Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation DOI Creative Commons
Kaidi Chen, Seongmin Ha, Leyao Xu

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 8, 2024

Biological-derived hydroxyapatite is widely used as a bone substitute for addressing defects, but its limited osteoconductive properties necessitate further improvement. The osteo-immunomodulatory hold crucial promise in maintaining homeostasis, and precise modulation of macrophage polarization essential this process. Metabolism serves guiding force immunity, fluoride modification represents promising strategy modulating the osteoimmunological environment by regulating immunometabolism. In context, we synthesized fluorinated porcine (FPHA), has demonstrated enhanced biological osteogenic capacity. However, it remains unknown whether how FPHA affects immune microenvironment defects.

Language: Английский

The impact of oxidative stress-induced mitochondrial dysfunction on diabetic microvascular complications DOI Creative Commons
Ziwei Zhang, Qingxia Huang,

Daqing Zhao

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 7, 2023

Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycaemia, with absolute insulin deficiency or resistance as the main cause, and causes damage to various target organs including heart, kidney neurovascular. In terms of pathological physiological mechanisms DM, oxidative stress one leading DM an important link between its complications. Oxidative phenomenon resulting from imbalance production free radicals scavenging antioxidant systems. The site reactive oxygen species (ROS) mitochondria, which are also organelles damaged. high glucose environment, impaired electron transport chain within mitochondria leads ROS, prompts increased proton leakage altered mitochondrial membrane potential (MMP), in turn releases cytochrome c (cyt-c), apoptosis. This subsequently vicious cycle clearance body's system, transcription protein synthesis DNA (mtDNA), responsible for encoding proteins, repair systems, contributing dysfunction. paper reviews dysfunction environment induced model, looks forward providing new treatment plan based on

Language: Английский

Citations

83
Calcium and Reactive Oxygen Species Signaling Interplays in Cardiac Physiology and Pathologies DOI Creative Commons

Bianca De Nicolo,

Erica Cataldi-Stagetti,

Chiara Diquigiovanni

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 353 - 353

Published: Feb. 2, 2023

Mitochondria are key players in energy production, critical activity for the smooth functioning of energy-demanding organs such as muscles, brain, and heart. Therefore, dysregulation or alterations mitochondrial bioenergetics primarily perturb these organs. Within cell, mitochondria major site reactive oxygen species (ROS) production through different enzymes since it is one organelles with availability oxygen. ROS can act signaling molecules a number pathways by modulating calcium (Ca2+) signaling. Interactions among be considered bidirectional, regulating cellular Ca2+ signaling, whereas essential production. In particular, we will discuss how crosstalk between lead to dysfunctions consequent damage tissues at high demand, Changes induce associated reduced ATP increased ROS. These changes levels generation completely paralyze cardiac contractility. Thus, hinder excitation–contraction coupling, inducing arrhythmias, hypertrophy, apoptosis, necrosis cells. interplays cardiovascular system focus this review.

Language: Английский

Citations

45
Targeting Mitochondrial Dysfunction in Cerebral Ischemia: Advances in Pharmacological Interventions DOI Creative Commons
И. Ф. Беленичев, Olena Popazova, Nina Bukhtiyarova

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 108 - 108

Published: Jan. 18, 2025

The study of mitochondrial dysfunction has become increasingly pivotal in elucidating the pathophysiology various cerebral pathologies, particularly neurodegenerative disorders. Mitochondria are essential for cellular energy metabolism, regulation reactive oxygen species (ROS), calcium homeostasis, and execution apoptotic processes. Disruptions function, driven by factors such as oxidative stress, excitotoxicity, altered ion balance, lead to neuronal death contribute cognitive impairments several brain diseases. Mitochondrial can arise from genetic mutations, ischemic events, hypoxia, other environmental factors. This article highlights critical role progression diseases discusses need targeted therapeutic strategies attenuate damage, restore enhance neuroprotection.

Language: Английский

Citations

3
Mitochondrial Dysfunction in Alzheimer’s Disease DOI Creative Commons
M. D’Alessandro, Salim Kanaan, Mauro Geller

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102713 - 102713

Published: Feb. 1, 2025

Language: Английский

Citations

2
Oxidative Stress, Gut Microbiota, and Extracellular Vesicles: Interconnected Pathways and Therapeutic Potentials DOI Open Access
Bo Ma, Muttiah Barathan, Min Hwei Ng

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3148 - 3148

Published: March 28, 2025

Oxidative stress (OS) and gut microbiota are crucial factors influencing human health, each playing a significant role in the development progression of chronic diseases. This review provides comprehensive analysis complex interplay between these two factors, focusing on how an imbalance reactive oxygen species (ROS) antioxidants leads to OS, disrupting cellular homeostasis contributing range conditions, including metabolic disorders, cardiovascular diseases, neurological cancer. The microbiota, diverse community microorganisms residing gastrointestinal tract, is essential for regulating immune responses, pathways, overall health. Dysbiosis, composition, closely associated with inflammation, dysfunction, various highlights influences influenced by complicating pathophysiology many conditions. Furthermore, emerging evidence has identified extracellular vesicles (EVs) as critical facilitators crosstalk OS microbiota. EVs also play signaling host tissues, modulating processes. function holds promise targeted therapies aimed at restoring microbial balance mitigating OS. Personalized therapeutic approaches, probiotics, antioxidants, fecal transplantation-based strategies, can be used address OS-related diseases improve health outcomes. Nonetheless, further research needed study molecular mechanisms underlying interactions potential innovative interventions offer novel strategies managing enhancing

Language: Английский

Citations

2
Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases DOI Creative Commons
Jinghan Li,

Sujuan Zheng,

Yumei Fan

et al.

