Gastrodin exerts perioperative myocardial protection by improving mitophagy through the PINK1/Parkin pathway to reduce myocardial ischemia-reperfusion injury DOI Creative Commons
Lu Chen, Yong Lv,

Hui-liang Wu

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 133, P. 155900 - 155900

Published: Aug. 1, 2024

Although blood flow is restored after treatment of myocardial infarction (MI), ischemia and reperfusion (I/R) can cause cardiac injury, which a leading heart failure. Gastrodin (GAS) exerts protective effects against brain, heart, kidney I/R. However, its pharmacological mechanism in I/R injury (MIRI) remains unclear. GAS regulates autophagy various diseases, such as acute hepatitis, vascular dementia, stroke. We hypothesized that could repair mitochondrial damage regulate to protect MIRI. Male C57BL/6 mice H9C2 cells were subjected hypoxia-reoxygenation (H/R) administration, respectively, assess the impact on cardiomyocyte phenotypes, structure function. The effect function patients undergoing surgery has been observed clinical practice. function, structure, expression related molecules an animal model MIRI evaluated using immunohistochemical staining, enzyme-linked immunosorbent assay (ELISA), transmission electron microscopy, western blotting, gene sequencing. Its morphological, molecular, functional phenotypes cardiomyocytes H/R real-time quantitative PCR, blotting. significantly reduces infarct size improves models increases viability cellular models. In practice, was alleviated with better application GAS; improvements mitochondria activation also observed. primarily cardioprotective through PINK1/Parkin pathway, promotes clear damaged mitochondria. promote mitophagy preserve PINK1/Parkin, thus indicating tremendous potential effective perioperative agent.

Language: Английский

Application of fermented Chinese herbal medicines in food and medicine field: From an antioxidant perspective DOI
Yuzhu Zhang, Jing Zhang,

Jingwen Yan

et al.

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 148, P. 104410 - 104410

Published: April 7, 2024

Language: Английский

Citations

18
Unraveling the Role of Quinoa in Managing Metabolic Disorders: A Comprehensive Review DOI Creative Commons

Aarzoo Jangra,

Vikram Kumar, Shiv Kumar

et al.

Current Nutrition Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 3, 2025

Language: Английский

Citations

2
From plants to antimicrobials: Natural products against bacterial membranes DOI
Fahimeh Nourbakhsh,

Marzieh Lotfalizadeh,

Mohaddeseh Badpeyma

et al.

Phytotherapy Research, Journal Year: 2021, Volume and Issue: 36(1), P. 33 - 52

Published: Sept. 16, 2021

Bacterial membrane barrier provides a cytoplasmic environment for organelles of bacteria. The is composed lipid compounds containing phosphatide protein and minimal amount sugars, responsible intercellular transfers chemicals. Several antimicrobials have been found that affect bacterial membranes. These generally disrupt the organization or perforate it. By destroying membrane, drugs can permeate replace effective macromolecules necessary cell life. Furthermore, they electrical gradients cells through impairment integrity. In recent years, considering spread microbial resistance side effects antibiotics, natural antimicrobial studied by researchers extensively. molecules are best alternative controlling infections reducing drug due to lack severe effects, low cost production, biocompatibility. Better understanding compounds' mechanisms against bacteria improved strategies therapies. this review, products with antibacterial activities focusing on damaging were described. However, further high‐quality research studies needed confirm clinical efficacy these products.

Language: Английский

Citations

82
A Review on Plant-Mediated Synthesis of Bimetallic Nanoparticles, Characterisation and Their Biological Applications DOI Open Access
Lavinia Berța,

Năstaca-Alina Coman,

Aura Rusu

et al.

Materials, Journal Year: 2021, Volume and Issue: 14(24), P. 7677 - 7677

Published: Dec. 13, 2021

The study of bimetallic nanoparticles (BNPs) has constantly been expanding, especially in the last decade. biosynthesis BNPs mediated by natural extracts is simple, low-cost, and safe for environment. Plant contain phenolic compounds that act as reducing agents (flavonoids, terpenoids, tannins, alkaloids) stabilising ligands moieties (carbonyl, carboxyl, amine groups), useful green synthesis (NPs), are free toxic by-products. Noble NPs (containing silver, gold, platinum, palladium) have potential biomedical applications due to their safety, stability biological environment, low toxicity. They substantially impact human health (applications medicine pharmacy) proven effects (catalytic, antioxidant, antibacterial, antidiabetic, antitumor, hepatoprotective, regenerative activity). To best our knowledge, there no review papers literature on characterisation plant-mediated pharmacological potential. Thus, an effort made provide a clear perspective anticancer, size/shape-dependent BNPs. Furthermore, we discussed factors influence biosyntheses such pH, temperature, time, metal ion concentration, plant extract.

