Brain organoid reservoir computing for artificial intelligence

Nature Electronics, Journal Year: 2023, Volume and Issue: 6(12), P. 1032 - 1039

Published: Dec. 11, 2023

Language: Английский

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Landscape of human organoids: Ideal model in clinics and research

The Innovation, Journal Year: 2024, Volume and Issue: 5(3), P. 100620 - 100620

Published: April 1, 2024

In the last decade, organoid research has entered a golden era, signifying pivotal shift in biomedical landscape. The year 2023 marked milestone with publication of thousands papers this arena, reflecting exponential growth. However, amid burgeoning expansion, comprehensive and accurate overview field been conspicuously absent. Our review is intended to bridge gap, providing panoramic view rapidly evolving We meticulously analyze from eight distinctive vantage points, harnessing our rich experience academic research, industrial application, clinical practice. present deep exploration advances technology, underpinned by long-standing involvement arena. narrative traverses historical genesis organoids their transformative impact across various sectors, including oncology, toxicology, drug development. delve into synergy between avant-garde technologies such as synthetic biology single-cell omics discuss role tailoring personalized medicine, enhancing high-throughput screening, constructing physiologically pertinent disease models. analysis reflective discourse provide dive existing landscape emerging trends technology. spotlight technological innovations, methodological evolution, broadening spectrum applications, emphasizing revolutionary influence discovery, other fields. Looking ahead, we cautiously anticipate future developments especially its potential implications for patient care, new avenues research. trust that will be an asset researchers, clinicians, patients keen interest medical strategies. offer broad prospective capabilities encompassing wide range current applications. summary, attempt field. reflections, summaries, projections might useful researchers hope contribute shaping trajectory dynamic advancing

Language: Английский

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Sentience, Vulcans, and zombies: the value of phenomenal consciousness

AI & Society, Journal Year: 2024, Volume and Issue: 39(6), P. 3005 - 3015

Published: Jan. 12, 2024

Abstract Many think that a specific aspect of phenomenal consciousness—valenced or affective experience—is essential to consciousness’s moral significance (valence sentientism). They hold valenced experience is necessary for well-being, status, psychological intrinsic value (or all three). Some consciousness generally non-derivative (broad Few unnecessary (non-necessitarianism). In this paper, I consider the prospects these views. first valence sentientism in light Vulcans, beings who are conscious but without affect any sort. Vulcans pressure us accept broad sentientism. But argue consideration explanations opens up possible non-necessitarianism about consciousness. That is, once one leans away from because should feel view on which not value.

Language: Английский

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Brain organoids and organoid intelligence from ethical, legal, and social points of view

Frontiers in Artificial Intelligence, Journal Year: 2024, Volume and Issue: 6

Published: Jan. 5, 2024

Human brain organoids, aka cerebral organoids or earlier "mini-brains", are 3D cellular models that recapitulate aspects of the developing human brain. They show tremendous promise for advancing our understanding neurodevelopment and neurological disorders. However, unprecedented ability to model development function

Language: Английский

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The Promise and Potential of Brain Organoids

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(21)

Published: Jan. 22, 2024

Brain organoids are 3D in vitro culture systems derived from human pluripotent stem cells that self-organize to model features of the (developing) brain. This review examines techniques behind organoid generation, their current and potential applications, future directions for field. possess complex architecture containing various neural cell types, synapses, myelination. They have been utilized toxicology testing, disease modeling, infection studies, personalized medicine, gene-environment interaction studies. An emerging concept termed Organoid Intelligence (OI) combines with artificial intelligence generate learning memory, goals modeling cognition enabling biological computing applications. allow neuroscience studies not previously achievable traditional techniques, transform drug development, understanding brain development disorders. The aspirational vision OI parallels origins intelligence, efforts underway map a roadmap toward its realization. In summary, constitute disruptive technology is rapidly advancing gaining traction across multiple disciplines.

