Role of ketogenic diet in neurodegenerative diseases focusing on Alzheimer diseases: The guardian angle

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 95, P. 102233 - 102233

Published: Feb. 14, 2024

Language: Английский

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BDNF/TrkB activators in Parkinson's disease: A new therapeutic strategy

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(10)

Published: May 1, 2024

Parkinson's disease (PD) is a neurodegenerative disorder of the brain and manifested by motor non-motor symptoms because degenerative changes in dopaminergic neurons substantia nigra. PD neuropathology associated with mitochondrial dysfunction, oxidative damage apoptosis. Thus, modulation apoptosis growth factors could be novel boulevard management PD. Brain-derived neurotrophic factor (BDNF) its receptor tropomyosin kinase type B (TrkB) are chiefly involved neuropathology. BDNF promotes survival nigra enhances functional activity striatal neurons. Deficiency TrkB triggers degeneration accumulation α-Syn As well, BDNF/TrkB signalling reduced early phase Targeting specific activators may attenuate this review aimed to discuss potential role against In conclusion, decreased linked severity long-term complications. Activation

Language: Английский

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A Potential Link Between Visceral Obesity and Risk of Alzheimer’s Disease

Neurochemical Research, Journal Year: 2022, Volume and Issue: 48(3), P. 745 - 766

Published: Nov. 21, 2022

Language: Английский

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Long-term use of metformin and Alzheimer’s disease: beneficial or detrimental effects

Inflammopharmacology, Journal Year: 2023, Volume and Issue: 31(3), P. 1107 - 1115

Published: Feb. 28, 2023

Language: Английский

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The beneficial role of autophagy in multiple sclerosis: Yes or No?

Autophagy, Journal Year: 2023, Volume and Issue: 20(2), P. 259 - 274

Published: Sept. 15, 2023

Multiple sclerosis (MS) is a chronic progressive demyelinating disease of the central nervous system (CNS) due to an increase abnormal peripherally auto-reactive T lymphocytes which elicit autoimmunity. The main pathophysiology MS myelin sheath damage by immune cells and defect in generation oligodendrocytes. Macroautophagy/autophagy critical degradation process that eliminates dysfunctional or superfluous cellular components. Autophagy has property double-edged sword it may have both beneficial detrimental effects on neuropathology. Therefore, this review illustrates protective harmful autophagy with regard disease. prevents progression reducing oxidative stress inflammatory disorders. In contrast, over-activated associated neuropathology case use inhibitors alleviate pathogenesis MS. Furthermore, provokes activation different supporting play intricate role functions modulation regulating cell proliferation related demyelination remyelination. enhances remyelination increasing activity oligodendrocytes, astrocytes. However, induces activating microglia cells. conclusion, specific autophagic activators astrocytes, dendritic (DCs), induce against

Language: Английский

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Pros and cons for statins use and risk of Parkinson's disease: An updated perspective

Pharmacology Research & Perspectives, Journal Year: 2023, Volume and Issue: 11(2)

Published: Feb. 22, 2023

Parkinson's disease (PD) is the second most frequent neurodegenerative brain (NBD) after Alzheimer's (AD). Statins are common lipid-lowering agents used in management of dyslipidemia and prevention primary secondary cardiovascular diseases (CVD) events. In addition, there a controversial point regarding role serum lipids pathogenesis PD. this bargain, as statins reduce cholesterol so they affect PD neuropathology bidirectional ways either protective or harmful. not PD, but frequently disorders commonly associated with elderly population. Therefore, use that population may outcomes. Concerning potential on neuropathology, conflicts controversies against development harmful by increasing risk for review aimed to clarify precise pros cons from published studies. Many studies suggest through modulation inflammatory lysosomal signaling pathways. Nevertheless, other observations statin therapy increase diverse mechanisms including reduction CoQ10. conclusion, strong neuropathology. retrospective prospective necessary regard.

Language: Английский

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Parkinson’s Disease Risk and Hyperhomocysteinemia: The Possible Link

Cellular and Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 43(6), P. 2743 - 2759

Published: April 19, 2023

Abstract Parkinson’s disease (PD) is one of the most common degenerative brain disorders caused by loss dopaminergic neurons in substantia nigra (SN). Lewy bodies and -synuclein accumulation SN are hallmarks neuropathology PD. Due to lifestyle changes prolonged L-dopa administration, patients with PD frequently have vitamin deficiencies, especially folate, B6, B12. These augment circulating levels Homocysteine development hyperhomocysteinemia, which may contribute pathogenesis Therefore, this review aimed ascertain if hyperhomocysteinemia play a part oxidative inflammatory signaling pathways that development. Hyperhomocysteinemia implicated neurodegenerative disorders, including triggers progression different mechanisms, stress, mitochondrial dysfunction, apoptosis, endothelial dysfunction. Particularly, linked high systemic disorders. induces immune activation stress. In turn, activated response promotes hyperhomocysteinemia. hyperhomocysteinemia-induced immunoinflammatory abnormal aggravate PD, leading more severity. Also, like nuclear factor kappa B (NF-κB) nod-like receptor pyrin 3 (NLRP3) inflammasome other intricate conclusion, involved either directly via induction degeneration or indirectly pathways.

Language: Английский

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The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 91, P. 102084 - 102084

Published: Oct. 5, 2023

Language: Английский

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The potential role of human islet amyloid polypeptide in type 2 diabetes mellitus and Alzheimer’s diseases

Diabetology & Metabolic Syndrome, Journal Year: 2023, Volume and Issue: 15(1)

Published: May 13, 2023

Abstract Human Islet amyloid polypeptide (hIAPP) from pancreatic β cells in the islet of Langerhans has different physiological functions including inhibiting release insulin and glucagon. Type 2 diabetes mellitus (T2DM) is an endocrine disorder due to relative insufficiency resistance (IR) associated with increased circulating hIAPP. Remarkably, hIAPP structural similarity beta (Aβ) can engage pathogenesis T2DM Alzheimer’s disease (AD). Therefore, present review aimed elucidate how acts as a link between AD. IR, aging low cell mass increase expression which binds membrane leading aberrant Ca 2+ activation proteolytic enzymes series events causing loss cells. Peripheral plays major role AD, high level AD risk patients. However, there no hard evidence for brain-derived Nevertheless, oxidative stress, mitochondrial dysfunction, chaperon-mediated autophagy, heparan sulfate proteoglycan (HSPG), immune response, zinc homeostasis could be possible mechanisms induction aggregation risk. In conclusion, increasing levels patients predispose them development progression Dipeptidyl peptidase 4 (DPP4) inhibitors glucagon-like peptide-1 (GLP-1) agonists attenuate by deposition hIAP.

Language: Английский

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The potential therapeutic effect of statins in multiple sclerosis: beneficial or detrimental effects

Inflammopharmacology, Journal Year: 2023, Volume and Issue: 31(4), P. 1671 - 1682

Published: May 9, 2023

Language: Английский

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