Melatonin-Derived Carbon Dots with Free Radical Scavenging Property for Effective Periodontitis Treatment via the Nrf2/HO-1 Pathway

ACS Nano, Journal Year: 2024, Volume and Issue: 18(11), P. 8307 - 8324

Published: March 4, 2024

Periodontitis is a chronic inflammatory disease closely associated with reactive oxygen species (ROS) involvement. Eliminating ROS to control the periodontal microenvironment and alleviate response could potentially serve as an efficacious therapy for periodontitis. Melatonin (MT), renowned its potent antioxidant anti-inflammatory characteristics, frequently employed scavenger in diseases. However, therapeutic efficacy of MT remains unsatisfactory due low water solubility poor bioavailability. Carbon dots have emerged promising innovative nanomaterial facile synthesis, environmental friendliness, cost. In this study, melatonin-derived carbon (MT-CDs) were successfully synthesized via hydrothermal method. The MT-CDs good biocompatibility feature excellent ROS-scavenging capacity without additional modification. vitro experiments proved that efficiently regulated intracellular ROS, which maintained mitochondrial homeostasis suppressed production mediators. Furthermore, findings from mouse model periodontitis indicated significantly inhibited deterioration alveolar bone reduced osteoclast activation inflammation, thereby contributing regeneration damaged tissue. terms mechanism, may scavenge preventing cellular damage factors by regulating nuclear factor erythroid 2-related 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. will offer vital understanding advancement secure effective platforms more biomedical applications.

Language: Английский

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The role of oxidative stress in intervertebral disc degeneration: Mechanisms and therapeutic implications

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 98, P. 102323 - 102323

Published: May 9, 2024

Oxidative stress is one of the main driving mechanisms intervertebral disc degeneration(IDD). has been associated with inflammation in disc, cellular senescence, autophagy, and epigenetics cells. It above pathological are closely linked through common hub reactive oxygen species(ROS), promote each other process degeneration development disease. This reveals important role oxidative IDD, importance great potential IDD therapy targeting stress. The efficacy traditional unstable or cannot be maintained. In recent years, due to rise materials science, many bioactive functional have applied treatment combination drugs, satisfactory achieved. At present, research review antioxidant not complete. Based on existing studies, mechanism were summarized this paper, strategies based emerging reviewed.

Language: Английский

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Immunomodulation in Bone Tissue Engineering: Recent Advancements in Scaffold Design and Biological Modifications for Enhanced Regeneration

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Bone defects, whether caused by trauma, cancer, infectious diseases, or surgery, can significantly impair people's quality of life. Although autografts are the gold standard for treating bone they often fall short in adequately forming tissue. The field tissue engineering has made strides using scaffolds with various biomaterials, stem cells, and growth factors to enhance healing. However, some biological structures do not yield satisfactory therapeutic outcomes new formation. Recent studies have shed light on crucial role immunomodulation, specifically interaction between implanted scaffold host immune systems, regeneration. Immune particularly macrophages, pivotal inflammatory response, angiogenesis, osteogenesis. This review delves into system's mechanism toward foreign bodies recent advancements scaffolds' physical properties that foster regeneration modulating macrophage polarization an anti-inflammatory phenotype enhancing osteoimmune microenvironment.

Language: Английский

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Oxidative Stress and Natural Products in Orthodontic Treatment: A Systematic Review

Nutrients, Journal Year: 2023, Volume and Issue: 16(1), P. 113 - 113

Published: Dec. 28, 2023

In recent years, orthodontics, a specialized branch of dentistry, has evolved considerably in terms both techniques and materials used. Aimed at correcting dental malocclusions craniofacial anomalies, it improves the functionality aesthetics face oral cavity. However, orthodontic treatment, its developmental stages, may induce oxidative stress (O.S.) phenomena, with an increase production reactive oxygen species (ROS), damaging periodontal tissues involved, affecting short-, medium- long-term results. Studies on antioxidant effects natural products (e.g., resveratrol, green tea, turmeric, etc.) medical field have aroused considerable interest years. A systematic literature review was conducted PubMed, Scopus, Web Science databases using (N.P.s), O.S., as keywords. The study aims to consider determinants ROS occurring during treatment possibility being able control neutralize biochemical phenomena by restoring physiological process which balance between ability body’s system them is favor latter.

