Diet and Male Fertility: The Impact of Nutrients and Antioxidants on Sperm Energetic Metabolism

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(5), P. 2542 - 2542

Published: Feb. 25, 2022

Diet might affect male reproductive potential, but the biochemical mechanisms involved in modulation of sperm quality remain poorly understood. While a Western diet is considered risk factor for infertility, Mediterranean seems to protect against infertility; moreover, role vegetarian habitus preservation controversial. The aim this review analyze molecular effects single nutrients on quality, focusing their involvement related bioenergetics. It appears that diets rich saturated fatty acids (SFA) and low polyunsaturated (PUFA) negatively whereas unsaturated supplementation ameliorates quality. In fact, administration PUFA, especially omega-3 determined an increase mitochondrial energetic metabolism reduction oxidative damage. Carbohydrates proteins are also nutritional modulators stress testosterone levels, which strictly linked function, key element Moreover, many dietary natural polyphenols differentially (positively or negatively) depending concentration. We believe understanding responsible will lead more targeted effective therapeutics infertility.

Language: Английский

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Oxidative Stress and Male Infertility: The Protective Role of Antioxidants

Medicina, Journal Year: 2023, Volume and Issue: 59(10), P. 1769 - 1769

Published: Oct. 4, 2023

Oxidative stress is a significant factor in male infertility, compromising sperm function and overall reproductive health. As infertility garners increasing attention, effective therapeutic interventions become paramount. This review investigates the role of antioxidants addressing infertility. A detailed examination was conducted on such as vitamin C, E, B12, D, coenzyme Q10, zinc, folic acid, selenium, l-carnitine, l-arginine, inositols, alpha-lipoic acid. analysis examines methodologies, outcomes, constraints current clinical studies. Antioxidants show notable potential counteracting negative effects oxidative sperm. Based evidence, these antioxidants, individually or synergistically, can enhance health outcomes. However, certain limitations studies call for careful interpretation. are integral tackling attributed to stress. The findings underscore their value, yet there’s pressing need deeper, comprehensive research. Future should focus refining dosage guidelines, identifying side effects, discerning most efficacious antioxidant combinations solutions.

Language: Английский

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Mitochondrial specific antioxidant MitoPBN mitigates oxidative stress and improves mitochondrial function in cryopreserved ram sperm

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 27, 2025

Oxidative stress impairs sperm function and fertility in rams, most notably during cryopreservation, is characterized by compromised motility. Mitochondria contribute immensely towards function, such as mitochondrial membrane potential (MMP) which crucial for ATP production. The purpose of this study was to assess the role MitoPBN supplementation on cryopreserved quality mature Ghezel ram sperm. Semen samples were treated with 0 (control), 100, 150, 200, 250 µmol/L then analyzed key factors. Results indicated that 100 150 significantly enhanced total motility, increasing 52.36 ± 4.26% 54.16 3.19%, respectively. Progressive motility similarly improved 24.82 3.27% 26.77 3.46%, Additionally, integrity markedly increased 50.01 4.22% 52.54 2.24%, while activity augmented from 35.14 4.09% 46.16 4.02% 50.26 6.69%. Sperm viability also improved, rising 48.99 3.98% 52.20 3.17%, Notably, reactive oxygen species (ROS) levels reduced 2.95 0.16% 2.80 0.11%, respectively, paralleled enhancements antioxidant capacity (TAC; 1.85 0.21% 1.93 0.16%, respectively) glutathione peroxidase (GPx) (61.16 4.77% 63.36 4.95%, respectively). Moreover, content reached a peak 116.29 5.83 group. In conclusion, our results evidence oxidative cryopreservation effectively countered MitoPBN, improving quality.

Language: Английский

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Redox Regulation and Oxidative Stress in Mammalian Oocytes and Embryos Developed In Vivo and In Vitro

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(21), P. 11374 - 11374

Published: Oct. 29, 2021

Oocytes and preimplantation embryos require careful regulation of the redox environment for optimal development both in vivo vitro. Reactive oxygen species (ROS) are generated throughout as a result cellular metabolism enzyme reactions. ROS production can (i) oxidative eustress, where helpful signalling molecules with beneficial physiological functions state cell is maintained within homeostatic range by closely coupled system antioxidants antioxidant enzymes, or (ii) distress, excess deleterious impair normal function. vitro culture exacerbates due to issues including culture-medium composition laboratory conditions. This increase be detrimental not only assisted reproductive success rates but also epigenetic genetic changes embryo, resulting transgenerational effects. review examines effects stress oocyte embryo environment, identifies mechanisms responsible oocyte/embryo approaches reduce these problems, briefly potential impacts on future generations.

Language: Английский

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A systematic review identifying fertility biomarkers in semen: a clinical approach through Omics to diagnose male infertility

Fertility and Sterility, Journal Year: 2022, Volume and Issue: 118(2), P. 291 - 313

Published: June 17, 2022

Language: Английский

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Effects of reactive oxygen species and mitochondrial dysfunction on reproductive aging

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 23, 2024

Mitochondria, the versatile organelles crucial for cellular and organismal viability, play a pivotal role in meeting energy requirements of cells through respiratory chain located inner mitochondrial membrane, concomitant with generation reactive oxygen species (ROS). A wealth evidence derived from contemporary investigations on reproductive longevity strongly indicates that aberrant elevation ROS level constitutes fundamental factor hastening aging process systems which are responsible transmission DNA to future generations. Constant changes redox status, pro-oxidant shift mainly ROS, linked modulation physiological pathological pathways gametes tissues. Furthermore, quantity quality mitochondria essential capacitation fertilization increasingly associated aging. The article aims provide current understanding contributions respiration Moreover, impact dysfunction both female male fertility is conducive finding therapeutic strategies slow, prevent or reverse gamete aging, thereby increase longevity.

