Metal Dyshomeostasis as a Driver of Gut Pathology in Autism Spectrum Disorders DOI Creative Commons

Kevin O’Grady,

Andreas M. Grabrucker

Journal of Neurochemistry, Journal Year: 2025, Volume and Issue: 169(3)

Published: March 1, 2025

ABSTRACT Despite being classified as neurodevelopmental disorders, in recent years, there has been a growing interest the association between autism spectrum disorders (ASDs) and gut pathology. This comprehensive systematic review explores potential mechanism underlying pathology ASDs, including alterations microbiota, intestinal permeability, immune dysregulation, gastrointestinal (GI) symptoms. Specifically, it delves into role of toxic essential metals their interplay, affecting development function GI tract. The also discusses implications this management ASDs. Studies have shown that heavy metal exposure, whether through environmental sources or dietary intake, can disrupt delicate balance trace elements gut. disruption adversely affect zinc homeostasis, potentially exacerbating individuals with impaired absorption resulting from exposure may contribute to oxidative stress, inflammation observed By shedding light on multifaceted nature pathology, impact dyshomeostasis non‐genetic factor ASD, underscores significance gut‐brain axis etiology image

Language: Английский

Dissection of the antibacterial mechanism of zinc oxide nanoparticles with manipulable nanoscale morphologies DOI
Xinyi Zhu, Jun Wang, Ling Cai

et al.

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 430, P. 128436 - 128436

Published: Feb. 7, 2022

Language: Английский

Citations

100
Copper Homeostasis in Chronic Kidney Disease and Its Crosstalk with Ferroptosis DOI Creative Commons

Huang Jiayi,

Tong Ziyuan,

Xu Tianhua

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 202, P. 107139 - 107139

Published: March 12, 2024

Chronic kidney disease (CKD) has become a global public health problem with high morbidity and mortality. Renal fibrosis can lead to end-stage renal (ESRD). However, there is still no effective treatment prevent or delay the progression of CKD into ESRD. Therefore, exploring pathogenesis essential for preventing treating CKD. There are variety trace elements in human body that interact each other within complex regulatory network. Iron copper both vital body. They critical maintaining bodily functions, dysregulation their metabolism cause many diseases, including disease. Ferroptosis new form cell death characterized by iron accumulation lipid peroxidation. Studies have shown ferroptosis closely related role abnormal its relationship remains unclear. Here, our current knowledge regarding metabolism, mechanism, diseases summarized. In addition, we discuss between explore possible provide potential therapeutic target

Language: Английский

Citations

20
Is Supplementation with Micronutrients Still Necessary during Pregnancy? A Review DOI Open Access

Sonia Santander Ballestín,

Marta Isabel Giménez Campos,

Jara Ballestín Ballestín

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(9), P. 3134 - 3134

Published: Sept. 8, 2021

Proper nutrition during pregnancy is important to prevent nutritional imbalances that interfere with pregnancy. Micronutrients play critical roles in embryogenesis, fetal growth, and maternal health, as energy, protein, vitamin, mineral needs can increase Increased be met by increasing the intake of dietary micronutrients. Severe micronutrient deficiency or excess have negative effects on growth (intrauterine retardation, low birth weight, congenital malformations) development (pre-eclampsia gestational diabetes). We investigate whether it necessary continue supplementation improve women's health this stage could control pathologies associated

Language: Английский

Citations

72
Iron, Zinc, Copper, Cadmium, Mercury, and Bone Tissue DOI Open Access
Żaneta Ciosek, Karolina Kot, Iwona Rotter

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(3), P. 2197 - 2197

Published: Jan. 26, 2023

The paper presents the current understanding on effects of five metals bone tissue, namely iron, zinc, copper, cadmium, and mercury. Iron, copper contribute significantly to human animal metabolism when present in sufficient amounts, but their excess or shortage increases risk developing disorders. In contrast, cadmium mercury serve no physiological purpose long-term accumulation damages osteoarticular system. We discuss methods action interactions between discussed elements as well concentrations each element distinct structures.

Language: Английский

Citations

39
The influence of microbiota on ferroptosis in intestinal diseases DOI Creative Commons
Ting Yao, Lanjuan Li

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(2)

Published: Oct. 5, 2023

Ferroptosis is a distinctive form of iron-dependent necrotic cell death, characterized by excessive lipid peroxidation on cellular membranes and compromised antioxidant defenses. Multiple metabolic pathways, including iron metabolism, as well systems, contribute to the execution ferroptosis. The gut microbiota exerts regulatory effects ferroptosis through its microbial composition, biological functions, metabolites. Notably, most pathogenic bacteria tend promote ferroptosis, thereby inducing or exacerbating diseases, while probiotics have been shown protect against death. Given colonization in gut, an intimate association found between intestinal diseases microbiota. This review consolidates essential aspects ferroptotic processes, emphasizing key molecules delineating intricate interplay Moreover, this underscores potential utility modulation regulating for treatment diseases.