Language: Английский

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Biomaterials Designed to Modulate Reactive Oxygen Species for Enhanced Bone Regeneration in Diabetic Conditions

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(8), P. 220 - 220

Published: Aug. 8, 2024

Diabetes mellitus, characterized by enduring hyperglycemia, precipitates oxidative stress, engendering a spectrum of complications, notably increased bone vulnerability. The genesis reactive oxygen species (ROS), byproduct metabolism, instigates detriment and impairs metabolism in diabetic conditions. This review delves into the mechanisms ROS generation its impact on homeostasis within context diabetes. Furthermore, summarizes cutting-edge progress development ROS-neutralizing biomaterials tailored for amelioration osteopathy. These are engineered to modulate dynamics, thereby mitigating inflammatory responses facilitating repair. Additionally, challenges therapeutic prospects ROS-targeted clinical application disease treatment is addressed.

Language: Английский

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Protective potential of naringenin and its nanoformulations in redox mechanisms of injury and disease

Heliyon, Journal Year: 2023, Volume and Issue: 9(12), P. e22820 - e22820

Published: Nov. 25, 2023

Increasing evidence suggests that elevated intracellular levels of reactive oxygen species (ROS) play a significant role in the pathogenesis many diseases. Increased ROS can lead to oxidation lipids, DNA, and proteins, contributing cellular damage. Hence, maintenance redox hemostasis is essential. Naringenin (NAR) flavonoid included flavanones subcategory. Various pharmacological actions have been ascribable this phytochemical composition, including antioxidant, anti-inflammatory, antibacterial, antiviral, antitumor, antiadipogenic, neuro-, cardio-protective activities. This review focused on underlying mechanism responsible for antioxidative stress properties NAR its' nanoformulations. Several lines vitro vivo investigations suggest effects its nanoformulation their target cells via modulating signaling pathways. These nanoformulations include nanoemulsion, nanocarriers, solid lipid nanoparticles (SLN), nanomicelle. also highlights several beneficial health human diseases brain disorders, cancer, rheumatoid arthritis, small intestine injuries. Employing improve pharmacokinetic consequently efficiency by reducing limitations, such as low bioavailability. The protective against oxidative may be linked modulation Nrf2-heme oxygenase-1, NO/cGMP/potassium channel, COX-2, NF-κB, AMPK/SIRT3, PI3K/Akt/mTOR, BDNF, NOX, LOX-1 Understanding behind facilitate drug development treatment stress-related disorders.

Language: Английский

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The association between periodontal disease and adverse pregnancy outcomes: a bibliometric analysis from 2000 to 2023

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 21, 2025

Background Periodontal disease (PD) refers to a chronic inflammatory disorder affecting the supporting tissues of teeth triggered by bacterial infection and is recognized promote systemic inflammation, leading dysfunction in specific organs. Adverse pregnancy outcomes (APOs), including preterm birth, small for gestational age infants, diabetes preeclampsia, are linked complications. Recently, correlation between periodontal adverse has garnered global attention. However, bibliometric studies this area remain limited. This study aimed visualize knowledge framework research trends concerning relationship from 2000 2023 through approaches. Methods On September 22, 2024, articles reviews on connection were retrieved Web Science Core Collection (WOSCC). CiteSpace [6.3.R1 (64-bit) Advanced] was used perform mapping studies. Results Over past 23 years, 932 73 countries collected, with U.S. contributing over one-third (355), followed Brazil (85) India (59). The literature field experienced multiple growth phases since 2000, particularly rapid observed after 2019. University North Carolina ( n = 34, 3.65%) institution terms publication output, primarily representing Notably, Journal Periodontology American Obstetrics Gynecology most frequently cited journals fields periodontology obstetrics, respectively. These publications authored 94 researchers, Steven Offenbacher being both productive highly author, making significant contributions field. A visual analysis keywords identifies “oral microbiota,” health,” “adverse outcomes,” “global burden” as emerging hotspots exploring outcomes. Conclusions first offers concise overview suggests future should focus risk factors, high-risk populations, oral microbiota, mechanisms, interventions, international collaboration.

