Evaluation of a Novel Lateral Emitting Laser Fiber for Near-Infrared Photoimmunotherapy DOI Open Access
Motofumi Suzuki, Hisataka Kobayashi, Hirofumi Hanaoka

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(14), P. 2558 - 2558

Published: July 17, 2024

Near-infrared photoimmunotherapy (NIR-PIT) is a new cancer therapy that uses NIR light and conjugates of tumor-targeting monoclonal antibody phthalocyanine dye. In clinical practice, frontal cylindrical diffusers are the only options for illumination. However, illumination in narrow space technically difficult with such diffusers. Therefore, we evaluated lateral system using emitting laser (LEL) fiber. The LEL fiber illuminated certain area direction. NIR-PIT an reduced luciferase activity light-dose-dependent manner A431-GFP-luc cells vitro significantly suppressed tumor proliferation xenograft mouse model. To evaluate usefulness space, was from inside cylinder, mimicking fluorescence intensity monitored. diffuser, unevenly delivered little reached distal side. By contrast, allowed uniform entire tumor, loss observed even areas. These findings suggested can be used suitable space.

Language: Английский

Progression in Near-Infrared Fluorescence Imaging Technology for Lung Cancer Management DOI Creative Commons
Xinglong Chen, Yuning Li, Jialin Su

et al.

Biosensors, Journal Year: 2024, Volume and Issue: 14(10), P. 501 - 501

Published: Oct. 14, 2024

Lung cancer is a major threat to human health and leading cause of death. Accurate localization tumors in vivo crucial for subsequent treatment. In recent years, fluorescent imaging technology has become focal point tumor diagnosis treatment due its high sensitivity, strong selectivity, non-invasiveness, multifunctionality. Molecular probes-based not only enables real-time through fluorescence signals but also integrates therapeutic functions, drug screening, efficacy monitoring facilitate comprehensive Among them, near-infrared (NIR) particularly prominent improved effect. This trend toward multifunctionality significant aspect the future advancement technology. past great progress been made field NIR lung management, as well emergence new problems challenges. paper generally summarizes application these areas five including design, detection principles, clinical applications, with aim advancing more efficient technologies enhance accuracy

Language: Английский

Citations

2
Near-Infrared Photoimmunotherapy for Thoracic Cancers: A Translational Perspective DOI Creative Commons

Kohei Matsuoka,

Mizuki Yamada,

Mitsuo Sato

et al.

Biomedicines, Journal Year: 2022, Volume and Issue: 10(7), P. 1662 - 1662

Published: July 11, 2022

The conventional treatment of thoracic tumors includes surgery, anticancer drugs, radiation, and cancer immunotherapy. Light therapy for has long been used as an alternative; light also called photodynamic (PDT) mainly early-stage lung cancer. Recently, near-infrared photoimmunotherapy (NIR-PIT), which is a completely different concept from PDT, developed approved in Japan the recurrent previously treated head neck because its specificity effectiveness. NIR-PIT can apply to any target by changing antigens. In recent years, it become clear that various specific promising targets are highly expressed tumors. combination with these targets, expected be ideal therapeutic approach Additionally, techniques being further develop clinical practice. this review, introduced, potential applications cancers described.

Language: Английский

Citations

10
Contrast-enhanced ultrasound imaging for monitoring the efficacy of near-infrared photoimmunotherapy DOI Creative Commons

Kohei Matsuoka,

Mizuki Yamada,

Noriaki Fukatsu

et al.

