Healthy Lifestyle and Cancer Risk: Modifiable Risk Factors to Prevent Cancer

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 800 - 800

Published: March 11, 2024

Cancer has become a serious problem worldwide, as it represents the main cause of death, and its incidence increased over years. A potential strategy to counter growing spread various forms cancer is adoption prevention strategies, in particular, use healthy lifestyles, such maintaining weight, following diet; being physically active; avoiding smoking, alcohol consumption, sun exposure; vitamin D supplementation. These modifiable risk factors are associated with this disease, contributing development, progression, severity. This review evaluates relationship between potentially overall specifically breast, colorectal, prostate cancer, highlights updated recommendations on prevention. The results numerous clinical epidemiological studies clearly show influence lifestyles development cancer. An incorrect diet, composed mainly saturated fats processed products, resulting body combined physical inactivity, induced an increase all three types under study. Given importance adopting correct prevent global institutions should develop strategies environments that encourage individuals adopt regular behaviors.

Language: Английский

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Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: March 11, 2024

Abstract Diet, serving as a vital source of nutrients, exerts profound influence on human health and disease progression. Recently, dietary interventions have emerged promising adjunctive treatment strategies not only for cancer but also neurodegenerative diseases, autoimmune cardiovascular metabolic disorders. These demonstrated substantial potential in modulating metabolism, trajectory, therapeutic responses. Metabolic reprogramming is hallmark malignant progression, deeper understanding this phenomenon tumors its effects immune regulation significant challenge that impedes eradication. Dietary intake, key environmental factor, can tumor metabolism. Emerging evidence indicates might affect the nutrient availability tumors, thereby increasing efficacy treatments. However, intricate interplay between pathogenesis other diseases complex. Despite encouraging results, mechanisms underlying diet-based remain largely unexplored, often resulting underutilization management. In review, we aim to illuminate various interventions, including calorie restriction, fasting-mimicking diet, ketogenic protein restriction high-salt high-fat high-fiber aforementioned diseases. We explore multifaceted impacts these encompassing their immunomodulatory effects, biological impacts, molecular mechanisms. This review offers valuable insights into application therapies

Language: Английский

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A deep learning architecture with an object-detection algorithm and a convolutional neural network for breast mass detection and visualization

Healthcare Analytics, Journal Year: 2023, Volume and Issue: 3, P. 100186 - 100186

Published: April 29, 2023

This study presents an integrated deep learning architecture with object-detection algorithm and a convolutional neural network (CNN) for breast mass detection visualization. Mammograms are analyzed to identify localize lesions aid clinician review. Two complementary forms of used the regions interest (ROIs). An algorithm, YOLO v5, analyzes entire mammogram discrete image likely represent masses. Object detections exhibit high precision, but stage alone has insufficient overall accuracy clinical application. A CNN independently after it been decomposed into subregion tiles is trained emphasize sensitivity (recall). The ROIs identified by each analysis highlighted in different colors facilitate efficient staged nearly always detects tumor masses when present typically occupies larger area image. By inspecting high-precision followed high-sensitivity regions, clinicians can quickly before completing review full mammogram. On average, occupy less than 20% tissue mammograms, even without removing pectoral muscle from analysis. As result, proposed system helps mammograms greater efficiency.

Language: Английский

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Nutrition Intervention and Microbiome Modulation in the Management of Breast Cancer

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2644 - 2644

Published: Aug. 10, 2024

Breast cancer (BC) is one of the most common cancers worldwide and a leading cause cancer-related deaths among women. The escalating incidence BC underscores necessity multi-level treatment. complex heterogeneous disease involving many genetic, lifestyle, environmental factors. Growing evidence suggests that nutrition intervention an evolving effective prevention treatment strategy for BC. In addition, human microbiota, particularly gut now widely recognized as significant player contributing to health or status. It also associated with risk development This review will focus on in BC, including dietary patterns, bioactive compounds, nutrients affect therapeutic responses both animal studies. Additionally, this paper examines impacts these interventions modulating composition functionality microbiome, highlighting microbiome-mediated mechanisms combination factors microbes discussed. Insights from emphasize comprehensive management focuses nutrition–microbiome axis.

Language: Английский

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The Association Between Physical Activity and Risk for Breast Cancer in US Female Adults: A Cross-sectional Study Based on NHANES 2011-2020

European Journal of Surgical Oncology, Journal Year: 2024, Volume and Issue: 50(12), P. 108647 - 108647

Published: Aug. 29, 2024

Breast cancer poses a significant threat to women's health worldwide. This study aimed evaluate the association between various levels of physical activity and incidence breast cancer.

