Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 17, 2024
Hypobaric
hypoxia
exposure
occurs
at
high
altitudes,
including
plateaus,
and
affects
normal
intestinal
function
microbiota
composition.
Exposure
induces
an
inflammatory
response
oxidative
stress
injury,
ultimately
disrupting
homeostasis
causing
barrier
damage.
Thus,
due
to
its
anti-inflammatory,
antioxidative,
microbiota-regulating
properties,
Bifidobacterium
longum
is
a
potentially
effective
probiotic
intervention
protect
the
during
low-pressure
on
plateaus.
However,
mechanism
of
action
not
fully
defined.
In
this
study,
we
investigate
by
which
B.
intervenes
in
damage
caused
plateau
hypoxia.
To
end,
vivo
model
established
exposing
rats
simulated
hypoxic
environment.
The
experimental
were
subsequently
supplemented
with
strain
(JBLC-141)
extracted
from
feces
healthy
adults
Bama,
Guangxi.
JBLC-141
mitigates
effects
rat
barrier.
This
achieved
activating
Kelch-like
ECH-associated
protein
1
(KEAP1)/nuclear
factor
erythroid
2-related
2
(NRF2)
pathway,
alleviating
hypoxia-induced
injury.
also
attenuates
upregulates
expression
tight
junction
proteins
claudin-1,
occludin,
zonula
occludens-1.
Furthermore,
it
reduces
permeability,
effectively
ameliorating
repairing
histological
induced
addition,
positively
regulates
microbiota,
increasing
relative
abundance
beneficial
bacteria
while
reducing
that
pathogenic
maintaining
flora
rats.
Journal of Cachexia Sarcopenia and Muscle,
Journal Year:
2024,
Volume and Issue:
15(5), P. 1641 - 1650
Published: Aug. 18, 2024
The
world
is
facing
a
global
nutrition
crisis,
as
evidenced
by
the
rising
incidence
of
metabolic
disorders
such
obesity,
insulin
resistance
and
chronic
inflammation.
Skeletal
muscle
largest
tissue
in
humans
plays
an
important
role
movement
host
metabolism.
Muscle
fibre
formation
occurs
mainly
during
embryonic
stage.
Therefore,
maternal
lifestyle,
especially
exercise
pregnancy,
has
critical
influence
on
foetal
skeletal
development
subsequent
health
offspring.
In
this
review,
malnutrition
micronutrient
intake
systematically
summarized.
We
also
aim
to
describe
how
shapes
gut
microbiota
its
metabolites
further
discussed,
although
field
still
'infancy'.
This
review
will
provide
new
insights
reduce
crisis
highlight
current
gaps
promote
research.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 11, 2024
Resveratrol
(Res),
a
natural
plant
antitoxin
polyphenol,
is
widely
used
in
animal
husbandry
due
to
its
antioxidant
and
anti-inflammatory
properties,
current
research
has
focused
on
humans,
sows,
female
mice.
This
study
aimed
analyze
the
effects
of
dietary
Res
supplementation
ewes
activity,
immune
responses,
hormone
levels,
rumen
microbiota
metabolites
across
various
reproductive
stages
(estrus,
pregnancy,
lactation).
Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 4, 2025
Young
rabbits
are
sensitive
to
surrounding
changes
and
conditioned
pathogens
in
intestine
which
might
result
slow
inflammation
diarrhea
after
microbial
invasion.
Traditional
medicine
herbs
could
provide
efficacious
treatment
on
infection
inflammation.
The
present
research
designed
an
Acanthopanax
senticosus
(ACS)
formula
consisted
of
five
types
Chinese
including
(Rupr
&
Maxim)
Harms
(Ciwujia
Chinese),
Astragalus
membranceus
(Fisch)
Bge
(Huangqi
Indigo
naturalis
(Qingdai
Houttuynia
cordata
Thunb
(Yuxingcao
Glycyrrhizae
radix
et
Rhizoma
(Gancao
Chinese).
effects
ACS
decoction
supplement
were
investigated
via
determination
cytokines
growth
performances
young
rabbits,
the
flora
intestinal
digesta
from
six
fragments
further
explored
using
16S
rRNA
gene
sequencing
technology.