Language: Английский

Citations

64
A Comprehensive Study of Therapeutic Applications of Chamomile DOI Creative Commons
Amit Sah,

Punnoth Poonkuzhi Naseef,

Mohamed Saheer Kuruniyan

et al.

Pharmaceuticals, Journal Year: 2022, Volume and Issue: 15(10), P. 1284 - 1284

Published: Oct. 19, 2022

Chamomile has a long history of traditional medicinal uses. The two commonly used varieties with therapeutic applications are German chamomile known as Matricaria chamomilla L. and Roman or Chamaemelum nobile plant contains many components, namely, flavonoids, terpenoids, coumarins, which responsible for its properties. review discusses recent developments that help in establishing role agent various areas an anti-inflammatory, antioxidant, analgesic, antimicrobial, hepatoprotective, anti-allergic, anticancer, anti-hypertensive agent. Not much is about the treatment CNS disorders metabolic syndromes, also discussed. chemical components activity respective mechanism action elaborated.

Language: Английский

Citations

57
Antioxidants for the Prevention and Treatment of Non-communicable Diseases DOI Open Access
Thecla Okeahunwa Ayoka, Benjamin O. Ezema, Chijioke Nwoye Eze

et al.

Journal of Exploratory Research in Pharmacology, Journal Year: 2022, Volume and Issue: 000(000), P. 000 - 000

Published: July 6, 2022

Abiotic environmental stress causes plants and animals to produce excessive superoxide radicals that are extremely toxic reactive, thereby causing injury tissue resulting in the occurrence of several disorders. Antioxidants can counteract free by preventing non-communicable diseases. There natural synthetic antioxidants. Natural antioxidants fruits, vegetables, spices be consumed, while produced laboratories via chemical processes. This review focused on sources, pharmacological properties, applications, prospects antioxidants, as well exogenous endogenous A literature search was done using different engines like Google Books, Science.gov, Microsoft Academic, Worldwide Science, ResearchGate, Bielefeld Academic Search Engine (BASE), Medline, PubMed Central. Different keywords, such radicals, oxidative stress, oxygen were used. The relevant collected used this review. inhibit oxidation help prevent diseases, aging inflammatory processes, tumors, kidney liver coronary heart disease, cataracts, renal toxicity, neurological It found diet have capacity anxiety-related

Language: Английский

Citations

55
Antioxidants and Bioactive Compounds in Food: Critical Review of Issues and Prospects DOI Creative Commons
Mia Kurek, Nadjet Debbache-Benaida, Ivona Elez Garofulić

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(4), P. 742 - 742

Published: April 8, 2022

This review paper gives an insight into the effective delivery mechanisms for health-promoting substances and highlights challenges of using antioxidants bioactives in foods. The selection criteria choosing their extraction bioavailable form with adequate incorporation techniques are covered. Moreover, overview existing methods determination bioactivity is given. importance scientifically evaluating effects foods or food components on consumer health before making claims about healthiness aligned. Finally, a scientific perspective how to respond booming demand products given, we acknowledge that despite work done, there still many need be overcome.

Language: Английский

Citations

52
Antioxidant Activity and Profile of Phenolic Compounds in Selected Herbal Plants DOI Creative Commons

Kamil Foss,

Katarzyna E. Przybyłowicz, Tomasz Sawicki

et al.