EBioMedicine, Journal Year: 2023, Volume and Issue: 95, P. 104737 - 104737

Published: Aug. 7, 2023

Near-infrared photoimmunotherapy (NIR-PIT) is a promising cancer therapy combining NIR-light irradiation with an antibody and IR700DX, light-sensitive substance, to destroy tumours. However, homogeneous difficult because the light varies depending on distance tissue environment. Therefore, markers that indicate sufficient are necessary. Nanoparticles sized 10∼200 nm show enhanced permeation retention within tumours, which further via NIR-PIT (super permeability retention, SUPR). We aimed monitor effectiveness of by measuring SUPR.A xenograft mouse tumour model was established inoculating human cells in both buttocks Balb/C-nu/nu mice, performed only one side. To evaluate SUPR, fluorescent signal examination using QD800-fluorescent nanoparticles NIR-fluorescent poly (d,l-lactide-co-glycolic acid) (NIR-PLGA) microparticles. Harmonic signals were evaluated micro-bubbles contrast agent Sonazoid contrast-enhanced ultrasound (CEUS) imaging. The correlation between SUPR immediately after treatment day evaluated.QD800 persisted treated intensity remaining showed high positive therapeutic effect. NIR-PLGA Sonazoid-derived harmonic remained for longer time tumours than controls, kE value two-compartment correlated effectiveness.SUPR measurement CEUS imaging could be easily adapted clinical use as image-based biomarker monitoring confirming efficacy.This research supported ARIM JAPAN MEXT, Program Developing Next-generation Researchers (Japan Science Technology Agency), KAKEN (18K15923, 21K07217) (JSPS), CREST (JPMJCR19H2, JST), FOREST-Souhatsu (JST). Mochida Memorial Foundation Medical Pharmaceutical Research; Takeda Foundation; Japan Health Princess Takamatsu Cancer Research Fund. Funders provided financial support had no role study design, data collection, analysis, interpretation, writing report.

Language: Английский

Citations

5
Recent Advances in Localized Immunomodulation Technology: Application of NIR-PIT toward Clinical Control of the Local Immune System DOI Creative Commons

Mizuki Yamada,

Kohei Matsuoka,

Mitsuo Sato

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 561 - 561

Published: Feb. 7, 2023

Current immunotherapies aim to modulate the balance among different immune cell populations, thereby controlling reactions. However, they often cause overactivation or over-suppression, which makes them difficult control. Thus, it would be ideal manipulate cells at a local site without disturbing homeostasis elsewhere in body. Recent technological developments have enabled selective targeting of and tissues Photo-targeted specific therapy has recently emerged these. Near-infrared photoimmunotherapy (NIR-PIT) surfaced as new modality for cancer treatment, combines antibodies photoabsorber, IR700DX. NIR-PIT is testing an international phase III clinical trial locoregional recurrent head neck squamous carcinoma (HNSCC) patients (LUZERA-301, NCT03769506), with fast-track designation by United States Food Drug Administration (US-FDA). In Japan, was conditionally approved 2020. Although commonly used therapy, could also exploited locally eliminate certain marker. This strategy can utilized anti-allergic therapy. Herein, we discuss recent advances immunomodulation technology. We introduce technology demonstrate example knockdown regulatory T (Tregs) enhance anti-tumor

Language: Английский

Citations

3
Evaluation of a Novel Lateral Emitting Laser Fiber for Near-Infrared Photoimmunotherapy DOI Open Access
Motofumi Suzuki, Hisataka Kobayashi, Hirofumi Hanaoka

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(14), P. 2558 - 2558

Published: July 17, 2024

Near-infrared photoimmunotherapy (NIR-PIT) is a new cancer therapy that uses NIR light and conjugates of tumor-targeting monoclonal antibody phthalocyanine dye. In clinical practice, frontal cylindrical diffusers are the only options for illumination. However, illumination in narrow space technically difficult with such diffusers. Therefore, we evaluated lateral system using emitting laser (LEL) fiber. The LEL fiber illuminated certain area direction. NIR-PIT an reduced luciferase activity light-dose-dependent manner A431-GFP-luc cells vitro significantly suppressed tumor proliferation xenograft mouse model. To evaluate usefulness space, was from inside cylinder, mimicking fluorescence intensity monitored. diffuser, unevenly delivered little reached distal side. By contrast, allowed uniform entire tumor, loss observed even areas. These findings suggested can be used suitable space.

Language: Английский

Citations

0