Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 239, P. 113952 - 113952
Published: May 8, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: July 1, 2024
The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.
Language: Английский
Citations
94
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 5837 - 5858
Published: June 1, 2024
Purpose: Phototherapy, known for its high selectivity, few side effects, strong controllability, and synergistic enhancement of combined treatments, is widely used in treating diseases like cervical cancer. Methods: In this study, hollow mesoporous manganese dioxide was as a carrier to construct positively charged, poly(allylamine hydrochloride)–modified nanoparticles (NPs). The NP efficiently loaded with the photosensitizer indocyanine green (ICG) via addition hydrogen phosphate ions produce counterion aggregation effect. HeLa cell membrane encapsulation performed achieve final M-HMnO 2 @ICG NP. structure, HMnO responsively degrades release ICG tumor microenvironment, self-generates O sensitization ICG-mediated photodynamic therapy (PDT), consumes GSH expand oxidative stress therapeutic effect [chemodynamic (CDT) + PDT]. accumulated tissues exerts PDT/photothermal (PTT) through single laser irradiation, improving efficiency reducing effects. increases nanomedicine accumulation confers an immune evasion ability. addition, local temperatures induced by PTT can enhance CDT. These properties enable full achievement PTT/PDT/CDT targeted Results: Mn 2+ serve magnetic resonance imaging agent guide therapy, be photothermal fluorescence imaging. After intravenous injection, effectively at mouse sites; optimal timing in-vivo treatment could verified near-infrared fluorescence, resonance, NPs had best antitumor effects among groups under light conditions, showed good biocompatibility. Conclusion: we designed nano-biomimetic delivery system that improves hypoxia, responds loads ICG. It provides new economical convenient strategy phototherapy CDT Keywords: phototherapy, reactive oxygen species, hypoxia relief, collaborative
Language: Английский
Citations
90
Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11
Published: Feb. 16, 2023
When hydrogel materials with excellent biocompatibility and biodegradability are used as new drug carriers in the treatment of cancer, they confer following three advantages. First, can be a precise controlled release systems, which continuously sequentially chemotherapeutic drugs, radionuclides, immunosuppressants, hyperthermia agents, phototherapy agents other substances widely cancer through radiotherapy, chemotherapy, immunotherapy, hyperthermia, photodynamic therapy photothermal therapy. Second, have multiple sizes delivery routes, targeted to different locations types cancer. This greatly improves targeting thereby reducing dose drugs improving effectiveness. Finally, intelligently respond environmental changes according internal external stimuli so that anti-cancer active remotely released on demand. Combining abovementioned advantages, transformed into hit field treatment, bringing hope further increase survival rate quality life patients
Language: Английский
Citations
52
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(4), P. 1116 - 1116
Published: March 31, 2023
Multidrug-resistant (MDR) bacteria are rapidly emerging, coupled with the failure of current antibiotic therapy; thus, new alternatives for effectively treating infections caused by MDR required. Hyperthermia-mediated photothermal therapy (PTT) and reactive oxygen species (ROS)-mediated photodynamic (PDT) have attracted extensive attention as antibacterial therapies owing to advantages such low invasiveness, toxicity, likelihood causing bacterial resistance. However, both strategies notable drawbacks, including high temperature requirements PTT weak ability PDT-derived ROS penetrate target cells. To overcome these limitations, a combination PDT has been used against bacteria. In this review, we discuss unique benefits limitations The mechanisms underlying synergistic effects PTT–PDT also discussed. Furthermore, introduced advancements in methods using nano-based agents treat Finally, highlight existing challenges future perspectives We believe that review will encourage PTT- PDT-based research can be referenced clinical applications.
