Cancers,
Journal Year:
2022,
Volume and Issue:
14(6), P. 1455 - 1455
Published: March 11, 2022
Many
of
the
anticancer
agents
that
are
currently
in
use
demonstrate
severe
side
effects
and
encounter
increasing
resistance
from
target
cancer
cells.
Thus,
despite
significant
advances
therapy
recent
decades,
there
is
still
a
need
to
discover
develop
new,
alternative
agents.
The
plant
kingdom
contains
range
phytochemicals
play
important
roles
prevention
treatment
many
diseases.
Solanaceae
family
widely
used
various
diseases,
including
cancer,
due
its
bioactive
ingredient
content.
purpose
this
literature
review
highlight
antitumour
activity
extracts-single
isolated
compounds
nanoparticles
with
extracts-and
their
synergistic
effect
chemotherapeutic
vitro
vivo
models.
In
addition,
biological
properties
plants
have
not
yet
been
investigated,
which
represents
challenge
an
opportunity
for
future
therapy.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(12), P. 6480 - 6480
Published: June 9, 2022
Extracellular
vesicles
(EVs)
are
lipid
bilayer
membrane
particles
that
play
critical
roles
in
intracellular
communication
through
EV-encapsulated
informative
content,
including
proteins,
lipids,
and
nucleic
acids.
Mesenchymal
stem
cells
(MSCs)
pluripotent
with
self-renewal
ability
derived
from
bone
marrow,
fat,
umbilical
cord,
menstruation
blood,
pulp,
etc.,
which
they
use
to
induce
tissue
regeneration
by
their
direct
recruitment
into
injured
tissues,
the
heart,
liver,
lung,
kidney,
or
secreting
factors,
such
as
vascular
endothelial
growth
factor
insulin-like
factor.
Recently,
MSC-derived
EVs
have
been
shown
regenerative
effects
against
various
diseases,
partially
due
post-transcriptional
regulation
of
target
genes
miRNAs.
Furthermore,
garnered
attention
novel
drug
delivery
systems,
because
can
specially
encapsulate
molecules.
In
this
review,
we
summarize
molecular
mechanisms
EVs.
Cancers,
Journal Year:
2022,
Volume and Issue:
14(21), P. 5444 - 5444
Published: Nov. 5, 2022
Breast
cancer
remains
the
most
frequently
diagnosed
form
of
female's
cancer,
and
in
recent
years
it
has
become
common
cause
death
women
worldwide.
Like
many
other
tumours,
breast
is
a
histologically
biologically
heterogeneous
disease.
In
years,
considerable
progress
been
made
diagnosis,
subtyping,
complex
treatment
with
aim
providing
best
suited
tumour-specific
personalized
therapy.
Traditional
methods
for
diagnosis
include
mammography,
MRI,
biopsy
histological
analysis
tumour
tissue
order
to
determine
classical
markers
such
as
estrogen
progesterone
receptors
(ER,
PR),
cytokeratins
(CK5/6,
CK14,
C19),
proliferation
index
(Ki67)
human
epidermal
growth
factor
type
2
receptor
(HER2).
these
have
supplemented
by
modern
molecular
methodologies
next-generation
sequencing,
microRNA,
situ
hybridization,
RT-qPCR
identify
novel
biomarkers.
MicroRNAs
(miR-10b,
miR-125b,
miR145,
miR-21,
miR-155,
mir-30,
let-7,
miR-25-3p),
altered
DNA
methylation
mutations
specific
genes
(p16,
BRCA1,
RASSF1A,
APC,
GSTP1),
circular
RNA
(hsa_circ_0072309,
hsa_circRNA_0001785),
circulating
cells,
levels
proteins
(apolipoprotein
C-I),
lipids,
gene
polymorphisms
or
nanoparticle
enhanced
imaging,
all
are
promising
diagnostic
prognostic
tools
disclose
any
features
from
multifaceted
nature
prepare
individualized
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(6), P. 3199 - 3199
Published: March 21, 2021
Chemotherapeutics
are
the
mainstay
treatment
for
metastatic
breast
cancers.
However,
chemotherapeutic
failure
caused
by
multidrug
resistance
(MDR)
remains
a
pivotal
obstacle
to
effective
chemotherapies
of
cancer.
Although
in
vitro
evidence
suggests
that
overexpression
ATP-Binding
Cassette
(ABC)
transporters
confers
cytotoxic
and
molecularly
targeted
reducing
intracellular
accumulation
active
moieties,
clinical
trials
target
ABCB1
reverse
drug
have
been
disappointing.
