Current Advances in Photodynamic Therapy (PDT) and the Future Potential of PDT-Combinatorial Cancer Therapies

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1023 - 1023

Published: Jan. 13, 2024

Photodynamic therapy (PDT) is a two-stage treatment that implies the use of light energy, oxygen, and light-activated compounds (photosensitizers) to elicit cancerous precancerous cell death after activation (phototoxicity). The biophysical, bioengineering aspects its combinations with other strategies are highlighted in this review, both conceptually as they currently applied clinically. We further explore recent advancements PDT nanotechnology, including quantum dots innovative photosensitizers or energy donors well combination radiotherapy immunotherapy future promising cancer treatments. Finally, we emphasize potential significance organoids physiologically relevant models for PDT.

Language: Английский

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NIR‐II Photoacoustic Imaging‐Guided Oxygen Delivery and Controlled Release Improves Photodynamic Therapy for Hepatocellular Carcinoma

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(4)

Published: Nov. 21, 2023

Abstract Hypoxia, a prominent hallmark of hepatocellular carcinoma (HCC), undermines curative outcomes, elevates recurrence rates, and fosters metastasis, particularly during photodynamic therapy (PDT) in clinical settings. Studies indicate that alleviating tumor hypoxia enhances PDT efficacy. However, persistent challenges, including suboptimal oxygen delivery efficiency absence real‐time feedback on blood fluctuations PDT, considerably impede therapeutic efficacy treatment. This study addresses these issues using near‐infrared‐II (NIR‐II) photoacoustic (PA) imaging for tumor‐targeted controlled release. For this purpose, biomimetic system designated BLICP@O 2 is developed, which utilizes hybrid cell membranes thermosensitive liposomes as carriers, incorporating the NIR‐II dye IR1048, photosensitizer chlorin e6 (Ce6), perfluorohexane. Upon sequential irradiation at 1064 690 nm, exhibits significant photothermal effects. Photothermal heating triggers release, enhancing effect Ce6. Blood changes are tracked by multispectral PA imaging. Enhanced efficacy, mediated relief, convincingly demonstrated both vitro vivo. work presents an imaging‐guided, dual‐wavelength programmed cascaded treatment strategy with monitoring imaging, offering valuable insights overcoming challenges PDT‐based cancer therapy.

Language: Английский

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“Three birds with one stone” nanoplatform: Efficient near‐infrared‐triggered type‑I AIE photosensitizer for mitochondria‐targeted photodynamic therapy against hypoxic tumors

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: March 24, 2024

Abstract Currently three major problems seriously limit the practical application of cancer photodynamic therapy (PDT): (i) hypoxic tumor microenvironment (TME); (ii) low generation efficiency toxic reactive oxygen species (ROS) in aggregates and (iii) shallow tissue penetration depth excitation light. Very limited approaches are available for addressing all above with a single design. Herein, rational “three birds one stone” molecular nanoengineering strategy is demonstrated: nanoplatform U‐Ir@PAA‐ABS based on covalent combination lanthanide‐doped upconversion nanoparticles (UCNPs) an AIE‐active dinuclear Ir(III) complex provides concentration‐dependent type‐I photochemical process upon 980 nm irradiation by Föster resonance energy transfer (FRET). targets mitochondria has excellent phototoxicity even severe hypoxia environments irradiation, inducing dual‐mode cell death mechanism apoptosis ferroptosis. Taken together, vitro vivo results demonstrate successful improving efficacy PDT against tumors.

Language: Английский

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Crucial Breakthrough of BODIPY‐Based NIR‐II Fluorescent Emitters for Advanced Biomedical Theranostics

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(36)

