Biomedicine & Pharmacotherapy,
Journal Year:
2022,
Volume and Issue:
156, P. 113923 - 113923
Published: Oct. 29, 2022
Malignant
tumors
are
non-communicable
diseases
that
affect
human
life
health
and
quality
of
life.
Anti-tumour-related
research
has
also
been
the
focus
difficulty
in
oncology
research.
With
rise
metabolomics,
tumour
biology,
theory
reprogramming,
amino
acid
metabolic
reprogramming
become
a
new
target
for
antitumor
Amino
acids
provide
biomolecules
such
as
nucleotides
cell
proliferation,
invasion,
immune
escape
processes.
They
essential
metabolites
activation
effects
microenvironment.
Abnormal
changes
metabolism
closely
related
to
development
immunity.
Some
proteins
or
critical
enzymes
their
pathways
can
be
used
diagnosis
prognosis
assessment
markers.
Therefore,
this
paper
reviews
on
proliferation
abnormal
alterations
during
cycle
analyzes
prospects
therapeutic
drugs
targeting
metabolism.
This
provides
theoretical
references
in-depth
study
regulation
its
possible
targets.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: July 29, 2024
Amino
acid
metabolism
plays
a
pivotal
role
in
tumor
microenvironment,
influencing
various
aspects
of
cancer
progression.
The
metabolic
reprogramming
amino
acids
cells
is
intricately
linked
to
protein
synthesis,
nucleotide
modulation
signaling
pathways,
regulation
cell
metabolism,
maintenance
oxidative
stress
homeostasis,
and
epigenetic
modifications.
Furthermore,
the
dysregulation
also
impacts
microenvironment
immunity.
can
act
as
molecules
that
modulate
immune
function
tolerance
within
reshaping
anti-tumor
response
promoting
evasion
by
cells.
Moreover,
influence
behavior
stromal
cells,
such
cancer-associated
fibroblasts,
regulate
ECM
remodeling
promote
angiogenesis,
thereby
facilitating
growth
metastasis.
Understanding
intricate
interplay
between
crucial
significance.
Expanding
our
knowledge
multifaceted
roles
holds
significant
promise
for
development
more
effective
therapies
aimed
at
disrupting
dependencies
modulating
enhance
responses
inhibit
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(17)
Published: March 5, 2024
Abstract
Ferroptosis
and
apoptosis
are
key
cell‐death
pathways
implicated
in
several
human
diseases
including
cancer.
is
driven
by
iron‐dependent
lipid
peroxidation
currently
has
no
characteristic
biomarkers
or
gene
signatures.
Here
a
continuous
phenotypic
gradient
between
ferroptosis
coupled
to
transcriptomic
metabolomic
landscapes
established.
The
gradual
ferroptosis‐to‐apoptosis
landscape
used
generate
unique,
unbiased
predictor,
the
Gradient
Gene
Set
(GGS),
which
classified
with
high
accuracy.
Further
GGS
optimization
using
multiple
ferroptotic
apoptotic
datasets
revealed
highly
specific
biomarkers,
robustly
validated
vitro
vivo.
A
subset
of
associated
poor
prognosis
breast
cancer
patients
PDXs
contains
different
repressors.
Depletion
one
representative,
PDGFA‐assaociated
protein
1(PDAP1),
found
suppress
basal‐like
tumor
growth
mouse
model.
Omics
mechanistic
studies
that
enhanced
lysosomal
function,
glutaminolysis,
tricarboxylic
acid
(TCA)
cycle,
while
its
transition
into
attributed
endoplasmic
reticulum(ER)‐stress
phosphatidylethanolamine
(PE)‐to‐phosphatidylcholine
(PC)
metabolic
shift.
Collectively,
this
study
highlights
molecular
mechanisms
underlying
execution,
identified
predictive
signature
prognostic
value,
versus
repressors
for
therapy.
Genes & Diseases,
Journal Year:
2022,
Volume and Issue:
11(1), P. 218 - 233
Published: Dec. 28, 2022
Ribonucleotide
reductase
M2
(RRM2)
is
a
small
subunit
in
ribonucleotide
reductases,
which
participate
nucleotide
metabolism
and
catalyze
the
conversion
of
nucleotides
to
deoxynucleotides,
maintaining
dNTP
pools
for
DNA
biosynthesis,
repair,
replication.
RRM2
performs
critical
role
malignant
biological
behaviors
cancers.
The
structure,
regulation,
function
its
inhibitors
were
discussed.
gene
can
produce
two
transcripts
encoding
same
ORF.
expression
regulated
at
multiple
levels
during
processes
from
transcription
translation.
Moreover,
this
associated
with
resistance,
cell
death,
tumor
immunity.
In
order
develop
design
RRM2,
appropriate
strategies
be
adopted
based
on
different
mechanisms.
Thus,
greater
appreciation
characteristics
benefit
understanding
tumorigenesis,
resistance
cancer,
microenvironment.
RRM2-targeted
therapy
will
more
attention
future
therapeutic
approaches
enhancement
treatment
effects
amelioration
dismal
prognosis.
European Journal of Cell Biology,
Journal Year:
2022,
Volume and Issue:
101(3), P. 151225 - 151225
Published: April 13, 2022
Metabolic
alterations
have
been
observed
in
many
cancer
types.
