Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(4), P. 3164 - 3174
Published: April 5, 2024
The
study
aimed
to
identify
common
differentially
expressed
lncRNAs
from
manually
curated
ulcerative
colitis
(UC)
gene
expression
omnibus
(GEO)
datasets.
Nine
UC
transcriptomic
datasets
of
clearly
annotated
human
colonic
biopsies
were
included
in
the
study.
select
active
samples
and
controls.
R
packages
geneknitR,
gprofiler,
clusterProfiler
used
for
symbol
annotation.
EdgeR
package
was
analyze
differential
expression.
This
resulted
a
total
nineteen
that
at
least
three
nine
GEO
Several
found
associated
with
promoting
colorectal
cancer
(CRC)
through
regulating
expression,
epithelial
mesenchymal
transition
(EMT),
cell
cycle
progression,
by
tumor
proliferation,
invasion,
migration.
several
varied
between
disease
states
tissue
locations
within
same
state.
identified
may
function
as
general
markers
independent
biopsy
location,
age,
gender,
or
treatment,
thereby
representing
comparative
resource
future
comparisons
using
available
Nanoscale,
Journal Year:
2024,
Volume and Issue:
16(8), P. 3881 - 3914
Published: Jan. 1, 2024
The
long
noncoding
RNAs
(lncRNAs)
comprise
a
wide
range
of
RNA
species
whose
length
exceeds
200
nucleotides,
which
regulate
the
expression
genes
and
cellular
functions
in
organisms.
Clinical and Experimental Medicine,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Sept. 26, 2024
Abstract
Long
non-coding
RNAs
(lncRNAs)
have
emerged
as
crucial
regulators
in
various
cellular
processes,
including
cancer
progression
and
stress
response.
Recent
studies
demonstrated
that
copper
accumulation
induces
a
unique
form
of
cell
death
known
cuproptosis,
with
lncRNAs
playing
key
role
regulating
cuproptosis-associated
pathways.
These
may
trigger
cell-specific
responses
to
stress,
presenting
new
opportunities
prognostic
markers
therapeutic
targets.
This
paper
delves
into
the
cuproptosis-mediated
cancer,
underscoring
their
potential
biomarkers
targets
for
innovative
strategies.
A
thorough
review
scientific
literature
was
conducted,
utilizing
databases
such
PubMed,
Google
Scholar,
ScienceDirect,
search
terms
like
'lncRNAs,'
'cuproptosis,'
'cancer.'
Studies
were
selected
based
on
relevance
lncRNA
regulation
cuproptosis
pathways
implications
prognosis
treatment.
The
highlights
significant
contribution
cuproptosis-related
genes
pathways,
impacting
metabolism,
mitochondrial
responses,
apoptotic
signaling.
Specific
are
breast,
lung,
liver,
ovarian,
pancreatic,
gastric
cancers.
objective
this
article
is
explore
cancers
mediated
by
cuproptosis.
Cell Biology International,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
Breast
cancer
is
a
multifaceted
and
prevalent
malignancy,
impacting
considerable
proportion
of
women
globally.
Numerous
signaling
pathways
intricately
regulate
cellular
functions
such
as
growth,
proliferation,
survival.
Among
the
various
regulators,
lncRNAs
have
emerged
significant
players
despite
their
inability
to
encode
proteins.
An
expanding
body
literature
underscores
pivotal
roles
play
in
biology,
particularly
context
breast
cancer.
Autophagy,
process
dedicated
degradation
recycling
components,
now
recognized
crucial
factor
initiation
progression.
The
interplay
between
lncRNAs,
pathways,
autophagy
pathophysiology
remains
an
active
area
investigation.
Researchers
identified
specific
that
are
dysregulated
patients,
influencing
modulation
key
pathways.
Using
experimental
methodologies
bioinformatics
approaches,
multiple
been
elucidated,
providing
deeper
insights
into
contributions
pathogenesis
metastatic
processes.
In
summary,
pathophysiological
landscape
characterized
by
complex
interactions
involving
lncRNA-mediated
autophagy.
