Associations of Coffee and Tea Consumption on Neural Network Connectivity: Unveiling the Role of Genetic Factors in Alzheimer’s Disease Risk DOI Open Access
Tianqi Li, Mohammad Fili,

Parvin Mohammadiarvejeh

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4303 - 4303

Published: Dec. 13, 2024

Background: Coffee and tea are widely consumed beverages, but their long-term effects on cognitive function aging remain largely unexplored. Lifestyle interventions, particularly dietary habits, offer promising strategies for enhancing performance preventing decline. Methods: This study utilized data from the UK Biobank cohort (n = 12,025) to examine associations between filtered coffee, green tea, standard consumption neural network functional connectivity across seven resting-state networks. We focused networks spanning prefrontal occipital areas that linked complex behavioral functions. Linear mixed models were used assess main of coffee consumption, as well interactions with Apolipoprotein E (APOE) genetic risk—the strongest risk factor Alzheimer’s disease (AD). Results: Higher was associated increased in several networks, including Motor Execution, Sensorimotor, Fronto-Cingular, a Prefrontal + ‘What’ Pathway Network. Similarly, greater intake enhanced Extrastriate Visual Primary Networks. In contrast, higher reduced such Memory Consolidation, “What” The APOE4 genotype family history AD influenced relationship Consolidation Additionally, modified association Sensorimotor Conclusions: distinct patterns brain activity may provide insights into AD-related changes. genotype, particular, appears play significant role modulating these relationships. These findings enhance our knowledge how commonly beverages influence potentially among older adults.

Language: Английский

Epigallocatechin 3-gallate-induced neuroprotection in neurodegenerative diseases: molecular mechanisms and clinical insights DOI Creative Commons
Md. Rezaul Islam, Abdur Rauf, S Akter

et al.

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Abstract Neurodegenerative diseases (NDs) are caused by progressive neuronal death and cognitive decline. Epigallocatechin 3-gallate (EGCG) is a polyphenolic molecule in green tea as neuroprotective agent. This review evaluates the therapeutic effects of EGCG explores molecular mechanisms that show its properties. protects neurons several ways, such lowering oxidative stress, stopping Aβ from aggregation together, changing cell signaling pathways, decreasing inflammation. Furthermore, it promotes autophagy improves mitochondrial activity, supporting survival. Clinical studies have demonstrated supplementation can reduce neurodegenerative biomarkers enhance function. provides insights into potential treating various NDs. reduces stress scavenging free radicals enhancing antioxidant enzyme aiding defense. It also abilities inhibiting toxicity peptides. changes important pathways like Nrf2, PI3K/Akt, MAPK, which necessary for survival, death, Additionally, has strong anti-inflammatory properties because inhibits microglial activation downregulates pro-inflammatory cytokines. function reducing increasing ATP synthesis, promoting biogenesis, neurons’ survival energy metabolism. In addition, triggers autophagy, cellular process breaks down recycles damaged proteins organelles, eliminating neurotoxic aggregates maintaining homeostasis. Moreover, holds significant promise an ND treatment, but future research should focus on bioavailability understanding long-term clinical effects. Future improving delivery settings. potentially be agent managing NDs, indicating need further research.

Language: Английский

Citations

3
Neuroprotective Effects of Olive Oil: A Comprehensive Review of Antioxidant Properties DOI Creative Commons
Marta Gonçalves, Nuno Vale, Paula Silva

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 762 - 762

Published: June 24, 2024

Neurodegenerative diseases are a significant challenge to global healthcare, and oxidative stress plays crucial role in their development. This paper presents comprehensive analysis of the neuroprotective potential olive oil, with primary focus on its antioxidant properties. The chemical composition including key antioxidants, such as oleuropein, hydroxytyrosol, oleocanthal, is systematically examined. mechanisms by which these compounds provide neuroprotection, counteracting damage modulating pathways, explored. efficacy oil evaluated synthesizing findings from various sources, vitro studies, animal models, clinical trials. integration into dietary patterns, particularly Mediterranean diet, broader implications neurodegenerative disease prevention also discussed. challenges translating preclinical applications acknowledged future research directions proposed better understand mitigating risk conditions. review highlights not only component, but promising candidate preventive neurology, advocating for further investigation context diseases.

