Targeting Glucose Metabolism to Overcome Resistance to Anticancer Chemotherapy in Breast Cancer

Cancers, Journal Year: 2020, Volume and Issue: 12(8), P. 2252 - 2252

Published: Aug. 12, 2020

Breast cancer (BC) is the most prevalent in women. BC heterogeneous, with distinct phenotypical and morphological characteristics. These are based on their gene expression profiles, which divide into different subtypes, among triple-negative breast (TNBC) subtype aggressive one. The growing interest tumor metabolism emphasizes role of altered glucose driving progression, response to treatment, its therapy resistance. Alterations characterized by increased uptake glucose, hyperactivated glycolysis, decreased oxidative phosphorylation (OXPHOS) component, accumulation lactate. deviations attributed upregulation key glycolytic enzymes transporters metabolic pathway. Key such as hexokinase, lactate dehydrogenase, enolase upregulated, thereby conferring resistance towards drugs cisplatin, paclitaxel, tamoxifen, doxorubicin. Besides, drug efflux detoxification two energy-dependent mechanisms contributing emergence chemotherapy can occur at an early or later stage thus limiting success outcome therapy. Therefore, understanding aberrant tumors link essential. Using combinatory treatment inhibitors, for example, 2-deoxy-D-glucose (2-DG) metformin, showed promising results countering Newer designs conjugated sugars peptides that utilize enhanced cell offer selective efficient delivery cells less toxicity healthy cells. Last but not least, naturally occurring compounds plants defined phytochemicals manifest a approach eradication via suppression essential other compartments associated glycolysis. Their benefits human health open new opportunities therapeutic intervention, either alone combination chemotherapeutic drugs. Importantly, efficacious instruments anticancer suppress events leading chemoresistance Here, we review current knowledge classical various ways target will serve strategy chemosensitizing overcoming BC.

Language: Английский

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Phytoconstituents as modulators of NF-κB signalling: Investigating therapeutic potential for diabetic wound healing

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117058 - 117058

Published: July 4, 2024

The NF-κB pathway plays a pivotal role in impeding the diabetic wound healing process, contributing to prolonged inflammation, diminished angiogenesis, and reduced proliferation. In contrast modern synthetic therapies, naturally occurring phytoconstituents are well-studied inhibitors of that now attracting increased attention context because lower toxicity, better safety efficacy, cost-effectiveness. This study explores recent research on phytoconstituent-based therapies delve into their action mechanisms targeting potential for assisting effective wounds. For this purpose, we have carried out surveys literature analyzed studies from prominent databases such as Science Direct, Scopus, PubMed, Google Scholar, EMBASE, Web Science. classification various categorie as: alkaloids, triterpenoids, phenolics, polyphenols, flavonoids, monoterpene glycosides, naphthoquinones tocopherols. Noteworthy phytoconstituents, including Neferine, Plumbagin, Boswellic acid, Genistein, Luteolin, Kirenol, Rutin, Vicenin-2, Gamma-tocopherol, Icariin, Resveratrol, Mangiferin, Betulinic Berberine, Syringic Gallocatechin, Curcumin, Loureirin-A, Loureirin-B, Lupeol, Paeoniflorin, Puerarin emerge these promising agents through inhibition pathway. Extensive has revealed how they modulate signalling pathways, NF-κB, demonstrate development therapeutic assist chronic

Language: Английский

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Curcumin in cancer therapy: A novel adjunct for combination chemotherapy with paclitaxel and alleviation of its adverse effects

Life Sciences, Journal Year: 2020, Volume and Issue: 256, P. 117984 - 117984

Published: June 25, 2020

Language: Английский

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Apigenin as Tumor Suppressor in Cancers: Biotherapeutic Activity, Nanodelivery, and Mechanisms With Emphasis on Pancreatic Cancer

Frontiers in Chemistry, Journal Year: 2020, Volume and Issue: 8

Published: Oct. 15, 2020

Pancreatic cancer is the most lethal malignancy of gastrointestinal tract. Because its propensity for early local and distant spread, affected patients possess extremely poor prognosis. Currently applied treatments are not effective enough to eradicate all cells, minimize their migration. Besides, these associated with adverse effects on normal cells organs. These therapies able increase overall survival rate patients; hence, finding novel adjuvants or alternatives so essential. Up now, medicinal herbs were utilized therapeutic goals. Herbal-based medicine, as traditional biotherapeutics, was employed treatment. Of them, apigenin, a bioactive flavonoid that possesses numerous biological properties (e.g., anti-inflammatory anti-oxidant effects), has shown substantial anticancer activity. It seems apigenin capable suppressing proliferation via induction cell cycle arrest apoptosis. inhibits metastasis down-regulation matrix metalloproteinases Akt signaling pathway. In pancreatic sensitizes into chemotherapy, affects molecular pathways such hypoxia inducible factor (HIF), vascular endothelial growth (VEGF), glucose transporter-1 (GLUT-1), etc. Herein, biotherapeutic activity mechanisms toward presented in current review shed some light anti-tumor different cancers, an emphasis cancer.