Plant Foods for Human Nutrition, Journal Year: 2022, Volume and Issue: 77(3), P. 383 - 389

Published: July 2, 2022

Herbs are characterized by a high content of biologically active substances that positively affect human health. Phenolic compounds one the main bioactive in these plants with highly beneficial properties (e.g., anti-carcinogenic, cardioprotective, immune system support and antibacterial). Therefore, this study aimed to determine composition free bound phenolic antioxidant activity 10 different herbs (bogbean leaves, sage whole Indian hemp, heartsease, horsetail, blessed thistle, thyme, chamomile flower, corn silk pine buds). were analyzed using HPLC-TOF-MS/MS method, total (TP) flavonoid (TF) contents measured spectrophotometric methods, while was determined ABTS DPPH assays. The highest TP found range released from ester glycosidic derivatives hydrolysis. In turn, values TF non-hydrolyzed extracts hemp. TF, including phenols observed obtained leaves. thirty-three found, constituting 16 acids, 9 flavonoids eight stilbenes. Moreover, appeared form than form. herb differed significantly across varieties (P < 0.05). research showed each tested possesses its own fingerprint properties.

Language: Английский

Citations

47
Investigation of the metal complexes and bioactive compound formed by coordination of bioactive phytochemical from ginger (Zingiber officinale) extracts to metal ions DOI Creative Commons
Great Iruoghene Edo, Ufuoma Ugbune, Favour Ogheneoruese Onoharigho

et al.

Food Chemistry Advances, Journal Year: 2023, Volume and Issue: 3, P. 100337 - 100337

Published: June 10, 2023

The Medicinal value of many plants is attributed to their bioactive compounds. research aimed investigate the metal complexes and compounds formed from ginger extract. n-hexane, ethanol, distilled water were used generate crude extract leaves. Solubility ligand with corresponding (Zn Cu) measured. Infra-red analysis each was measured using FT-IR spectrometer. According findings, soluble in ethanol but not n-hexane. salts n-hexane ginger. In this investigation, significant phytochemicals reported. Ginger contains like alkaloids, glycosides, anthraquinone cardiac glycosides saponins, tannin, phenol, flavonoid, steroids, terpenoids, protein carbohydrate. amino alcohol functional groups. results study show that an increase groups' absorption peak extracts indicates occurrence varied donor sites plant Hence, it may be concluded possesses

Language: Английский

Citations

38
The ethnobotanical, bioactive compounds, pharmacological activities and toxicological evaluation of garlic (Allium sativum): A review DOI Creative Commons
Benedict Chukwuebuka Okoro, Titilope M. Dokunmu, Esther Okafor

et al.

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2023, Volume and Issue: 8, P. 100273 - 100273

Published: June 5, 2023

Garlic (Allium sativum) is a medicinal plant exploited for its diverse pharmacological benefits and used as cooking spice globally. In traditional Chinese medicine, garlic prepared served in different forms such syrup, extract, decoct, oil, tincture, infusion, they are their the treatment of several diseases food poisoning, cholera, fever, headache, dysentery, lowering blood pressure, stimulant, diuretic, expectorant, diaphoretic agent. This study reviewed ethnomedicinal uses, bioactive compounds, activities, toxicological evaluation garlic. Literature searches were carried out on following databases: PubMed, Frontiers, Science Direct, Springer, Wiley, MDPI databases. Chemical structures identified drawn using ChemDraw (version 12.0.2) after thorough search PubChem databases, NIST Chemistry Webbook, ChemSpider. "Allium sativum", "garlic", sativum pharmacological", ethnomedicine", compounds", other similar keywords to relevant journals contents. The rich source carbohydrate, minerals, fat, vitamins, fibers, phenolic compounds that promote good health. sulfur-containing extracted from include Allicin, Vinyl-4H-1, 3-dithiin, E-Ajoene, Diallyl trisulfide, Alliin, Allyl methyl sulfide, 2-Diallyl Z-Ajoene, disulfide, Quercetin, mercaptan, propyl Thiacremonone, Gamma-glutamylcysteine. Several vitro vivo studies have reported constituents including anti-inflammatory, anticancer, antidiabetic, antihypertensive, anti-obesity, antimicrobial, antioxidant, antithrombotic, anti-Alzheimer activities. suggested effective use treating various diseases, which may be attributed presence plant. Additionally, powerful antioxidant action also contributes reducing harm oxidative stress causes critical biomolecules body helps disease prevention. can by pharmaceutical industries development therapeutic products. However, more comprehensive human clinical trials needed validate safe doses diseases.

Language: Английский

Citations

37