Biotechnology Letters, Journal Year: 2022, Volume and Issue: 45(2), P. 235 - 253
Published: Dec. 22, 2022
Language: Английский
Molecules, Journal Year: 2021, Volume and Issue: 26(19), P. 5991 - 5991
Published: Oct. 2, 2021
Citrus fruits (CF) are among the most widely cultivated fruit crops throughout world and their production is constantly increasing along with consumers’ demand. Therefore, huge amounts of waste annually generated through CF processing, causing high costs for disposal, as well environmental human health damage, if inappropriately performed. According to recent indications an economic, pharmaceutical nature, processing residues must be transformed from a disposed valuable resource reused. Based on circular economy model, (i.e., seeds, exhausted peel, pressed pulp, secondary juice leaves) have increasingly been re-evaluated also obtain, but not limited to, compounds employed in food, packaging, cosmetic industries. However, use by-products still because underestimated nutritional economic value, hence more awareness knowledge needed overcome traditional approaches disposal. This review summarizes evidence pharmacological potential support switch towards environmentally sustainable society.
Language: Английский
Citations
120
Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 272, P. 116023 - 116023
Published: Jan. 30, 2024
An in vivo model is necessary for toxicology. This review analyzed the uses of zebrafish (Danio rerio) toxicology based on bibliometrics. Totally 56,816 publications about from 2002 to 2023 were found Web Science Core Collection, with Toxicology as top 6 among all disciplines. Accordingly, bibliometric map reveals that "toxicity" has become a hot keyword. It further most common exposure types include acute, chronic, and combined exposure. The toxicological effects behavioral, intestinal, cardiovascular, hepatic, endocrine toxicity, neurotoxicity, immunotoxicity, genotoxicity, reproductive transgenerational toxicity. mechanisms oxidative stress, inflammation, autophagy, dysbiosis gut microbiota. toxicants commonly evaluated by using nanomaterials, arsenic, metals, bisphenol, dioxin. Overall, provide unique well-accepted investigate mechanisms. We also discussed possible ways address some limitations model, such combination human organoids avoid species differences.
Language: Английский
Citations
34
Biology, Journal Year: 2025, Volume and Issue: 14(1), P. 87 - 87
Published: Jan. 17, 2025
Oxidative stress, a critical factor affecting the health and productivity of aquatic organisms, arises from imbalance between reactive oxygen species (ROS) production antioxidant defenses. In aquaculture, natural antioxidants have gained increasing attention as sustainable feed additives to mitigate oxidative damage, enhance immune responses, improve overall growth performance. This review provides comprehensive synthesis antioxidative mechanisms key antioxidants, including carotenoids, polysaccharides, vitamins, polyphenols, flavonoids. By neutralizing ROS modulating cellular signaling pathways such Nrf2/ARE, these compounds offer significant protective effects against damage in species. The manuscript consolidates recent advancements research, highlighting their practical applications formulation role promoting sustainability aquaculture. aims provide an integrative framework for understanding antioxidants’ potential, guiding future research implementation aquaculture systems.
Language: Английский
Citations
2
iScience, Journal Year: 2023, Volume and Issue: 26(7), P. 107041 - 107041
Published: June 8, 2023
In the last years, extracellular vesicles (EVs) from different plant matrices have been isolated and gained interest of scientific community for their intriguing biological properties. this study, we characterized nanovesicles lemon juice (LNVs) evaluated antioxidant effects. We tested LNV activity using human dermal fibroblasts that were pre-treated with LNVs 24 h then stimulated hydrogen peroxide (H
Language: Английский
Citations
27
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2899 - 2899
Published: Feb. 2, 2023
A Mediterranean-style diet is highly encouraged thanks to its healthy food pattern, which includes valuable nutraceuticals such as polyphenols. Among these, flavonoids are associated with relevant biological properties through they prevent or fight the onset of several human pathologies. Globally, enhanced incidence overweight and obese people has caused a dramatic increase in comorbidities, raising need provide better therapies. Therefore, development sophisticated animal models metabolic dysregulation allowed for deepening knowledge on this subject. Recent advances using zebrafish (Danio rerio) model disease have yielded fundamental insights into potential anti-obesity effects flavonoids. Chronic low-grade inflammation immune system activation seem characterize pathogenesis obesity; thus, their reduction might improve lipid profile patients illnesses. In review, we highlight beneficial role obesity related diseases linked anti-inflammatory properties. light summarized studies, suggest that therapies could place prevention treatment disorders.
