Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 976 - 976

Published: March 17, 2023

Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The 21st century has seen a transformation study medicine thanks to advancement field material science and nanomedicine. Improved drug delivery systems with proven efficacy fewer side effects made possible. Nanoformulations varied functions are being created using lipids, polymers, inorganic peptide-based nanomedicines. Therefore, thorough knowledge these intelligent nanomedicines is crucial for developing very promising systems. Polymeric micelles often simple make high solubilization characteristics; result, they seem be alternative other nanosystems. Even though recent studies provided an overview polymeric micelles, here we included discussion on “intelligent” from We also summarized state-of-the-art most micellar respect treatments. Additionally, gave significant attention clinical translation potential treatment various cancers.

Language: Английский

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Polymeric Micelles for Breast Cancer Therapy: Recent Updates, Clinical Translation and Regulatory Considerations

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(9), P. 1860 - 1860

Published: Sept. 3, 2022

With the growing burden of cancer, parallel advancements in anticancer nanotechnological solutions have been witnessed. Among different types cancers, breast cancer accounts for approximately 25% and leads to 15% deaths. Nanomedicine its allied fields material science revolutionized medicine 21st century. Novel treatments paved way improved drug delivery systems that better efficacy reduced adverse effects. A variety nanoformulations using lipids, polymers, inorganic, peptide-based nanomedicines with various functionalities are being synthesized. Thus, elaborate knowledge these intelligent highly promising is prime importance. Polymeric micelles (PMs) generally easy prepare good solubilization properties; hence, they appear be an attractive alternative over other nanosystems. Although overall perspective PM has presented recent reviews, a brief discussion provided on PMs cancer. This review provides state-of-the-art together most advances this field. Furthermore, special emphasis placed regulatory guidelines, clinical translation potential, future aspects use treatment. The developments micelle formulations look promising, guidelines now more clearly defined; we anticipate early near future.

Language: Английский

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Curcumin-Based Nanoformulations: A Promising Adjuvant towards Cancer Treatment

Molecules, Journal Year: 2022, Volume and Issue: 27(16), P. 5236 - 5236

Published: Aug. 16, 2022

Throughout the United States, cancer remains second leading cause of death. Traditional treatments induce significant medical toxic effects and unpleasant adverse reactions, making them inappropriate for long-term use. Consequently, anticancer-drug resistance relapse are frequent in certain situations. Thus, there is an urgent necessity to find effective antitumor medications that specific have few consequences. Curcumin a polyphenol derivative found turmeric plant (Curcuma longa L.), provides chemopreventive, antitumor, chemo-, radio-sensitizing properties. In this paper, we summarize new nano-based formulations polyphenolic curcumin because growing interest its application against cancers tumors. According recent studies, use nanoparticles can overcome hydrophobic nature curcumin, as well improving stability cellular bioavailability vitro vivo. Several strategies nanocurcumin production been developed, each with own set advantages unique features. Because majority curcumin-based nanoformulation evidence still conceptual stage, numerous issues impeding provision possible therapeutic option. To support science, further work necessary develop viable anti-cancer adjuvant. review, cover various nanoformulations implications uses cancer, current state clinical studies patents. We address knowledge gaps future research orientations required feasible treatment candidate.

Language: Английский

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Recent advances in developing polymeric micelles for treating cancer: Breakthroughs and bottlenecks in their clinical translation

Drug Discovery Today, Journal Year: 2022, Volume and Issue: 27(5), P. 1495 - 1512

Published: Feb. 11, 2022

Language: Английский

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Advances in anti-breast cancer drugs and the application of nano-drug delivery systems in breast cancer therapy

Journal of Drug Delivery Science and Technology, Journal Year: 2020, Volume and Issue: 57, P. 101662 - 101662

Published: March 6, 2020

Language: Английский

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Environmental impact of increased soap consumption during COVID-19 pandemic: Biodegradable soap production and sustainable packaging

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 796, P. 149013 - 149013

Published: July 10, 2021

Language: Английский

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Bioactive Nanoparticles for Cancer Immunotherapy

International Journal of Molecular Sciences, Journal Year: 2018, Volume and Issue: 19(12), P. 3877 - 3877

Published: Dec. 4, 2018

Currently, immunotherapy is considered to be one of the effective treatment modalities for cancer. All developments and discoveries in this field up recent Nobel Prize add interest research into vast area study. Targeting tumor environment as well immune system a suitable strategy applied cancer treatment. Usage nanoparticle systems delivery immunotherapeutic agents body being widely studied found promising investigated further. Nanoparticles would options therapy future due their high specificity, efficacy, ability diagnose, imaging, therapeutic effect. Among many systems, polylactic-co-glycolic acid (PLGA) nanoparticles, liposomes, micelles, gold iron oxide, dendrimers, artificial exosomes are used Moreover, combination more way treating tumor. Here, we review current trends efficiency these nanosystems delivering antigens, adjuvants, drugs, other agents. This summarizes currently available bioactive immunotherapy.

Language: Английский

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Thallium and selenite doped carbonated hydroxyapatite: Microstructural features and anticancer activity assessment against human lung carcinoma

Ceramics International, Journal Year: 2019, Volume and Issue: 46(4), P. 5201 - 5212

Published: Nov. 2, 2019

Language: Английский

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An overview on natural product drug formulations from conventional medicines to nanomedicines: Past, present and future

Journal of Drug Delivery Science and Technology, Journal Year: 2021, Volume and Issue: 63, P. 102459 - 102459

Published: March 7, 2021

Language: Английский

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Will curcumin nanosystems be the next promising antiviral alternatives in COVID-19 treatment trials?

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 139, P. 111578 - 111578

Published: April 6, 2021

The COVID-19 has become of striking interest since the number deaths is constantly rising all over globe, and search for an efficient treatment more urgent. In light this worrisome scenario, opinion review aimed to discuss current knowledge about potential role curcumin its nanostructured systems on SARS-CoV-2 targets. From perspective, work demonstrated that urges as a antiviral key based relation infection pathways. Moreover, use curcumin-loaded nanocarriers increasing bioavailability therapeutic efficiency was highlighted. Additionally, by themselves their synergic action with molecular targets viral infections have been explored. Finally, viewpoint studies need be carried out implant addressed.

Language: Английский

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