Calcipotriol Attenuates Form Deprivation Myopia Through a Signaling Pathway Parallel to TGF-β2–Induced Increases in Collagen Expression

Investigative Ophthalmology & Visual Science, Journal Year: 2023, Volume and Issue: 64(2), P. 2 - 2

Published: Feb. 1, 2023

Purpose: To determine the role of calcipotriol, a vitamin D3 analogue, in myopia development and altering expression scleral α1 chain type I collagen (Col1α1) mice. We also aimed to identify if signaling pathway mediating above changes is different from one involved transforming growth factor β2 (TGF-β2)–mediated increases COL1A1 cultured human fibroblasts (HSFs). Methods: C57BL/6J mice were either intraperitoneally injected with calcipotriol subjected form deprivation (FD) or exposed normal refractive for 4 weeks. Scleral D receptor (Vdr) was knocked down using Sub-Tenon's capsule injection an adeno-associated virus–packaged short hairpin RNA (AAV8-shRNA). Refraction biometric measurements evaluated development. A combination knockdown induction strategies determined relative contributions TGF-β2 pathways modulating HSFs. Results: Calcipotriol injections suppressed FD-induced (FDM), but it had no significant effect on AAV8-shRNA reduced Vdr mRNA by 42% shifted refraction toward (−3.15 ± 0.99D, means SEM) eyes. In HSFs, VDR calcipotriol-induced rises expression, did not alter TGF-β2–induced expression. Additionally, augmented TGF-β (TGFBRI/II) blunted whereas levels unaltered. Conclusions: inhibits mice, potentially activating VDR-dependent increasing levels.

Language: Английский

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Social Media Impact of Myopia Research

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(12), P. 7270 - 7270

Published: June 14, 2022

Myopia has become a public health issue worldwide. The fast increase in myopia prevalence the last years been accompanied by an information through social and conventional media. This led to fight not only against pandemic but also infodemic. excess of made it increasingly difficult for professionals identify high-quality articles. Alternative Metrics are useful tools publications that provoke attention society. research aims study impact on had media.Almetric Explorer was used make search using "myopia" as keyword. 100 outputs with highest were analyzed correlated number cites Web Science Spearman's correlation coefficient.The top Altmetric Attention Score published 47 journals mean value 437.61 ± 718.33. mostly discussed Twitter, 296.36 1585.58 tweets retweets, 185.18 211.57 readers Mendeley. There low between Cites top-100 outputs.although is topic high interest society, most cited articles those researchers should more effort promoting their goals, media tool share them.

Language: Английский

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Comparisons of objective and subjective refraction with and without cycloplegia using binocular wavefront optometer with autorefraction and retinoscopy in school-age children

Graefe s Archive for Clinical and Experimental Ophthalmology, Journal Year: 2022, Volume and Issue: 261(5), P. 1465 - 1472

Published: Dec. 17, 2022

To compare school-age children's objective and subjective refraction using a binocular wavefront optometer (BWFOM) with autorefraction retinoscopy before after cycloplegia.Eighty-six eyes from 86 children (6-15 years old) were enrolled in this cross-sectional study. BWFOM refractions compared under cycloplegia. was evaluated Measurements paired t-test; agreement assessed Bland-Altman plots.Under cycloplegia, the sphere, spherical equivalence, J45 significantly more negative on than (- 1.39 ± 2.20 D vs. - 1.28 2.23 D, P = 0.003; 1.84 2.38 1.72 2.43 0.001; 0.02 0.17 0.03 0.21 0.004). The sphere of less myopic, cylinder those 1.17 2.09 1.25 0.02; 0.91 0.92 0.76 < 0.01 0.15 0.028). For both refraction, equivalence noncycloplegia myopic cycloplegia (objective: 1.76 2.10 2.21 2.30 subjective: 1.57 1.92 2.01 2.13 1.62 2.27 0.001). plots showed good between (mean difference 0.12 95% confidence interval [CI] 0.52 to 0.76), CI 0.65 0.64), or without mean 0.37 1.31 0.57; 0.39 1.30 0.51). time cost by total (264.88 90.67 s 315.89 95.31 s, 0.001).BWFOM is new device that realizes refraction. refractive errors, it convenient quicker obtain proper prescription at 0.05-D interval, accurate

Language: Английский

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Epidemiologie der Myopie: Prävalenz, Risikofaktoren und Auswirkungen der Myopie

Klinische Monatsblätter für Augenheilkunde, Journal Year: 2024, Volume and Issue: 241(10), P. 1119 - 1125

Published: Oct. 1, 2024

Myopia is the most common cause of visual impairment in children and young adults. In order to assess consequences for society, it necessary know temporal trends prevalence, incidence associated factors childhood adolescence, as well rate myopia progression, based on epidemiological research. This paper presents a literature review publications from 2020 up March 2024, supplemented by other relevant publications. The prevalence adolescents Germany almost stable significantly lower than Asia. development influenced outdoor activity, parental myopia, genetics near work, while insufficient time spent outdoors significant controllable risk factor myopia-related complications such myopic maculopathy, glaucoma, retinal detachment.

