Castrati singers as a musical and sociocultural phenomenon. Exhumation of Farinelli DOI

Vasilisa Alekseevna Zharkova

Uchenyy Sovet (Academic Council), Journal Year: 2024, Volume and Issue: 11, P. 671 - 685

Published: Oct. 31, 2024

The article is devoted to a rare topic – the art of castrati singers, vibrant musical and social phenomenon. This issue remained in shadows for long time. However, if we judge skill singers by what their contemporaries described, today's most excellent vocal performers only barely come close castrati’s extraordinary capabilities. It natural that best true stars stage, were called Great then. And must have maximum information about everything connected with them. But why Farinelli? Notably, there are people who specialize Farinelli studies, quite lot them; they form whole movement musicology. Certainly, those study Caff arelli, Tenducci, Vellutti… all this remains within framework disparate experience, which does not allow us talk arellists, Tenduccists, Veluttists. examines page related history Farinelli, namely, story his exhumation. approach analysis both sociocultural phenomena. Meanwhile, such turn can be vivid illustration bell canto, materials striking addition courses “History Vocal Art” Foreign Music”.

Language: Английский

Impact of Multimorbidity on Symptom Burden and Symptom Clusters in Patients Receiving Chemotherapy DOI Creative Commons
Carolyn Harris, Marilyn J. Hammer, Yvette P. Conley

et al.

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(3)

Published: Feb. 1, 2025

ABSTRACT Background Detailed information on patient characteristics and symptom burden associated with multimorbidity in oncology patients is extremely limited. Purposes were to determine the prevalence of low (≤ 2) high (≥ 3) a sample outpatients ( n = 1343) undergoing chemotherapy evaluate for differences between two groups demographic clinical characteristics; occurrence, severity, distress 38 symptoms; stability consistency clusters. Methods Using Self‐Administered Comorbidity Questionnaire, classified into groups. Memorial Symptom Assessment Scale was used assess symptoms prior patients' second or third cycle chemotherapy. For each group, clusters based occurrence rates identified using exploratory factor analysis. Results Compared group (61.4%), (38.6%) older, had fewer years education, less likely be married partnered, employed, lower annual income. In addition, they higher body mass index, poorer functional status, longer time since their cancer diagnosis, more have received previous treatments metastatic disease. Patients reported 12.7 (±6.7) 15.9 (±7.5) concurrent symptoms, respectively. Eight seven groups, Psychological, gastrointestinal, weight gain, hormonal, respiratory stable across Weight gain consistent. Three unstable group. Conclusions Findings suggest that various social determinants health burden. Differences may related aging, treatments, and/or comorbid conditions.

Language: Английский

Citations

1
Paracetamol Combination Therapy for Back Pain and Osteoarthritis: A Systematic Review and Meta-Analyses DOI Creative Commons
Zhiying Cao, Kaiyue Han,

Hanting Lu

et al.

Drugs, Journal Year: 2024, Volume and Issue: 84(8), P. 953 - 967

Published: June 28, 2024

Although paracetamol (acetaminophen) combined with other analgesics can reduce pain intensity in some conditions, its effectiveness managing low back and osteoarthritis is unclear. This systematic review investigated whether combination therapy more effective safer than monotherapy or placebo osteoarthritis.

Language: Английский

Citations

4
Jianpi Qingre Tongluo prescription alleviates the senescence-associated secretory phenotype with osteoarthritis by regulating STAG1/TP53/P21 signaling pathway DOI
Qiao Zhou, Jian Liu,

Yajun Qi

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 118953 - 118953

Published: Oct. 1, 2024

Language: Английский

Citations

4
Recent advances in the management of knee osteoarthritis: a narrative review DOI Creative Commons
Viktor Shtroblia, Pavlo Petakh, Iryna Kamyshna

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 21, 2025

Knee osteoarthritis (OA) is a common condition that causes pain and reduces the quality of life for many people. It also leads to high health financial costs. Managing knee OA requires using different methods together best results. This review overviews current therapeutic options pain, focusing on their efficacy, safety, potential roles in clinical practice. Topical treatments, such as NSAIDs capsaicin, offer significant relief with minimal systemic side effects are suitable initial therapy, nonpharmacologic interventions like exercise and, when relevant, weight loss. Oral analgesics, including acetaminophen opioids, have limited efficacy serious effects, making them appropriate only short-term or rescue therapy. Intra-articular injections, corticosteroids, hyaluronic acid, platelet rich plasma, demonstrate varying levels safety. Nutritional supplements, curcumin, Boswellia serrata , glucosaminechondroitin combinations, modest benefits used adjuncts standart treatment. Nonpharmacological transcutaneous electrical nerve stimulation (TENS), acupuncture, local heat provide variable should be customized based individual patient responses. Targeted biologic agents, antibodies TNF-α, IL-1, NGF, hold promise more precise relief; however, further research required establish routine use. Treating personalized, combining several methods. Research must continue improve treatments make safer.

