Angiotensin converting enzyme expression on circulating immune cells from colorectal cancer patients correlates with the disease stage. Results from a preliminary study. DOI Creative Commons
Valquíria Bueno, Daniela Frasca,

Nora Manoukian Forones

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 26, 2024

Abstract Colorectal cancer (CRC) is the third most common and second leading cause of cancer-related mortality worldwide. Because CRC a very complex disease, sometimes patients at same disease stage are treated with combinations systemic therapy surgery to different outcomes. Immune T B cells infiltrating tumor has been associated disease-free survival, cancer-specific survival overall survival. In opposite, Myeloid-derived suppressor linked poor outcome. The peripheral blood evaluation immune less invasive, easy be performed in follow-up visits, could used as guide for interventions. expression angiotensin converting enzyme (ACE) can biomarker prognosis an also target treatment since ACE macrophages neutrophils related improved immunity. Our aim therefore was investigate subsets T, B, myeloid-derived from patients. We found that increased Naïve Effector III. These findings open opportunities targeting new colorectal cancer.

Language: Английский

Endotheliopathy in Acute COVID-19 and Long COVID DOI Open Access
Alice G. Vassiliou, Charikleia S. Vrettou, Chrysi Keskinidou

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8237 - 8237

Published: May 4, 2023

The pulmonary endothelium is a highly regulated organ that performs wide range of functions under physiological and pathological conditions. Since endothelial dysfunction has been demonstrated to play direct role in sepsis acute respiratory distress syndrome, its COVID-19 also extensively investigated. Indeed, apart from the COVID-19-associated coagulopathy biomarkers, new biomarkers were recognised early during pandemic, including markers cell activation or injury. We systematically searched literature up 10 March 2023 for studies examining association between long severity outcomes biomarkers.

Language: Английский

Citations

31
Causal association between colorectal cancer and Alzheimer’s disease: a bidirectional two-sample mendelian randomization study DOI Creative Commons

Chunsheng Yuan,

Saisai Liu,

Kezhen Yang

et al.

Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 5, 2024

Background: Colorectal cancer and Alzheimer’s disease are both common life-threatening diseases in the elderly population. Some studies suggest a possible inverse relationship between colorectal disease, but real-world research is subject to many biases. We hope clarify causal two through bidirectional two-sample Mendelian randomization study. Methods: In our study, we used genetic summary data from large-scale genome-wide association investigate disease. Our primary analysis employed inverse-variance weighted method also complementary techniques, including MR-Egger, median estimator, Maximum likelihood. applied simex adjustment MR-Egger results. utilized MRlap package detect potential sample overlap its impact on bias of addition, performed several sensitivity heterogeneity analyses, ensure reliability Results: The combined effect size results indicate that may decrease incidence with an odds ratio (OR) 0.846 (95% CI: 0.762–0.929). Similar were observed using other methods such as On hand, slightly increase cancer, OR 1.014 1.001–1.027). However, one subgroup not significant, indicated introduced into Therefore, reverse validation reliable. F-statistic for all SNPs was greater than 20. Four related outcome excluded Phenoscanner website did affect overall direction these statistics further validated by MR-PRESSO, funnel plots, leave-one-out Cochran’s Q, demonstrating findings. Conclusion: According findings this there appears be These could have important implications clinical practice terms how treated. To better understand diseases, more screening needed settings.

Language: Английский

Citations

5
IPIAD- an augmentation regimen added to standard treatment of pancreatic ductal adenocarcinoma using already-marketed repurposed drugs irbesartan, pyrimethamine, itraconazole, azithromycin, and dapsone DOI Open Access
Richard E. Kast

Oncoscience, Journal Year: 2024, Volume and Issue: 11, P. 15 - 31

Published: Feb. 7, 2024

This short note presents the data and rationale for adding five generic nononcology drugs from general medical practice to gemcitabine, nab-paclitaxel, a current standard cytotoxic chemotherapy of pancreatic ductal adenocarcinoma.The regimen, called IPIAD, uses an angiotensin receptor blocker (ARB) irbesartan indicated treating hypertension, old antimicrobial drug pyrimethamine toxoplasmosis or malaria, antifungal itraconazole, broad spectrum antibiotic azithromycin dapsone.In reviewing selected growth driving systems active in adenocarcinoma then comparing these with detailed on ancillary attributes IPIAD drugs, one can predict clinical benefit slowing by this augmentation regimen.