Language: Английский

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Identifying the effective behaviour change techniques in nutrition and physical activity interventions for the treatment of overweight/obesity in post-treatment breast cancer survivors: a systematic review

Cancer Causes & Control, Journal Year: 2023, Volume and Issue: 34(8), P. 683 - 703

Published: May 6, 2023

Abstract Purpose Updated evidence for the treatment of obesity in cancer survivors includes behavioural lifestyle interventions underpinning at least one theoretical framework. The aim this systematic review was to assess effectiveness theory-based overweight/obesity breast and report effective change techniques (BCTs) components used these interventions. Methods Four databases were searched RCTs published between database inception July 2022. search strategy included MeSH terms text words, using PICO-framework guide eligibility criteria. PRISMA guidelines followed. Risk-of-bias, TIDier Checklist interventions’ content, extent behaviour theories application assessed. To evaluate interventions, trials categorised as “very,” “quite,” or “non” promising according their potential reduce body weight, BCTs promise ratios calculated within decrease weight. Results Eleven met inclusion Seven classified “very”, three “quite” study promising. Studies’ size, design, intervention strategies varied greatly, but weight-loss goal all studies ≥ 5% initial weight through a 500–1000 kcal/day energy deficit gradually increased exercise 30 min/day. Social Cognitive Theory most commonly theory ( n = 10). ranged from 10 23 setting, self-monitoring, instructions on behaviour, credible source. risk-of-bias “moderate” eight “high” three. Conclusion present identified nutrition physical activity that may be beneficial survivors. mentioned, addition reported models BCTs, should considered when developing

Language: Английский

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Research Progress on Host-Related Factors Affecting Breast Cancer Recurrence

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(03), P. 192 - 199

Published: Jan. 1, 2025

Language: Английский

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Breast Cancer Stem Cells and Tumor Heterogeneity: Characteristics and Therapeutic Strategies

Cancers, Journal Year: 2024, Volume and Issue: 16(13), P. 2481 - 2481

Published: July 7, 2024

Breast cancer is one of the most frequently detected malignancies worldwide. It responsible for more than 15% all death cases caused by in women. a heterogeneous disease representing various histological types, molecular characteristics, and clinical profiles. However, breast cancers are organized hierarchy cell populations, with small proportion stem cells (breast (BCSCs)) playing putative role progression, they therapeutic failure. In different subtypes cancer, present specific marker profiles, prognoses, treatments. Recent efforts have focused on tackling Wnt, Notch, Hedgehog, PI3K/Akt/mTOR, HER2 signaling pathways. Developing diagnostics strategies enables efficient elimination tumor mass together population. Thus, knowledge about appropriate methods targeting both “normal” subpopulations crucial success elimination.

Language: Английский

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Breast cancer status, grading system, etiology, and challenges in Asia: an updated review

ONCOLOGIE, Journal Year: 2023, Volume and Issue: 25(2), P. 99 - 110

Published: March 1, 2023

Abstract The number of breast cancer incidences reported worldwide has increased tremendously over the years. Scoping down to Asia, in 2020, are appalling, comprising 1,026,171 cases, occupying up 45.4% cases across globe. Breast is a non-communicable disease, that emerges variegated forms, self-subsistent, and etiology observed be multifactorial, dependent on individual reproductive pattern, hormonal factors, diet, physical activity, lifestyle, exposure certain advent procedures. Given this complexity, expected undergo persistent increment near future, exacerbating public health quality, regardless race, ethnicity, geographical subgroups, socioeconomic. In review article, authors examine multiple facets, updated statistics cancer, typically Asia; cancer; diagnosis grading system; challenges from country’s income perspective. Realizing ever-increasing demand for quality treatment, here, article also contemplates common therapies such as breast-conserving therapy, mastectomy, postmastectomy radiation neoadjuvant chemotherapy, axillary surgery, adjuvant medical therapies, biological targeted endocrine therapy. This intended provide brief yet broad panoramic view readers, ranging newcomers, existing researchers, relevant stakeholders topic interest.

Language: Английский

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Host-Related Factors in the Interplay among Inflammation, Immunity and Dormancy in Breast Cancer Recurrence and Prognosis: An Overview for Clinicians

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4974 - 4974

Published: March 4, 2023

A significant proportion of patients treated for early breast cancer develop medium-term and late distant recurrence. The delayed manifestation metastatic disease is defined as “dormancy”. This model describes the aspects clinical latency isolated cells. Dormancy regulated by extremely complex interactions between disseminated cells microenvironment where they reside, latter in turn influenced directly host. Among these entangled mechanisms, inflammation immunity may play leading roles. review divided into two parts: first biological underpinnings dormancy role immune response, particular, cancer; second provides an overview host-related factors that influence systemic subsequently impacting dynamics dormancy. aim this to provide physicians medical oncologists a useful tool understand implications relevant topic.

Language: Английский

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