Authorea (Authorea),
Journal Year:
2023,
Volume and Issue:
unknown
Published: July 14, 2023
Background
:
The
incidence
of
eczema
is
higher
in
children
aged
0-2
years,
but
the
long-term
effect
air
pollutants
exposure
early
life
on
risk
development
unclear.
Methods
We
conducted
a
birth
cohort
study
Jinan,
China,
to
explore
pollutant
younger
children.
An
inverse
distance
weighting
method
was
used
for
individual
assessment.
Binary
and
multivariate
logistic
models
were
investigate
effects
eczema,
distributed
lag
model
find
sensitive
windows
exposure,
weighted
quantile
sum
principal
component
analysis
combined
multiple
pollutants.
Results
cumulative
rate
among
5819
2
19.8%.
Exposure
high
levels
O
during
pregnancy
(
OR
1.12,
95%
CI
1.06-1.19)
first
year
after
1.24,
1.03-1.50)
increased
eczema.
PM
1.31,
1.20-1.43),
1.08,
1.01-1.15)
1.07,
1.00-1.14)
also
critical
window
third
trimester
postnatal
period.
Moreover,
pollutants,
played
dominant
role
(weighting
>
0.3),
with
predominantly
associated
(adjusted
1.011,
1.007-1.015).
Conclusions
at
years
age,
sensitivity
appeared
earlier.
key
risk.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: March 26, 2024
Abstract
In
recent
years,
the
rapid
advancement
of
digital
technology
has
supported
growth
economy.
The
transformation
towards
digitization
in
public
health
sector
serves
as
a
key
indicator
this
economic
shift.
Understanding
how
economy
continuously
improves
efficiency
services
and
its
various
pathways
influence
become
increasingly
important.
It
is
essential
to
clarify
impact
mechanism
on
optimize
expenditures
advance
construction.
This
study
investigates
development
from
novel
perspective,
considering
social
media
usage
urban–rural
healthcare
disparities
while
constructing
comprehensive
index
development.
findings
indicate
that
reduces
primarily
through
two
transmission
mechanisms:
promotion
widening
gap.
Moreover,
these
impacts
exhibit
spatial
heterogeneity.
unveils
intrinsic
connection
mechanisms
interaction
between
services,
providing
theoretical
basis
reference
for
government
policy
formulation.
However,
it
also
prompts
further
considerations
achieving
synergy
services.
Frontiers in Neurology,
Journal Year:
2023,
Volume and Issue:
14
Published: Dec. 11, 2023
Background
Epilepsy
is
associated
with
a
significant
global
burden
of
disease,
affecting
over
50
million
people
worldwide.
The
specific
aim
this
study
to
compare
the
epilepsy
in
People’s
Republic
China
(PRC)
burden,
and
analyze
epidemiological
trends
epilepsy,
relationship
between
social
demographic
index
(SDI),
relative
contributions
factors.
Methods
This
retrospective
population-based
study,
data
were
obtained
from
Global
Burden
Disease
(GBD)
2019.
We
employed
Joinpoint
software
age-period-cohort
(APC)
model
epilepsy’s
trends.
Health
inequality
analysis
was
conducted
investigate
impact
SDI
on
burden.
Decomposition
performed
examine
age,
population,
changes
epilepsy.
Results
Between
1990
2019,
incidence
rate
PRC
increased
by
45%,
significantly
surpassing
However,
Disability-Adjusted
Life
Years
(DALY)
decreased
notably,
proportion
Lost
(YLL)
62.73
39.03%.
Concerning
incidence,
period
Rate
Ratio
(RR)
initially
then
decreased,
while
cohort
RR
globally
exhibited
consistent
upward
trend.
In
terms
mortality,
displayed
gradual
decrease,
mortality
starting
higher
but
eventually
falling
below
mortality.
net
drifts
greater
than
0,
whereas
less
both
lower
at
level.
indicated
that
mainly
attributed
changes.
Additionally,
disparities
concentrating
low
countries.
Conclusion
rose
during
30-year
period,
decreased.
improved
survival
predominantly
attributable
affects
males,
children,
elderly,
Chinese
government
should
focus
populations.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: March 12, 2024
Abstract
When
analyzing
health
data
in
relation
to
environmental
stressors,
it
is
crucial
identify
which
variables
include
the
statistical
model
exclude
dependencies
among
variables.
