[Retracted] Periodontitis Exacerbates Benign Prostatic Hyperplasia through Regulation of Oxidative Stress and Inflammation DOI Creative Commons
Cheng Fang, Lan Wu,

Ming-Juan Zhao

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2021, Volume and Issue: 2021(1)

Published: Jan. 1, 2021

Epidemiological studies demonstrate that men with periodontitis are also susceptible to benign prostatic hyperplasia (BPH) and periodontal treatment can improve the symptom. However, molecular links of this relationship largely unknown. The goal current study was elucidate effects experimental on prostate whether oxidative stress inflammation participated in process. For purpose, ligature‐induced periodontitis, testosterone‐induced BPH, composite models rats were established. Four weeks later, all sacrificed following items measured: alveolar bone loss histological examination tissues taken assess establishment model, index test BPH inflammatory cytokines plasma assessed, Bax/Bcl‐2 proteins related cell apoptosis analyzed via western blot analysis. To further investigate participates aggravation vitro conducted measure production intracellular reactive oxygen species (ROS) hydrogen peroxide (H 2 O ) concentration. We found simultaneous synergistically aggravated changes, significantly increased Ki67 proliferation, reduced rat tissues. Also, our results showed ligation induced Bcl‐2 protein expression, whereas Bax expression decreased than normal rats. Compared control group, both enhanced cytokine levels TNF‐ α , IL‐6, IL‐1 β CRP. Furthermore, Porphyromonas gingivalis lipopolysaccharide generation ROS H BPH‐1 cells. Our evidence demonstrated might promote development through regulation process, thus providing new strategies for prevention BPH.

Language: Английский

Oxidative Stress in the Pathogenesis of Oral Cancer DOI Creative Commons
Cătălina Ionescu, Fatima Zahra Kamal, Alin Ciobîcă

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(6), P. 1150 - 1150

Published: May 23, 2024

Oxidative stress, arising from an imbalance between reactive oxygen species (ROS) and antioxidants, contributes significantly to oral cancer such as squamous cell carcinoma (OSCC) initiation, promotion, progression. ROS, generated both internally externally, induce cellular damage including DNA mutations lipid peroxidation, fostering oncogene activation carcinogenesis. The objective of this review was cover analyze the interplay ROS influencing key processes proliferation, apoptosis, angiogenesis, shaping trajectory OSCC development. Despite promise antioxidants halt progression mitigate oxidative damage, their therapeutic efficacy remains debated. conducted literature search highlighted potential biomarkers that indicate levels showing for early detection monitoring OSCC. Furthermore, melatonin has emerged a promising adjunct therapy OSCC, exerting antioxidant oncostatic effects by modulating tumor-associated neutrophils inhibiting survival migration. In addition, aims shed light on developing personalized strategies patients with therapy, which will be discussed. Research is needed elucidate underlying mechanisms clinical implications stress modulation in context cancer.

Language: Английский

Citations

6
Redox balance and autophagy regulation in cancer progression and their therapeutic perspective DOI
Sameer Ullah Khan, Kaneez Fatima,

Shariqa Aisha

et al.

Medical Oncology, Journal Year: 2022, Volume and Issue: 40(1)

Published: Nov. 9, 2022

Language: Английский

Citations

26
An injectable multifunctional thermo-sensitive chitosan-based hydrogel for periodontitis therapy DOI
Shiqing Ma,

Xuemei Lu,

Xinying Yu

et al.

Biomaterials Advances, Journal Year: 2022, Volume and Issue: 142, P. 213158 - 213158

Published: Oct. 17, 2022

Language: Английский

Citations

24
UPLC‒ESI‒MS/MS profiling of active polyphenolics in Morinda coreia leaf extract and in vitro antioxidant and antibacterial activity DOI
Sandhanasamy Devanesan,

Kasber Elankathirselvan,

Abdulaziz AlSalhi

et al.