Language: Английский

Citations

3
Genetic Modulation of HPV Infection and Cervical Lesions: Role of Oxidative Stress-Related Genes DOI Creative Commons
Ângela Inácio, Laura Aguiar, Beatriz Rodrigues

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(10), P. 1806 - 1806

Published: Sept. 27, 2023

Human papillomavirus (HPV) infection is a necessary but not sufficient factor for the development of invasive cervical cancer (ICC) and high-grade intraepithelial lesion (HSIL). Oxidative stress known to play crucial role in HPV carcinogenesis. In this study, we comprehensively investigate modulation infection, HSIL ICC, ICC through an exploration oxidative stress-related genes: CβS, MTHFR, NOS3, ACE1, CYBA, HAP, ACP1, GSTT1, GSTM1, CYP1A1. Notably, ACE1 gene emerges as prominent with presence I allele offering protection against infection. The association NOS3 perceived 4a showing protective effect. GSTT1 null mutant correlates increased susceptibility ICC. This study also uncovers intriguing epistatic interactions among some genes that further accentuate their roles disease modulation. Indeed, between BB genotype (ACP1) DD (ECA1) were shown increase risk interaction 0.0 (GSTT1) was associated lesions. These findings underscore pivotal four HPV-associated lesions development, enriching our clinical understanding genetic influences on manifestation. awareness these variations holds potential implications.

Language: Английский

Citations

5
Emerging paradigms in Alzheimer's therapy DOI

Agnes Preethy H.,

Kayalvizhi Rajendran,

Anitha Josephine Sukumar

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 981, P. 176872 - 176872

Published: Aug. 6, 2024

Language: Английский

Citations

1
Decoding Angiotensin Receptors: TOMAHAQ‐Based Detection and Quantification of Angiotensin Type‐1 and Type‐2 Receptors DOI Creative Commons
Çağlar Coşarderelioğlu, Simion Kreimer,

Alma I. Plaza‐Rodriguez

et al.

Journal of the American Heart Association, Journal Year: 2023, Volume and Issue: 12(18)

Published: Sept. 8, 2023

Background The renin-angiotensin system plays a crucial role in human physiology, and its main hormone, angiotensin, activates 2 G-protein-coupled receptors, the angiotensin type-1 type-2 almost every organ. However, controversy exists about location, distribution, expression levels of these receptors. Concerns have been raised over low sensitivity, specificity, large variability between lots commercially available antibodies for which makes it difficult to reconciliate results different studies. Here, we describe first non-antibody-based sensitive specific targeted quantitative mass spectrometry assay Methods Results Using technique that allows analysis multiple peptides across samples single analysis, known as TOMAHAQ (triggered by offset, multiplexed, accurate mass, high resolution, absolute quantification), identified validated tryptic permit identification quantification receptors biological samples. Several peptide sequences are conserved rodents, making assays amenable both preclinical clinical We used this method quantify postmortem frontal cortex older adults (n=28) with Alzheimer dementia. correlated biomarkers classically linked activation, including oxidative stress, inflammation, amyloid-β load, paired helical filament-tau tangle burden. Conclusions These robust high-throughput will not only catalyze novel mechanistic studies research field but may also help identify patients an unbalanced receptor distribution who would benefit from blocker treatment.

Language: Английский

Citations

2
Sarkopenija kod osoba oboljelih od demencije DOI Creative Commons

Tonći Mastelić,

Vitomir Višić,

Tonka Borovina Marasović

et al.

Socijalna psihijatrija, Journal Year: 2024, Volume and Issue: 51(4), P. 340 - 353

Published: March 18, 2024

prehrana bogata proteinima i proteinski dodatci.O mogućim biomarkerima sarkopenije potrebna su dodatna istraživanja.Valjalo bi provesti istraživanja

Citations

0
Angiotensin converting enzyme expression on circulating immune cells from colorectal cancer patients correlates with the disease stage. Results from a preliminary study. DOI Creative Commons
Valquíria Bueno, Daniela Frasca,

Nora Manoukian Forones

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 26, 2024

Abstract Colorectal cancer (CRC) is the third most common and second leading cause of cancer-related mortality worldwide. Because CRC a very complex disease, sometimes patients at same disease stage are treated with combinations systemic therapy surgery to different outcomes. Immune T B cells infiltrating tumor has been associated disease-free survival, cancer-specific survival overall survival. In opposite, Myeloid-derived suppressor linked poor outcome. The peripheral blood evaluation immune less invasive, easy be performed in follow-up visits, could used as guide for interventions. expression angiotensin converting enzyme (ACE) can biomarker prognosis an also target treatment since ACE macrophages neutrophils related improved immunity. Our aim therefore was investigate subsets T, B, myeloid-derived from patients. We found that increased Naïve Effector III. These findings open opportunities targeting new colorectal cancer.

Language: Английский

Citations

0