Language: Английский
Citations
45
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5632 - 5632
Published: May 22, 2024
Photothermal therapy (PTT) is a promising cancer modality with significant advantages such as precise targeting, convenient drug delivery, better efficacy, and minimal adverse effects. effectively absorbs the photothermal transducers in near-infrared region (NIR), which induces effect to work. Although PTT has role tumor therapy, it also suffers from low conversion efficiency, biosafety, incomplete elimination. Therefore, use of nanomaterials themselves photosensitizers, targeted modification improve targeting or combined other therapies can therapeutic effects reduce side Notably, noble metal have attracted much attention because they strong surface plasmon resonance an effective absorbance light at specific wavelengths. be used excellent photosensitizers mediate its efficiency. This paper provides comprehensive review key played by therapy. It describes major challenges encountered during implementation
Language: Английский
Citations
20
Deleted Journal, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Abstract Photodynamic therapy (PDT) has significant potential in the treatment of dermatological, oncological, and nonneoplastic conditions through induction cell death, immune regulation, antimicrobial effects, etc. However, response some patients is unsatisfactory, there a lack an ideal protocol for multiple specific diseases (subtypes) to choose proper photosensitizer (PS), light source, dose. A thorough understanding underlying mechanism integral solving these problems, death gained much attention. In addition apoptosis, autophagy, necrosis, several novel pathways, such as necroptosis, mitotic catastrophe, paraptosis pyroptosis, have been reported PDT treatment. The type induced depends on dose PDT, subcellular location PSs, regulation signaling pathways. addition, different types by same apoptosis may interact with each other. Some can also trigger immunogenic (ICD), which ignite against antigens derived from dying/dead cells present improved antitumor effects. On basis mechanisms, strategies, targeted combined immunotherapy ICD‐based vaccines, proposed improve therapeutic efficacy. Future studies are needed elucidate relationship between effects shed new exploration precise patients.
Language: Английский
Citations
2
Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 69 - 69
Published: Jan. 21, 2025
Photodynamic therapy is a non-ionizing radiation treatment that utilizes photosensitizer in combination with light to produce singlet oxygen. This oxygen induces anti-cancer effects by causing apoptotic, necrotic, or autophagic cell death tumor cells. Currently, photodynamic employed oncology treat various cancers. In the presence of oxygen, this non-invasive approach leads direct death, damage microvasculature, and induction local inflammatory response. These allow be effective treating early-stage tumors, extending survival cases where surgery not feasible, significantly improving quality life. paper, we provide state art on cytomolecular mechanisms associated pathways involved therapy. By integrating these mechanistic insights most recent advancements nanotechnology, phototherapeutic has potential become prevalent option within conventional cancer therapies, enhancing its application precision medicine.
Language: Английский
Citations
2
Drug Discovery Today, Journal Year: 2023, Volume and Issue: 29(1), P. 103851 - 103851
Published: Dec. 12, 2023
Breast cancer is the most common and malignant tumor among women. Chitosan (CS)-based nanoparticles have been introduced into breast therapy as a way to increase targeted delivery of drugs genes site. CS nanostructures suppress tumorigenesis by enhancing both cargo (drug gene) its accumulation in cells. The cells internalize CS-based through endocytosis. Moreover, chitosan nanocarriers can also induce phototherapy-mediated ablation. Smart multifunctional types nanoparticles, including pH-, light- redox-responsive be used improve potential for removal. In addition, acceleration immunotherapy has achieved, there develop CS-nanoparticle hydrogels that tumorigenesis.
Language: Английский
Citations
37
Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)
Published: May 6, 2023
Abstract Nanobiotechnology, as a novel and more specialized branch of science, has provided number nanostructures such nanoparticles, by utilizing the methods, techniques, protocols other branches science. Due to unique features physiobiological characteristics, these or nanocarriers have vast methods therapeutic against microbial infections cancers for tissue regeneration, engineering, immunotherapies, gene therapies, through drug delivery systems. However, reduced carrying capacity, abrupt non-targeted delivery, solubility agents, can affect applications biotechnological products. In this article, we explored discussed prominent nanobiotechnological products nanocarriers, highlighted challenges associated with products, attempted conclude if available offer any scope improvement enhancement. We aimed identify emphasize greater prospect capacity improvements enhancements. found that nanostructures, nanocomposites, micelles, hydrogels, microneedles, artificial cells, address inherited drawbacks, help conjugations, sustained stimuli-responsive release, ligand binding, targeted delivery. recommend nanobiotechnology, despite having few offers immense opportunities be harnessed in delivering quality therapeutics precision prediction. also that, exploring branched domains rigorously, bottlenecks obstacles addressed resolved return. Graphical
Language: Английский
Citations
35
Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 172, P. 67 - 91
Published: Oct. 6, 2023
Language: Английский
Citations
32