Chemosphere, Journal Year: 2023, Volume and Issue: 323, P. 138179 - 138179

Published: Feb. 24, 2023

Language: Английский

Citations

13
Recent Advances in Apical Periodontitis Treatment: A Narrative Review DOI Creative Commons
Zulema Arias, Mohammed Zahedul Islam Nizami, Xiaoting Chen

et al.

Bioengineering, Journal Year: 2023, Volume and Issue: 10(4), P. 488 - 488

Published: April 19, 2023

Apical periodontitis is an inflammatory response caused by pulp infection. It induces bone resorption in the apical and periapical regions of tooth. The most conservative approach to treat this condition nonsurgical endodontic treatment. However, clinical failure has been reported with approach; thus, alternative procedures are required. This review highlights recent literature regarding advanced approaches for treatment periodontitis. Various therapies, including biological medications, antioxidants, specialized pro-resolving lipid mediators, stem cell therapy, have tested increase success rate Some these remain vivo phase research, while others just entered translational research validate application. a detailed understanding molecular mechanisms that occur during development immunoinflammatory reaction remains unclear. aim was summarize Further can confirm potential approaches.

Language: Английский

Citations

13
Graphene Quantum Dots in Bacterial Cellulose Hydrogels for Visible Light-Activated Antibiofilm and Angiogenesis in Infection Management DOI Open Access
Danica Zmejkoski, Nemanja Zdravković, Dijana Mitić

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1053 - 1053

Published: Jan. 26, 2025

A novel bacterial cellulose (BC)-based composite hydrogel with graphene quantum dots (BC-GQDs) was developed for photodynamic therapy using blue and green light (BC-GQD_blue BC-GQD_green) to target pathogenic biofilms. This approach aims address complications in treating nosocomial infections combating multi-drug-resistant organisms. Short-term illumination (30 min) of both BC-GQD samples led singlet oxygen production a reduction Significant antibiofilm activity (>50% reduction) achieved against Staphylococcus aureus Escherichia coli BC-GQD_green, Pseudomonas aeruginosa BC-GQD_blue. Atomic force microscopy images revealed substantial decrease biofilm mass, accompanied by changes surface roughness area, further confirming the efficacy BC-GQDs under light, without any observed chemical alterations. Additionally, biocompatibility demonstrated human gingival fibroblasts (HGFs). For first time, vitro studies explored visible light-induced potential composites promote wound healing processes, showing increased migratory upregulation eNOS MMP9 gene expressions HGFs. Chemical characterization 70 nm upshift photoluminescence emission spectra compared excitation wavelength. These photoactive show great promise as effective agents regeneration infection management.

Language: Английский

Citations

0
Taurine levels in periodontitis: A pilot study DOI Open Access
M. Fatih Donmez, Nur Balcı,

Aslı Ergene Sunkar

et al.

Journal of Periodontology, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Abstract Background Periodontitis is a chronic inflammatory condition that affects the supporting structures of teeth. It closely associated with oxidative stress and inflammation. Taurine, semi‐essential amino acid recognized for its antioxidant anti‐inflammatory properties, has not been extensively investigated in context periodontitis. This pilot study sought to evaluate levels taurine cytokines, including interleukin‐1 beta (IL‐1β), interleukin‐6 (IL‐6), tumor necrosis factor‐alpha (TNF‐α), gingival crevicular fluid (GCF) individuals Methods Systemically healthy participants periodontitis periodontally were enrolled. GCF samples collected, clinical periodontal parameters such as bleeding on probing (BOP), attachment loss (CAL), plaque index (PI), depth (PD) documented. The taurine, TNF‐α, IL‐1ß, IL‐16 quantified using enzyme‐linked immunosorbent assay (ELISA). Results case‐control included 40 individuals, divided into 2 groups: 20 stage III, grade B generalized group exhibited significantly higher than ( p < 0.05). Taurine lower, while TNF‐α No significant differences between groups found IL‐6 IL‐1β > A moderate positive correlation was observed BOP r = 0.581, 0.007). Conclusions These findings indicated increased health. Plain Language Summary serious disease gums can lead teeth by destruction tissues. potential link naturally occurring compound We measured inflammation‐related proteins gum from those Subjects had lower protein compared gums, suggesting could be involved inflammation processes

