Modular Synthesis and Cytotoxicity Evaluation of Dragocins A—C and Their Analogues: Discovery of a Potential Anticancer Agent DOI Open Access
Ziqiang Wang, Jianjun Wang, Peng Wang

et al.

Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Comprehensive Summary Dragocins A—C are structurally unique marine natural products featuring an uncommon tri‐oxa‐tricyclic[6.2.1]undecane moiety. However, their extremely low abundance has hindered extensive screening of bioactivities. We hereby describe efficient and modular approach to synthesizing dragocins analogues using commercially available inexpensive anisomycin D‐ribosyl thioglycoside derivative as the starting materials. A key feature our synthesis is construction skeleton. This challenging architecture achieved by stereocontrolled formation β‐ribofuranosidic bond DDQ (2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone)‐promoted intramolecular cross‐dehydrogenative etherification at benzylic position. Our also characterized successful installation a chlorine atom methoxy group tertiary C‐4' position via late‐stage silver‐catalyzed decarboxylative chlorination reaction electrophilic enol intermediate. Cytotoxicity evaluations synthesized compounds revealed demethyl dragocin A, N ‐demethylated potential anticancer candidate due its strong cytotoxicity against A549 lung, HCT116 colorectal MCF7 breast cancer cell lines. work demonstrated preliminary structure‐activity relationship this compound, setting solid foundation for developing novel candidates.

Language: Английский

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies DOI Creative Commons

Neelakanta Sarvashiva Kiran,

Chandrashekar Yashaswini,

Rahul Maheshwari

et al.

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(4), P. 967 - 990

Published: March 19, 2024

Precision medicine is transforming colorectal cancer treatment through the integration of advanced technologies and biomarkers, enhancing personalized effective disease management. Identification key driver mutations molecular profiling have deepened our comprehension genetic alterations in cancer, facilitating targeted therapy immunotherapy selection. Biomarkers such as microsatellite instability (MSI) DNA mismatch repair deficiency (dMMR) guide decisions, opening avenues for immunotherapy. Emerging liquid biopsies, artificial intelligence, machine learning promise to revolutionize early detection, monitoring, selection precision medicine. Despite these advancements, ethical regulatory challenges, including equitable access data privacy, emphasize importance responsible implementation. The dynamic nature with its tumor heterogeneity clonal evolution, underscores necessity adaptive strategies. future lies potential enhance patient care, clinical outcomes, understanding this intricate disease, marked by ongoing evolution field. current reviews focus on providing in-depth knowledge various diverse approaches utilized against at both biochemical levels.

Language: Английский

Citations

15
Green Extraction of Plant Materials Using Supercritical CO2: Insights into Methods, Analysis, and Bioactivity DOI Creative Commons
Metin Yıldırım, Mehmet Erşatır, Samet Poyraz

et al.

Plants, Journal Year: 2024, Volume and Issue: 13(16), P. 2295 - 2295

Published: Aug. 18, 2024

In recent years, the supercritical CO

Language: Английский

Citations

10
Potential of MMP-2 and MMP-9 Gelatinase Blockade as a Therapeutic Strategy in Fibrosarcoma Treatment: A Decadal Review DOI Open Access
Alireza Shoari

Targets, Journal Year: 2024, Volume and Issue: 2(2), P. 104 - 125

Published: June 5, 2024

Fibrosarcoma represents a significant challenge in oncology, characterized by high invasiveness and poor prognosis. Gelatinases, particularly matrix metalloproteinases MMP-2 MMP-9, play pivotal role the degradation of extracellular matrix, facilitating tumor invasion metastasis. Inhibiting these enzymes has emerged as promising therapeutic strategy. This review evaluates progress development potential gelatinase inhibitors treatments for fibrosarcoma over last decade, highlighting molecular mechanisms future directions. A comprehensive literature was conducted, focusing on studies published from 2013 to 2023. Research articles papers relevant inhibition were examined assess efficacy inhibitors. Gelatinase have shown reduce progression, invasion, metastasis fibrosarcoma. Clinical trials, although limited, indicated that can be effectively integrated into existing regimens, offering reduction metastatic spread potentially improving patient survival rates. Mechanistic suggest MMP-9 disrupts critical pathways involved growth cell invasion. viable approach treatment. Future research should focus developing more specific inhibitors, understanding long-term outcomes, integrating multimodal treatment strategies enhance efficacy.

Language: Английский

Citations

9
Phytochemicals in Drug Discovery—A Confluence of Tradition and Innovation DOI Open Access

Patience Chihomvu,

A. Ganesan, Simon Gibbons

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8792 - 8792

Published: Aug. 13, 2024

Phytochemicals have a long and successful history in drug discovery. With recent advancements analytical techniques methodologies, discovering bioactive leads from natural compounds has become easier. Computational like molecular docking, QSAR modelling machine learning, network pharmacology are among the most promising new tools that allow researchers to make predictions concerning products’ potential targets, thereby guiding experimental validation efforts. Additionally, approaches LC-MS or LC-NMR speed up compound identification by streamlining processes. Integrating structural computational biology aids lead identification, thus providing invaluable information understand how phytochemicals interact with targets body. An emerging approach is learning involving deep neural networks interrelate phytochemical properties diverse physiological activities such as antimicrobial anticancer effects.