Language: Английский

Citations

10
The Interplay of Protein Aggregation, Genetics, and Oxidative Stress in Alzheimer’s Disease: Role for Natural Antioxidants and Immunotherapeutics DOI Creative Commons
Ali Jawad, Kyonghwan Choe, Jun Sung Park

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 862 - 862

Published: July 18, 2024

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that comprises amyloid-beta protein (Aβ) as main component of neuritic plaques. Its deposition considered trigger for AD pathogenesis, progression, and the clinical symptoms cognitive impairment. Some distinct pathological features include phosphorylation tau protein, oxidative stress, mitochondrial dysfunction. These consequences tend to produce reactive oxygen species (ROS), resulting in dysregulation various signaling pathways neuroinflammation neurodegeneration. The relationship between Aβ cascade stress pathogenesis like “chicken egg” story, with etiology regarding these two factors remaining question “which comes first.” However, this review, we have tried our best clarify interconnection mechanisms show precise cause-and-effect relationship. Based on above hallmarks AD, several therapeutic strategies using natural antioxidants, monoclonal antibodies, vaccines are employed anti-Aβ therapy decrease ROS, burden, chronic neuroinflammation, synaptic failure. antioxidants immunotherapeutics demonstrated significant neuroprotective effects symptomatic relief vitro vivo models, well trials AD. none them received final approval enter drug market mitigating In extensively elaborate pitfalls, assurances, important crosstalk concerning current therapy. Additionally, discuss future development more Aβ-targeted approaches optimization treatment mitigation.

Language: Английский

Citations

8
Proteostasis disruption and senescence in Alzheimer’s disease pathways to neurodegeneration DOI
Riya Thapa, Asif Ahmad Bhat, Moyad Shahwan

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1845, P. 149202 - 149202

Published: Aug. 30, 2024

Language: Английский

Citations

8
Tea, coffee, and caffeine intake and risk of dementia and Alzheimer's disease: a systematic review and meta-analysis of cohort studies DOI
Fengjuan Li, Xiaoning Liu, Bin Jiang

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(16), P. 8330 - 8344

Published: Jan. 1, 2024

: Limited and conflicting evidence exists for the associations between tea, coffee, caffeine intake risk of dementia Alzheimer's disease (AD). This meta-analysis aimed to elucidate these quantify potential dose-response relationships.

Language: Английский

Citations

7
Biosynthesis of Nanoparticles with Green Tea for Inhibition of β-Amyloid Fibrillation Coupled with Ligands Analysis DOI Creative Commons
Mai Zhang, Yan Li,

Chunli Han

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 4299 - 4317

Published: May 1, 2024

Background: Inhibition of amyloid β protein fragment (Aβ) aggregation is considered to be one the most effective strategies for treatment Alzheimer's disease. (-)-Epigallocatechin-3-gallate (EGCG) has been found in this regard; however, owing its low bioavailability, nanodelivery recommended practical applications. Compared chemical reduction methods, biosynthesis avoids possible biotoxicity and cumbersome preparation processes. Materials Methods: The interaction between EGCG Aβ 42 was simulated by molecular docking, green tea-conjugated gold nanoparticles (GT-Au NPs) EGCG-Au NPs were synthesized using EGCG-enriched tea solutions, respectively. Surface active molecules particles identified analyzed various liquid chromatography-tandem triple quadrupole mass spectrometry methods. ThT fluorescence assay, circular dichroism, TEM used investigate effect on inhibition aggregation. Results: as well apigenin, quercetin, baicalin, glutathione capping ligands stabilized surface GT-Au NPs. They more or less inhibited promoted fibril disaggregation, with being effective, which bound through hydrogen bonding, hydrophobic interactions, etc. resulting 39.86% 88.50% disaggregation effects, not free EGCG, whereas multiple thiols polyphenols accelerated optimized heavy metal detoxification. conferred efficacy diverse particles, effects 54.69% 88.75%, respectively, while increasing yield, enhancing water solubility, decreasing cost. Conclusion: Biosynthesis a promising simple economical drug-carrying approach confer pharmacophore Au This could design new drug candidates treat Keywords: nanoparticles, synthesis, (-)-epigallocatechin-3-gallate, chromatography tandem spectrometry, protein,