Language: Английский

Citations

0
Immune cells differentiation in osteoarthritic cartilage damage: friends or foes? DOI Creative Commons
Min Liu, Chaoqun Wu,

Chaofan Wu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 25, 2025

Osteoarthritis (OA) is a chronic disease primarily characterized by degenerative changes in articular cartilage and synovitis, for which there are currently no targeted or curative therapies available clinical practice. In recent years, the in-depth analysis of OA using single-cell sequencing immunomics technologies has revealed presence multiple immune cell subsets, as well different differentiation states within same subset, OA. Through immune-immune immune-joint tissue interactions, these cells collectively promote inhibit progression arthritis. This complex network, where “friends foes coexist,” made therapeutic strategies aimed at directly eliminating challenging, highlighting urgent need detailed review composition, distribution, functional heterogeneity, potential, potential risks subsets joint. Additionally, similarities differences between rheumatoid arthritis (RA) terms diagnosis immunotherapy to be precisely understood, order draw lessons from reject RA-based immunotherapies. To this end, summarizes major triggers inflammation OA, characteristics key compares RA treatment. It also outlines current immunomodulatory their limitations. Furthermore, we provide focused discussion on that act foes” arthritis, covering M1/M2 polarization macrophages, heterogeneity neutrophils, unique roles dendritic maturation states, balance pro-inflammatory T regulatory (Tregs), diverse functions B cells, plasma (Bregs) By interpreting clarifies dynamic interactions joints, providing theoretical foundation more precise interventions future

Language: Английский

Citations

0
Suppression of CGRP and TRPV1 Expression in Dorsal Root Ganglia of Knee Osteoarthritis Rats by Huojing Decoction via TrkA/MKK3/6/p38 Pathway DOI Creative Commons
Xinchao Jiang,

Yinyin Guo,

Mei Fang

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 5311 - 5326

Published: Aug. 1, 2024

Knee osteoarthritis (KOA) is a chronic condition characterized by persistent pain that can lead to severe disability. In this study, we primarily investigated the analgesic effect of Huojing decoction on MIA-induced knee arthritis.

Language: Английский

Citations

0
Innate Immunity and Synovitis: Key Players in Osteoarthritis Progression DOI Open Access
Veronica Panichi, Silvia Costantini,

Mirko Grasso

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12082 - 12082

Published: Nov. 11, 2024

Osteoarthritis (OA) is a chronic progressive disease of the joint. Although representing most frequent cause disability in elderly, OA remains partly obscure its pathogenic mechanisms and still orphan resolutive therapies. The concept what was once considered "wear tear" articular cartilage now that an inflammation-related affects over time whole attention increasingly focused on synovium. Even from earliest clinical stages, synovial inflammation (or synovitis) crucial factor involved progression major player pain onset. release inflammatory molecules synovium mediates worsening features. activation tissue-resident cells recalls innate immunity bloodstream, creating proinflammatory milieu fuels maintains damaging condition low-grade In such context, cellular molecular behaviors could be

Language: Английский

Citations

0
Investigation of GPM6B as a novel therapeutic target in Osteoarthritis DOI Creative Commons

Chongyang Feng,

Lin Liu, Jinxue Zhang

et al.

Arthritis Research & Therapy, Journal Year: 2024, Volume and Issue: 26(1)

Published: Nov. 12, 2024

Osteoarthritis (OA) is the most common motor system disease in older people, characterized by a high incidence and significant social economic burden. Women have higher risk of OA, more severe clinical symptoms, rate disabilities than men. However, pathogenesis OA remains unclear. Therefore, we screened for differentially expressed genes (DEGs) patients different sex searched new targets that may be involved regulating development OA.

Language: Английский

Citations

0
Castrati singers as a musical and sociocultural phenomenon. Exhumation of Farinelli DOI

Vasilisa Alekseevna Zharkova

Uchenyy Sovet (Academic Council), Journal Year: 2024, Volume and Issue: 11, P. 671 - 685

Published: Oct. 31, 2024

The article is devoted to a rare topic – the art of castrati singers, vibrant musical and social phenomenon. This issue remained in shadows for long time. However, if we judge skill singers by what their contemporaries described, today's most excellent vocal performers only barely come close castrati’s extraordinary capabilities. It natural that best true stars stage, were called Great then. And must have maximum information about everything connected with them. But why Farinelli? Notably, there are people who specialize Farinelli studies, quite lot them; they form whole movement musicology. Certainly, those study Caff arelli, Tenducci, Vellutti… all this remains within framework disparate experience, which does not allow us talk arellists, Tenduccists, Veluttists. examines page related history Farinelli, namely, story his exhumation. approach analysis both sociocultural phenomena. Meanwhile, such turn can be vivid illustration bell canto, materials striking addition courses “History Vocal Art” Foreign Music”.

Language: Английский

Citations

0