Role of Antioxidants of Natural Herbs in Management of Male Infertility

Journal for Research in Applied Sciences and Biotechnology, Journal Year: 2023, Volume and Issue: 2(1), P. 55 - 80

Published: Feb. 5, 2023

If you and your spouse have been trying to conceive for a year neither of has successful, there is possibility that are one the 50–80 million people throughout world who struggle with infertility. There male component present in approximately 20%-30% these instances. It common knowledge low-quality sperm oxidative stress (OS) both role aetiology Because oxidation DNA, proteins, lipids, excessive levels reactive oxygen species (ROS) potential disrupt viability, motility, morphology cells. ROS responsible changes. Methods: Through use PubMed interface, we searched MEDLINE database studies had completed published during past ten years analysed effect antioxidants on infertile guys (2012–2022). A number different phrases, including infertility, alpha-lipoic acid, zinc, folate, coenzyme Q10, selenium, vitamin, were utilised search. The study's findings indicate inositol serves purpose mechanisms foster contacts between oocytes, it also affects OS cells by way its engagement mitochondrial events. Alpha-lipoic acid (ALA) lessens damage caused improves quality ways, morphology, count. might be connection not getting enough zinc diet having sperm. Zinc folate two nutrients can boost quantity When taken orally, Q10 increases as well their overall motility forward movement. therapy selenium (Se) results an improvement sperm's quality, this connected increase ejaculatory production. Only vitamin B12 found improve sperm; does boosting count decreasing DNA damage. Vitamin only proved do this. Conclusions: Dietary supplementation may men semen reducing OS-induced increasing hormone synthesis spermatozoa concentration, morphology. This achieved low semen. Antioxidants exert effects variety ways; hence, important researchers conducting future clinical trials study combining antioxidants.

Language: Английский

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From oxidative imbalance to compromised standard sperm parameters: Toxicological aspect of phthalate esters on spermatozoa

Environmental Toxicology and Pharmacology, Journal Year: 2023, Volume and Issue: 98, P. 104085 - 104085

Published: Feb. 23, 2023

Language: Английский

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Putative adverse outcome pathways of the male reproductive toxicity derived from toxicological studies of perfluoroalkyl acids

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 873, P. 162439 - 162439

Published: Feb. 26, 2023

Language: Английский

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Redox Balance in Male Infertility: Excellence through Moderation—“Μέτρον ἄριστον”

Antioxidants, Journal Year: 2021, Volume and Issue: 10(10), P. 1534 - 1534

Published: Sept. 27, 2021

Male infertility, a relatively common and multifactorial medical condition, affects approximately 15% of couples globally. Based on WHO estimates, staggering 190 million people struggle with this health male factor is the sole or contributing in roughly 20–50% these cases. Nowadays, urologists are confronted wide spectrum conditions ranging from typical infertile to more complex cases either unexplained idiopathic requiring specific patient-tailored diagnostic approach management. Strikingly enough, no identifiable cause routine workup can be found 30% 50% males. The term oxidative stress infertility (MOSI) was recently coined describe men abnormal sperm parameters (OS), including those previously classified as having infertility. OS critical component entailing an imbalance between reactive oxygen species (ROS) antioxidants. ROS abundance has been implicated abnormalities, while exact impact fertilization pregnancy long subject considerable debate. In attempt counteract deleterious effects OS, resorted antioxidant supplementation. Mounting evidence indicates that indiscriminate consumption antioxidants led some cell damage through reductive-stress-induced state. “antioxidant paradox”, one biggest andrological challenges, remains lurking danger needs carefully avoided thoroughly investigated. For reason, oxidation-reduction potential (ORP) emerged viable ancillary tool basic semen analysis, measuring overall balance oxidants (reductants). A novel biomarker, Oxidative System (MiOXSYS®), paradigm shift towards goal, offering quantification via quick, reliable, reproducible measurement ORP. Moderation “Μέτρον” according ancient Greeks key successfully safeguarding redox balance, MiOXSYS® earnestly claiming its position guarantor homeostasis intracellular milieu. present paper, we aim offer narrative summary relevant regulation reproduction, analyze reductive function, shed light paradox” phenomenon. Finally, examine most up-to-date scientific literature regarding ORP by developed assay.