Language: Английский

Citations

5
Role of Flavonoids in Mitigating the Pathological Complexities and Treatment Hurdles in Alzheimer's Disease DOI
Shivani Chib, Bhaskar Jyoti Dutta, Rishabh Chalotra

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

With the passage of time, people step toward old age and become more prone to several diseases associated with age. One such is Alzheimer's disease (AD) which results into neuronal damage dementia progression The existing therapeutics has been hindered by various enkindles like less eminent between remote populations, affordability issues toxicity profiles. Moreover, lack suitable therapeutic option further worsens quality life in older population. Developing an efficient intervention cure AD still a challenge for medical fraternity. Recently, alternative approaches attain attention researchers focus on plant-based therapy mitigating AD. In this context, flavonoids gained centrality as feasible treatment modifying neurological deficits. This review mainly focuses pathological facets economic burden Furthermore, we have explored possible mechanism preclinical clinical aspects curing Flavonoids being potential therapeutic, target pathogenic factors oxidative stress, inflammation, metal toxicity, Aβ accumulation, modulate neurotransmission insulin signaling. review, emphasized neuroprotective effects pathology, both experimental findings. While studies suggest promising benefits, data remains limited inconclusive. Thus, high-quality trials are necessary validate efficacy study aim promote therapies encourage add regular diet avail beneficial preventive

Language: Английский

Citations

5
Environmental Toxins and Alzheimer’s Disease: a Comprehensive Analysis of Pathogenic Mechanisms and Therapeutic Modulation DOI

Rishika Dhapola,

Prajjwal Sharma,

Sneha Kumari

et al.

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 61(6), P. 3657 - 3677

Published: Nov. 25, 2023

Language: Английский

Citations

12
Luteoloside inhibits Aβ1–42 fibrillogenesis, disintegrates preformed fibrils, and alleviates amyloid-induced cytotoxicity DOI
Di Zhang, Juanli Zhang, Zhongying Ma

et al.

Biophysical Chemistry, Journal Year: 2024, Volume and Issue: 306, P. 107171 - 107171

Published: Jan. 3, 2024

Language: Английский

Citations

4
Epigallocatechin-3-Gallate attenuates lipopolysacharide-induced pneumonia via modification of inflammation, oxidative stress, apoptosis, and autophagy DOI Creative Commons
Meili Shen,

Yuting You,

Chengna Xu

et al.

BMC Complementary Medicine and Therapies, Journal Year: 2024, Volume and Issue: 24(1)

Published: April 5, 2024

Abstract Background Pneumonia, the acute inflammation of lung tissue, is multi-factorial in etiology. Hence, continuous studies are conducted to determine mechanisms involved progression disease and subsequently suggest effective treatment. The present study attempted evaluate effects Epigallocatechin-3-Gallate (EGCG), an herbal antioxidant, on inflammation, oxidative stress, apoptosis, autophagy a rat pneumonia model. Methods Forty male Wistar rats, 5 months old 250–290 g were divided into four groups including control, EGCG, experimental (i/p LPS injection, 1 mg/kg), treated with EGCG (i/p, 15 mg/kg, h before 3 after instillation). Total cell number bronchoalveolar lavage fluid, (TNF-a, Il-6, IL-1β, NO), stress (Nrf2, HO-1, SOD, CAT, GSH, GPX, MDA, TAC), apoptosis (BCL-2, BAX, CASP-3 CASP-9), (mTOR, LC3, BECN1) evaluated. Results findings demonstrated that suppresses LPS-induced activation inflammatory pathways by significant reduction markers ( p -value < 0.001). In addition, upregulation BCL-2 downregulation BAX caspases revealed suppressed apoptosis. Furthermore, ECGC injury while promoting rats 0.05). Conclusion current could suppress promote models suggesting promising therapeutical properties this compound be used management.

Language: Английский

Citations

4