Language: Английский

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Progress in Natural Compounds/siRNA Co-delivery Employing Nanovehicles for Cancer Therapy

ACS Combinatorial Science, Journal Year: 2020, Volume and Issue: 22(12), P. 669 - 700

Published: Oct. 23, 2020

Chemotherapy using natural compounds, such as resveratrol, curcumin, paclitaxel, docetaxel, etoposide, doxorubicin, and camptothecin, is of importance in cancer therapy because the outstanding therapeutic activity multitargeting capability these compounds. However, poor solubility bioavailability compounds have limited their efficacy therapy. To circumvent this hurdle, nanocarriers been designed to improve antitumor aforementioned Nevertheless, treatment still a challenge, demanding novel strategies. It well-known that combination products gene advantageous over monotherapy. Delivery multiple agents/small interfering RNA (siRNA) potent gene-editing tool can maximize synergistic effects against tumor cells. In present review, co-delivery compounds/siRNA nanovehicles are highlighted provide backdrop for future research.

Language: Английский

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Progress in Delivery of siRNA-Based Therapeutics Employing Nano-Vehicles for Treatment of Prostate Cancer

Bioengineering, Journal Year: 2020, Volume and Issue: 7(3), P. 91 - 91

Published: Aug. 10, 2020

Prostate cancer (PCa) accounts for a high number of deaths in males with no available curative treatments. Patients PCa are commonly diagnosed advanced stages due to the lack symptoms early stages. Recently, research focus was directed toward gene editing therapy. Small interfering RNA (siRNA) intervention is considered as powerful tool silencing (knockdown), enabling suppression oncogene factors cancer. This strategy applied treatment various cancers including PCa. The siRNA can inhibit proliferation and invasion cells able promote anti-tumor activity chemotherapeutic agents. However, off-target effects therapy remarkably reduce its efficacy To date, carriers were designed improve delivery and, among them, nanoparticles importance. Nanoparticles enable targeted siRNAs enhance their potential downregulation target genes interest. Additionally, provide platform co-delivery drugs, resulting decreased growth migration cells. efficacy, specificity, comprehensively discussed this review direct further studies using nanoscale-delivery systems perhaps other types.

Language: Английский

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Effects of Curcumin on Vessel Formation Insight into the Pro- and Antiangiogenesis of Curcumin

Evidence-based Complementary and Alternative Medicine, Journal Year: 2019, Volume and Issue: 2019, P. 1 - 9

Published: June 19, 2019

Curcumin is a compound extracted from the Curcuma longa L, which possesses wide range of pharmacological effects. However, few studies have collected scientific evidence on its dual effect angiogenesis. The present review gathered fragmented information available in literature to discuss and possible mechanisms curcumin Available concerning angiogenesis compiled databases, including PubMed Web Science using key term (curcumin angiogenesis). results were reviewed identify relevant articles. Related demonstrated that has antiangiogenesis via regulating multiple factors, proangiogenesis factor VEGF, MMPs, FGF, both vivo vitro, could promote under certain circumstances these factors. This paper provided short bidirectional action curcumin, should be useful for further study application this require studies.

Language: Английский

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Sensing the scent of death: Modulation of microRNAs by Curcumin in gastrointestinal cancers

Pharmacological Research, Journal Year: 2020, Volume and Issue: 160, P. 105199 - 105199

Published: Sept. 14, 2020

Language: Английский

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The role of microRNA-338-3p in cancer: growth, invasion, chemoresistance, and mediators

Life Sciences, Journal Year: 2021, Volume and Issue: 268, P. 119005 - 119005

Published: Jan. 7, 2021

Language: Английский

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Dual relationship between long non-coding RNAs and STAT3 signaling in different cancers: New insight to proliferation and metastasis

Life Sciences, Journal Year: 2021, Volume and Issue: 270, P. 119006 - 119006

Published: Jan. 7, 2021

Language: Английский

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