The effect of soy isoflavones in brain development: the emerging role of multiple signaling pathways and future perspectives DOI Creative Commons
Winda Ariyani, Noriyuki Koibuchi

Endocrine Journal, Journal Year: 2024, Volume and Issue: 71(4), P. 317 - 333

Published: Jan. 1, 2024

Soybean is a source of protein, fibers, and phytochemical isoflavones which are considered to have numerous health benefits for children adulthood. On the other hand, widely known as phytoestrogens that exert their action via estrogen signaling pathway. With this regard, also endocrine-disrupting chemicals. Endogenous plays crucial role in brain development through binding receptors (ERs) or G protein-coupled 1 (GPER1) regulates morphogenesis, migration, functional maturation, intracellular metabolism neurons glial cells. Soy can bind ERs, GPER1, and, furthermore, modulate action. Therefore, soy isoflavone consumption may affect during pre-and post-natal periods. This review summarizes current knowledge on mechanisms action, particularly early stages by introducing representative human, animal models, vitro studies, discusses beneficial adverse impact neurobehavior. As conclusion, product periods under proper range dose showed effects neurobehavior development, including improvement anxiety, aggression, hyperactive behavior, cognition, whereas effect taking higher doses cannot be excluded. We present novel research lines further assess administration development.

Language: Английский

Dietary Phenolic Compounds: Their Health Benefits and Association with the Gut Microbiota DOI Creative Commons

Yoko Matsumura,

Masahiro Kitabatake,

Shin-ichi Kayano

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 880 - 880

Published: April 4, 2023

Oxidative stress causes various diseases, such as type II diabetes and dyslipidemia, while antioxidants in foods may prevent a number of diseases delay aging by exerting their effects vivo. Phenolic compounds are phytochemicals flavonoids which consist flavonols, flavones, flavanonols, flavanones, anthocyanidins, isoflavones, lignans, stilbenoids, curcuminoids, phenolic acids, tannins. They have hydroxyl groups molecular structures. These present most plants, abundant nature, contribute to the bitterness color foods. Dietary compounds, quercetin onions sesamin sesame, exhibit antioxidant activity help cell diseases. In addition, other kinds tannins, larger weights, many unexplained aspects still exist. The activities be beneficial for human health. On hand, metabolism intestinal bacteria changes structures these with properties, resulting metabolites exert recent years, it has become possible analyze composition microbiota. augmentation microbiota intake been implicated disease prevention symptom recovery. Furthermore, "brain-gut axis", is communication system between gut microbiome brain, attracting increasing attention, research revealed that dietary affect brain homeostasis. this review, we discuss usefulness against some biotransformation microbiota, microflora, on brain-gut axis.

Language: Английский

Citations

60
Cryopreservation of bioflavonoid-rich plant sources and bioflavonoid-microcapsules: emerging technologies for preserving bioactivity and enhancing nutraceutical applications DOI Creative Commons

Jia Xiang,

Ronald Mlambo, Ibrahim Shaw

et al.

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Sept. 14, 2023

Bioflavonoids are natural polyphenolic secondary metabolites that medicinal. These compounds possess antitumor, cardioprotective, anti-inflammatory, antimicrobial, antiviral, and anti-psoriasis properties to mention a few. Plant species contain bioflavonoids should be preserved as such. Also, the bioactivity of neutraceutical is compromised following extraction due their sensitivity environmental factors like light, pH, temperature. In other words, bioflavonoids’ shelf-life affected. Scientists noticed have low solubility properties, poor absorption, bioavailability consumption. Researchers came up with methods encapsulate in order circumvent challenges above also mask unpleasant these chemicals may have. Besides, scientists cryopreserve plant bioflavonoids. this review, we discuss cryopreservation bioflavonoid microencapsulation focusing mainly on vitrification, slow freezing, freeze-drying techniques. addition, highlight techniques, medicinal challenges, future perspectives Regardless uniqueness preserve sources bioactivity, there reported. Freeze-drying technology costly. Cryoprotectants damage integrity cells, say least. working very hard overcome challenges. Encapsulating via coaxial electrospray then cryopreserving micro/nanocapsules produced can interesting.

Language: Английский

Citations

44
Role of Natural and Synthetic Compounds in Modulating NRF2/KEAP1 Signaling Pathway in Prostate Cancer DOI Open Access
Giovanni Tossetta, Sonia Fantone, Daniela Marzioni

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(11), P. 3037 - 3037

Published: June 2, 2023

Prostate cancer is the second most common in men worldwide. can be treated by surgery or active surveillance when early diagnosed but, at an advanced metastatic stage, radiation therapy androgen-deprivation needed to reduce progression. However, both of these therapies cause prostate resistance treatment. Several studies demonstrated that oxidative stress involved occurrence, development, progression and treatment resistance. The nuclear factor erythroid 2-related 2 (NRF2)/KEAP1 (Kelch-Like ECH-Associated Protein 1) pathway plays important role protecting cells against damage. Reactive oxygen species (ROS) levels NRF2 activation determine cell fate. In particular, toxic ROS lead physiological death tumor suppression, while lower are associated with carcinogenesis On contrary, a high level promotes survival related activating adaptive antioxidant response. this review, we analyzed current literature regarding natural synthetic compounds modulating NRF2/KEAP1 signaling cancer.

Language: Английский

Citations

42
Insights and implications of sexual dimorphism in osteoporosis DOI Creative Commons
Yuanyuan Zhang, Na Xie,

Xiaodong Sun

et al.