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(9)

Published: Sept. 22, 2023

Abstract Kidney diseases remain one of the leading causes human death and have placed a heavy burden on medical system. Regulated cell contributes to pathology plethora renal diseases. Recently, with in-depth studies into kidney death, new iron-dependent modality, known as ferroptosis, has been identified attracted considerable attention among researchers in pathogenesis therapeutics treat them. The majority suggest that ferroptosis plays an important role pathologies multiple diseases, such acute injury (AKI), chronic disease, carcinoma. In this review, we summarize recently regulatory molecular mechanisms discuss pathways action various describe protective effect inhibitors against especially AKI. By summarizing prominent roles different progress made studying provide directions strategies for future research summary, ferroptotic factors are potential targets therapeutic intervention alleviate targeting them may lead treatments patients

Language: Английский

Citations

28
Polystyrene Microplastics of Varying Sizes and Shapes Induce Distinct Redox and Mitochondrial Stress Responses in a Caco-2 Monolayer DOI Creative Commons
Nelly D. Saenen, M. Witters, Inneke Hantoro

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 739 - 739

Published: March 17, 2023

Currently, we lack crucial knowledge on how the physicochemical properties of particles affect cellular health, resulting in an important gap our understanding human toxicity microplastics (MPs). Our aim was to evaluate impact size and shape MPs uptake intracellular effects a epithelial colorectal adenocarcinoma (Caco-2) cell line. Spherical (200 nm 2 µm) fibre-/fragment-shaped (8.9 ± 10.1 µm by 1.14 0.97 polystyrene (PS-MPs) were used study their potential induce redox mitochondrial stress responses after 24 h exposure. We demonstrated both spherical size-dependent manner. In response spheres, observed differential expressions redox-related genes, including HMOX1, CAT, GPX1. All PS-MPs decreased H2O2 levels, which can be attributed responses, such as increased DNA content, footprint, morphology. Altogether, uptakes changes parameters for all PS-MPs, with 200 spheres showing most profound effects. This suggests that induction defensive Caco-2 cells mainly correlates number taken up.

Language: Английский

Citations

27
Mitochondria Deregulations in Cancer Offer Several Potential Targets of Therapeutic Interventions DOI Open Access
Clara Musicco, Anna Signorile, Vito Pesce

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 10420 - 10420

Published: June 21, 2023

Mitochondria play a key role in cancer and their involvement is not limited to the production of ATP only. also produce reactive oxygen species building blocks sustain rapid cell proliferation; thus, deregulation mitochondrial function associated with disease development progression. In cells, metabolic reprogramming takes place through different modulation pathways, including oxidative phosphorylation, fatty acid oxidation, Krebs cycle, glutamine heme metabolism. Alterations homeostasis, particular, biogenesis, mitophagy, dynamics, redox balance, protein were observed cells. The use drugs acting on destabilization may represent promising therapeutic approach tumors which respiration predominant energy source. this review, we summarize main features pathways altered moreover, present best known that, by homeostasis induce alterations death. addition, new strategies that damage, such as photodynamic, photothermal chemodynamic therapies, nanoformulations specifically target mitochondria are described. Thus, mitochondria-targeted open frontiers tailored personalized therapy.

Language: Английский

Citations

27
Complex II ambiguities—FADH2 in the electron transfer system DOI Creative Commons
Erich Gnaiger

Journal of Biological Chemistry, Journal Year: 2023, Volume and Issue: 300(1), P. 105470 - 105470

Published: Nov. 22, 2023

The prevailing notion that reduced cofactors NADH and FADH

Language: Английский

Citations

23
Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to alleviate ulcerative colitis DOI Creative Commons
Ning Li, Леи Жао, Xinyu Geng

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(11), P. 4278 - 4296

Published: Jan. 1, 2024

Background: Ulcerative colitis (UC) is an intestinal inflammatory disease that strongly associated with mitochondrial damage and dysfunction as well mitophagy lacks of satisfactory treatments.Hair follicle mesenchymal stem cell (HF-MSC)-derived exosomes owe benefit effectiveness on therapies.Hypoxia-preconditioned HF-MSCs exhibit enhanced proliferation migration abilities, their exert stronger effects than normal exosomes.However, the therapeutic function Hy-Exos in UC unknown.Methods: The inflammation model was established LPS-treated MODE-K cells, mouse by dextran sulfate sodium (DSS) administration.The HF-MSC-derived (Exos) hypoxia-preconditioned (Hy-Exos) were compared vitro vivo.Immunofluorescence staining western blotting used to explore function, fission fusion mitophagy.MiRNA sequencing analysis applied investigate differences components between Exos Hy-Exos.Results: had a better effect cells DSS-induced mice.Hy-Exos promoted colonic tight junction proteins expression, suppressed oxidative stress response, reduced UC-related injury.Hy-Exos may these via miR-214-3p-mediated inhibition PI3K/AKT/mTOR signaling pathway, maintenance dynamic stability, alleviation enhancement mitophagy. Conclusion:This study revealed vital role for suppressing progression suggested miR-214-3p potential critical target alleviating UC.

Language: Английский

Citations

13