Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(15), P. 1294 - 1294
Published: July 31, 2024
Curcumin
is
a
nutraceutical
known
to
have
numerous
medicinal
effects
including
anticancer
activity.
However,
due
its
poor
water
solubility
and
bioavailability,
the
therapeutic
impact
of
curcumin
against
cancer,
breast
has
been
constrained.
Encapsulating
into
chitosan
nanoparticles
(CHNPs)
an
effective
method
increase
bioavailability
as
well
antitumorigenic
In
current
study,
curcumin-encapsulated
CHNPs
(Cur-CHNPs)
on
cell
migration,
targeted
homing
tumor
growth
were
examined
using
in
vitro
vivo
cancer
models.
Cur-CHNPs
possessed
monodispersed
nature
with
long-term
colloidal
stability,
demonstrated
significant
inhibition
viability
vitro,
which
was
potentiated
by
5-Fluorouracil
(5-FU).
Outcomes
imaging
studies
confirmed
targeting
retention
ability
Cur-CHNPs,
thereby
suppressing
mice
Overall,
results
that
could
be
candidate
drug
formulation
for
management
cancer.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(6), P. 5208 - 5208
Published: March 8, 2023
Breast
cancer
(BC)
continues
to
be
the
most
diagnosed
tumor
in
women
and
a
very
heterogeneous
disease
both
inter-
intratumoral,
mainly
given
by
variety
of
molecular
profiles
with
different
biological
clinical
characteristics.
Despite
advancements
early
detection
therapeutic
strategies,
survival
rate
is
low
patients
who
develop
metastatic
disease.
Therefore,
it
mandatory
explore
new
approaches
achieve
better
responses.
In
this
regard,
immunotherapy
arose
as
promising
alternative
conventional
treatments
due
its
ability
modulate
immune
system,
which
may
play
dual
role
since
relationship
between
system
BC
cells
depends
on
several
factors:
histology
size,
well
involvement
lymph
nodes,
cells,
molecules
that
are
part
microenvironment.
Particularly,
myeloid-derived
suppressor
cell
(MDSC)
expansion
one
major
immunosuppressive
mechanisms
used
breast
tumors
has
been
associated
worse
stage,
burden,
poor
efficacy
immunotherapies.
This
review
focuses
immunotherapies
last
five
years.
Additionally,
MDSC
target
will
described.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(7), P. 815 - 815
Published: July 7, 2024
Colorectal
cancer
(CRC)
is
a
leading
cause
of
deaths
worldwide.
Despite
significant
advances
in
medical
treatment,
chemotherapy
as
monotherapy
can
lead
to
substantial
side
effects
and
chemoresistance.
This
underscores
the
need
for
therapeutic
approaches
that
are
not
only
pharmacologically
safe
but
also
modulate
multiple
potent
signaling
pathways
sensitize
cells
overcome
resistance
standard
drugs.
In
recent
years,
scientists
have
been
searching
natural
compounds
be
used
chemosensitizers
addition
conventional
medications
synergistic
treatment
CRC.
Polyphenols
represent
diverse
group
target
induce
anti-cancer
effects.
Additionally,
polyphenols
shown
work
synergistically
with
chemotherapeutics
other
cells.
review
aims
provide
comprehensive
insight
into
mechanisms
selected
CRC
Further
research
clinical
trials
warranted
fully
harness
combined
or
improving
outcomes.
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(15), P. 1294 - 1294
Published: July 31, 2024
Curcumin
is
a
nutraceutical
known
to
have
numerous
medicinal
effects
including
anticancer
activity.
However,
due
its
poor
water
solubility
and
bioavailability,
the
therapeutic
impact
of
curcumin
against
cancer,
breast
has
been
constrained.
Encapsulating
into
chitosan
nanoparticles
(CHNPs)
an
effective
method
increase
bioavailability
as
well
antitumorigenic
In
current
study,
curcumin-encapsulated
CHNPs
(Cur-CHNPs)
on
cell
migration,
targeted
homing
tumor
growth
were
examined
using
in
vitro
vivo
cancer
models.
Cur-CHNPs
possessed
monodispersed
nature
with
long-term
colloidal
stability,
demonstrated
significant
inhibition
viability
vitro,
which
was
potentiated
by
5-Fluorouracil
(5-FU).
Outcomes
imaging
studies
confirmed
targeting
retention
ability
Cur-CHNPs,
thereby
suppressing
mice
Overall,
results
that
could
be
candidate
drug
formulation
for
management
cancer.