Bone Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Feb. 18, 2024

Osteoporosis, a metabolic bone disease characterized by low mineral density and deterioration of microarchitecture, has led to high risk fatal osteoporotic fractures worldwide. Accumulating evidence revealed that sexual dimorphism is notable feature osteoporosis, with sex-specific differences in epidemiology pathogenesis. Specifically, females are more susceptible than males while prone disability or death from the disease. To date, sex chromosome abnormalities steroid hormones have been proven contribute greatly osteoporosis regulating functions cells. Understanding its related complications essential for improving treatment strategies tailored women men. This literature review focuses on mechanisms underlying mainly population aging patients, chronic glucocorticoid administration, diabetes. Moreover, we highlight implications developing therapeutics preventive screening approaches Additionally, challenges translating bench research bedside treatments future directions overcome these obstacles will be discussed.

Language: Английский

Citations

27
Probiotics: Health benefits, food application, and colonization in the human gastrointestinal tract DOI Creative Commons
Li Ying Jessie Lau, Siew Young Quek

Food Bioengineering, Journal Year: 2024, Volume and Issue: 3(1), P. 41 - 64

Published: March 1, 2024

Abstract Probiotics have become increasingly popular over the past two decades due to continuously expanding scientific evidence indicating their beneficial effects on human health. Therefore, they been applied in food industry produce functional food, which plays a significant role health and reduces disease risk. However, maintaining viability of probiotics targeting successful delivery gastrointestinal tract remain challenging tasks applications. Specifically, this paper reviews potentially properties probiotics, highlighting use challenges application associated benefits. Of foremost importance, also explores potential underlying molecular mechanisms enhanced effect epithelial cells, including discussion various surface adhesion‐related proteins probiotic cell that facilitate colonization.

Language: Английский

Citations

16
Estrogens and phytoestrogens in body functions DOI
Ilaria Ceccarelli,

Lucia Bioletti,

Sofia Peparini

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 132, P. 648 - 663

Published: Dec. 8, 2021

Language: Английский

Citations

63
Therapeutic potentials of genistein: New insights and perspectives DOI Open Access
Sumbal Rasheed, Kanwal Rehman, Momina Shahid

et al.

Journal of Food Biochemistry, Journal Year: 2022, Volume and Issue: 46(9)

Published: May 17, 2022

Genistein, a polyphenolic isoflavone compound found abundantly in soy or soy-based products, is widely consumed the Asian population. Genistein has poor bioavailability, to overcome this problem many advanced nano-drug delivery carrier systems are designed enhance its water solubility and stability. However, further research required develop more efficient bioavailability improvement strategies. phytoestrogen which been associated with reducing risk of cancer, cardiovascular disorders, diabetes mellitus. This plant-based bioactive possesses numerous biological activities such as anti-oxidant, anti-inflammatory, anti-obesity, anti-cancer, cardioprotective, anti-diabetic treat various disease states. used an active therapeutic agent medications. Moreover, several clinical trials ongoing stage treatment therapies, especially for cancer treatment. article highlights protective benefits genistein different ailments, specifically elaborates on anti-cancer potential regarding types cancers. Practical applications versatile activities, including anti-diabetic, anti-angiogenic. The most studied activity anti-cancer. Currently, number pre-clinical being carried out anti-neoplastic cytotoxic novel agents excellent kinds cancer. enhancement strategies have developed improve genistein. shows significant hypoglycemic effects alone combination other agents. chemotherapeutic prostate, bone, colorectal, glioma, breast, bladder

Language: Английский

Citations

48
The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer DOI Creative Commons
T. Pejcic, Milica Zeković, Uroš Bumbaširević

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 368 - 368

Published: Feb. 3, 2023

This narrative review summarizes epidemiological studies on breast cancer and prostate with an overview of their global incidence distribution to investigate the relationship between these diseases diet. The biological properties, mechanisms action, available data supporting potential role isoflavones in prevention are discussed. Studies evaluating effects tissue cultures normal malignant cells, as well current body research regarding attained through multiple modifications cellular molecular signaling pathways control oxidative stress, summarized. Furthermore, this compiles literature sources reporting following: (1) levels estrogen tissue; (2) organs European Asian populations; (3) average concentrations secretion (milk semen). Finally, particular emphasis is placed investigating effect tissues via receptors (ER).

Language: Английский

Citations

34
Exploring functional plant-based seafood: Ingredients and health implications DOI Creative Commons
Niaz Mahmud,

Shahriyar Valizadeh,

William Oyom

et al.

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 144, P. 104346 - 104346

Published: Jan. 21, 2024

Language: Английский

Citations

9
Exploring Impact of Probiotic‐Fermented Soymilk on Dextran‐Sulfate‐Sodium‐Induced Ulcerative Colitis via Modulating Inflammation and Gut Microbiota Profile DOI
Philippe Madjirebaye, Fei Peng, Abdul Mueed

et al.

Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: 68(5)

Published: Feb. 1, 2024

Scope Lactic acid bacteria with probiotic functions and their fermentation products play a role in regulating ulcerative colitis (UC). This study investigates the potential of fermented soymilk (FSM4) rich isoflavones on DSS‐induced UC. Methods Results Mice received 3% DSS are supplemented daily once for 1 week by NFSM FSM4. usually causes intestinal inflammation alters gut microbiota. FSM4 intervention improves UC‐related microbiota alteration. It considerably decreases pro‐inflammatories such as TNF‐α, IL‐1β, IL‐6 serum COX‐2 MPO colon tissues pathogenic ( Escherichia‐Shigella) . facilitates gut‐healthy growth. These healthy negatively correlat pro‐inflammatory factors but positively associated acetic acid, butyric propionic which may act PPAR‐γ pathway activating NF‐κB p65 inhibiting, lowering risk Overall, might alleviate UC significantly reverse dysbiosis via activation. could be good alternative developing functional food to protect against Conclusion attenuates modulates SCFA‐producing growth, enable activation target, dietary strategy health.

Language: Английский

Citations

8