Oxidative Stress as a Target for Non-Pharmacological Intervention in MAFLD: Could There Be a Role for EVOO?

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 731 - 731

Published: June 16, 2024

Oxidative stress plays a central role in most chronic liver diseases and, particular, metabolic dysfunction-associated fatty disease (MAFLD), the new definition of an old condition known as non-alcoholic (NAFLD). The mechanisms leading to hepatocellular fat accumulation genetically predisposed individuals who adopt sedentary lifestyle and consume obesogenic diet progress through mitochondrial endoplasmic reticulum dysfunction, which amplifies reactive oxygen species (ROS) production, lipid peroxidation, malondialdehyde (MDA) formation, influence release inflammation damage biomarkers, such pro-inflammatory cytokines. This close pathogenetic link has been key stimulus search for therapeutic approaches targeting oxidative treat steatosis, number clinical trials have conducted date on subjects with NAFLD using drugs well supplements or nutraceutical products. Vitamin E, D, Silybin are studied substances, but several non-pharmacological also explored, especially modifications. Among dietary approaches, Mediterranean Diet (MD) seems be reliable affecting probably added value presence extra virgin olive oil (EVOO), healthy food high content monounsaturated acids, oleic acid, variable concentrations phenols (oleocanthal) phenolic alcohols, hydroxytyrosol (HT) tyrosol (Tyr). In this review, we focus interventions MAFLD treatment that target EVOO one main antioxidant components MD.

Language: Английский

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Fucoidan Supplementation Improves Antioxidant Capacity via Regulating the Keap1/Nrf2 Signaling Pathway and Mitochondrial Function in Low-Weaning Weight Piglets

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 407 - 407

Published: March 28, 2024

Fucoidan (FC) is known for its antioxidant properties, but it has unclear effects and mechanisms on weaned piglets. Two experiments were conducted to determine the optimal FC dosage in piglet diets protective effect against lipopolysaccharide (LPS)-induced oxidative stress. In experiment one, 24 low weight piglets randomly assigned four dietary treatments: a basal diet (FC 0), or supplemented with 150 150), 300 300), 600 mg/kg 600). two, 72 low-weaning allocated into (CON), of fucoidan added challenged LPS (100 µg LPS/kg body weight) not. The results showed that treatments increased G:F ratio, reduced diarrhea incidence plasma IGF-1 concentrations. addition, supplementation SOD activity MDA concentration. challenge triggered strong systemic redox imbalance mitochondrial dysfunction. However, (300 mg/kg) enzymes, including SOD, decreased concentration liver, down-regulated Keap1 gene expression, up-regulated Nrf2, CAT, MFN2, SDHA, UQCRB expression liver. These indicated improved growth performance capacity piglets, which might be attributed modulation Keap1/Nrf2 signaling pathway function

Language: Английский

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Effects of taurine on the growth performance, diarrhea, oxidative stress and intestinal barrier function of weanling piglets

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 7, 2024

Oxidative damage resulting from weaning stress significantly impacts the growth performance and health status of piglets. Taurine, a dietary antioxidant with diverse functions, was investigated in this study for its protective role against stress-induced oxidative underlying mechanism. Forty 28-day-old male castrated weaned piglets were randomly assigned to four groups. The control group received basal diet, while experimental groups fed diet supplemented 0.1, 0.2%, or 0.3% taurine over 28-day period.

Language: Английский

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Putative role of 6-chogaol against tramadol-induced hepatotoxicity in albino rats via anti-inflammatory, antifibrotic, and antiapoptotic effects

Tissue and Cell, Journal Year: 2024, Volume and Issue: 91, P. 102562 - 102562

Published: Sept. 13, 2024

Language: Английский

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Indole-3-propionic acid enhances growth performance and reduces diarrhea via modulating redox status and intestinal inflammation in weaned piglets

Animal nutrition, Journal Year: 2024, Volume and Issue: 19, P. 240 - 247

Published: Sept. 26, 2024

Language: Английский

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Novel Antioxidants for Animal Nutrition

MDPI eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: May 14, 2024

It am enthused to announce that the printed version of our successful Special Issue, which delves into realm innovative antioxidants for animal nutrition, is now available.Our journey this fascinating field novel nutrition has been marked by insights, discoveries, and collective efforts important researchers.As we navigate intricate pathways it becomes increasingly evident play a pivotal role in shaping health well-being both humans animals.In design functional diets, their importance cannot be neglected.I would like take opportunity extend my sincerest gratitude Prof. Luciana Rossi her unwavering dedication unparalleled expertise.Prof. Rossi's invaluable awareness fundamental trajectory guidance beacon light throughout journey.

Language: Английский

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Indole-3-Propionic Acid Enhances Growth Performance and Reduces Diarrhea Via Modulating Redox Status and Intestinal Inflammation in Weaned Piglets

Published: Jan. 1, 2024

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Language: Английский

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