) other units hospital (non-IDU). completed online self-administered survey form demographic data (age, sex, average income, known contact patient). used semi-structured interview guides understand providers’ lived experiences stress, anxiety, depression, their associated factors. transcribed verbatim coded analyzed transcripts derive thematic concepts related experiences. Results: had median age 37 years [IQR 20.0–58.0], 56.7% female, 30.0% nurses, 18.3% medical doctors, 11.7% laboratory technologists. reported increased stress during pandemic, attributed high demand for patient care, changes social life, fear infection. They also anxiety depression as result limited knowledge beginning pandemic perception that “COVID-19 resulted death”. Testing positive COVID-19, exposure risks, death patients colleagues reportedly affected health. Additionally, support through debriefing meetings, peer-to-peer support, psychological counseling, privacy confidentiality concerns. Conclusions: Healthcare faced issues such taking patients. An effective response requires institutional practices address context-specific challenges confidentiality.

Language: Английский

Citations

1

COVID-19 Vaccination Strategies in the Endemic Period: Lessons from Influenza DOI Creative Commons
Eliel Nham, Ji Yun Noh,

Ok Hyun Park

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(5), P. 514 - 514

Published: May 9, 2024

Coronavirus disease 2019 (COVID-19) is a highly contagious zoonotic respiratory with many similarities to influenza. Effective vaccines are available for both; however, rapid viral evolution and waning immunity make them virtually impossible eradicate vaccines. Thus, the practical goal of vaccination reduce incidence serious illnesses death. Three years after introduction COVID-19 vaccines, optimal strategy in endemic period remains elusive, health authorities worldwide have begun adopt various approaches. Herein, we propose based on data until early 2024 discuss aspects that require further clarification better decision making. Drawing from comparisons between influenza strategies, our proposed prioritizes high-risk groups, emphasizes seasonal administration aligned campaigns, advocates co-administration increase coverage.

Language: Английский

Citations

1

Alternations in miR-155 and miR-200 serum levels can serve as biomarkers for COVID-19 in the post-mass vaccination era DOI
Aliaa Aboulela, M. Y. M. Taha, Abeer Ghazal

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: May 25, 2024

Language: Английский

Citations

1