Language: Английский

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Dietary Patterns and Fertility

Biology, Journal Year: 2024, Volume and Issue: 13(2), P. 131 - 131

Published: Feb. 19, 2024

Diet has a key role in the reproductive axis both males and females. This review aims to analyze impacts of different dietary patterns on fertility. It appears that Mediterranean diet predominantly protective against infertility, while Western seems be risk factor for infertility. Moreover, we focus attention also countries World (Middle Eastern diet, Asian diet). In particular, when analyzing single nutrients, rich saturated fatty acids, cholesterol, animal proteins, carbohydrates with high glycemic index is highly associated male female Finally, evaluate effects vegetarian, vegan, ketogenic diets fertility, which seem still unclear. We believe comprehension molecular mechanisms involved infertility will lead more effective targeted treatments infertile couples.

Language: Английский

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Advancements in Understanding and Enhancing Antioxidant-Mediated Sperm Cryopreservation in Small Ruminants: Challenges and Perspectives

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 624 - 624

Published: May 21, 2024

Cryopreservation poses significant challenges to the preservation of sperm integrity and function, particularly in small ruminants where cryodamage is pronounced. This review explores molecular mechanisms underlying strategies for improving cryopreservation outcomes, with a focus on role antioxidants. Cryopreservation-induced alterations proteins RNA transcripts critical including motility, capacitation, fertilization, embryo development, are discussed. Proteomic, transcriptomic, epigenomic advancements have provided valuable insights into these mechanisms, offering potential biomarkers predicting freezability enhancing strategies. Combining technologies such as mass spectrometry flow cytometry allows comprehensive understanding cellular changes induced by freezing–thawing process. However, remain optimizing cryoprotectant formulations antioxidant supplementation improve post-thaw fertility. Further research needed explore wider range novel cryoprotectants, antioxidants, media, well validate their efficacy viability function. Additionally, investigations effects epigenetic factors ruminant species warranted advance our preservation. Overall, this highlights importance antioxidants mitigating underscores need continued refine protocols reproductive outcomes ruminants.

Language: Английский

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The impact of mitochondrial impairments on sperm function and male fertility: a systematic review

Reproductive Biology and Endocrinology, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 17, 2024

Abstract Background Besides adenine triphosphate (ATP) production for sustaining motility, the mitochondria of sperm also host other critical cellular functions during germ cell development and fertilization including calcium homeostasis, generation reactive oxygen species (ROS), apoptosis, in some cases steroid hormone biosynthesis. Normal mitochondrial membrane potential with optimal performance is essential capacitation, acrosome reaction, DNA integrity. Results Defects function can severely harm fertility males. The role its final fate after still controversial. Here, we review current knowledge on human characteristics their physiological pathological conditions, paying special attention to improvements assistant reproductive technology available treatments ameliorate male infertility. Conclusion Although variants associated infertility have clinical use, research limited. Further understanding needed determine how these lead adverse pregnancy outcomes affect potential.

Language: Английский

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Uncovering the impact of alcohol on internal organs and reproductive health: Exploring TLR4/NF‐kB and CYP2E1/ROS/Nrf2 pathways

Animal Models and Experimental Medicine, Journal Year: 2024, Volume and Issue: 7(4), P. 444 - 459

Published: June 9, 2024

This review delves into the detrimental impact of alcohol consumption on internal organs and reproductive health, elucidating underlying mechanisms involving Toll-like receptor 4 (TLR4)/Nuclear factor kappa light chain enhancer activated B cells (NF-kB) pathway Cytochrome P450 2E1 (CYP2E1)/reactive oxygen species (ROS)/nuclear erythroid 2-related 2 (Nrf2) pathways. The TLR4/NF-kB pathway, crucial for inflammatory immune responses, triggers production pro-inflammatory agents type-1 interferon, disrupting balance between antioxidant responses when tissues are chronically exposed to alcohol. Alcohol-induced dysbiosis in gut microbes heightens wall permeability pathogen-associated molecular patterns (PAMPs), leading liver cell infection subsequent inflammation. Concurrently, CYP2E1-mediated metabolism generates ROS, causing oxidative stress damaging cells, lipids, proteins, deoxyribonucleic acid (DNA). To counteract this imbalance, Nrf2 regulates gene expression, inhibiting progression promoting responses. Excessive intake results elevated enzymes (ADH, CYP2E1, catalase), NADH, acetaldehyde, acetate, damage vital such as heart, brain, lungs. Moreover, negatively affects health by hypothalamic-pituitary-gonadal axis, infertility both men women. These findings underscore profound concerns associated with alcohol-induced damage, emphasizing need public awareness regarding intricate interplay multi-organ impacts consumption.

Language: Английский

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