Foods,
Journal Year:
2022,
Volume and Issue:
11(3), P. 408 - 408
Published: Jan. 30, 2022
The
coronavirus
19
(COVID-19)
pandemic
has
brought
many
changes
in
terms
of
lifestyle,
education,
stress
levels,
and
social
contacts.
aim
our
research
was
to
evaluate
eating
habits,
physical
activity,
selected
lifestyle
elements
a
group
school
staff,
as
well
their
immune
response
vaccination
against
COVID-19,
FRAP
(ferric
reducing
antioxidant
power)
level.
In
total,
108
primary
teachers
other
staff
with
integration
departments
were
included
the
study.
An
original
survey
conducted
staff.
Of
study
group,
45.4%
chose
be
vaccinated
COVID-19.
this
level
IgG
antibodies
assessed,
before
vaccination,
after
first
second
dose.
questionnaire
also
carried
out.
A
decrease
activity
an
increase
time
spent
front
computer
have
been
demonstrated,
but
positive
observation
favorable
change
most
habits.
After
dose
all
subjects
achieved
appropriate
(above
22
U/mL),
maximum
recorded
51%.
There
significant
levels
vaccine
compared
baseline
level;
issue
that
requires
further
observation.
Cancers,
Journal Year:
2019,
Volume and Issue:
11(1), P. 62 - 62
Published: Jan. 9, 2019
The
prevalence
of
obesity
has
been
steadily
increasing
over
the
past
few
decades
in
several
developed
and
developing
countries,
with
resultant
hazardous
health
implications.
Substantial
epidemiological
evidence
shown
that
excessive
adiposity
strongly
influences
risk,
prognosis,
progression
various
malignancies,
including
breast
cancer.
Indeed,
it
is
now
well
recognized
a
complex
physiologic
state
associated
multiple
molecular
changes
capable
modulating
behavior
tumor
cells
as
surrounding
microenvironment.
Particularly,
insulin
resistance,
hyperactivation
insulin-like
growth
factor
pathways,
increased
levels
estrogen
due
to
aromatization
by
adipose
tissue,
inflammatory
cytokines,
adipokines
contribute
cancerogenesis.
Among
adipokines,
leptin,
whose
circulating
increase
proportionally
total
tissue
mass,
identified
key
member
network
obesity.
This
review
summarizes
current
knowledge
on
link
existing
between
cancer
outlines
mechanisms
underlying
this
connection.
multifaceted
role
adipokine
leptin
respect
also
discussed.
PLoS ONE,
Journal Year:
2025,
Volume and Issue:
20(1), P. e0312217 - e0312217
Published: Jan. 21, 2025
Obesity,
a
complex
metabolic
chronic
illness,
is
commonly
accompanied
by
an
excessive
production
of
free
radicals,
which
influences
the
development
its
comorbidities.
Uric
acid
linked
to
pro-oxidant
effects
on
human
health.
Though
recent
evidence
suggests
potential
antioxidant
properties,
it
possible
that
increase
in
circulating
uric
levels
adaptive
protective
response
against
detrimental
excess
radicals
and
oxidative
stress
present
obese
individuals.
Hence,
purpose
this
study
was
evaluate
association
between
capacity
damage
markers
with
overweight
individuals
who
live
at
sea
level.
This
cross-sectional
included
93
adult
volunteers
(28
men
65
women)
from
city
Machala,
El
Oro,
Ecuador,
divided
into
three
groups
according
Body
Mass
Index
(normal
weight,
overweight,
obese).
Sociodemographic
characteristics,
lifestyle
elements,
physical
measurements
were
evaluated,
blood
samples
collected
all
participants.
Antioxidant
oxidant
markers,
including
Radical-Scavenging
Activity
Assay
(DPPH),
Ferric
Reducing
Ability
Plasma
(FRAP),
Catalase
(CAT)
activity,
Thiobarbituric
Acid
Reactive
Substances
(TBARS),
Protein
Thiol
Groups
(SH
groups),
assayed
plasma
samples.
Coefficients
correlations
linear
regression
models
applied
antioxidant/oxidant
parameters
levels.
