International Journal of Nanomedicine,
Journal Year:
2021,
Volume and Issue:
Volume 16, P. 4289 - 4319
Published: June 1, 2021
Abstract:
Recent
developments
in
three-dimensional
(3D)
printing
technology
offer
immense
potential
fabricating
scaffolds
and
implants
for
various
biomedical
applications,
especially
bone
repair
regeneration.
As
the
availability
of
autologous
sources
commercial
products
is
limited
surgical
methods
do
not
help
complete
regeneration,
it
necessary
to
develop
alternative
approaches
repairing
large
segmental
defects.
The
3D
can
effectively
integrate
different
types
living
cells
within
a
construct
made
up
conventional
micro-
or
nanoscale
biomaterials
create
an
artificial
graft
capable
regenerating
damaged
tissues.
This
article
reviews
applications
tissue
engineering
highlights
numerous
nanomaterials
that
have
been
used
production
3D-printed
scaffolds.
A
comprehensive
overview
such
as
stereolithography
(SLA),
selective
laser
sintering
(SLS),
fused
deposition
modeling
(FDM),
ink-jet
printing,
their
technical
clinical
regeneration
has
provided.
review
expected
be
useful
readers
gain
insight
into
state-of-the-art
substitutes
translational
perspectives.
Keywords:
bone,
engineering,
biomaterials,
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Journal Year:
2024,
Volume and Issue:
151, P. 106391 - 106391
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 651 - 671
Published: Jan. 1, 2024
Background:
Polyvinyl
alcohol/Chitosan
hydrogel
is
often
employed
as
a
carrier
because
it
non-toxic,
biodegradable,
and
has
three-dimensional
network
structure.
Meanwhile,
Magnesium-doped
nano-hydroxyapatite(Mg-nHA)
demonstrated
high
characterization
to
promote
the
osteogenic
differentiation
of
bone
marrow
derived
mesenchymal
stem
cell(BMSCs).
Therefore,
in
order
develop
porous
scaffold
for
application
tissue
engineering,
an
appropriate-type
Mg-nHA
was
developed
evaluated.
Methods:
A
composite
containing
magnesium-doped
nano-hydroxyapatite
(Mg-nHA/PVA/CS)
using
magnetic
stirring-ion
exchange
method
cyclic
freeze-thaw
design,
with
polyvinyl
alcohol
chitosan
main
components.
Fourier
transform
infrared
spectra
(FTIR),
electron
energy
dispersive
spectroscopy
(EDS),
X-ray
photoelectron
spectrometer
(XPS)
scanning
microscopy
(SEM)
were
analyze
chemical
structure,
porosity,
elemental
composition
each
hydrogels.
The
equilibrium
swelling
degree,
moisture
content,
pH
change,
potential
biomineralization,
biocompatibility,
magnesium
ion
release
rate
also
Results:
SEM
analysis
revealed
well-defined
3D
spatial
structure
micropores
synthesised
hydrogel.
FTIR
showed
that
doping
nanoparticles
had
little
effect
on
hydrogel's
both
5%
Mg-nHA/PVA/CS
10%
groups
promoted
amide
bond
formation.
EDS
observation
indicated
new
material
exhibited
favourable
biomineralization
ability,
optimal
performance
seen
group.
not
only
displayed
water
enhanced
porosity
(similar
human
cancellous
bone),
but
maintained
degree
released
ions
created
alkaline
environment
around
it.
Additionally,
facilitated
proliferation
cells
their
differentiation.
Conclusion:
demonstrates
significant
field
repair,
making
excellent
engineering.
Keywords:
nano-hydroxyapatite,
alcohol,
chitosan,
hydrogel,
physical
crosslinking
Frontiers in Chemistry,
Journal Year:
2020,
Volume and Issue:
8
Published: May 7, 2020
Three-dimensional
(3D)
printing
is
a
revolutionary
manufacturing
technique
that
can
fabricate
3D
object
by
depositing
materials
layer
layer.
Different
such
as
metals,
polymers,
concretes
are
generally
used
for
printing.