Language: Английский

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Oxidative Stress Is Associated with Telomere Interaction Impairment and Chromatin Condensation Defects in Spermatozoa of Infertile Males

Antioxidants, Journal Year: 2021, Volume and Issue: 10(4), P. 593 - 593

Published: April 12, 2021

Telomere length can be influenced by reactive oxygen species (ROS) generated lifestyle factors or environmental exposure. We sought to determine whether oxidative stress has an impact on sperm nuclear alterations, especially chromatin organization and telomere interactions in the spermatozoa of infertile males. performed observational prospective study including fifty-two males, allocated “case group” (30 males presenting conventional semen parameter alterations) “control (22 with normal parameters). ROS detection was determined using CellROX© probes. Sperm damage assessed quantitative fluorescence situ hybridization (Q-FISH) for relative number, aniline blue staining condensation, terminal deoxynucleotidyl transferase dUTP nick-end labeling DNA fragmentation, FISH aneuploidy 8-hydroxy-2′-deoxyguanosine immunostaining damages. Infertile had significantly increased levels cytoplasmic condensation defects as well a higher mean number signals per spermatozoon comparison controls. In addition, were positively correlated percentage defect. is associated interaction impairment defects.

Language: Английский

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Male Reproductive Toxicity of Antifouling Chemicals: Insights into Oxidative Stress-Induced Infertility and Molecular Mechanisms of Zinc Pyrithione (ZPT)

Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 173 - 173

Published: Jan. 29, 2024

Zinc pyrithione (ZPT), a widely utilized industrial chemical, is recognized for its versatile properties, including antimicrobial, antibacterial, antifungal, and antifouling activities. Despite widespread use, recent research has shed light on toxicity, particularly towards the male reproductive system. While investigations into ZPT’s impact reproduction have been conducted, most of attention directed marine organisms. Notably, ZPT identified as catalyst oxidative stress, contributing to various indicators infertility, such reduced sperm count, impaired motility, diminished testosterone levels, apoptosis, degenerative changes in testicular tissue. Furthermore, discussions surrounding effects DNA cellular structures emerged. abundance information regarding molecular mechanisms underlying detrimental system remain poorly understood. This review focuses specifically ZPT, delving reported toxicity reproduction, while also addressing broader context by discussing other chemicals, emphasizing need further exploration mechanisms.

Language: Английский

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Micronucleus counts correlating with male infertility: a clinical analysis of chromosomal abnormalities and reproductive parameters

Asian Journal of Andrology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Investigating the correlation between micronucleus formation and male infertility has potential to improve clinical diagnosis deepen our understanding of pathological progression. Our study enrolled 2252 patients whose semen was analyzed from March 2023 July 2023. Their data, including parameters age, were also collected. Genetic analysis used determine whether sex chromosome involved in abnormal (including increase, deletion, translocation X Y chromosomes), subsequent conducted for grouping purposes. The participants categorized into five groups: normozoospermia, asthenozoospermia, oligozoospermia, oligoasthenozoospermia, azoospermia. Patients randomly selected further study; 41 with normozoospermia included control group 117 non-normozoospermia according proportions all patients. Cytokinesis-block (CBMN) screening through peripheral blood. Statistical differences micronuclei (MNi) among groups relationships MNi data. There a significant increase infertile men, those azoospermia, compared normozoospermic patients, but there no difference genetic nongenetic azoospermic men. presence associated sperm concentration, progressive motility, immotile spermatozoa, malformed total count, motility. This underscores utility as diagnostic tool highlights need research elucidate underlying mechanisms infertility.

