Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 665 - 674
Published: Oct. 1, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1098 - 1098
Published: Jan. 27, 2025
This article reviews the synergistic effects of antioxidant-enriched functional foods and exercise in improving metabolic health, focusing on underlying molecular mechanisms. The review incorporates evidence from PubMed, SCOPUS, Web Science, PsycINFO, reference lists relevant up to 20 December 2024, highlighting central role Nrf2 pathway. As a critical regulator oxidative stress adaptation, mediates benefits these interventions. presents an innovative approach understanding regulation inflammation, its potential prevention treatment various diseases, including cancer, neurodegenerative disorders, cardiovascular pulmonary diabetes, inflammatory conditions, ageing, infections such as COVID-19. novelty this study is investigate bioactive compounds found (such polyphenols, flavonoids, vitamins) exercise-induced activation combined reveals their improve insulin sensitivity lipid metabolism reduce offering promising strategy for management chronic diseases. However, there are significant gaps current research, particularly regarding mechanisms interaction between diet, physical activity, activation, well long-term different populations, those with In addition, interactions other signalling pathways, AMPK, NF-κB, PI3K/Akt, collective contributions health explored. Furthermore, novel biomarkers presented assess impact strategies, NAD+/NADH ratio, GSH markers mitochondrial health. findings provide valuable insights into how integration antioxidant-rich diet regular can by activating related pathways represent strategies disorders. Further studies needed fully understand therapeutic interventions diseases stress, disease, cancer.
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1645 - 1645
Published: Feb. 14, 2025
The relationship between neuroinflammation and depression is a complex area of research that has garnered significant attention in recent years. Neuroinflammation, characterized by the activation glial cells release pro-inflammatory cytokines, been implicated pathophysiology depression. bidirectional; not only can inflammation contribute to onset depressive symptoms, but itself also exacerbate inflammatory responses, creating vicious cycle complicates treatment recovery. present comprehensive review aimed explore current findings on interplay depression, as well mechanisms, risk factors, therapeutic implications. mechanisms which induces depressive-like behaviors are diverse. Neuroinflammation increase activate hypothalamus-pituitary-adrenal (HPA) axis, impair serotonin synthesis, all symptoms. Furthermore, microglia linked mediators disrupt neuronal function mood disorders. Stress-induced neuroinflammatory responses lead cytokines affect brain influence behavior mood. Understanding these crucial for developing targeted therapies mitigate effects
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8675 - 8675
Published: Aug. 8, 2024
Omega-3 polyunsaturated fatty acids have received considerable attention in the field of mental health, particular regarding treatment depression. This review presents an overview current research on role omega-3 prevention and depressive disorders. The existing body evidence demonstrates that acids, eicosapentaenoic acid (EPA) docosahexaenoic (DHA), antidepressant effects can be attributed to their modulation neuroinflammation, neurotransmitter function, neuroplasticity. Nevertheless, clinical trials supplementation yielded inconsistent results. Some studies demonstrated significant reductions symptoms following treatment, whereas others shown minimal no beneficial impact. A range factors, encompassing dosage, ratio EPA DHA, baseline nutritional status, been identified as having a potential impact noted Furthermore, it has suggested may act adjunctive for those undergoing treatment. Notwithstanding these encouraging findings, discrepancies study designs variability individual responses underscore necessity further order establish uniform, standardized guidelines use management
Language: Английский
Citations
13
Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(3), P. 305 - 305
Published: March 13, 2024
In recent years, although life expectancy has increased significantly, non-communicable diseases (NCDs) continue to pose a significant threat the health of global population. Therefore, eating habits have been recognized as key modifiable factors that influence people’s and well-being. For this reason, it is interesting study dietary patterns, since human diet complex mixture macronutrients, micronutrients, bioactive compounds, can modulate multiple physiological processes, including immune function, metabolism, inflammation. To ensure data we acquired were current relevant, searched primary secondary sources, scientific journals, bibliographic indexes, databases in last 15 years with most relevant articles. After search, observed all research on NCDs suggests critical factor shaping an individual’s outcomes. Thus, cardiovascular, metabolic, mental, dental, visual depends largely intake, nutritional behaviors. A high processed refined foods, added sugars, saturated fats increase risk developing chronic diseases. On other hand, rich whole, nutrient-dense such vegetables, fruits, nuts, legumes, adherence Mediterranean improve health’s people.