In
order
to
make
sustainable,
researchers
working
on
the
use
of
different
bio-derived
Because
abundant
and
sustainable
sources,
versatile
properties;
biomaterials
considered
potential
candidates
have
ability
replace
petroleum-based
polymers.
This
review
highlights
basic
overview
fused
deposition
modeling
(FDM)
recent
developments
occurred
FDM
using
biomaterials.
Specifically,
process,
final
properties
characteristics
biopolymers,
their
composites
polymers
containing
biofillers
discussed.
Nanomaterials,
Journal Year:
2019,
Volume and Issue:
10(1), P. 51 - 51
Published: Dec. 24, 2019
Biodegradable
blends
and
nanocomposites
were
produced
from
polylactic
acid
(PLA),
poly(3-hydroxybutyrate)
(PHB)
cellulose
nanocrystals
(NC)
by
a
single
step
reactive
blending
process
using
dicumyl
peroxide
(DCP)
as
cross-linking
agent.
With
the
aim
of
gaining
more
insight
into
impact
processing
methods
upon
morphological,
thermal
mechanical
properties
these
nanocomposites,
three
different
techniques
employed:
compression
molding,
extrusion,
3D
printing.
The
addition
DCP
improved
interfacial
adhesion
dispersion
NC
in
observed
scanning
electron
microscopy
atomic
force
microscopy.
carbonyl
index
calculated
Fourier
transform
infrared
spectroscopy
showed
increased
crystallinity
after
PLA/PHB
PLA/PHB/NC,
also
confirmed
differential
calorimetry
analyses.
nucleating
activity
favored
crystallization
PLA,
increasing
its
16%
to
38%
crosslinked
blend
43%
PLA/PHB/NC
nanocomposite.
influenced
melting-recrystallization
processes
due
generation
lower
molecular
weight
products
with
mobility.
thermo-mechanical
characterization
uncross-linked
cross-linked
influence
technique.
Higher
storage
modulus
values
obtained
for
filaments
extrusion
printed
meshes
compared
molded
films.
Similarly,
thermogravimetric
analysis
an
increase
onset
degradation
temperature,
even
than
10
°C
3D-printing,
molding.
This
study
shows
that
enhanced
adhesion,
stability,
can
be
right
choice
method
conditions
balancing
properties.
Biomacromolecules,
Journal Year:
2018,
Volume and Issue:
19(3), P. 701 - 711
Published: Feb. 28, 2018
Three-dimensional
(3D)
printing
has
rapidly
emerged
as
a
new
technology
with
wide
range
of
applications
that
includes
biomedicine.
Some
common
3D
methods
are
based
on
the
suitability
biopolymers
to
be
extruded
through
nozzle
construct
structure
layer
by
layer.
Nanocelluloses
specific
rheological
characteristics
suitable
components
form
inks
for
printing.
This
review
considers
various
nanocelluloses
have
been
proposed
focus
potential
advantages,
limitations,
and
requirements
when
used
biomedical
devices
in
contact
human
body.
e-Polymers,
Journal Year:
2020,
Volume and Issue:
20(1), P. 571 - 599
Published: Jan. 1, 2020
Abstract
Polylactic
acid
(PLA)
is
one
of
the
most
commonly
used
materials
in
biomedical
sector
because
its
processability,
mechanical
properties
and
biocompatibility.
Among
different
techniques
that
are
feasible
to
process
this
biomaterial,
additive
manufacturing
(AM)
has
gained
attention
recently,
as
it
provides
possibility
tuning
design
structures.
This
flexibility
stage
allows
customization
parts
order
optimize
their
use
tissue
engineering
field.
In
recent
years,
application
PLA
for
manufacture
bone
scaffolds
been
especially
relevant,
since
numerous
studies
have
proven
potential
biomaterial
regeneration.
review
contains
a
description
specific
requirements
regeneration
how
state
art
tried
address
them
with
strategies
develop
PLA-based
by
AM
improved
biofunctionality.