Language: Английский
Citations
23
Toxicology Letters, Journal Year: 2025, Volume and Issue: 405, P. 30 - 40
Published: Feb. 6, 2025
Language: Английский
Citations
1
Food Chemistry, Journal Year: 2022, Volume and Issue: 402, P. 134351 - 134351
Published: Sept. 22, 2022
Language: Английский
Citations
37
Cells, Journal Year: 2023, Volume and Issue: 12(2), P. 252 - 252
Published: Jan. 7, 2023
Over the past century, advances in biotechnology, biochemistry, and pharmacognosy have spotlighted flavonoids, polyphenolic secondary metabolites that ability to modulate many pathways involved various biological mechanisms, including those neuronal plasticity, learning, memory. Moreover, flavonoids are known impact processes developing neurodegenerative diseases, namely oxidative stress, neuroinflammation, mitochondrial dysfunction. Thus, several could be used as adjuvants prevent counteract disorders such Alzheimer’s Parkinson’s diseases. Zebrafish is an interesting model organism can offer new opportunities study beneficial effects of on Indeed, high genome homology 70% humans, brain organization largely similar human well neuroanatomical neurochemical processes, neurogenic activity maintained adult makes zebrafish a valuable for diseases deciphering disorders.
Language: Английский
Citations
17
Nutrients, Journal Year: 2024, Volume and Issue: 16(2), P. 259 - 259
Published: Jan. 15, 2024
Chronic inflammation is the result of an acute inflammatory response that fails to eliminate pathogenic agent or heal tissue injury. The consequence this failure lays foundations onset several chronic ailments, including skin disorders, respiratory and neurodegenerative diseases, metabolic syndrome, and, eventually, cancer. In context, long-term use synthetic anti-inflammatory drugs treat illnesses cannot be tolerated by patients owing severe side effects. Based on this, need for novel agents endowed with effects prompted search potential candidates also within plant kingdom, being recognized as a source molecules currently employed in therapeutical areas. Indeed, ever-growing evidence properties dietary polyphenols traced route towards study flavonoid-rich sources, such Citrus bergamia (bergamot) its derivatives. Interestingly, recent paradigm circular economy has promoted valorization fruit waste regard bergamot, it brought light new corroborating bergamot byproducts, thus increasing scientific knowledge field. Therefore, review aims gather latest literature supporting beneficial role both derivatives products different models inflammatory-based highlighting great potentiality re-evaluation perspective.
Language: Английский
Citations
7
Zebrafish, Journal Year: 2022, Volume and Issue: 19(5), P. 165 - 176
Published: Sept. 1, 2022
Dioxygen is an integral part of every living organism, but its concentration varies from organ to organ. Production metabolites dioxygen may result in oxidative stress. Since stress has the potential damage various biomolecules cell, therefore, it presently become active field research. Oxidative been studied a wide range model organisms vertebrates invertebrates, rodents piscine organisms, and vivo vitro models. But zebrafish (adults, larvae, or embryonic stage) emerged out be most promising vertebrate organism study because vast advantages (transparent embryo, cost-effectiveness, similarity human genome, easy developmental processes, numerous offspring per spawning, many more). This evidenced by voluminous number researches on exposed chemicals, radiations, nanoparticles, pesticides, heavy metals, etc. On these backgrounds, this review attempts highlight potentiality as compared with other companion Several areas, biomedical environmental research, have covered explain more convenient reliable animal for experimental research mechanisms.
Language: Английский
Citations
27