TLR2 and NLRP3 Orchestrate Regulatory Roles in Escherichia coli Infection-Induced Septicemia in Mouse Models DOI Creative Commons

Zhiguo Gong,

W. F. Mader, Jiamin Zhao

et al.

Journal of Innate Immunity, Journal Year: 2024, Volume and Issue: 16(1), P. 513 - 528

Published: Oct. 15, 2024

Introduction: Escherichia coli (E. coli) is a significant commensal gram-negative bacterium that can give rise to various diseases. The roles of Toll-like receptor 2 (TLR2) and the NOD-like pyrin domain-containing protein 3 (NLRP3) inflammasome in sepsis induced by E. infection remain unclear. Methods: In vivo, we investigated differences mortality, production inflammatory mediators, organ damage, neutrophil count, bacterial load during C57BL/6J mice, as well mice deficient TLR2 or NLRP3. vitro, impact on activation NLRP3 macrophages influence signaling pathways secretion mediators infection. Results: TLR2-deficient (TLR2−/−) NLRP3-deficient (NLRP3−/−) exhibit significantly increased mortality damage after These also show elevated levels TNF-α IL-10 serum peritoneal lavage fluid. Additionally, TLR2−/− NLRP3−/− display heightened recruitment blood. Furthermore, from these demonstrate reduction MAPK pathway. Conclusion: play crucial modulating mediator expression, immune cell recruitment, bactericidal activity, thereby preventing excessive tissue reducing coli-induced sepsis.

Language: Английский

Gut microbiota immune cross-talk in amyotrophic lateral sclerosis DOI Creative Commons

Megha Kaul,

Debanjan Mukherjee,

Howard L. Weiner

et al.

Neurotherapeutics, Journal Year: 2024, Volume and Issue: 21(6), P. e00469 - e00469

Published: Oct. 1, 2024

Language: Английский

Citations

4
The Impact of Microbiota on Neurological Disorders: Mechanisms and Therapeutic Implications DOI Open Access
Giuseppe Merra,

Giada La Placa,

Marcello Covino

et al.

OBM Neurobiology, Journal Year: 2025, Volume and Issue: 09(01), P. 1 - 12

Published: Feb. 28, 2025

Interactions in the gut-brain crosstalk have led to development of an entirely new concept: "microbiota-gut-brain axis". Microbiota has gained considerable attention relation disorders a more neurological nature, such as neurodevelopmental and neuropsychiatric illnesses like autism spectrum disorder, anxiety, mood disorders. This review aims summarize recent trends insights into role consequences gut microbiota brain health pediatric Dysbiosis may be associated with increased risk diseases that lead different disruptions conditions, including mental issues. During dysbiosis, neuropsychological stress hormones usually affect oxytocin GABA neurons are significantly reduced. Current studies report major depression, cognitive dysfunction closely dysbiosis. In last few years, handful clinical emerged, illustrating potential for bidirectional relationship interactions humans. Perhaps some most crucial investigations demonstrating overlapping relationships human axis come from trials focusing on modulating noting significant correlates. A field is emerging gene-editing technology could represent tool improve microbial characteristics. approach particularly relevant neurodegenerative brain-gut linked loss species and/or high pathobiont load.

Language: Английский

Citations

0
Potential Relationship Between Helicobacter pylori Infection and Autoimmune Disorders: A Narrative Review DOI
Aref Yarahmadi, Hamed Afkhami

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107572 - 107572

Published: April 1, 2025

Language: Английский

Citations

0
Global Status, Recent Trends, and Knowledge Mapping of Olive Bioactivity Research Through Bibliometric Analysis (2000–2024) DOI Creative Commons
Manuel Garrido‐Romero, Marina Díez‐Municio, F. Javier Moreno

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(8), P. 1349 - 1349

Published: April 14, 2025

Over the past two decades, both academic and industrial interest in olive bioactive compounds has grown significantly due to their remarkable health benefits, such as antioxidant, anti-inflammatory, cardioprotective properties. These compounds, found fruit leaves, have become a central focus research on functional foods nutraceuticals. A comprehensive bibliometric analysis of scientific publications from 2000 2024 highlights notable increase this field, with 2228 documents published high-impact journals an estimated annual growth rate 0.2694 year−1, particularly last decade. This surge reflects growing recognition compounds’ potential promoting human through nutritional therapeutic interventions, role expanding nutraceutical industry. is further reaffirmed by patent analysis, which shows significant rise filings related compounds. The also examined nearly 6000 keywords identify most influential domains, pinpoint knowledge gaps, reveal important olives preventing various diseases.