Language: Английский

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Global research dynamics in the Mediterranean diet and diabetes mellitus: a bibliometric study from 2014 to 2024

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 14, 2024

Objective The Mediterranean diet (MedDiet) has been found to have benefits for diabetes mellitus (DM), but a bibliometric analysis of its association with DM yet be conducted. This paper aims explore the current status and research hotspots on connection between from 2014 2024, providing reference future studies. Methods We retrieved articles published 2024 Web Science database analyzed them using R software, VOSviewer, CiteSpace. Results A total 2,806 were included in this study. Research relationship MedDiet showed steady increase publication volume 2019, followed by sharp rise 2020 2023. Spain was leading country terms volume, Italy, United States, China, Greece. also led international collaborations, CIBER—Centro de Investigación Biomédica en Red Harvard University being most prominent collaboration centers. Nutrients frequently cited journal field. Common keywords literature components such as olive oil, legumes, red wine. Mechanisms studied field primarily focused antioxidant effects, improvements insulin sensitivity secretion, regulation lipid metabolism, modulation gut microbiota. Conclusion beneficial effects patients garnered significant attention researchers worldwide, it is expected become major focus prevention treatment. study provides comprehensive regarding DM, offering valuable references research.

Language: Английский

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Refractive surgery for the glaucoma suspect

Current Opinion in Ophthalmology, Journal Year: 2023, Volume and Issue: 34(4), P. 290 - 295

Published: March 29, 2023

Purpose of review The aim this study was to provide an update on perioperative considerations in the evaluation and management patients undergoing primary corneal intraocular refractive procedures who are at risk for progressive glaucomatous optic neuropathy. Recent findings necessity a comprehensive baseline assessment prior with structural functional testing, along documentation preoperative pressure (IOP) measurements, is highlighted recent literature. Substantiation increased postoperative IOP elevation keratorefractive higher lower CCT, but not necessarily degree myopia, has been variably evidenced. Tonometry methods which less influenced by change should be considered procedures. Vigilence monitoring neuropathy suggested given evidence steroid-response glaucoma these patients. Additional IOP-lowering impact cataract surgery provided, irrespective lens choice. Summary Performing remains controversial. Definitive steps optimize patient selection vigilance disease state longitudinal testing can help mitigate potential adverse events.

Language: Английский

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Bibliometric and visual analysis of spinal cord injury-associated macrophages from 2002 to 2023

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 21, 2023

Background Spinal cord injury (SCI) triggers motor, sensory, and autonomic impairments that adversely damage patients' quality of life. Its pathophysiological processes include inflammation, oxidative stress, apoptosis, although existing treatment options have little success. Macrophages a vital function in controlling inflammation SCI, with their M1-type M2-type macrophages dominating early inflammatory effects late brain tissue repair regeneration, respectively. However, there is dearth rigorous bibliometric study this sector to explore its dynamics trends. This intends examine the current status trends macrophage usage SCI using methodologies, which may drive novel therapeutic options. Methods In study, Web Science Core Collection (WOSCC) was utilized collect publications reviews on from 2002 2023. Bibliometrics visualization analyses were performed by VOSviewer, CiteSpace, R package “bibliometrix”, online analytic platforms. These covered variety aspects, including countries institutions, authors co-cited authors, journals journals, subject categories, references, keyword co-occurrences, order provide insights into research hotspots field. Results 1,775 papers included comprising 1,528 articles 247 reviews. Our analysis demonstrates number relevant studies expanding, specifically United States China has risen dramatically. are fewer collaborations between institutions different nations, international cooperation needs be reinforced. Among them, Popovich PG became leader field, significant Experimental Neurology, Journal Neurotrauma, Neuroscience. Research involve polarization, microglia, astrocytes, signaling, cytokines, neuroprotection. Conclusions gives, for first time, comprehensive overview over past 20 years. not only gives an extensive picture knowledge structure but also indicates subject. The systematic summarization complete intuitive understanding link spinal provides great reference future related studies.

