Food Chemistry X,
Journal Year:
2024,
Volume and Issue:
23, P. 101625 - 101625
Published: July 5, 2024
Cherry
kernels
are
a
by-product
of
cherries
that
usually
discarded,
leading
to
waste
and
pollution.
In
this
study,
the
chemical
composition
21
batches
cherry
from
two
different
species
was
analyzed
using
untargeted
metabolomics.
The
in
vitro
antioxidant
activity,
cellular
antiproliferative
activity
these
kernel
extracts
were
also
determined,
correlation
analysis
conducted
between
differential
compounds
biological
activity.
A
total
49
screened.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(2), P. 692 - 710
Published: Feb. 6, 2024
In
order
to
improve
bioavailability,
stability,
control
release,
and
target
delivery
of
active
pharmaceutical
ingredients
(APIs),
as
well
mask
their
bitter
taste,
increase
efficacy,
minimize
side
effects,
a
variety
microencapsulation
(including
nanoencapsulation,
particle
size
<100
nm)
technologies
have
been
widely
used
in
the
industry.
Commonly
are
emulsion,
coacervation,
extrusion,
spray
drying,
freeze-drying,
molecular
inclusion,
microbubbles
microsponge,
fluidized
bed
coating,
supercritical
fluid
encapsulation,
electro
spinning/spray,
polymerization.
this
review,
APIs
categorized
by
complexity:
small
(compounds
with
low
weight,
like
Aspirin,
Ibuprofen,
Cannabidiol),
medium
weight
insulin,
peptides,
nucleic
acids),
living
microorganisms
(such
probiotics,
bacteria,
bacteriophages).
This
article
provides
an
overview
these
including
processes,
matrix,
recent
applications
APIs.
Furthermore,
advantages
disadvantages
common
terms
improving
efficacy
for
treatments
comprehensively
analyzed.
The
objective
is
summarize
most
progresses
on
enhancing
delivery,
masking
taste
thus
increasing
minimizing
effects.
At
end,
future
perspectives
highlighted.
Acta Pharmaceutica Sinica B,
Journal Year:
2023,
Volume and Issue:
13(9), P. 3598 - 3637
Published: June 5, 2023
Coronavirus
disease
2019
(COVID-19),
caused
by
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
has
spread
worldwide.
Effective
treatments
against
COVID-19
remain
urgently
in
need
although
vaccination
significantly
reduces
the
incidence,
hospitalization,
and
mortality.
At
present,
antiviral
drugs
including
Nirmatrelvir/Ritonavir
(Paxlovid
Journal of Industrial Microbiology & Biotechnology,
Journal Year:
2023,
Volume and Issue:
50(1)
Published: Jan. 1, 2023
Abstract
Actinobacteria
are
a
large
and
diverse
group
of
bacteria
that
known
to
produce
wide
range
secondary
metabolites,
many
which
have
important
biological
activities,
including
antibiotics,
anti-cancer
agents,
immunosuppressants.
The
biosynthesis
these
compounds
is
often
highly
regulated
with
natural
products
(NPs)
being
produced
at
very
low
levels
in
laboratory
settings.
Environmental
factors,
such
as
small
molecule
elicitors,
can
induce
the
production
metabolites.
Specifically,
they
increase
titers
NPs
well
enabling
discovery
novel
typically
undetectable
levels.
These
elicitors
be
NPs,
antibiotics
or
hormones,
synthetic
compounds.
In
recent
years,
there
has
been
growing
interest
use
metabolites
from
actinobacteria,
especially
for
“silent”
biosynthetic
gene
clusters.
This
review
aims
highlight
classes
molecules
metabolite
actinobacteria
describe
potential
mechanisms
induction.
One-Sentence
Summary
describes
chemical
described
date
proposed
Discover Nano,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: April 4, 2024
Abstract
In
recent
years,
the
development
of
antitumor
drugs
has
been
dedicated
to
natural
products.
Amygdalin
is
a
herbal
cyanoglycoside
that
anticarcinogenic
effect
on
many
types
cancers
once
hydrogen
cyanide
(HCN)
released.
The
main
objective
present
study
synthesize
and
investigate
potential
carboxymethyl
chitosan
nanoparticles
(CMC
NPs)
as
drug
delivery
agents
for
amygdalin
encapsulation
its
cancer
normal
cell
lines.
this
study,
encapsulated
with
(CMC-Am
were
prepared
characterized
through
their
particle
size,
surface
charge,
chemical
structure
dielectric
properties.
Also,
invitro
release
from
CMC
NPs
was
studied.
Additionally,
cytotoxcity
CMC-loaded
evaluated
MTT
assay.
results
showed
exhibited
small
size
129
nm,
high
zeta
value
−
43
mV
confirmed
stability
compatibility
NPs.
Furthermore,
demonstrated
sustained
during
24
h.
Moreover,
compared
free
amygdalin,
amygdalin-loaded
have
significant
anti-cancerous
human
colon
HCT-116
breast
MCF-7
lines
while
being
safe
cells
BJ1.
conclusion,
can
be
employed
an
efficient
vehicle
controlled
enhanced
cytotoxicity
malignant
without
harming
cells.
Cell Biology International,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
ABSTRACT
Laetrile,
known
as
vitamin
B17,
is
often
used
interchangeably
with
amygdalin.
Laetrile
a
semi‐synthesis
product
of
amygdalin,
whereas
amygdalin
naturally
occurring
substance
in
many
plants.
Both
compounds
have
nitrile
functional
group
that,
when
activated
by
the
intestinal
enzyme
β‐glucosidases,
releases
hydrogen
cyanide.
The
two
been
considered
for
long
time
alternative
therapy
cancer
treatment
however,
findings
available
literature
are
discordant
on
real
efficacy
laetrile/amygdalin
cancer,
highlighting
negative
benefit‐risk
ratio.
In
this
regard,
study
aimed
to
comprehensively
analyze
scientific
data
laetrile/amygdalin,
special
emphasis
their
pharmacokinetics,
underlying
pharmacological
properties,
mode
action
potent
antitumor
agent,
and
effect
human
health.
results
showed
that
there
no
clear
evidence
following
administration,
especially
at
clinical
trial
level.
However,
vitro
studies
biological
activity
these
positive
effects
related
antifibrotic,
anti‐inflammatory,
antiasthmatic,
immunoregulatory
processes.
Laetrile's
mechanism
closely
resembles
affecting
signaling
pathways.
due
its
cyanide
toxicity,
it
was
banned
food
drug
administration
(FDA)
safety
concerns.
Despite
not
receiving
permission
from
FDA,
laetrile
emerged
an
1970s.
Nonetheless,
continuing
research
investigating
safer
methods
activating
targeted
treatment.
This
opens
interesting
prospects
using
medical
therapies,
which,
further
needed.