The
capacity,
as
measured
FRAP
scavenging
CAT,
significantly
higher
group
compared
normal
weight
group,
presented
significant
positive
(b:
0.578,
R:
0.459,
p:
0.003)
CAT
activity
1.326;
0.432,
0.005)
Consequently,
supports
role
pathogenesis
obesity,
contributing
our
understanding
inflammation
characterizes
illness.
Frontiers in Endocrinology,
Journal Year:
2019,
Volume and Issue:
10
Published: Sept. 19, 2019
Obesity
is
one
of
the
most
serious
worldwide
epidemics
twenty-first
century
according
to
World
Health
Organization.
Frequently
associated
with
a
number
comorbidities,
obesity
threatens
and
compromises
individual
health
quality
life.
Bariatric
surgery
(BS)
has
been
demonstrated
be
an
effective
treatment
achieve
not
only
sustained
weight
loss
but
also
significant
metabolic
improvement
that
goes
beyond
mere
loss.
The
beneficial
effects
BS
on
traits
are
so
widely
recognized
some
authors
have
proposed
as
could
prescribed
even
for
moderate
obesity.
However,
procedures
imply
malabsorption
and/or
gastric
acid
reduction
which
lead
nutrient
deficiency
and,
consequently,
further
complications
developed
in
long
term.
In
fact,
affects
homeostasis
pronounced
endocrine
systems
other
than
those
exclusively
involved
function.
somatotropic,
corticotropic
gonadal
axes
well
bone
shown
affected
by
various
procedures.
Accordingly,
consequences
term
system
need
addressed
large
cohorts,
taking
into
account
each
bariatric
procedure
before
making
generalized
recommendations
BS.
this
review,
current
data
regarding
these
issues
summarized,
paying
special
attention
corticotropic,
postoperative
health.
Antioxidants,
Journal Year:
2020,
Volume and Issue:
9(5), P. 450 - 450
Published: May 23, 2020
Periodontitis
is
inextricably
linked
to
oxidative-reductive
(redox)
imbalance.
However,
little
still
known
about
the
resultant
ability
scavenge
oxygen
free
radicals
in
saliva
and
gingival
crevicular
fluid
patients
with
periodontitis.
The
multitude
of
enzymatic
non-enzymatic
antioxidants
their
synergistic
effects
cause
an
interest
evaluation
total
antioxidative
capacity.
Thus,
our
study
aimed
evaluate
oxidative
activity
periodontitis,
as
well
relate
these
biomarkers
clinical
indices
periodontopathy.
Additionally,
by
calculating
stress
index
(OSI),
intensity
redox
disturbances
was
also
evaluated.
Fifty-eight
periodontitis
were
included
divided
into
two
subgroups
depending
on
severity
disease.
In
non-stimulated/stimulated
a
group,
we
found
significantly
higher
OSI
oxidant
status
(TOS)
lower
antioxidant
capacity
(TAC).
reduce
iron
ions
(FRAP)
only
stimulated
non-stimulated
examined
parameters
correlated
periodontium’s
condition,
which
indicates
exacerbation
inflammatory
process.
TAC,
TOS,
OSI,
FRAP
did
not
differentiate
individual
stages
Journal of Clinical Medicine,
Journal Year:
2020,
Volume and Issue:
9(3), P. 837 - 837
Published: March 19, 2020
Oxidative
stress
plays
a
critical
role
in
the
pathogenesis
of
hypertension;
however,
there
are
no
data
on
salivary
redox
homeostasis
and
gland
function
children
with
hypertension.
A
total
53
hypertension
age-
sex-matched
controls
were
classified
for
study.
The
antioxidant
barrier
oxidative/nitrosative
evaluated
non-stimulated
(NWS)
stimulated
(SWS)
whole
saliva,
plasma,
erythrocytes,
Student’s
t-test
Mann–Whitney
U-test
used
statistical
analysis.