This
understanding
paves
way
for
identifying
novel
therapeutic
targets,
prognostic
markers,
diagnostic
ultimately
contributing
improved
treatment
outcomes
management.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(3), P. 1473 - 1473
Published: Jan. 25, 2024
More
than
75%
of
traumatic
brain
injuries
(TBIs)
are
mild
(mTBI)
and
military
service
members
often
experience
repeated
combat-related
mTBI.
The
chronic
comorbidities
concomitant
with
repetitive
mTBI
(rmTBI)
include
depression,
post-traumatic
stress
disorder
or
neurological
dysfunction.
This
study
sought
to
determine
a
long
noncoding
RNA
(lncRNA)
expression
signature
in
serum
samples
that
correlated
rmTBI
years
after
the
incidences.
Serum
were
obtained
from
Long-Term
Impact
Military-Relevant
Brain-Injury
Consortium
Chronic
Effects
Neurotrauma
(LIMBIC
CENC)
repository,
participants
unexposed
TBI
who
had
rmTBI.
Four
lncRNAs
identified
as
consistently
present
all
samples,
detected
via
droplet
digital
PCR
packaged
exosomes
enriched
for
CNS
origin.
results,
using
qPCR,
demonstrated
lncRNA
VLDLR-AS1
levels
significantly
lower
among
individuals
compared
those
no
lifetime
TBI.
ROC
analysis
determined
an
AUC
0.74
(95%
CI:
0.6124
0.8741;
p
=
0.0012).
optimal
cutoff
was
≤153.8
ng.
A
secondary
clinical
data
LIMBIC
CENC
conducted
evaluate
psychological
symptom
burden,
results
show
MALAT1
symptoms
depression.
In
conclusion,
may
serve
blood
biomarker
identifying
depression
patients.
Cancer Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 12, 2025
ABSTRACT
Long
non‐coding
RNAs
(lncRNAs)
have
emerged
as
crucial
regulators
of
cancer
development
and
progression.
Among
them,
Differentiation
Antagonizing
Non‐Protein
Coding
RNA
(DANCR)
has
been
implicated
in
various
malignancies,
including
esophageal
squamous
cell
carcinoma
(ESCC).
This
study
explores
the
clinical
characteristics,
prognostic
implications,
functional
roles,
molecular
mechanisms
DANCR
ESCC.
Our
results
demonstrate
that
is
highly
expressed
ESCC,
acts
an
oncogene
ESCC
both
vitro
vivo.
Through
bioinformatics
analysis
experimental
validation,
we
revealed
promotes
progression
by
sponging
miR‐3193
regulating
its
target
gene
DDIT3
expression.
These
findings
highlight
critical
role
suggest
potential
a
predictor
drug
therapeutic
target.
Cells,
Journal Year:
2025,
Volume and Issue:
14(7), P. 555 - 555
Published: April 7, 2025
Long
noncoding
RNAs
(lncRNAs)
are
RNA
molecules
exceeding
200
nucleotides
that
do
not
encode
proteins
yet
play
critical
roles
in
regulating
gene
expression
at
multiple
levels,
such
as
chromatin
modification
and
transcription.
These
significantly
engaged
cancer
progression,
development,
metastasis,
chemoresistance.
However,
the
function
of
lncRNAs
epithelial
ovarian
(EOC)
has
been
thoroughly
studied.
EOC
remains
challenging
due
to
its
complex
molecular
pathogenesis,
characterized
by
genetic
epigenetic
alterations.
Emerging
evidence
suggests
lncRNAs,
XIST,
H19,
NEAT1,
MALAT1,
involved
modulating
signaling
pathways,
influencing
processes
like
cell
proliferation,
invasion,
migration,
Despite
extensive
research,
precise
mechanism
acting
pathogenesis
treatment
resistance
still
needs
be
fully
understood,
highlighting
need
for
further
studies.
This
review
aims
provide
an
updated
overview
current
understanding
EOC,
emphasizing
their
potential
biomarkers
therapeutic
targets.
We
point
out
gaps
knowledge
regarding
lncRNAs’
influence
on
(EOC),
deliberating
new
possible
research
areas.
