AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 146, P. 112563 - 112563

Published: Dec. 29, 2021

Diabetes mellitus (DM) is considered as a main challenge in both developing and developed countries, lifestyle has changed its management seems to be vital. Type I type II diabetes are the kinds they result hyperglycemia patients related complications. The gene expression alteration can lead development of DM AMP-activated protein kinase (AMPK) an energy sensor with aberrant various diseases including cancer, cardiovascular DM. present review focuses on understanding AMPK role Inducing signaling promotes glucose that importance for ameliorating hyperglycemia. Further investigation reveals enhancing insulin sensitivity treatment diabetic patients. Furthermore, upregulation inhibits stress cell death β cells preventing development. clinical studies have shown improving complications such brain disorders. improve neuropathy, nephropathy, liver reproductive alterations occurring during For exerting protective impacts, interacts other molecular pathways PGC-1α, PI3K/Akt, NOX4 NF-κB among others. Therefore, providing therapeutics based targeting beneficial amelioration

Language: Английский

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Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects

Phytotherapy Research, Journal Year: 2021, Volume and Issue: 36(1), P. 189 - 213

Published: Oct. 25, 2021

Abstract Curcumin is a phytochemical isolated from Curcuma longa with potent tumor‐suppressor activity, which has shown significant efficacy in pre‐clinical and clinical studies. stimulates cell death, triggers cycle arrest, suppresses oncogenic pathways, thereby suppressing cancer progression. Cisplatin (CP) DNA damage apoptosis chemotherapy. However, CP adverse effects on several organs of the body, drug resistance frequently observed. The purpose present review to show function curcumin decreasing CP's impacts improving its antitumor activity. administration reduces ROS levels prevent normal cells. Furthermore, can inhibit inflammation via down‐regulation NF‐κB maintain organs. nanoformulations reduce hepatoxicity, neurotoxicity, renal toxicity, ototoxicity, cardiotoxicity caused by CP. Notably, potentiates cytotoxicity mediating death arrest. Besides, STAT3 NF‐ĸB as tumor‐promoting enhance sensitivity resistance. targeted delivery tumor cells be mediated nanostructures. In addition, derivatives are also able CP‐mediated side effects, increase against various types.

Language: Английский

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Advances in understanding the role of P-gp in doxorubicin resistance: Molecular pathways, therapeutic strategies, and prospects

Drug Discovery Today, Journal Year: 2021, Volume and Issue: 27(2), P. 436 - 455

Published: Oct. 7, 2021

P-glycoprotein (P-gp) is a drug efflux transporter that triggers doxorubicin (DOX) resistance. In this review, we highlight the molecular avenues regulating P-gp, such as Nrf2, HIF-1α, miRNAs, and long noncoding (lnc)RNAs, to reveal their participation in DOX These antitumor compounds genetic tools synergistically reduce P-gp expression. Furthermore, ATP depletion impairs activity enhance of DOX. Nanoarchitectures, including liposomes, micelles, polymeric nanoparticles (NPs), solid lipid nanocarriers, have been developed for co-delivery with anticancer genes enhancing cytotoxicity. Surface modification instance hyaluronic acid (HA), can promote selectivity toward cancer cells. We discuss these aspects focus on expression activity.

Language: Английский

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Stimuli-responsive liposomal nanoformulations in cancer therapy: Pre-clinical & clinical approaches

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 351, P. 50 - 80

Published: Sept. 20, 2022

The site-specific delivery of antitumor agents is importance for providing effective cancer suppression. Poor bioavailability anticancer compounds and the presence biological barriers prevent their accumulation in tumor sites. These obstacles can be overcome using liposomal nanostructures. challenges chemotherapy stimuli-responsive nanocarriers are first described current review. Then, liposomes including pH-, redox-, enzyme-, light-, thermo- magneto-sensitive nanoparticles discussed potential drugs emphasized. pH- or redox-sensitive based on internal stimulus release drug response to a mildly acidic pH GSH, respectively. pH-sensitive mediate endosomal escape via proton sponge. multifunctional responsive both redox have more capacity at site compared alone. magnetic field NIR irradiation exploited external stimulation liposomes. light-responsive when they exposed irradiation; thermosensitive-liposomes temperature >40 °C there hyperthermia; magneto-responsive field. smart nanoliposomes also co-delivery genes synergistic therapy. Due lack long-term toxicity liposomes, utilized near future treatment patients.