Language: Английский

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Nanotherapies Based on ROS Regulation in Oral Diseases

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Abstract Oral diseases rank among the most prevalent clinical conditions globally, typically involving detrimental factors such as infection, inflammation, and injury in their occurrence, development, outcomes. The concentration of reactive oxygen species (ROS) within cells has been demonstrated a pivotal player modulating these intricate pathological processes, exerting significant roles restoring oral functionality maintaining tissue structural integrity. Due to enzyme‐like catalytic properties, unique composition, intelligent design, ROS‐based nanomaterials have garnered considerable attention nanomedicine. Such capacity influence spatiotemporal dynamics ROS biological systems, guiding evolution intra‐ROS facilitate therapeutic interventions. This paper reviews latest advancements functional customization, medical applications nanomaterials. Through analysis components designs various novel nanozymes nanoplatforms responsive different stimuli dimensions, it elaborates on impacts dynamic behavior potential regulatory mechanisms body. Furthermore, discusses prospects strategies nanotherapies based scavenging generation diseases, offering alternative insights for design development treating ROS‐related conditions.

Language: Английский

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Extracellular Vesicles From Dental Pulp Cells Promote Osteogenic Differentiation in Periodontal Ligament Cells

Journal of Periodontal Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Periodontal osseous defects are mainly caused by periodontitis, which seriously affects the quality of patient life. Dental pulp cells (DpCs)-derived extracellular vesicles (EVs) can effectively promote tissue regeneration. Homeobox A9 (HOXA9) mRNA is abundant in EVs derived from DSCs, may be related to promoting alveolar bone regeneration, but specific mechanism unclear. We aimed elucidate through HOXA9 DPCs-derived impact osteogenic differentiation periodontal ligament (PDLCs). were isolated and characterized transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), western blot. Lipopolysaccharide (LPS) was employed induce inflammatory environment. Cell viability assessed CCK8 assay. Calcium deposition determined Alizarin red staining. H3K27ac enrichment FLI1 enhancer region interaction between C/EBPα, HOXA9, analyzed ChIP The 293T dual luciferase reporter gene promoted PDLC osteogenesis under LPS treatment increased expression PDLCs. knockdown DPCs reversed effect on differentiation. facilitating competitively binding with C/EBPα. Moreover, activating PI3K/AKT pathway upregulating FLI1. Our study identified a previously unknown that HOXA9/FLI1 signaling axis participates processes treat injury. research presents theoretical basis for using

Language: Английский

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Impact of Smoking and Smokeless Tobacco on Salivary Flow Rate, pH Levels and Salivary Electrolytes

Pakistan Journal of Medicine and Dentistry, Journal Year: 2025, Volume and Issue: 14(1), P. 32 - 38

Published: Jan. 10, 2025

Background: Tobacco use, both in smoked and smokeless forms, poses a significant threat to public health. The specific impact of tobacco use on the parameters saliva still needs be explored. Hence, current study aimed identify smoking salivary flow rate, pH levels, electrolytes. Methods: This cross-sectional was conducted at community health centers, dental clinics, spaces Hyderabad from January 2024 July 2024. A total 150 smokers users who were >18 years old recruited via convenience sampling technique. MedCalc software used, one-way analysis variances run differences values groups. level significance kept 95% CI. Results: Salivary electrolyte measurements analyzed, findings revealed that levels unstimulated rate noticeably less (p<0.001) user groups compared control group. Conclusion: Overall, results underscore dangerous oral health, highlighting need for targeted interventions reduce promote awareness.

Language: Английский

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