Nanotheranostics,
Journal Year:
2023,
Volume and Issue:
7(4), P. 368 - 379
Published: Jan. 1, 2023
Cancer
diagnosis
and
management
have
been
a
slow-evolving
area
in
medical
science.Conventional
therapies
by
far
proved
to
various
limitations.Also,
the
concept
of
immunotherapy
which
was
thought
revolutionize
cancer
has
presented
its
range
drawbacks.To
overcome
these
limitations
nanoparticulate-derived
diagnostic
therapeutic
strategies
are
emerging.These
nanomaterials
be
explored
as
they
serve
prospect
for
theranostics.Nanoparticles
significant
yet
unclear
role
screening
well
therapy
cancer.However,
nanogels
Photodynamic
is
one
such
approach
developed
theranostics.Photoactive
theranostics
vivid
that
might
prove
help
manage
cancer.Also,
utilization
quantum
dots
tool
selectively
kill
cells,
especially
CNS
tumors.Additionally,
redox-sensitive
micelles
targeting
tumor
microenvironment
also
an
important
theranostic
tool.This
review
focuses
on
exploring
agents
currently
being
studied
or
can
further
theranostics.
Cancers,
Journal Year:
2021,
Volume and Issue:
13(14), P. 3484 - 3484
Published: July 13, 2021
Photodynamic
therapy
(PDT)
is
a
cancer
treatment
with
strong
potential
over
well-established
standard
therapies
in
certain
cases.
Non-ionising
radiation,
localisation,
possible
repeated
treatments,
and
stimulation
of
immunological
response
are
some
the
main
beneficial
features
PDT.
Despite
great
potential,
its
application
remains
challenging.
Limited
light
penetration
depth,
non-ideal
photosensitisers,
complex
dosimetry,
complicated
implementations
clinic
limiting
factors
hindering
extended
use
To
surpass
actual
technological
paradigms,
radically
new
sources,
light-based
devices,
advanced
measurement
innovative
strategies
under
extensive
investigation.
The
aim
this
review
to
highlight
advantages/pitfalls,
technical
challenges
opportunities
PDT,
focus
on
technologies
for
activation
such
as
delivery
systems.
In
vein,
broad
overview
current
status
superficial,
interstitial,
deep
PDT
modalities-and
critical
sources
their
effects
process-are
presented.
Insight
into
advancements
remaining
optical
devices
provided
from
physical
bioengineering
perspective.
Frontiers in Oncology,
Journal Year:
2022,
Volume and Issue:
12
Published: March 29, 2022
Cancer
is
a
prominent
cause
of
mortality
globally,
and
it
becomes
fatal
incurable
if
delayed
in
diagnosis.
Chemotherapy
type
treatment
that
used
to
eliminate,
diminish,
or
restrict
tumor
progression.
Chemotherapeutic
medicines
are
available
various
formulations.
Some
tumors
require
just
one
chemotherapy
medication,
while
others
may
combination
surgery
and/or
radiotherapy.
Treatments
might
last
from
few
minutes
many
hours
several
days.
Each
medication
has
potential
adverse
effects
associated
with
it.
Researchers
have
recently
become
interested
the
use
natural
bioactive
compounds
anticancer
therapy.
phytochemicals
on
cellular
processes
signaling
pathways
antitumor
properties.
Beneficial
were
observed
both
vivo
vitro
investigations.
Encapsulating
different
drug
delivery
methods
improve
their
efficacy.
Greater
stability
bioavailability,
as
well
reduction
undesirable
an
enhancement
target-specific
activity,
will
increase
effectiveness
compounds.
This
review
work
focuses
novel
system
entraps
substances.
It
also
provides
idea
bioavailability
phytochemicals,
challenges
limitations
standard
cancer
encompasses
recent
patents
nanoparticle
formulations
containing
anti-cancer
molecule.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(24)
Published: April 26, 2023
Photodynamic
therapy
(PDT),
with
its
advantages
of
high
targeting,
minimally
invasive,
and
low
toxicity
side
effects,
has
been
widely
used
in
the
clinical
various
tumors,
especially
superficial
tumors.
However,
tumor
microenvironment
(TME)
presents
hypoxia
due
to
oxygen
(O2
)
supply
caused
by
abnormal
vascularization
neoplastic
tissues
O2
consumption
induced
rapid
proliferation
cells.
The
efficacy
oxygen-consumping
PDT
can
be
hampered
a
hypoxic
TME.
To
address
this
problem,
researchers
have
developing
advanced
nanoplatforms
strategies
enhance
therapeutic
effect
treatment.
This
review
summarizes
recent
against
TME,
thus
enhancing
efficacy,
including
increasing
content
TME
through
delivering
tumors
situ
generations
;
decreasing
during
design
type
I
photosensitizers.
Moreover,
synergistically
combined
other
methods
such
as
chemotherapy,
photothermal
therapy,
immunotherapy,
gas
is
accounted
for
addressing
challenging
problems
mono
environments,
resistance,
proliferation,
metastasis.
Finally,
perspectives
opportunities
challenges
future
research
translations
are
provided.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(9), P. 2073 - 2073
Published: April 30, 2024
The
concept
of
nanomedicine
has
evolved
significantly
in
recent
decades,
leveraging
the
unique
phenomenon
known
as
enhanced
permeability
and
retention
(EPR)
effect.
This
facilitated
major
advancements
targeted
drug
delivery,
imaging,
individualized
therapy
through
integration
nanotechnology
principles
into
medicine.
