Endocrine, Journal Year: 2022, Volume and Issue: 78(2), P. 247 - 254
Published: July 20, 2022
Language: Английский
International Journal of Biological Sciences, Journal Year: 2022, Volume and Issue: 18(12), P. 4768 - 4780
Published: Jan. 1, 2022
The pandemic of COVID-19 is the biggest public health crisis in 21
Language: Английский
Citations
219
BMJ, Journal Year: 2022, Volume and Issue: unknown, P. e071230 - e071230
Published: Sept. 7, 2022
To determine the effect of population level implementation a test-and-treat approach to correction suboptimal vitamin D status (25-hydroxyvitamin (25(OH)D) <75 nmol/L) on risk all cause acute respiratory tract infection and covid 19.Phase 3 open label randomised controlled trial.United Kingdom.6200 people aged ≥16 years who were not taking supplements at baseline.Offer postal finger prick test blood 25(OH)D concentration with provision six month supply lower dose (800 IU/day, n=1550) or higher (3200 those nmol/L, compared no offer testing supplementation (n=3100). Follow-up was for months.The primary outcome proportion participants least one swab doctor confirmed any cause. A secondary covid-19. Logistic regression used calculate odds ratios associated 95% confidence intervals. The analysis conducted by intention treat.Of 3100 offered test, 2958 (95.4%) accepted 2674 (86.3%) had concentrations nmol/L received (n=1328 dose, n=1346 dose). Compared 136/2949 (4.6%) in group, occurred 87/1515 (5.7%) group (odds ratio 1.26, interval 0.96 1.66) 76/1515 (5.0%) (1.09, 0.82 1.46). 78/2949 (2.6%) 55/1515 (3.6%) developed covid-19 (1.39, 0.98 1.97) 45/1515 (3.0%) (1.13, 0.78 1.63).Among 16 older high baseline prevalence status, reduction covid-19.ClinicalTrials.gov NCT04579640.
Language: Английский
Citations
93
Archives of Medical Research, Journal Year: 2022, Volume and Issue: 53(4), P. 423 - 430
Published: April 18, 2022
Language: Английский
Citations
85
The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 108(10), P. e1106 - e1116
Published: April 13, 2023
Long COVID is an emerging syndrome affecting 50% to 70% of COVID-19 survivors that still lacks predicting factors.Due the extraskeletal effects vitamin D, we retrospectively assessed association between 25(OH) D levels and long in 6 months after hospitalization.Long was defined according NICE guidelines. Fifty 50 non-long-COVID subjects matched on a 1:1 basis were enrolled from outpatient clinic post-COVID cohort seen August November 2020. Therapies/comorbidities calcium/vitamin D/bone metabolism, and/or admission intensive care unit during hospitalization exclusion criteria. Vitamin measured at hospital discharge.We observed lower levels, evaluated follow-up, with than those without (20.1 vs 23.2 ng/mL, P = .03). Regarding affected health areas entire cohort, neurocognitive symptoms follow-up (n 7) 93) (14.6 20.6 .042). In patients presenting deficiency (<20 ng/mL), both 42), by 22) presented not 20) (12.7 15.2 .041). multiple regression analyses, only variable significantly associated our (P .008, OR 1.09, CI 1.01-1.16).COVID-19 have COVID. Our data suggest should be discharge. The role supplementation as preventive strategy sequelae tested randomized controlled trials.
Language: Английский
Citations
65
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(1), P. 130 - 130
Published: Jan. 16, 2023
Background: The COVID-19 pandemic represents one of the world’s most important challenges for global public healthcare. Various studies have found an association between severe vitamin D deficiency and COVID-19-related outcomes. Vitamin plays a crucial role in immune function inflammation. Recent data suggested protective health purpose this meta-analysis trial sequential analysis (TSA) was to better explain strength supplementation risk mortality admission intensive care units (ICUs) patients with COVID-19. Methods: We searched four databases on 20 September 2022. Two reviewers screened randomized clinical trials (RCTs) assessed bias, independently duplicate. pre-specified outcomes interest were ICU admission. Results: identified 78 bibliographic citations. After reviewers’ screening, only five RCTs be suitable our analysis. performed meta-analyses then TSAs. administration results decreased death (standardized mean difference (95% CI): 0.49 (0.34–0.72) 0.28 (0.20–0.39), respectively). TSA showed that, since pooling reached definite sample size, positive is conclusive. that z-curve inside alpha boundaries, indicating need further studies. Discussion: respective TSAs suggest definitive hospitalization.
Language: Английский
Citations
59
Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)
Published: Nov. 12, 2022
Abstract Vitamin D deficiency has long been associated with reduced immune function that can lead to viral infection. Several studies have shown is increases the risk of infection COVID-19. However, it unknown if treatment reduce COVID-19 infection, which focus this study. In population US veterans, we show 2 and 3 fills were reductions in 28% 20%, respectively [(D Hazard Ratio (HR) = 0.80, [95% CI 0.77, 0.83]), HR 0.72, 0.65, 0.79]]. Mortality within 30-days was similarly 33% lower 25% (D 0.67, 0.59, 0.75]; 0.75, 0.55, 1.04]). We also find after controlling for vitamin blood levels, veterans receiving higher dosages obtained greater benefits from supplementation than dosages. Veterans levels between 0 19 ng/ml exhibited largest decrease following supplementation. Black received White veterans. As a safe, widely available, affordable treatment, may help severity pandemic.
Language: Английский
Citations
63
Endocrine, Journal Year: 2023, Volume and Issue: 80(3), P. 669 - 683
Published: March 1, 2023
Language: Английский
Citations
35
Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 150, P. 112965 - 112965
Published: April 14, 2022
Main cause of severe illness and death in COVID-19 patients appears to be an excessive but ineffectual inflammatory immune response that may acute respiratory distress syndrome (ARDS). Vitamin D favour anti-inflammatory environment improve cytotoxic against some infectious diseases. A multicenter, single-blind, prospective, randomized clinical trial was approved with pneumonia levels 25-hydroxyvitamin (25(OH)D) 14.8 ng/ml (SD: 6.18) test antiviral efficacy, tolerance safety 10,000 IU/day cholecalciferol (vitamin
Language: Английский
Citations
38
Foods, Journal Year: 2022, Volume and Issue: 11(18), P. 2884 - 2884
Published: Sept. 17, 2022
The beginning of the end or beginning? After two years mastered by coronavirus disease 19 (COVID-19) pandemic, we are now witnessing a turnaround. reduction severe cases and deaths from COVID-19 led to increasing importance new called post-COVID syndrome. term is used indicate permanency symptoms in patients who have recovered acute respiratory syndrome 2 (SARS-CoV-2) infection. Immune, antiviral, antimicrobial therapies, as well ozone therapy been treat disease. Vaccines then become available administered worldwide prevent insurgence However, pandemic not over yet at all given emergence omicron variants. New therapeutic strategies urgently needed. In this view, great interest was found nutraceutical products, including vitamins (C, D, E), minerals (zinc), melatonin, probiotics, flavonoids (quercetin), curcumin. This review summarizes role nutraceuticals prevention and/or treatment
Language: Английский
Citations
36
Clinics in Geriatric Medicine, Journal Year: 2022, Volume and Issue: 38(3), P. 565 - 591
Published: June 20, 2022
Language: Английский
Citations
35