A framework for advancing our understanding of cancer-associated fibroblasts

Nature reviews. Cancer, Journal Year: 2020, Volume and Issue: 20(3), P. 174 - 186

Published: Jan. 24, 2020

Abstract Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signalling interactions cancer cells crosstalk infiltrating leukocytes. As such, they potential target for optimizing therapeutic strategies against cancer. However, many challenges present in ongoing attempts to modulate CAFs benefit. These include limitations our understanding origin heterogeneity CAF function, it being desirable retain some antitumorigenic functions. On basis meeting experts field biology, we summarize this Consensus Statement current knowledge framework advancing critical cell type within microenvironment.

Language: Английский

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Collagen- and hyaluronic acid-based hydrogels and their biomedical applications

Materials Science and Engineering R Reports, Journal Year: 2021, Volume and Issue: 146, P. 100641 - 100641

Published: July 30, 2021

Language: Английский

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Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer

Pharmacological Research, Journal Year: 2021, Volume and Issue: 171, P. 105759 - 105759

Published: July 8, 2021

Language: Английский

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The Extracellular Matrix: Its Composition, Function, Remodeling, and Role in Tumorigenesis

Biomimetics, Journal Year: 2023, Volume and Issue: 8(2), P. 146 - 146

Published: April 5, 2023

The extracellular matrix (ECM) is a ubiquitous member of the body and key to maintenance tissue organ integrity. Initially thought be bystander in many cellular processes, has been shown have diverse components that regulate activate processes ultimately influence cell phenotype. Importantly, ECM’s composition, architecture, stiffness/elasticity phenotypes. Under normal conditions during development, synthesized ECM constantly undergoes degradation remodeling via action proteases maintain homeostasis. In pathological including fibrosis cancer, synthesis, remodeling, dysregulated, causing its integrity altered. Both physical chemical cues from are sensed receptors integrins play roles driving proliferation differentiation progression various diseases such as cancers. Advances ‘omics’ technologies seen an increase studies focusing on bidirectional cell–matrix interactions, here, we highlight emerging knowledge role played by development conditions. This review summarizes current ECM-targeted therapies can modify tumors overcome drug resistance better cancer treatment.

Language: Английский

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The pleiotropic role of transcription factor STAT3 in oncogenesis and its targeting through natural products for cancer prevention and therapy

Medicinal Research Reviews, Journal Year: 2020, Volume and Issue: 41(3), P. 1291 - 1336

Published: Dec. 1, 2020

Abstract Signal transducer and activator of transcription 3 (STAT3) is one the crucial factors, responsible for regulating cellular proliferation, differentiation, migration, programmed cell death, inflammatory response, angiogenesis, immune activation. In this review, we have discussed classical regulation STAT3 via diverse growth cytokines, G‐protein‐coupled receptors, as well toll‐like receptors. We also highlighted potential role noncoding RNAs in signaling. However, deregulation signaling has been found to be associated with initiation progression both solid hematological malignancies. Additionally, hyperactivation can maintain cancer stem phenotype by modulating tumor microenvironment, metabolism, responses favor drug resistance metastasis. Finally, several plausible ways target oncogenic using various small molecules derived from natural products.

Language: Английский

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The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer: New challenges and therapeutic opportunities

Cellular Oncology, Journal Year: 2021, Volume and Issue: 44(6), P. 1209 - 1229

Published: Sept. 16, 2021

Language: Английский

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Cisplatin-induced ototoxicity: Updates on molecular mechanisms and otoprotective strategies

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2021, Volume and Issue: 163, P. 60 - 71

Published: March 26, 2021

Language: Английский

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Progression-Free Survival and Overall Survival of CDK 4/6 Inhibitors Plus Endocrine Therapy in Metastatic Breast Cancer: A Systematic Review and Meta-Analysis

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(17), P. 6400 - 6400

Published: Sept. 3, 2020

The introduction of CDK4/6 inhibitors in combination with endocrine therapy (ET) represents the most relevant advance management hormone receptor (HR) positive, HER2-negative metastatic breast cancer over last few years. This meta-analysis randomized controlled trials (RCTs) is aimed to better characterize efficacy some subgroups and test heterogeneity between different compounds a particular focus on their ability improve overall survival (OS). Pooled estimates hazard ratios (HRs) were computed for progression-free (PFS), OS, objective response rate (ORR) analysis predefined understand treatment effect concerning specific patients’ characteristics. To estimate absolute benefit terms PFS, pooled curves generated by pooling data all trials. A total eight RCTs included. Adding inhibitor ET beneficial irrespective presence or not visceral metastases, number sites, length treatment-free interval (TFI). addition produces significant OS improvement, both aromatase (AI)-sensitive (HR 0.75, 95% CI) AI-resistant patients 0.77, CI [0.67–0.89]). from each single drug show that palbociclib remains only class member showing statistically HR 0.83, [0.68–1.02]).

Language: Английский

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Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer‐based precipitation and size exclusion chromatography

Journal of Extracellular Vesicles, Journal Year: 2021, Volume and Issue: 10(6)

Published: April 1, 2021

Abstract The molecular characterization of extracellular vesicles (EVs) has revealed a great heterogeneity in their composition at cellular and tissue level. Current isolation methods fail to efficiently separate EV subtypes for proteomic functional analysis. aim this study was develop reproducible scalable workflow increase the yield purity preparations. Through combination polymer‐based precipitation size exclusion chromatography (Pre‐SEC), we analyzed two subsets EVs based on CD9, CD63 CD81 content elution time. were characterized using transmission electron microscopy, nanoparticle tracking analysis, Western blot assays. To evaluate differences protein between early‐ late‐eluting fractions, performed quantitative analysis MDA‐MB‐468‐derived EVs. We identified 286 exclusive proteins early‐eluting fractions 148 with differential concentration fractions. A density gradient further within each subgroup. systems biology approach, found significant interactions among contained which suggest existence clusters related specific biological processes. presented here allows single cell type contributes standardizing studies.

Language: Английский

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Characteristics of pre-metastatic niche: the landscape of molecular and cellular pathways

Molecular Biomedicine, Journal Year: 2021, Volume and Issue: 2(1)

Published: Jan. 30, 2021

Metastasis is a major contributor to cancer-associated deaths. It involves complex interactions between primary tumorigenic sites and future metastatic sites. Accumulation studies have revealed that tumour metastasis not disorderly spontaneous incident but the climax of series sequential dynamic events including development pre-metastatic niche (PMN) suitable for subpopulation cells colonize develop into metastases. A deep understanding formation, characteristics function PMN required developing new therapeutic strategies treat patients. rapidly becoming evident therapies targeting may be successful in averting at an early stage. This review highlights key components main describes potential strategies, providing promising foundation studies.

Language: Английский

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