Language: Английский

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Beyond the Spice Rack: The Therapeutic Benefits of Curcumin for Male Reproductive Health

Journal of Pharmacy and Nutrition Sciences, Journal Year: 2025, Volume and Issue: 15, P. 1 - 14

Published: Feb. 20, 2025

Turmeric, derived from the rhizome of Curcuma longa, is a widely utilized spice. It characterized by warm and slightly bitter flavor, often employed to enhance taste color curry powders. The active compound, curcumin has been subject extensive research due its anti-inflammatory, antioxidant, potential anticancer properties, among others. This review explores therapeutic curcumin, ingredient in turmeric, for male reproductive health, going beyond culinary uses. articles used this narrative were obtained some search engines including National Library Medicine (PubMed), Science Alert, Google Scholar, Excerta Medical database (EMBASE) Cumulated Index Nursing Allied Health Literature (CINAHL). summarizes current scientific evidence regarding curcumin's effects on various aspects fertility, sperm quality. also highlights anti-apoptotic properties how these contribute benefits addressing issues. Evidence overview existing literature suggests supplementation alleviating infertility. An avenue future investigations into role maintaining improving health human open.

Language: Английский

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Detrimental Effects of Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphism on Human Reproductive Health: A Review

Clinical Journal of Obstetrics and Gynecology, Journal Year: 2025, Volume and Issue: 8(1), P. 007 - 014

Published: March 5, 2025

Methylenetetrahydrofolate Reductase (MTHFR) is an important enzyme of the folate cycle, which required to convert 5,10-methyltetrahydrofolate into 5-methyltetrahydrofolate (5-methylTHHF). 5-methyl THF a methyl group donor for several cellular methylation processes. It also donates conversion homocysteine methionine, higher concentration toxic. MTHFR gene C677T polymorphism clinically and variant (A222V) has reduced activity, hence increasing requirement folic acid. Less 5-methyl-THF due results in plasma (hyperhomocysteinemia). Individuals having are susceptible various diseases, including reproductive problems like male infertility, polycystic ovary syndrome, Recurrent Pregnancy Loss (RPL), Preeclampsia (PE), placental abruption, adverse pregnancy outcomes. mimics deficiency, DNA synthesis, repair, methylation, proper chromosome segregation, all these processes foetal growth normal development. Methylation demethylation control expression about 45% human genes. Impaired influences genes involved regulation hormones, spermatogenesis, oogenesis. In males, oxidative stress damages sperm decreases motility, may impair fertilization capability. pregnant women, hyperhomocysteinemia increases inflammation within placenta, causes damage tissue, impairs its function, disrupts Further, (HHcy) embryotoxic neurotoxic responsible congenital anomalies foetus. This review supports idea that associated with increased risk PCOS, RPL, PE, anomalies. provide clue toward better understanding correlation between detrimental effects on health.

Language: Английский

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Extender development for optimal cryopreservation of buck sperm to increase reproductive efficiency of goats

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: April 2, 2025

Preservation of sperm significantly contributes to the advancement assisted reproductive technologies, genetic conservation and improvement efforts, precision breeding livestock. This review distills knowledge from existing information emerging patterns in field buck cryopreservation. The primary focus is on challenges opportunities associated with improving extender formulations freezing techniques order enhance vitality after thawing increase potential for conception. assesses efficacy limitations conventional extenders derived egg yolk or soybean lecithin, adverse impacts seminal plasma enzymes quality during processes chilling Significant progress has been made fields molecular biology namely lipidomics, proteomics, metabolomics, DNA methylation providing valuable regarding unique reactions utilization "omics" technologies shown intricate transformation that occur thawing. Moreover, detection biomarkers indicate their ability withstand provides choose best samples This, turn, enhances results artificial insemination endeavors. emphasizes necessity adopting a comprehensive approach combines cellular practical methods cryopreservation ensure production goats as major food animals global scale.

Language: Английский

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