Language: Английский

Citations

0
The Role of Sulfhydryl (Thiols) Groups in Oral and Periodontal Diseases DOI Creative Commons

Sabetim Cerkezi,

Marija Nakova,

Icko Gorgoski

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 882 - 882

Published: April 16, 2024

Aim. The sulfhydryl (thiols) group of glutathione plays an important role in the neutralization foreign organic compounds and reduction peroxides. purpose study is to evaluate concentration groups gingival tissue healthy individuals those with gingivitis or periodontitis, examine differences between these groups. Material methods. To assess we used spectrophotometric analysis using dithionitrobenzoate (DTNB) as a reagent measure accessible present proteins. sample was divided into three distinct groups: periodontal health, gingivitis, different indices were status participants. Next, statistical conducted compare concentrations among patients. Conclusions. results this showed significantly decreased levels from patients compared people (control group). These confirm defense against free radicals. They share significant detoxification, signal transduction, apoptosis, various other functions at molecular level.

Language: Английский

Citations

4
Patent Mining on the Use of Antioxidant Phytochemicals in the Technological Development for the Prevention and Treatment of Periodontitis DOI Creative Commons
Paulo José Lima Juíz,

Luiza Teles Barbalho Ferreira,

Edilson Araújo Pires

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 566 - 566

Published: May 3, 2024

Periodontal disease is an inflammatory condition characterized by aberrant immune response against a dysbiotic dental biofilm, with oxidative stress performing essential role in its pathogenesis. This paper presents patent mining, performed the Orbit Intelligence database, related to antioxidant phytochemicals technological developments that are working prevent and treat periodontal disease. To access documents, descriptors “PERIODONTAL” “ANTIOXIDANT” were typed title, abstract, claim search fields. A total of 322 patents demonstrate growing interest researching natural antioxidants for scientific purposes. The top ten countries regarding number family produced United States, European Office, Japan, South Korea, China, India, Mexico, Denmark, Canada, Great Britain. most cited compounds vitamin C, green tea, quercetin, melatonin, lycopene, resveratrol, curcumin. These have been used development gels, membranes, dentifrices, chewing gum, orally disintegrating film, mouthwash, mouth spray, massage cream exhibit ability neutralize free radicals reduce stress, critical factor progression diseases. documents shown using conjunction traditional treatments promising area therapy.

Language: Английский

Citations

4
The use of traditional herbal medicine in Pakistani dentistry and mechanistic overview of some phytochemicals against oral and dental disease categories DOI
Suryani As’ád, Suryani As’ád,

Malaika Khan

et al.

CABI Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Due to the chronic nature and rapid development, oral dental diseases remained major health concerns. In this regard, herbal medicines could be very vital in controlling such complications. Here, we provide a comprehensive data on plants used as alternate medicine against Pakistan with an overview of reported mechanisms action some phytochemicals these diseases. Data were searched across scientific databases including Scopus, PubMed, Web Science, SciELO Science Direct particular keywords. Overall, 234 from 177 genera 77 plant families have been Acacia Solanum 6 species each, Rumex Ficus 4 Artemisia , Ferula, Plantago Tephrosia 3 each maximally Herb highly prevalent growth habit for 125 (54%), following shrubs (56 species, 24%) tree (50 21%). A total 16 different parts where leaves (97 41.45%), roots (66 28.20%) stem (34 14.52%) 15 modes remedies decoction (77 species), raw form (69 species) powder (60 preferred modes. The toothache (189 gum infections (39 species). Further, review presented possible provides crucial information curing complications further studies are recommended clarify their safety effectiveness.

Language: Английский

Citations

0