We
demonstrated
that
activities
superoxide
dismutase,
catalase,
peroxidase
significantly
higher
NWS,
SWS,
erythrocytes
hypertension,
similar
to
oxidative
damage
proteins
(advanced
glycation
end
products)
lipids
(malondialdehyde)
as
well
nitrosative
markers
(peroxynitrite
nitrotyrosine).
level
uric
acid
(UA)
was
plasma
UA
concentration
SWS
correlated
positively
systolic
diastolic
blood
pressure
content
plasma.
This
parameter
differentiates
from
healthy
(AUC
=
0.98)
high
degree
sensitivity
(94%)
specificity
(94%).
Stimulated
flow
lower
group,
protein
amylase
activity.
In
summary,
childhood
is
associated
hyposalivation
disturbances
defense
enhanced
both
plasma/erythrocytes
saliva.
Salivary
may
be
potential
biomarker
children.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2021,
Volume and Issue:
2021(1)
Published: Jan. 1, 2021
Cerebral
stroke
is
a
serious
worldwide
health
problem,
as
can
be
seen
by
the
global
epidemic
of
disease.
In
this
disorder,
when
blood
flow
compromised
ruptures
or
blocked
arteries,
sudden
death
neurons
observed
result
lack
oxygen
and
nutrients.
Numerous
severe
problems
frequent
complications
also
exist
in
patients;
therefore,
there
an
urgent
need
to
develop
new
therapeutic,
diagnostic,
prognostic
methods
for
At
present,
diagnosis
based
on
neurological
examination,
medical
history,
neuroimaging,
due
fact
that
rapid
noninvasive
diagnostic
tests
are
unavailable.
Nevertheless,
oxidative
stress
inflammation
considered
key
factors
pathogenesis.
Oxygen
free
radicals
responsible
oxidation
lipids,
proteins,
DNA/RNA,
which
turn
contributes
damage
brain.
Toxic
products
reactions
act
cytostatically
cell
damaging
membranes
leading
neuronal
apoptosis
necrosis.
Thus,
it
seems
redox/inflammatory
biomarkers
might
used
Nowadays,
saliva
increasing
interest
clinical
laboratory
medicine.
Redox
could
obtained
easily,
noninvasively,
cheaply,
stress‐free
from
saliva.
This
minireview
aimed
at
presenting
current
knowledge
concerning
use
salivary
prognosis
stroke.
Journal of Clinical Medicine,
Journal Year:
2020,
Volume and Issue:
9(4), P. 976 - 976
Published: April 1, 2020
This
is
the
first
study
to
evaluate
both
antioxidant
barrier,
glutathione
metabolism,
and
oxidative
damage
proteins
lipids
in
morbidly
obese
patients
undergoing
bariatric
treatment.
The
included
65
with
class
3
obesity
divided
into
two
subgroups:
without
metabolic
syndrome
(OB)
(OB
+
MS).
Blood
samples
were
collected
before
surgery
as
well
one,
three,
six,
twelve
months
after
Superoxide
dismutase
reduced
(GSH)
significantly
decreased,
whereas
reductase
uric
acid
enhanced
compared
lean
control.
Moreover,
OB
group,
we
observed
increase
of
superoxide
(SOD)
decrease
(UA)
treatment;
however,
these
changes
not
MS
group.
(advanced
glycation
end
products,
AGE;
advanced
oxidation
protein
AOPP)
(8-isoprostanes,
8-isop;
4-hydroxynoneal)
was
higher
patients.
We
noticed
that
AGE
AOPP
levels
diminished
treatment,
redox
status
(ratio
GSH
oxidized
glutathione)
still
Summarizing,
morbid
associated
disturbances
barrier
lipids.
Although
improves
homeostasis
patients,
those
show
a
continuous
status.
In
supplementation
may
be
considered.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2020,
Volume and Issue:
2020, P. 1 - 10
Published: Sept. 10, 2020
In
this
pathbreaking
study,
we
evaluated
nitrosative
stress
in
morbidly
obese
patients
with
and
without
metabolic
syndrome.