Compared
control
group,
supplied
with
different
doses
possessed
lower
death
rates,
together
IL-10
concentration,
while
declined
IL-1β
IL-12
levels
inflammatory
factor
expressions
tissues.
Additionally,
addition
changed
diversity
each
segments
intestine.
Functional
prediction
abundances
genera
enriched
seven
KEGG
immunity
pathways.
Moreover,
strong
correlations
determined
between
abundance
bacteria
interleukins
contents,
predictive
immune
signaling
abundances,
respectively.
Especially,
exhibited
anti-inflammation
decreasing
Bacteroides
,
Clostridia_vadinBB60_group
NK4A214_group
dgA_11_gut_group
rabbits.
In
conclusion,
dietary
exerted
diarrhea-reducing
effects,
improved
homeostasis
by
modulating
Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(4), P. 844 - 844
Published: April 7, 2025
Microorganisms
play
an
important
role
in
regulating
various
biological
processes
our
bodies.
In
women,
abnormal
changes
the
reproductive
tract
microbiome
are
associated
with
gynecological
diseases
and
infertility.
Recent
studies
suggest
that
patients
recurrent
implantation
failure
(RIF)
have
a
reduced
genus
Lactobacillus
population,
predominant
bacterial
species
vagina
uterus
protects
from
pathogenic
growth
via
production
of
metabolites
(e.g.,
lactic
acid,
bacteriocin,
H2O2).
Moreover,
higher
percentage
bacteria
genera,
including
Atopobium,
Gardnerella,
Prevotella,
Pseudomonas,
Streptococcus,
was
found
RIF
patients.
This
review
aimed
to
examine
RIF,
determine
factors
altering
endometrial
microbiome,
assess
impact
on
embryo
RIF.
Several
can
influence
microbial
balance,
extrinsic
elements
such
as
semen
antibiotics,
which
lead
dysbiosis
female
affect
implantation.
Additionally,
probiotics
Lacticaseibacillus
rhamnosus
were
reported
clinical
potential
Future
needed
develop
targeted
probiotic
therapies
restore
balance
enhance
fertility
outcomes.
Research
should
also
focus
understanding
mechanisms
by
microorganisms
generate
suppress
for
Identifying
these
interactions
may
contribute
innovative
microbiome-based
interventions
health.
Beverages,
Journal Year:
2025,
Volume and Issue:
11(3), P. 62 - 62
Published: April 29, 2025
The
present
study
aimed
to
analyze
the
physicochemical
properties
and
biological
activity
of
an
L-malic
acid
descaler.
treated
water
with
descaler
complies
EU
Directive
No.
2020/2184
for
quality
intended
human
consumption.
contains
as
active
component,
while
polyethylene
activated
charcoal
function
structural
absorbent
materials,
respectively.
composition
was
analyzed
in
a
licensed
laboratory
using
Chemical
Abstracts
Service
Number
(CAS)
European
List
Notified
Substances
(EINECS)
standards.
Fourier
Transform
Infrared
(FT-IR)
analysis
confirmed
presence
hydroxyl
(–OH),
carbonyl
(C=O),
carboxyl
(–COOH)
groups
descaler,
which
are
connected
proton-donating
ability,
redox
activity.
evaluated
Saccharomyces
cerevisiae
model
system.
role
YAP1
transcription
factor,
key
regulator
oxidative
stress
defense
mechanisms,
also
examined.
detrimental
effects
on
cellular
level
were
induced
by
well-known
mutagen—methyl
methanesulfonate
(MMS).
Our
data
revealed
that
yeast
cells
such
decrease
MMS-induced
superoxide
anions
(3.5-fold),
total
glutathione
lipid
peroxidation
(1.5-fold),
(3-fold)
increase
cell
survival
(2-fold).
In
conclusion,
possesses
antioxidant
yeast-cell-based
tests,
independent
factor
This
provides
preliminary
evidence
acid,
when
dissolved
water,
significantly
reduced
anions,
one
biomarkers
contributing
genotoxic
carcinogenic
MMS.
Food & Function,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Emerging
evidence
suggests
that
Parkinson's
disease
(PD)
is
strongly
associated
with
altered
gut
microbiota.
The
present
study
investigated
the
prophylactic
effects
of
anthocyanins
(ACNs)
from