Language: Английский

Citations

24
Prenatal Exposure to Metals Is Associated with Placental Decelerated Epigenetic Gestational Age in a Sex-Dependent Manner in Infants Born Extremely Preterm DOI Creative Commons

Katelyn Huff,

Kyle R. Roell, Lauren A. Eaves

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(4), P. 306 - 306

Published: Feb. 18, 2025

Prenatal exposure to metals can influence fetal programming via DNA methylation and has been linked adverse birth outcomes long-term consequences. Epigenetic clocks estimate the biological age of a given tissue based on are potential health biomarkers. This study leveraged Extremely Low Gestational Age Newborn (ELGAN) (n = 265) evaluate associations between umbilical cord concentrations 11 as single exposures well mixtures in relation (1) placental epigenetic gestational acceleration (eGAA) (2) status Robust Placental Clock (RPC) CpGs. Linear mixed effect regression models were stratified by infant sex. Both copper (Cu) manganese (Mn) significantly associated with decelerated eGA -0.98 (95% confidence interval (CI): -1.89, -0.07) -0.90 weeks CI: -1.78, -0.01), respectively, male infants. Cu Mn levels also at RPC CpGs within genes related processes including energy homeostasis inflammatory response placenta. Overall, these findings suggest that prenatal impact eGAA sex-dependent manner ELGANs, future work could examine mechanism mediating utero metal later life

Language: Английский

Citations

1
Environmental and human health implications of metal(loid)s: Source identification, contamination, toxicity, and sustainable clean-up technologies DOI Creative Commons
Pankaj Kumar, Amel Gacem,

Mohammad Tauheed Ahmad

et al.

Frontiers in Environmental Science, Journal Year: 2022, Volume and Issue: 10

Published: Aug. 26, 2022

Environmental pollution is becoming more prevalent in both human life and the ecosystem. The increased use of fossil fuels, mining, burning wastes, as well industrial wastewater discharge, are polluting natural resources such water, soil, air. Metals (loid)s (Cu, Cr, Cd, Zn, Ni, Pb, Hg, Sb, Sn, As) contribute to several ecological problems when exposed humans environment resulting serious health environmental risks. aquatic terrestrial sites with these elements an issue public significance. present review highlights instigated by toxic metal (loid)s, their source, respective health/environmental concern along importance creating low-cost, environmentally acceptable clean-up technologies for treating household wastewater. Various physical, chemical, biological, and/or biochemical various combinations have been described from sustainable technological point view. Techniques ion exchange, membrane filtration, photocatalysis, bioremediation, phytoremediation, economical biosorbents, nanomaterials discussed detail recent case studies gain a significant inside towards solution focused action-oriented development. Thus, this article significantly provides deep insight into toxicity, source identification, influences on ecosystem conventional technologies.

Language: Английский

Citations

36
Association between magnesium, copper, and potassium intakes with risk of rheumatoid arthritis: a cross-sectional study from National Health and Nutrition Examination Survey (NHANES) DOI Creative Commons

Jianguo Fang,

Tingwei Cao,

Cai Liu

et al.

BMC Public Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: Oct. 24, 2023

The relationship between Mg (magnesium), Cu (copper), and K (potassium) intakes the risk of rheumatoid arthritis (RA) remains limited. aim present study was to examine associations Mg, with RA.Using data from National Health Nutrition Examination Survey (NHANES) 2003-2018, we examined association RA among US adults. After adjustment for age, sex, race, BMI, educational level, smoking history, alcohol consumption, family Poverty Income Ratio (PIR), diabetes total daily energy intake, logistic regression models smooth curve fitting were applied RA.A 18,338 participants included (1,008 RA). multivariate adjusted ORs (95% CI) [0.66 (0.51, 0.84)], [0.76 (0.60, 0.97)], [0.75 (0.58, 0.97)] in highest versus lowest quartile magnesium intakes, respectively. A nonlinear found. When intake (ln) 0.6-2.2 mg, reduced by 26% every 1 mg increase [0.74 0.96)].Higher may be inversely associated adults, an inverse L-shaped dietary

Language: Английский

Citations

13
Associations between multiple metal exposure and fertility in women: A nested case-control study DOI Creative Commons
Xiang Hong, Wei Wang, Lingling Huang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 272, P. 116030 - 116030

Published: Feb. 3, 2024

Metal pollution can cause a decline in female fertility, however, previous studies have focused more on the effect of single metal fertility. In this study, we evaluated mixtures fertility based nested case-control samples. The plasma levels 22 elements from 180 women were determined by an inductively coupled mass spectrometer (ICP-MS). Minimum absolute contraction and selection operator (LASSO) penalty regression selected metals with greatest influence clinical outcome. Logistic was used to analyze correlation between while Bayesian kernel function (BKMR) model mixed metals. Eight (Calcium (Ca), Chromium (Cr), Cobalt (Co), Copper (Cu), Zinc (Zn), Rubidium (Rb), Strontium (Sr) Zirconium (Zr)) LASSO for subsequent analysis. After adjusting covariates, logistic showed that Cu (Odds Ratio(OR):0.33, 95% CI: 0.13 − 0.84) Co (OR:0.38, 0.15 −0.94) caused significant reduction identified protective Zn (OR: 2.96, CI:1.21 −7.50) Trend tests increased Cr, Cu, Rb associated reduced BKMR Co, had nonlinear relationship when controlling concentrations other suggested Cr might exert Analysis negative Rb, positive Furthermore, found evidence interaction Cr. Our findings require further validation may identify new mechanisms future.

Language: Английский

Citations

5
Towards prolonging ovarian reproductive life: Insights into trace elements homeostasis DOI
Weicheng Tang, Xiaoran Zhu, Runsheng Chen

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 97, P. 102311 - 102311

Published: April 17, 2024

Language: Английский

Citations

5