Nevertheless,
studies
indicate
ABC
may
contribute
cancer
development
metastasis
independent
their
efflux
function.
A
broader
more
clarified
understanding
functions
roles
biology
will
potentially
stratifying
patients
precision
regimens
promote
novel
therapies.
Herein,
we
summarise
current
knowledge
relating
mechanisms,
regulations
transporters,
with
focus
on
chemoresistance,
progression
metastasis.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(19), P. 6196 - 6196
Published: Sept. 21, 2022
Matrix-assisted
laser
desorption/ionization
(MALDI)
mass
spectrometry
(MS)
is
one
of
the
most
widely
used
techniques
in
proteomics
to
achieve
structural
identification
and
characterization
proteins
peptides,
including
their
variety
proteoforms
due
post-translational
modifications
(PTMs)
or
protein-protein
interactions
(PPIs).
MALDI-MS
MALDI
tandem
(MS/MS)
have
been
developed
as
analytical
study
small
large
molecules,
offering
picomole
femtomole
sensitivity
enabling
direct
analysis
biological
samples,
such
biofluids,
solid
tissues,
tissue/cell
homogenates,
cell
culture
lysates,
with
a
minimized
procedure
sample
preparation.
In
last
decades,
peptides
achieved
by
MALDI-MS/MS
helped
researchers
clinicians
decipher
molecular
function,
process,
cellular
component,
related
pathways
gene
products
well
involvement
pathogenesis
diseases.
this
review,
we
highlight
applications
ionization
source
approaches
for
MS
analyzing
biomedical
relevant
proteins.
Furthermore,
provide
"molecular
pictures",
which
offer
situ
information
about
weight
without
labeling
potential
targets.
Histology-directed
MALDI-mass
imaging
(MSI)
uses
MALDI-ToF/ToF
other
spectrometers
accurate
sequence
peptide
biomarkers
active
compounds
directly
assure
complementary
essential
spatial
data
compared
those
obtained
LC-ESI-MS/MS
technique.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(8), P. 7426 - 7426
Published: April 18, 2023
Given
their
tumor-specific
and
stage-specific
gene
expression,
long
non-coding
RNAs
(lncRNAs)
have
demonstrated
to
be
potential
molecular
biomarkers
for
diagnosis,
prognosis,
treatment
response.
Particularly,
the
lncRNAs
DSCAM-AS1
GATA3-AS1
serve
as
examples
of
this
because
high
subtype-specific
expression
profile
in
luminal
B-like
breast
cancer.
This
makes
them
candidates
use
clinical
practice.
However,
lncRNA
studies
cancer
are
limited
sample
size
restricted
determination
biological
function,
which
represents
an
obstacle
its
inclusion
utility.
Nevertheless,
due
specificity
among
diseases,
such
cancer,
stability
body
fluids,
promising
that
could
improve
reliability,
sensitivity,
techniques
used
diagnosis.
The
development
lncRNA-based
diagnostics
therapeutics
will
useful
routine
medical
practice
patient
management
quality
life.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(4), P. 1051 - 1051
Published: March 29, 2023
Biosensing
and
microfluidics
technologies
are
transforming
diagnostic
medicine
by
accurately
detecting
biomolecules
in
biological
samples.
Urine
is
a
promising
fluid
for
diagnostics
due
to
its
noninvasive
collection
wide
range
of
biomarkers.
Point-of-care
urinalysis,
which
integrates
biosensing
microfluidics,
has
the
potential
bring
affordable
rapid
into
home
continuing
monitoring,
but
challenges
still
remain.
As
such,
this
review
aims
provide
an
overview
biomarkers
that
or
could
be
used
diagnose
monitor
diseases,
including
cancer,
cardiovascular
kidney
neurodegenerative
disorders,
such
as
Alzheimer’s
disease.
Additionally,
different
materials
techniques
fabrication
microfluidic
structures
along
with
often
detect
quantify
molecules
organisms
reviewed.
Ultimately,
discusses
current
state
point-of-care
urinalysis
devices
highlights
these
improve
patient
outcomes.
Traditional
require
manual
urine,
may
unpleasant,
cumbersome,
prone
errors.
To
overcome
issue,
toilet
itself
can
alternative
specimen
device.
This
then
presents
several
smart
systems
incorporated
sanitary
purpose.