Language: Английский

Citations

0
From the Gut to the Brain: Is Microbiota a New Paradigm in Parkinson’s Disease Treatment? DOI Creative Commons
Cristiana Vilela, Bruna Araújo, Carla Guedes

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(9), P. 770 - 770

Published: April 30, 2024

Parkinson’s disease (PD) is recognized as the second most prevalent primary chronic neurodegenerative disorder of central nervous system. Clinically, PD characterized a movement disorder, exhibiting an incidence and mortality rate that increasing faster than any other neurological condition. In recent years, there has been growing interest concerning role gut microbiota in etiology pathophysiology PD. The establishment brain–gut axis now real, with evidence denoting bidirectional communication between brain through metabolic, immune, neuronal, endocrine mechanisms pathways. Among these, vagus nerve represents direct form gut. Given potential interactions bacteria drugs, it observed therapies for can have impact on composition microbiota. Therefore, scope present review, we will discuss current understanding whether this may be new paradigm treating devastating disease.

Language: Английский

Citations

3
Exploring Therapeutic Potential of Phytoconstituents as a Gut Microbiota Modulator in the Management of Neurological and Psychological Disorders DOI

Prarit Chandel,

Komal Thapa, Neha Kanojia

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: 551, P. 69 - 78

Published: May 14, 2024

Language: Английский

Citations

3
Hemp hull fiber and two constituent compounds, N-trans-caffeoyltyramine and N-trans-feruloyltyramine, shape the human gut microbiome in vitro DOI Creative Commons

Karla E. Flores Martinez,

Clay S. Bloszies,

Matthew Bolino

et al.

Food Chemistry X, Journal Year: 2024, Volume and Issue: 23, P. 101611 - 101611

Published: July 2, 2024

Mounting evidence supports the potential of dietary bioactives to reduce chronic disease risk. N-trans-caffeoyltyramine (NCT) and N-trans-feruloyltyramine (NFT) have been hypothesized drive regulation gut permeability, but these components not yet studied in context human microbiome. This work examined whether purified NCT NFT, or a hemp hull product containing NFT (Brightseed® Bio Gut Fiber™), can impact microbiome using an vitro fermentation assay. Representative microbiomes were treated with Fiber™ compared starch methylcellulose, as controls, vitro. Stronger changes exerted by Fiber™, NCT, NFT. Communities saw increased productivity diversity. We found dose-dependent effect on microbial communities. Here, we describe novel for hemp-derived shape

Language: Английский

Citations

3
Functional Foods and Adapted Physical Activity as New Adjuvant Therapy for Chronic Kidney Disease Patients DOI Open Access
Giulia Marrone, Arianna Murri, Silvia Urciuoli

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2325 - 2325

Published: July 19, 2024

Background: Chronic kidney disease (CKD) will become the fifth leading cause of death in world by 2040. It is fundamental to prevent and treat this pathology reduce its impact on national health costs. This trial’s aim evaluate effects induced a combination consumed functional foods (FFs) with adapted physical activity (APA) progression CKD-related comorbidities. Methods: The study lasted 12 weeks. We divided 40 CKD patients into four groups: mixed (FF + APA), APA, FF control group (usual care). FFs were characterized their total antioxidant capacity antiradical activity. APA was performed though an online training protocol, three times per week, 1 h each session. Results: At end study, we observed, group, decrease azotemia (p = 0.0272), diastolic blood pressure 0.0169), C-reactive protein 0.0313), increases FORD test 0.0203) fat free mass 0.0258). showed reduction cholesterol 0.0039). Conclusions: can help counteract several comorbidities, such as arterial hypertension, dyslipidemia uremic sarcopenia, improve patients’ quality life.

Language: Английский

Citations

3
From the Gut to the Brain: Is Microbiome a New Paradigm in Parkinson’s Disease Treatment? DOI Open Access
Cristiana Vilela, Bruna Araújo, Carla Guedes

et al.

Published: April 19, 2024

Parkinson's disease (PD) is recognized as the second most prevalent primary chronic neurodegenerative disorder of central nervous system. Clinically, PD characterized a movement disorder, exhibiting an incidence and mortality rate that increasing faster than any other neurological condition. In recent years, there has been growing interest concerning role gut microbiome in etiology pathophysiology PD. The establishment brain-gut axis now real, with evidence denoting bidirectional communication between brain microbiota through metabolic, immune, neuronal, endocrine mechanisms pathways. Among these, vagus nerve represents direct form gut. Given potential interactions bacteria drugs, it observed therapies for can have impact on composition microbiome. Therefore, scope present review, we will discuss current understanding whether this may be new paradigm treating devastating disease.

Language: Английский

Citations

2
Exploring Microbial Contributions to Nutraceutical Production: From Natural to Designed Foods DOI

Babita Thakur,

Sukhminderjit Kaur, Nitu Rani

et al.

Molecular Biotechnology, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 10, 2023

Language: Английский

Citations

4