Language: Английский

Citations

9
Phytochemical-mediated modulation of signaling pathways: A promising avenue for drug discovery DOI Creative Commons

Jibon Kumar Paul,

Mahir Azmal,

ANM Shah Newaz Been Haque

et al.

Advances in Redox Research, Journal Year: 2024, Volume and Issue: 13, P. 100113 - 100113

Published: Aug. 31, 2024

Language: Английский

Citations

9
Camptothecin and its derivatives: Advancements, mechanisms and clinical potential in cancer therapy DOI
Madhu Kamle, Shikha Pandhi, Sadhna Mishra

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(11)

Published: Oct. 9, 2024

Language: Английский

Citations

9
Hydrogels with Essential Oils: Recent Advances in Designs and Applications DOI Creative Commons
Mariana Chelu

Gels, Journal Year: 2024, Volume and Issue: 10(10), P. 636 - 636

Published: Sept. 30, 2024

The innovative fusion of essential oils with hydrogel engineering offers an optimistic perspective for the design and development next-generation materials incorporating natural bioactive compounds. This review provides a comprehensive overview latest advances in use hydrogels containing biomedical, dental, cosmetic, food, food packaging, restoration cultural heritage applications. Polymeric sources, methods obtaining, cross-linking techniques, functional properties are discussed. unique characteristics polymer agents highlighted. These include biocompatibility, nontoxicity, effective antibacterial activity, control sustained prolonged release active substances, optimal porosity, outstanding cytocompatibility. Additionally, specific distinctive explored, along their extraction encapsulation methods. advantages disadvantages these also We have considered limitations due to volatility, solubility, environmental factors, stability. importance loading hydrogels, stability, biological activity is analyzed. highlights through in-depth analysis, recent innovations, challenges, future prospects encapsulated potential multiple applications including biomedicine, dentistry, cosmetics, conservation.

Language: Английский

Citations

8
Herbal based nanoparticles as a possible and potential treatment of cancer: a review DOI Creative Commons
Roshan Yadav, Himmat Singh Chawra, Gaurav Dubey

et al.

Exploration of Targeted Anti-tumor Therapy, Journal Year: 2025, Volume and Issue: 6

Published: Jan. 3, 2025

Cancer is the greatest cause of mortality worldwide. Various drug classes treat various cancers. Nanoformulations made from natural sources are being studied for treating several diseases, including cancer. Surgery, chemotherapy, immunotherapy, and radiation have mostly failed to These drugs may damage quickly dividing healthy tissues, structural anomalies, bodily toxicity, long-term side effects, tumor cell resistance, psychiatric disturbances. Researchers developing nanoscale medicines using medications like Malva sylvestris Curcumin lower concentrations improve target specificity. Nanoparticles' small size unique properties make them beneficial. They encapsulate medicinal ingredients, improving solubility, medication release, cellular absorption, delivery. Nanoparticles better identify bind cancer cells when functionalized with ligands. Natural chemicals nanotechnology availability, distribution, targeting cells, making treatments more effective safe. Nanomedicine, which employs nanoparticles malignant has grown rapidly because nanodrugs fewer effects than current commercial drugs. Nanotechnology-based pharmaceutical delivery methods therapy covered in this review article. The paper discusses nanoparticle pros cons chemicals' cancer-fighting appeal.

Language: Английский

Citations

1
Development of a versatile biomaterial of chitosan polymer/ginger (Zingiber officinale Roscoe) extract/ZnO bionanocomposite: physicochemical properties, antioxidant activity, and breast cancer therapy DOI

Muthanna O. Hussein,

Ahmed Saud Abdulhameed

Research on Chemical Intermediates, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Language: Английский

Citations

1
Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 422 - 422

Published: Feb. 10, 2025

The intricate relationship between anticancer drugs and the gut microbiome influences cancer treatment outcomes. This review paper focuses on role of integrity in enhancing efficacy safety drug therapy, emphasizing pharmacokinetic interactions microbiota. It explores how disruptions to composition, or dysbiosis, can alter metabolism, immune responses, side effects. By examining mechanisms disruption caused by drugs, this highlights specific case studies like cyclophosphamide, 5-fluorouracil, irinotecan, their impact microbial diversity clinical also discusses microbiome-targeted strategies, including prebiotics, probiotics, postbiotics, fecal microbiota transplantation (FMT), as promising interventions enhance treatment. Furthermore, potential profiling personalizing therapy integrating these into practice is explored. Finally, proposes future research directions, developing novel biomarkers a deeper comprehension drug-microbiome interactions, respond current gaps knowledge improve patient outcomes care.

Language: Английский

Citations

1