Биологические мембраны Журнал мембранной и клеточной биологии, Journal Year: 2023, Volume and Issue: 40(6), P. 415 - 431
Published: Nov. 1, 2023
Language: Английский
In Silico Pharmacology, Journal Year: 2025, Volume and Issue: 13(1)
Published: Jan. 21, 2025
Language: Английский
Citations
2
Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(11), P. 9110 - 9124
Published: April 8, 2024
Language: Английский
Citations
9
Neuroscience Letters, Journal Year: 2022, Volume and Issue: 791, P. 136907 - 136907
Published: Oct. 7, 2022
Language: Английский
Citations
29
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(2), P. 216 - 216
Published: Jan. 31, 2023
Neurodegenerative disorders (NDDs) are major health issues in Western countries. Despite significant efforts, no effective therapeutics for NDDs exist. Several drugs that target epigenetic mechanisms (epidrugs) have been recently developed the treatment of NDDs, and several these currently being tested clinical trials. Furthermore, various bioproducts shown important biological effects potential prevention disorders. Here, we review use natural products as epidrugs to treat order explore benefits functional foods on neurodegeneration.
Language: Английский
Citations
15
Cells, Journal Year: 2023, Volume and Issue: 12(2), P. 245 - 245
Published: Jan. 6, 2023
Among candidate neurodegenerative/neuropsychiatric risk-predictive biomarkers, platelet count, mean volume and distribution width have been associated with the risk of major depressive disorder (MDD), Alzheimer’s disease (AD) Parkinson’s (PD) through epidemiological genomic studies, suggesting partial co-heritability. We exploited these relationships for a multi-trait association analysis, using publicly available summary statistics genome-wide studies (GWASs) all traits reported above. Gene-based enrichment tests were carried out, as well network analysis significantly enriched genes. analyzed 4,540,326 single nucleotide polymorphisms shared among GWASs, observing 149 significant LD-independent associations (p < 5 × 10−8) AD, 70 PD 139 MDD. these, 27 novel detected 34 40 Out 18,781 genes annotated variants within ±10 kb, 62 125 MDD 2.7 10−6). Of seven susceptibility loci AD (EPPK1, TTLL1, PACSIN2, TPM4, PIF1, ZNF689, AZGP1P1), two (SLC26A1, EFNA3) (HSPH1, TRMT61A). The resulting showed excess interactions (enrichment p = 1.0 10−16). that identified are involved in organization cytoskeletal architecture TPM4), telomere shortening (PIF1), regulation cellular aging (ZNF689, AZGP1P1) neurodevelopment (EFNA3), thus, providing insights into underlying biology brain disorders parameters.
Language: Английский
Citations
14
Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown
Published: April 4, 2024
Language: Английский
Citations
6
Brain Sciences, Journal Year: 2024, Volume and Issue: 14(6), P. 553 - 553
Published: May 29, 2024
Parkinson’s disease (PD), multiple sclerosis (MS), and amyotrophic lateral (ALS) are examples of neurodegenerative movement disorders (NMDs), which defined by a gradual loss motor function that is frequently accompanied cognitive decline. Although genetic abnormalities have long been acknowledged as significant factors, new research indicates epigenetic alterations crucial for the initiation development disease. This review delves into complex interactions exist between pathophysiology NMDs mechanisms such DNA methylation, histone modifications, non-coding RNAs. Here, we examine how these changes could affect protein aggregation, neuroinflammation, gene expression patterns, thereby influencing viability functionality neurons. Through clarification terrain underpinning disorders, this seeks to enhance comprehension underlying illness augment creation innovative therapeutic strategies.
Language: Английский
Citations
4
BMC Genomics, Journal Year: 2025, Volume and Issue: 26(1)
Published: March 5, 2025
With the rapid development of high-throughput sequencing technology, data has grown on a massive scale, leading to emergence multiple public databases, such as EBI and GEO. Conducting secondary mining in these databases can yield more valuable insights. Meta-analysis quantitatively combine from same topic. It increases sample size for analysis, enhances statistical power, results consistent reliable conclusions. This study proposes new between-study variance estimator Em . We prove that is non-negative Emτ^m2 with increase τ^m2 , satisfying general conditions estimator. get DSLE2 (two-step estimation starting DSL estimate second step) random-effects meta-analysis model based Em. The accuracy series evaluation metrics are better than those other 6 models. applied lung cancer Parkinson's methylation data. Significantly differentially methylated sites identified by genes significantly closely related two diseases, indicating effectiveness model. paper propose performs well
Language: Английский
Citations
0
npj Parkinson s Disease, Journal Year: 2025, Volume and Issue: 11(1)
Published: March 19, 2025
Abstract Epidemiological studies reveal that inflammatory bowel disease (IBD) is associated with an increased risk of Parkinson’s (PD). Gut dysbiosis has been documented in both PD and IBD, however it currently unknown whether gut underlies the epidemiological association between diseases. To identify shared distinct features IBD microbiome, we recruited 54 PD, 26 16 healthy control individuals performed first joint analysis metagenomes. Larger, publicly available metagenomic datasets were also analyzed to validate extend our findings. Depletions short-chain fatty acid (SCFA)-producing bacteria, including Roseburia intestinalis, Faecalibacterium prausnitzii, Anaerostipes hadrus , Eubacterium rectale as well depletion SCFA-synthesis pathways detected across datasets, suggesting these microbes may influence for development.
Language: Английский
Citations
0
ACS Chemical Neuroscience, Journal Year: 2025, Volume and Issue: unknown
Published: April 3, 2025
Parkinson's disease (PD) poses a global menace, as the available treatment methods solely aim to mitigate symptoms. An effective strategy address pathogenesis of PD involves eliminating accumulation aggregated alpha-synuclein, emphasizing role epigenetics. Aberrant epigenetic changes significantly influence gene expression, which is pivotal in progression, impacting neuronal growth and degeneration. Epigenetic-related genes are regulated by histone modification DNA methylation processes. Nevertheless, their significance has not been confirmed. This research was carried out using both vitro vivo approaches. In investigations, N2A cell lines were utilized, neuroprotective effect decitabine (DB) observed at concentrations 0.1 μM 0.5 μM. study, induction led significant motor deficits, notably ameliorated highest dose. improvement accompanied marked attenuation inflammatory mediators, including TNF-α, IL-6, IL-1β, CRP levels. Additionally, there enhancement antioxidative defense, evidenced increased GSH (glutathione) levels reduced oxidative stress marker NO (nitric oxide). Neurochemical analysis revealed substantial rise dopamine levels, critical marker, alongside an elevation BDNF, indicating effects. Furthermore, expression indicated notable upregulation mRNA proteins linked pathology. Histological assessments, IHC, H&E, CV staining substantia nigra, showed enhanced structural integrity following treatment. Collectively, these insights reveal DB's promise therapeutic solution for mitigating symptoms pathology exacerbated 6-OHDA.
Language: Английский
Citations
0