Published: March 29, 2024

Abstract Fluorescence imaging in the second near‐infrared window (NIR‐II, 1000–1700 nm) has aroused immense attention for biomedical applications, offering exceptional advantages such as ultra‐low photon scattering and increased tissue penetration. Among NIR‐II‐emitted organic dyes, Boron dipyrromethene (BODIPY), emerged a noteworthy candidate. BODIPY, distinguished by its controllable molecular structure optical properties, outstanding fluorescence quantum yields, high molar absorption coefficients, remarkable chemical stability, undergone comprehensive investigation extensive exploration within realm of biological theranostics. This work aims to provide summary advancements development design strategies NIR‐II BODIPY fluorophores tailored advanced phototheranostics. Initially, elucidates several representative strategies, concluding electron‐programming strategy, extension conjugated backbone, J‐aggregation strategic establishment activatable fluorophores, which enhance skeletons. Subsequently, developments fluorescent BODIPY‐based nanoplatforms applications are intricately elaborated. In conclusion, this outlines future efforts directions refining meet evolving clinical demands. It is anticipated that contribution may feasible reference thereby advancing their potential practices.

Language: Английский

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Deciphering Oxygen‐Independent Augmented Photodynamic Oncotherapy by Facilitating the Separation of Electron‐Hole Pairs

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(15)

Published: Feb. 16, 2024

Developing Type-I photosensitizers provides an attractive approach to solve the dilemma of inadequate efficacy photodynamic therapy (PDT) caused by inherent oxygen consumption traditional Type-II PDT and anoxic tumor microenvironment. The challenge for exploration PSs is facilitate electron transfer ability photosensitization molecules transforming or H

Language: Английский

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Tumor microenvironment triggered iron-based metal organic frameworks for magnetic resonance imaging and photodynamic-enhanced ferroptosis therapy

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 685, P. 382 - 395

Published: Jan. 17, 2025

Language: Английский

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Samarium doped carbon dots for near-infrared photo-therapy

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 488, P. 150661 - 150661

Published: March 24, 2024

Language: Английский

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Metal–Organic Framework Nanocomposites in Conquering Hypoxia for Tumor Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(17)

Published: Jan. 3, 2024

Abstract Hypoxia, as a distinctive feature of tumors, is closely related to tumor recurrence, metastasis, and treatment resistance. Metal–organic framework (MOF) exhibits an increasing number advantages in cancer therapy owing its porous structure, large specific surface area, tunable function. The MOF nanocomposites constructed by adjusting components can effectively overcome hypoxia significantly enhance the anti‐tumor effect. In this review, hypoxic characteristics tumors current strategies for constructing that are summarized, including delivering O 2 or endogenously generating elevate intra‐tumor content; inhibiting HIF‐1 induced products alleviate hypoxia; reducing cellular aerobic respiration decrease consumption, exacerbating improve efficacy hypoxia‐activated pre‐drugs. At same time, applications applied different therapeutic methods at present stage described, finally, challenges opportunities further development discussed.

Language: Английский

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Natural-product-based, carrier-free, noncovalent nanoparticles for tumor chemo-photodynamic combination therapy

Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107150 - 107150

Published: March 21, 2024

Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global morbidity, disability, mortality, highlighting the necessity for transformative treatment approaches. Photodynamic therapy (PDT) has aroused continuous interest as viable alternative conventional cancer treatments that encounter drug resistance. Nanotechnology brought new advances in medicine shown great potential delivery treatment. For precise efficient therapeutic utilization of such tumor approach high spatiotemporal selectivity minimal invasiveness, carrier-free noncovalent nanoparticles (NPs) based on chemo-photodynamic combination essential. Utilizing natural products foundation nanodrug development offers unparalleled advantages, including exceptional pharmacological activity, easy functionalization/modification, well biocompatibility. The natural-product-based, carrier-free, NPs revealed excellent synergistic anticancer activity comparison free photosensitizers bioactive products, representing an favorable avenue improve efficacy. Herein, comprehensive summary current strategies representative application examples past decade (such paclitaxel, 10-hydroxycamptothecin, doxorubicin, etoposide, combretastatin A4, epigallocatechin gallate, curcumin) therapy. We highlight insightful design synthesis smart aim enhance PDT Meanwhile, we discuss future challenges opportunities associated these provide enlightenment, spur innovative ideas, facilitate PDT-mediated clinical transformation.

Language: Английский

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Current advances in modulating tumor hypoxia for enhanced therapeutic efficacy

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 176, P. 1 - 27

Published: Jan. 21, 2024

Language: Английский

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