Language: Английский

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Highly Customizable 3D Microelectrode Arrays for In Vitro and In Vivo Neuronal Tissue Recordings

Advanced Science, Journal Year: 2024, Volume and Issue: 11(13)

Published: Jan. 19, 2024

Abstract Planar microelectrode arrays (MEAs) for – in vitro or vivo neuronal signal recordings lack the spatial resolution and sufficient signal‐to‐noise ratio (SNR) required a detailed understanding of neural network function synaptic plasticity. To overcome these limitations, highly customizable three‐dimensional (3D) printing process is used combination with thin film technology self‐aligned template‐assisted electrochemical deposition to fabricate 3D‐printed‐based MEAs on stiff flexible substrates. Devices design flexibility physical robustness are shown recording activity different applications, achieving high‐aspect 3D microelectrodes up 33:1. Here, successfully record cultures, retinal explants, cortex living mice, thereby demonstrating versatility MEA while maintaining high‐quality recordings. Customizable provide unique opportunities study under regular various pathological conditions, both vivo, contribute development drug screening neuromodulation systems that can accurately monitor large networks over time.

Language: Английский

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On the present-future impact of AI technologies on personnel selection and the exponential increase in meta-algorithmic judgments

Futures, Journal Year: 2025, Volume and Issue: unknown, P. 103538 - 103538

Published: Jan. 1, 2025

Language: Английский

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First Organoid Intelligence (OI) workshop to form an OI community

Frontiers in Artificial Intelligence, Journal Year: 2023, Volume and Issue: 6

Published: Feb. 28, 2023

The brain is arguably the most powerful computation system known. It extremely efficient in processing large amounts of information and can discern signals from noise, adapt, filter faulty all while running on only 20 watts power. human brain's efficiency, progressive learning, plasticity are unmatched by any computer system. Recent advances stem cell technology have elevated field culture to higher levels complexity, such as development three-dimensional (3D) organoids that recapitulate functionality better than traditional monolayer systems. Organoid Intelligence (OI) aims harness innate biological capabilities for biocomputing synthetic intelligence interfacing them with technology. With latest strides technology, bioengineering, machine we explore ability compute, store given (input), execute a task (output), study how this affects structural functional connections themselves. Furthermore, understanding learning generates changes patterns connectivity shed light early stages cognition brain. Investigating these concepts an enormous, multidisciplinary endeavor necessitates engagement both scientific community public. Thus, Feb 22–24 2022, Johns Hopkins University held first Workshop form OI Community lay out groundwork establishment new discipline. potential revolutionize computing, neurological research, drug was discussed, along vision roadmap its over coming decade.

Language: Английский

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Too-Many-Oids: The paradox in constructing an organoid ethics framework

Molecular Psychology Brain Behavior and Society, Journal Year: 2023, Volume and Issue: 2, P. 10 - 10

Published: May 25, 2023

Background: The field of organoid ethics is complex and multifaceted, the need for flexibility adaptability in face its moral complexity great importance. Certain kinds organoids may be deemed morally controversial due to their intrinsic characteristics (e.g., brain organoids, embryoids, or intelligence models) debates are underway over possible standing. Furthermore, different domains applications, such as transplantation, precision medicine, disease modeling have fundamentally concerns. Methods: In this paper, we argue that it a mistake near impossible develop an overarching, all-in-one ethical framework can sufficiently cover myriad contexts. We first identify ontological categories technologies along with problematic properties. then present contexts which applied. Results: Constructing both consider all relevant properties contexts, useful lens examination lead paradox; more tries incorporate, abstract less becomes. Conclusions: It bioethicists take on collaborative contextual approaches ethics.

Language: Английский

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Organoid intelligence: Integration of organoid technology and artificial intelligence in the new era of in vitro models

Medicine in Novel Technology and Devices, Journal Year: 2023, Volume and Issue: 21, P. 100276 - 100276

Published: Nov. 27, 2023

Language: Английский

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