Language: Английский
Citations
10
Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105107 - 105107
Published: Sept. 1, 2024
Language: Английский
Citations
4
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 28, 2025
Language: Английский
Citations
0
Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 238 - 238
Published: Feb. 24, 2025
Background: Major depressive disorder is a common mental health issue characterized by persistently low mood and high morbidity mortality. The major pathophysiology neuroinflammation, as evidenced elevated cytokine levels. Patients often fail to achieve full remission with the use of currently available antidepressants, prompting search for new treatment options. Schaftoside (SS), flavonoid found in traditional Chinese herbs, has both antioxidant anti-inflammatory properties. However, its antidepressant effects are poorly understood. Methods: Male C57BL/6 mice underwent chronic unpredictable mild stress (CUMS) lipopolysaccharide (LPS) induce depression- anxiety-like behaviors. SS was administered at 40, 80, 160 mg/kg 28 days. effect on depression-like behaviors assessed using behavioral assays, ELISA used measure pro-inflammatory cytokines serum hippocampus. Results: significantly decreased immobility forced swim tail suspension tests, increased sucrose preference test, reduced feeding latency novelty-suppressed test. These findings indicate improved depression showed that lowered interleukin-1 beta (IL-1β), IL-6, tumor necrosis factor-alpha levels hippocampus CUMS mice. Conclusions: Our study indicates anxiolytic effects, possibly through neuroinflammatory processes, making it promising therapeutic candidate depression, thus deserves further investigation into mechanisms clinical efficacy.
Language: Английский
Citations
0
Cells, Journal Year: 2025, Volume and Issue: 14(9), P. 629 - 629
Published: April 23, 2025
Major depressive disorder (MDD) is a prevalent psychiatric with complex pathogenesis influenced by various factors. Recent research has highlighted significant connection between psychological stress and MDD, inflammation playing central role in this relationship. Studies have demonstrated that peripheral immune changes patients MDD mouse models of social are closely linked to symptoms. These findings suggest targeting factors could represent novel approach for treating stress-related neuropsychiatric disorders. Stress triggers cascade inflammatory responses, leading disruptions neurotransmitter metabolism reduced synaptic plasticity. exacerbate depression contribute cognitive decline. This study examines the bidirectional relationship stress, focusing on interplay. studies identified specific elevated serum stress-exposed mice, indicating mechanism which responses can affect nervous system function behavior. Furthermore, proteins, such as nuclear factor kappa-B (NF-κB), reportedly play critical regulation hormones associated behaviors. Understanding these mechanisms essential advancing diagnostic, intervention, treatment strategies MDD.
Language: Английский
Citations
0
Beverages, Journal Year: 2024, Volume and Issue: 10(1), P. 12 - 12
Published: Jan. 23, 2024
Health-related nutritional human studies rely on the validity of dietary data provided by study participants. Reliable biomarkers for food intake help objectify collected frequency questionnaires. They facilitate monitoring compliance with requirements, e.g., abstinence from food, clean biased data, and remove non-compliant individuals. Biomarker candidates are often revealed sophisticated metabolomics analyses body fluids, urine or plasma, case control populations. However, validation using a biomarker candidate in real-life scenarios is seldomly executed. Coffee item high interest because abundance bioactive compounds regularity life-time consumption large part population. has been found to positively impact cardiovascular risk, type 2 diabetes, cognitive decline. its health implications, therefore, interest. A suitable coffee desirable clear classification participants as drinkers non-coffee enable correlation physiological response habits, consumption. Here, we propose roast compound N-methylpyridinium (NMP) promising pragmatic use distinguish drinker drinker. NMP an easily accessible analytical target plasma matrix that can determine precedent exposure roasted products. We review published information foods, coffee, plasma/urine after consumption, evaluate context proposed criteria “plausibility”, “time- dose–response”, “robustness”, “reliability”, “stability”, “analytical performance”, “reproducibility”. An additional set acquired fill gaps literature. In summary, conclude serve reliable tool verify recent coffee. The appears limited being qualitative, biosamples affected several parameters, roasting conditions volume time consumed.
Language: Английский
Citations
2
Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2305 - 2305
Published: July 18, 2024
Depressive disorders are the most prevalent mental health conditions in world. The commonly prescribed antidepressant medications can have serious side effects, and their efficacy varies widely. Thus, simple, effective adjunct therapies needed. Vinegar, a fermented acetic acid solution, is emerging as healthful dietary supplement linked to favorable outcomes for blood glucose management, heart disease risk, adiposity reduction, recent report suggests vinegar may improve symptoms of depression. This randomized controlled study examined 4-week change scores Center Epidemiological Studies Depression (CES-D) questionnaire Patient Health Questionnaire (PHQ-9) healthy overweight adults ingesting 2.95 g (4 tablespoons vinegar) vs. 0.025 (one pill) daily. A secondary objective explored possible underlying mechanisms using metabolomics analyses. At week 4, mean CES-D fell 26% 5% VIN CON participants respectively, non-significant difference between groups, PHQ-9 42% 18% (p = 0.036). Metabolomics analyses revealed increased nicotinamide concentrations upregulation NAD+ salvage pathway compared controls, metabolic alterations previously improved mood. daily ingestion over four weeks self-reported depression symptomology adults, enhancements niacin metabolism factor into this improvement.
Language: Английский
Citations
1