Quantitative proteomics of the miR-301a/SOCS3/STAT3 axis reveals underlying autism and anxiety-like behavior DOI Creative Commons
Xun Li,

Qi Fu,

Mingtian Zhong

et al.

Molecular Therapy — Nucleic Acids, Journal Year: 2024, Volume and Issue: 35(1), P. 102136 - 102136

Published: Feb. 2, 2024

Autism is a widespread neurodevelopmental disorder. Although the research on autism spectrum disorders has been increasing in past decade, there still no specific answer to its mechanism of action and treatment. As pro-inflammatory microRNA, miR-301a abnormally expressed various psychiatric diseases including autism. Here, we show that deletion inhibition exhibited two distinct abnormal behavioral phenotypes mice. We observed mice impaired learning/memory, enhanced anxiety. On contrary, effectively reduced maternal immune activation (MIA)-induced autism-like behaviors further demonstrated bound 3′UTR region SOCS3, led upregulation SOCS3 hippocampus. The last result reduction inflammatory response by inhibiting phosphorylation AKT STAT3, expression level IL-17A poly(I:C)-induced features obtained data revealed as critical participant partial behavior phenotypes, which may exhibit divergent role between gene knockout knockdown. Our findings ascertain negatively regulates MIA-induced could present new therapeutic target for ameliorating abnormalities

Language: Английский

From aberrant neurodevelopment to neurodegeneration: Insights into the hub gene associated with autism and alzheimer's disease DOI
Yu Fu,

Guangming Xie,

Rong-qi Liu

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1838, P. 148992 - 148992

Published: May 8, 2024

Language: Английский

Citations

2
Psychiatric Disease as a Potential Risk Factor for Dementia: A Narrative Review DOI Creative Commons
William O. Dawson,

Morgan Chase,

Thomas J. Farrer

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(7), P. 722 - 722

Published: July 18, 2024

Neurodegenerative disease is a major global health problem with 150 million people predicted to have dementia by 2050. Genetic factors, environmental demographics, and some diseases been associated dementia. In addition associations between such as hypertension cerebrovascular dementia, emerging findings associate psychiatric disorders incident Because of the high increasing prevalence worldwide disorders, primary objective this narrative review was evaluate published that association bipolar disorder, depression, anxiety, post-traumatic stress obsessive–compulsive attention-deficit/hyperactivity autism spectrum schizophrenia other psychosis syndromes, personality traits Here, we highlight indicating possible these subsequent suggest may be risk factors for Further research, including more large longitudinal studies additional meta-analyses, however, needed better characterize identify mechanisms putative associations, within predispose disorder but not others Additional important questions concern how treatment might affect

Language: Английский

Citations

2
Taurine inhibits KDM3a production and microglia activation in lipopolysaccharide-treated mice and BV-2 cells DOI
K. Liu,

Runying Zhu,

Hongwei� Jiang

et al.

Molecular and Cellular Neuroscience, Journal Year: 2022, Volume and Issue: 122, P. 103759 - 103759

Published: July 26, 2022

Language: Английский

Citations

11
Multi-layered transcriptomic analysis reveals a pivotal role of FMR1 and other developmental genes in Alzheimer's disease-associated brain ceRNA network DOI Creative Commons
Rafael Mina Piergiorge, Ronaldo da Silva Francisco, Ana Tereza Ribeiro de Vasconcelos

et al.

Computers in Biology and Medicine, Journal Year: 2023, Volume and Issue: 166, P. 107494 - 107494

Published: Sept. 21, 2023

Language: Английский

Citations

5
Neurodevelopmental disorders and microcephaly: how apoptosis, the cell cycle, tau and amyloid-β precursor protein APPly DOI Creative Commons
Deborah K. Sokol, Debomoy K. Lahiri

Frontiers in Molecular Neuroscience, Journal Year: 2023, Volume and Issue: 16

Published: Sept. 22, 2023

Recent studies promote new interest in the intersectionality between autism spectrum disorder (ASD) and Alzheimer’s Disease. We have reported high levels of Amyloid-β Precursor Protein (APP) secreted APP-alpha (sAPP a ) low amyloid-beta (Aβ) peptides 1–40 1–42 (Aβ40, Aβ42) plasma brain tissue from children with ASD. A higher incidence microcephaly (head circumference less than 3 rd percentile) associates ASD compared to head size individuals typical development. The role Aβ as contributors acquired is proposed. may lead via disruption neurogenesis, elongation G1/S cell cycle, arrested cycle promoting apoptosis. As APP gene exists on Chromosome 21, excess occur Trisomy 21-T21 (Down’s Syndrome). Microcephaly some forms associate T21, therefore potential mechanisms underlying these associations will be examined this review. peptides’ other neurodevelopmental disorders that feature are reviewed, including dup 15q11.2-q13, Angelman Rett syndrome.