Four
meteorological
parameters:
temperature,
ultraviolet
radiation,
precipitation,
and
vapor
pressure
four
outdoor
air
pollution
ozone
(
$$\text{O}_3$$
O3
),
nitrogen
dioxide
$$\text{NO}_2$$
NO2
particulate
matter
$$PM_{2.5}$$
PM2.5
,
$$PM_{10}$$
10
)
were
studied
on
a
daily
basis
for
Baden-Württemberg
(Germany).
This
federal
state
covers
urban
rural
compartments
including
mountainous
river
areas.
A
temporal
spatial
analysis
of
internal
relationships
was
performed
using
(a)
cross-correlations,
both
grand
ensemble
as
well
within
subsets,
(b)
Local
Indications
Spatial
Association
(LISA)
method.
Meteorological
strongly
correlated
themselves
time
space.
We
found
strong
interaction
between
ozone,
with
correlation
coefficients
varying
over
time.
The
ranged
from
negative
correlations
January
(−0.84),
April
(−0.47),
October
(−0.54)
positive
July
(0.45).
cross-correlation
plot
showed
noticeable
change
direction
.
Spatially,
concentrations
significantly
higher
than
regions.
For
this
effect
reversed.
LISA
confirmed
distinct
hot
cold
spots
stressors.
work
examined
quantified
spatio-temporal
relationship
conditions
recommended
prioritize
future
impact
analyses.
results
are
line
underlying
physico-chemical
atmospheric
processes.
It
also
identified
postal
code
areas
dominant
stressors
further
studies.
International Journal of Environmental Research and Public Health,
Journal Year:
2024,
Volume and Issue:
21(3), P. 326 - 326
Published: March 11, 2024
The
objective
of
the
study
was
to
investigate
association
between
outdoor
and
indoor
air
pollution
sources
atopic
eczema
among
preschool
children
in
South
Africa.
A
cross-sectional
design,
following
International
Study
Asthma
Allergies
Childhood
(ISAAC)
Phase
III
protocol,
applied.
conducted
Mabopane
Soshanguve
Townships
City
Tshwane
Metropolitan
Municipality
Gauteng,
total
population
1844
aged
7
years
below
participated
study;
1840
were
included
final
data
analysis.
Data
analyzed
using
multilevel
logistic
regression
prevalence
ever
(EE)
current
symptoms
(ESs)
11.9%
13.3%,
respectively.
use
open
fires
(paraffin,
wood,
or
coal)
for
cooking
heating
increased
likelihood
EE
(OR
=
1.63;
95%
CI:
0.76–3.52)
ESs
1.94;
1.00–3.74).
Environmental
tobacco
smoke
(ETS)
exposure
at
home
1.66;
1.08–2.55)
1.61;
1.07–2.43).
Mothers
female
guardians
smoking
cigarettes
1.50;
0.86–2.62)
1.23;
0.71–2.13).
combined
building
materials
homes
EE,
corrugated
iron
significantly
ESs.
frequency
trucks
passing
near
children’s
residences
on
weekdays
found
be
associated
with
ESs,
a
significant
observed
when
passed
almost
all
day
weekdays.
Atopic
positively
sources.
Clinical Cosmetic and Investigational Dermatology,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 1165 - 1181
Published: May 1, 2024
Autophagy
is
recognized
as
a
crucial
regulatory
process,
instrumental
in
the
removal
of
senescent,
dysfunctional,
and
damaged
cells.
Within
autophagic
lysosomal
digestion
plays
critical
role
elimination
impaired
organelles,
thus
preserving
fundamental
cellular
metabolic
functions
various
biological
processes.
Mitophagy,
targeted
process
that
specifically
focuses
on
mitochondria,
essential
for
sustaining
health
energy
balance.
Therefore,
deep
comprehension
operational
mechanisms
implications
autophagy
mitophagy
vital
disease
prevention
treatment.
In
this
context,
we
examine
during
hair
follicle
cycles,
closely
scrutinizing
their
potential
association
with
loss.
We
also
conduct
thorough
review
behind
mitophagy,
highlighting
interaction
stem
cells
dermal
papilla
conclusion,
investigate
manipulating
pathways
to
develop
innovative
therapeutic
strategies