Language: Английский

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Bibliometric analysis of neonatal sepsis from 2002 to 2022

Pediatric Discovery, Journal Year: 2024, Volume and Issue: 2(1)

Published: March 1, 2024

Abstract This study aimed to visualize the knowledge structure and research trends in neonatal sepsis through bibliometric methods. Articles reviews regarding from 2002 2022 were retrieved Web of Science Core Collection database. CiteSpace software was used network countries/regions, institutions, authors, journals, keywords, references this field. Altogether, 2314 publications identified. During period, number increased yearly. The USA is leading country research. Duke University most prolific institution, with Pediatric Infectious Disease Journal BASU S being journal author field, respectively. Pathogen, diagnosis, management main topics research, future studies may concentrate on novel diagnostic biomarkers judicious use antibiotics. In summary, results our analysis revealed views current situation for first time. provide guidance promoting sepsis.

Language: Английский

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LED light sources with a sun-like emission spectrum for children’s institutions

Hygiene and Sanitation, Journal Year: 2024, Volume and Issue: 103(3), P. 273 - 282

Published: April 10, 2024

The article looks more like a scientific-theoretical than an experimental one, so it is proposed to remove the IMRAD structure, especially since given only in summary, but not itself. “In Russia, under national project “Education”, large-scale program for construction of schools underway. About 700 have already been built, and if general all programs, this 900 schools..... Many swimming pools, modern canteens...” noted head relevant ministry at meeting with President Russian Federation Vladimir Putin beginning 2023. In total, about 750 billion rubles were allocated finance new schools. (it includes 454 from federal budget). planned build 1,300 educational institutions, which will 1 million places. addition schools, plan provides implementation capital repairs technical renovation existing education institutions by end 2026: include 7,300 buildings. pace renovations has also accelerated 2022–2023: three thousand buildings be renovated, mainly rural areas. By 2024, 27 according requirements, equipped equipment. equip computer classes computing equipment, energy saving plans provide widespread use LED lighting. reasons negative effects light spectrum lighting personal monitors on health children adolescents, particular increase myopia, yet sufficiently studied. Analytical, sociological, statistical methods used. relationship between physiological behavioural factors that may lead decreased vision described. restructuring work visual analyzer, associated selection information accordance models social environment suggested contribute formation myopia; decrease one’s own search activity increased functioning internal processing systems perception actions. Limitations. study was limited area subject research, materials Scopus, Web Science, MedLine, Cochrane Library, EMBASE, Global Health, CyberLeninka, RSCI databases our experiments. Conclusion. spectral composition artificial its intensity give rise prerequisites development myopia or another functional-structural response variety ganglion, amacrine cells, receptors analyzer multicellular animals. narrow incomplete domestic lamps cannot good choice prevention children. Considering diversity opsins human we developed manufactured artificial, source using LEDs phosphors, considers photosensitivity eye close as possible sunlight correlated colour temperature 4000 3000 K. first one now batch lamps, emitted no analogues ahead world’s best samples terms efficiency level. demonstrated presentation Erisman Readings To elucidate biological mechanisms children, additional efforts are needed within framework scientific direction - evolutionary hygiene. This make establish how small changes (emission region 410–450 nm, dip 480 nm absence 380 nm) sources influenced catastrophic (chaotic) genetic level humans entire living world.

Language: Английский

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Effects of Acute Mental Stress on Choroidal Thickness

Bioengineering, Journal Year: 2024, Volume and Issue: 11(7), P. 684 - 684

Published: July 5, 2024

Purpose: Previous studies have indicated an association between education and myopia, suggesting that numerous stress events during the educational process may influence eye health. This study aimed to investigate impact of mental induced by arithmetic (MA) on choroidal thickness (CT). Methods: included 33 participants aged 19 29 years. Swept-source optical coherence tomography (SS-OCT) was used capture images posterior segment left baseline MA assess changes in CT. After denoising compensation, had been rigidly registered resampled were segmented using a deep learning-based method. Based segmentation results, CT within regions 1 mm 3 diameter centered at lowest point fovea calculated. Results: Significant increases observed both CT1mm CT3mm MA, with mean 2.742 ± 7.098 μm (p = 0.034) 3.326 6.143 < 0.001), respectively. Conclusions: Thickening choroid has acute stress. We speculate long-term or chronic could potential adverse myopia progression.

Language: Английский

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