Language: Английский

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STAT3-EMT axis in tumors: Modulation of cancer metastasis, stemness and therapy response

Pharmacological Research, Journal Year: 2022, Volume and Issue: 182, P. 106311 - 106311

Published: June 15, 2022

Language: Английский

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(Nano)platforms in breast cancer therapy: Drug/gene delivery, advanced nanocarriers and immunotherapy

Medicinal Research Reviews, Journal Year: 2023, Volume and Issue: 43(6), P. 2115 - 2176

Published: May 11, 2023

Abstract Breast cancer is the most malignant tumor in women, and there no absolute cure for it. Although treatment modalities including surgery, chemotherapy, radiotherapy are utilized breast cancer, it still a life‐threatening disease humans. Nanomedicine has provided new opportunity treatment, which focus of current study. The nanocarriers deliver chemotherapeutic agents natural products, both increase cytotoxicity against cells prevent development drug resistance. efficacy gene therapy boosted by nanoparticles delivery CRISPR/Cas9, Noncoding RNAs, RNAi, promoting their potential expression regulation. codelivery can exert synergistic impact on tumors enhance cellular uptake via endocytosis. Nanostructures able to induce photothermal photodynamic ablation cell death induction. provide microenvironment remodeling repolarization macrophages antitumor immunity. stimuli‐responsive nanocarriers, pH‐, redox‐, light‐sensitive, mediate targeted suppression tumors. Besides, diagnosis detect biomarkers. Various kinds have been employed therapy, carbon‐, lipid‐, polymeric‐ metal‐based nanostructures, different terms biocompatibility efficiency.

Language: Английский

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(Nano)platforms in bladder cancer therapy: Challenges and opportunities

Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(1)

Published: June 8, 2022

Urological cancers are among the most common malignancies around world. In particular, bladder cancer severely threatens human health due to its aggressive and heterogeneous nature. Various therapeutic modalities have been considered for treatment of although prognosis remains unfavorable. It is perceived that depends on an interdisciplinary approach combining biology engineering. The nanotechnological approaches introduced in various cancers, especially cancer. current review aims emphasize highlight possible applications nanomedicine eradication tumor. Nanoparticles can improve efficacy drugs therapy through elevating their bioavailability. potential genetic tools such as siRNA miRNA gene expression regulation be boosted using nanostructures by facilitating internalization accumulation at tumor sites cells. provide photodynamic photothermal ROS overgeneration hyperthermia, respectively, suppression Furthermore, remodeling microenvironment infiltration immune cells purpose immunotherapy achieved cargo-loaded nanocarriers. Nanocarriers mainly internalized endocytosis, proper design smart nanoparticles pH-, redox-, light-responsive nanocarriers importance targeted therapy. Bladder biomarkers detected timely diagnosis patients. Based site, they employed imaging. clinical translation challenges also covered review.

Language: Английский

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Progress in targeting PTEN/PI3K/Akt axis in glioblastoma therapy: Revisiting molecular interactions

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 158, P. 114204 - 114204

Published: Jan. 4, 2023

Glioblastoma (GBM) is one of the most malignant cancers central nervous system and due to its sensitive location, surgical resection has high risk therefore, chemotherapy radiotherapy are utilized for treatment. However, chemoresistance radio-resistance other problems in GBM Hence, new therapies based on genes recommended treatment GBM. PTEN a tumor-suppressor operator cancer that inhibits PI3K/Akt/mTOR axis diminishing growth, metastasis drug resistance. In current review, function PTEN/PI3K/Akt progression evaluated. Mutation or depletion leads increase progression. Low expression level mediates poor prognosis by increasing proliferation invasion, promotes malignancy tumor cells. Moreover, loss signaling can result therapy resistance Activation impairs metabolism via glycolysis inhibition. contrast PTEN, PI3K/Akt oncogenic during progression, enhances. shows positive association with pathways similar signaling, regulated non-coding RNAs. upregulation inhibition anti-cancer agents be beneficial interfering This review emphasizes networks related provides insights targeting this effective

Language: Английский

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Non-coding RNA-based regulation of inflammation

Seminars in Immunology, Journal Year: 2022, Volume and Issue: 59, P. 101606 - 101606

Published: Jan. 1, 2022

Language: Английский

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Targeted therapies of curcumin focus on its therapeutic benefits in cancers and human health: Molecular signaling pathway-based approaches and future perspectives

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 116034 - 116034

Published: Dec. 22, 2023

The curry powder spices turmeric (Curcuma longa L.), which contains curcumin (diferuloylmethane), an orange-yellow chemical. Polyphenols are the most commonly used sources of curcumin. It combats oxidative stress and inflammation in diseases, such as hyperlipidemia, metabolic syndrome, arthritis, depression. Most these benefits due to their anti-inflammatory antioxidant properties. Curcumin consumption leads decreased bioavailability, resulting limited absorption, quick metabolism, excretion, hinders health improvement. Numerous factors can increase its bioavailability. Piperine enhances bioavailability when combined with a complex. When other enhancing agents, has wide spectrum benefits. This review evaluates therapeutic potential specific emphasis on approach based molecular signaling pathways. study investigated influence progression cancer, inflammation, many health-related mechanisms, cell proliferation, apoptosis, metastasis. significant for prevention treatment various diseases. modulates several biochemical pathways targets involved cancer growth. Despite tissue accumulation administered orally, proven useful. provides in-depth analysis curcumin's applications, pathway-based approach, precision medicine human health.

Language: Английский

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