Language: Английский

Citations

5
APOE ε4-Allele in Middle-Aged and Older Autistic Adults: Associations with Verbal Learning and Memory DOI Open Access
Samantha A. Harker,

Lamees Al-Hassan,

Matthew J. Huentelman

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15988 - 15988

Published: Nov. 5, 2023

Autism spectrum disorder (ASD) is a neurodevelopmental disability and recent evidence suggests that autistic adults are more likely to develop Alzheimer’s disease (Alz) other dementias compared neurotypical (NT) adults. The ε4-allele of the Apolipoprotein E (APOE) gene strongest genetic risk factor for Alz negatively impacts cognition in middle-aged older (MA+) This study aimed determine impact APOE on verbal learning memory MA+ (ages 40–71 years) matched NT Using Auditory Verbal Learning Test (AVLT), we found ε4 carriers performed worse short-term across diagnosis groups, but there was no interaction with diagnosis. In exploratory analyses within sex only men carrying showed (p = 0.02), who were not carriers. Finally, did significantly affect long-term this sample. These findings replicate previous work indicating presents new preliminary may be vulnerable effects learning. Future larger sample needed if women also vulnerable.

Language: Английский

Citations

5
Nuak kinase signaling in development and disease of the central nervous system DOI Creative Commons
Sarah A. Bennison, Xiaonan Liu, Kazuhito Toyo‐oka

et al.

Cellular Signalling, Journal Year: 2022, Volume and Issue: 100, P. 110472 - 110472

Published: Sept. 16, 2022

Language: Английский

Citations

8
Is autism a PIN1 deficiency syndrome? A proposed etiological role for glyphosate DOI Creative Commons
Stephanie Seneff, Anthony M. Kyriakopoulos, Greg Nigh

et al.

Journal of Neurochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: May 29, 2024

Autism is a neurodevelopmental disorder, the prevalence of which has increased dramatically in United States over past two decades. It characterized by stereotyped behaviors and impairments social interaction communication. In this paper, we present evidence that autism can be viewed as PIN1 deficiency syndrome. Peptidyl-prolyl cis/trans isomerase, NIMA-Interacting 1 (PIN1) peptidyl-prolyl it widespread influences biological organisms. Broadly speaking, linked to many neurodegenerative diseases, whereas over-expression cancer. Death-associated protein kinase (DAPK1) strongly inhibits PIN1, hormone melatonin DAPK1. Melatonin autism. recently been shown glyphosate exposure rats synthesis result glutamate release from glial cells expression metabotropic receptors. Glyphosate's inhibition leads reduction availability neurons. show explain unique morphological features autism, including dendritic spine density, missing or thin corpus callosum, reduced bone density. We how disrupts functioning powerful high-level signaling molecules, such nuclear factor erythroid 2-related 2 (NRF2) p53. Dysregulation both these proteins Severe depletion glutathione brain resulting chronic oxidative stressors extracellular oxidation cysteine residue inactivating further contributing deficiency. Impaired autophagy sensitivity neurons ferroptosis. imperative research conducted experimentally validate whether mechanisms described here take place response ultimately

Language: Английский

Citations

1
GPR56: A potential therapeutic target for neurological and psychiatric disorders DOI
Wang Qi, Wei Guan

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 226, P. 116395 - 116395

Published: June 26, 2024

Language: Английский

Citations

1
Preclinical Evidence for the Role of the Yin/Yang Angiotensin System Components in Autism Spectrum Disorder: A Therapeutic Target of Astaxanthin DOI Creative Commons

Ayat I. Samra,

Ahmed S. Kamel, Dalaal M. Abdallah

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(12), P. 3156 - 3156

Published: Nov. 27, 2023

Autism spectrum disorder (ASD) prevalence is emerging with an unclear etiology, hindering effective therapeutic interventions. Recent studies suggest potential renin-angiotensin system (RAS) alterations in different neurological pathologies. However, its implications ASD are unexplored. This research fulfills the critical gap by investigating dual arms of RAS and their interplay Notch signaling ASD, using a valproic acid (VPA) model assessing astaxanthin's (AST) modulatory impacts. Experimentally, male pups from pregnant rats receiving either saline or VPA on gestation day 12.5 were divided into control groups, subsequent AST treatment subset (postnatal days 34-58). Behavioral analyses, histopathological investigations, electron microscopy provided insights neurobehavioral structural changes induced AST. Molecular investigations pups' cortices revealed that outweighs protective elements inhibition detrimental arm. established neuroprotective anti-inflammatory axes (ACE2/Ang1-7/MasR) context. The results showed AST's normalization components underscore novel avenue impacting neuronal integrity behavioral outcomes. These findings affirm integral role highlight as promising intervention, inviting further implications.

Language: Английский

Citations

3