Numerous
nanomedicines
have
been
developed
applied
for
disease
treatment,
with
a
particular
focus
on
cancer
therapy.
Recently,
utilized
various
advanced
fields,
including
diagnosis,
vaccines,
immunotherapy,
gene
tissue
engineering.
Multifunctional
facilitate
concurrent
medication
therapeutic
monitoring,
allowing
immediate
responses
personalized
treatment
plans.
review
concerns
advancement
nanomaterials
their
potential
applications
biological
medical
fields.
Along
this,
we
also
mention
clinical
translations
challenges
that
is
currently
facing
to
overcome
translation
barrier.
Molecules,
Journal Year:
2021,
Volume and Issue:
26(21), P. 6532 - 6532
Published: Oct. 29, 2021
Breast
cancer
(BC)
is
the
most
common
malignant
tumor
in
women
worldwide,
which
seriously
threatens
women's
physical
and
mental
health.
In
recent
years,
photodynamic
therapy
(PDT)
has
shown
significant
advantages
treatment.
PDT
involves
activating
photosensitizers
with
appropriate
wavelengths
of
light,
producing
transient
levels
reactive
oxygen
species
(ROS).
Compared
free
photosensitizers,
use
nanoparticles
shows
great
terms
solubility,
early
degradation,
biodistribution,
as
well
more
effective
intercellular
penetration
targeted
cell
uptake.
Under
current
circumstances,
researchers
have
made
promising
efforts
to
develop
nanocarrier
photosensitizers.
Reasonably
designed
photosensitizer
(PS)
can
be
achieved
through
non-covalent
(self-aggregation,
interfacial
deposition,
polymerization
or
core-shell
embedding
adsorption)
covalent
(chemical
immobilization
coupling)
processes
accumulate
certain
tumors
passive
and/or
active
targeting.
These
PS
loading
methods
provide
chemical
stability
payload.
Among
nanoparticles,
metal
high
stability,
adjustable
size,
optical
properties,
easy
surface
functionalization,
making
them
biocompatible
biological
applications.
this
review,
we
summarize
development
application
status
for
breast
cancer,
especially
latest
developments
nanocarriers
PDT,
highlight
some
synergistic
therapies,
hopefully
providing
an
accessible
overview
knowledge
that
may
act
a
basis
new
ideas
systematic
evaluations
already
results.
Scientific Reports,
Journal Year:
2021,
Volume and Issue:
11(1)
Published: Jan. 18, 2021
Cancer-associated
fibroblasts
(CAFs)
have
an
important
role
in
the
tumor
microenvironment.
CAFs
multifunctionality
which
strongly
support
cancer
progression
and
acquisition
of
therapeutic
resistance
by
cells.
Near-infrared
photoimmunotherapy
(NIR-PIT)
is
a
novel
treatment
that
uses
highly
selective
monoclonal
antibody
(mAb)-photosensitizer
conjugate.
We
developed
fibroblast
activation
protein
(FAP)-targeted
NIR-PIT,
IR700
was
conjugated
to
FAP-specific
target
(CAFs-targeted
NIR-PIT:
CAFs-PIT).
Thus,
we
hypothesized
control
could
overcome
conventional
chemotherapy
esophageal
(EC).
In
this
study,
evaluated
whether
EC
cell
stronger
malignant
characteristics
refractoriness
chemoradiotherapy
are
mediated
CAFs.
Next,
assessed
be
rescued
eliminating
CAF
stimulation
CAFs-PIT
vitro
vivo.
Cancer
cells
acquired
via
5-fluorouracil
(FU)
CAF-coinoculated
models
promoted
migration/invasion
stem-like
phenotype
vitro,
were
elimination
stimulation.
had
effect
on
vitro.
Finally,
vivo
demonstrated
combination
5-FU
NIR-PIT
succeeded
producing
70.9%
reduction,
while
alone
achieved
only
13.3%
suggesting
recovery
sensitivity
CAF-rich
tumors.
conclusion,
elimination.
The
combined
use
targeted
with
anticancer
treatments
can
expected
provide
more
effective
sensible
strategy.
Polymers,
Journal Year:
2022,
Volume and Issue:
14(7), P. 1286 - 1286
Published: March 23, 2022
Chemotherapeutic
drugs
are
highly
effective
in
treating
cancer.
However,
the
side
effects
associated
with
this
treatment
lower
quality
of
life
cancer
patients.
Smart
nanocarriers
able
to
encapsulate
these
deliver
them
tumors
while
reducing
their
contact
healthy
cells
and
subsequent
effects.
Upon
reaching
target,
release
encapsulated
should
be
carefully
controlled
achieve
therapeutic
levels
at
required
time.
Light
is
one
promising
triggering
mechanisms
used
as
external
stimuli
trigger
drug
from
light-responsive
nanocarriers.
Photo-induced
can
achieved
a
wide
range
wavelengths:
UV,
visible,
NIR
depending
on
many
factors.
In
review,
photo-induced
were
summarized,
focusing
liposomes
micelles.
general,
light-triggering
based
following:
changing
hydrophobicity
nanocarrier
constituent(s)
make
it
more
soluble,
introducing
local
defects
within
(by
conformational
transformation
or
photo-cleavage
its
lipids/polymers
chains)
porous
concentrating
heat
for
thermo-sensitive
payload.
Several
research
studies
also
presented
explore
potentials
limitations
mechanism.