62
women
class
3
obesity
(BMI>40kg/m2)
were
divided
into
three
subgroups:
(OB),
hypertension
(OB+HYP),
syndrome
(OB+MS).
comparison
to
the
lean
patients,
OB
had
increased
levels
of
serum
myeloperoxidase
(MPO),
plasma
nitric
oxide
(NO),
S-nitrosothiols,
peroxynitrite
(ONOO
−
),
as
well
nitrotyrosine,
while
oxidized
glutathione
(GSSG)
rose
only
OB+HYP
group.
Interestingly,
ONOO
was
significantly
higher
OB+MS
compared
group,
MPO
greater
nitrotyrosine
S-nitrosothiol
values
than
OB+HYP.
Moreover,
could
differentiate
from
(AUC
0.9292;
p<0.0001;
87.5%
sensitivity,
90%
specificity)
between
group
0.9125;
id="M3">p<0.0001;
81.25%
83.33%).
conclusion,
showed
that
activity,
NO
formation,
damage
proteins
parallel
progression
disturbances
obesity.
Evaluation
concentrations
may
help
predict
development
morbid
obesity;
however,
longer-term
studies
are
required
for
larger
numbers
patients.
Antioxidants,
Journal Year:
2021,
Volume and Issue:
10(11), P. 1834 - 1834
Published: Nov. 18, 2021
Androgens
have
diverse
functions
in
muscle
physiology,
lean
body
mass,
the
regulation
of
adipose
tissue,
bone
density,
neurocognitive
regulation,
and
spermatogenesis,
male
reproductive
sexual
function.
Male
hypogonadism,
characterized
by
reduced
testosterone,
is
commonly
seen
ageing
males,
has
a
complex
relationship
as
risk
factor
comorbidity
age-related
noncommunicable
chronic
diseases
(NCDs),
such
obesity,
metabolic
syndrome,
type
2
diabetes,
malignancy.
Oxidative
stress,
significant
contributor
to
process,
common
feature
between
NCDs,
related
comorbidities,
including
hypertension,
dyslipidemia,
hyperglycemia,
hyperinsulinemia,
inflammation.
stress
may
also
be
mediator
hypogonadism
males.
Consequently,
management
oxidative
represent
novel
therapeutic
approach
this
context.
Therefore,
narrative
review
aims
discuss
mechanisms
associated
with
NCDs
discusses
current
potential
approaches
for
clinical
these
patients,
which
include
conventional
hormone
replacement
therapy,
nutrition
lifestyle
changes,
adherence
optimal
mass
index,
dietary
antioxidant
supplementation
and/or
phytomedicines.
Pharmaceuticals,
Journal Year:
2020,
Volume and Issue:
13(9), P. 240 - 240
Published: Sept. 10, 2020
Meloxicam
is
a
non-steroidal
anti-inflammatory
drug,
which
has
preferential
inhibitory
effect
to
cyclooxyganase-2
(COX-2).
Although
the
drug
inhibits
prostaglandin
synthesis,
exact
mechanism
of
meloxicam
still
unknown.
This
first
study
assess
on
protein
glyco-oxidation
as
well
antioxidant
activity.
For
this
purpose,
we
used
an
in
vitro
model
oxidized
bovine
serum
albumin
(BSA).
Glucose,
fructose,
ribose,
glyoxal
and
methylglyoxal
were
glycating
agents,
while
chloramine
T
was
oxidant.
We
evaluated
properties
(2,2-di-phenyl-1-picrylhydrazyl
radical
scavenging
capacity,
total
capacity
ferric
reducing
power),
intensity
glycation
(Amadori
products,
advanced
end
products)
(dityrosine,
kynurenine,
N-formylkynurenine,
tryptophan
amyloid-β)
content
oxidation
products
(advanced
carbonyl
groups
thiol
groups).
have
demonstrated
that
enhances
prevents
under
influence
various
factors
such
sugars,
aldehydes
oxidants.
Importantly,
anti-glycating
activity
similar
routinely
antioxidants
captopril,
Trolox,
reduced
glutathione
lipoic
acid
inhibitors
(aminoguanidine).
Pleiotropic
action
may
increase
effectiveness
treatment
diseases
with
oxidative
stress
etiology.