The
deregulated
metabolism
has
thus
become
an
emerging
hallmark
of
the
disease,
where
is
frequently
rewired
to
aerobic
glycolysis.
This
led
concept
"metabolic
reprogramming",
which
therefore
extensively
studied.
Over
years,
it
characterized
enhancement
glycolysis,
key
mutations
some
enzymes
TCA
cycle,
and
increased
glucose
uptake,
are
used
by
cells
achieve
a
phenotype"
useful
gain
proliferation
advantage.
Many
studies
highlighted
detail
signaling
pathways
molecular
mechanisms
responsible
for
glycolytic
switch.
However,
glycolysis
not
only
metabolic
process
that
rely
on.
Oxidative
Phosphorylation
(OXPHOS),
gluconeogenesis
or
beta-oxidation
fatty
acids
(FAO)
may
be
involved
development
progression
several
tumors.
In
cases,
these
metabolisms
even
more
crucial
than
tumor
survival.
review
will
focus
on
contribution
survival
cancers.
We
also
analyze
balance
between
processes
regulated,
as
well
therapeutical
approaches
can
derive
from
their
study.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(5), P. 2150 - 2150
Published: Feb. 24, 2023
Arginine
is
a
semi-essential
amino
acid
which
becomes
wholly
essential
in
many
cancers
commonly
due
to
the
functional
loss
of
Argininosuccinate
Synthetase
1
(ASS1).
As
arginine
vital
for
plethora
cellular
processes,
its
deprivation
provides
rationale
strategy
combatting
arginine-dependent
cancers.
Here
we
have
focused
on
pegylated
deiminase
(ADI-PEG20,
pegargiminase)–mediated
therapy
from
preclinical
through
clinical
investigation,
monotherapy
combinations
with
other
anticancer
therapeutics.
The
translation
ADI-PEG20
first
vitro
studies
positive
phase
3
trial
depletion
cancer
highlighted.
Finally,
this
review
discusses
how
identification
biomarkers
that
may
denote
enhanced
sensitivity
beyond
ASS1
be
realized
future
practice,
thus
personalising
patients
cancer.
Discover Oncology,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: May 18, 2024
Abstract
Cellular
proliferation,
function
and
survival
is
reliant
upon
maintaining
appropriate
intracellular
polyamine
levels.
Due
to
increased
metabolic
needs,
cancer
cells
elevate
their
pools
through
coordinated
metabolism
uptake.
High
levels
of
polyamines
have
been
linked
more
immunosuppressive
tumor
microenvironments
(TME)
as
support
the
growth
many
cell
types
such
MDSCs,
macrophages
regulatory
T-cells.
As
other
pro-tumorigenic
are
highly
dependent
on
for
survival,
pharmacological
modulation
a
promising
therapeutic
strategy.
This
review
covers
roles
in
various
TME
including
both
immune
stromal
cells,
well
how
competition
nutrients,
namely
precursors,
influences
cellular
landscape
TME.
It
also
details
use
biomarkers
ways
which
depletion
can
increase
immunogenicity
reprogram
tumors
become
responsive
immunotherapy.
BMC Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: June 24, 2024
Abstract
Background
A
better
understanding
of
lung
cancer
etiology
and
the
development
screening
biomarkers
have
important
implications
for
prevention.
Methods
We
included
623
matched
case–control
pairs
from
Cancer
Prevention
Study
(CPS)
cohorts.
Pre-diagnosis
blood
samples
were
collected
between
1998
2001
in
CPS-II
Nutrition
cohort
2006
2013
CPS-3
sent
metabolomics
profiling
simultaneously.
Cancer-free
controls
at
time
case
diagnosis
1:1
to
cases
on
date
birth,
draw
date,
sex,
race/ethnicity.
Odds
ratios
(ORs)
95%
confidence
intervals
(CIs)
estimated
using
conditional
logistic
regression,
controlling
confounders.
The
Benjamini–Hochberg
method
was
used
correct
multiple
comparisons.
Results
Sphingomyelin
(d18:0/22:0)
(OR:
1.32;
CI:
1.15,
1.53,
FDR
=
0.15)
taurodeoxycholic
acid
3-sulfate
1.33;
1.14,
1.55,
positively
associated
with
risk.
Participants
diagnosed
within
3
years
had
a
55%
48%
higher
risk
per
standard
deviation
increase
natural
log-transformed
sphingomyelin
level,
while
26%
28%
those
beyond
years,
compared
controls.
Lipid
amino
metabolism
accounted
47%
80%
cancer-associated
metabolites
P
<
0.05
across
all
participants
subgroups.
Notably,
ever-smokers
exhibited
proportion
(
0.05)
xenobiotic-
lipid-associated
pathways,
whereas
never-smokers
showed
more
pronounced
involvement
acid-
metabolic
pathways.
Conclusions
This
is
largest
prospective
study
examining
untargeted
profiles
regarding
(d18:0/22:0),
sphingolipid,
3-sulfate,
bile
salt,
may
be
factors
potential
cancer.
contribute
significantly
which
varied
by
smoking
status.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 2, 2024
Pancreatic
cancer
is
a
highly
aggressive
malignant
tumor,
that
becoming
increasingly
common
in
recent
years.
Despite
advances
intensive
treatment
modalities
including
surgery,
radiotherapy,
biological
therapy,
and
targeted
the
overall
survival
rate
has
not
significantly
improved
patients
with
pancreatic
cancer.
This
may
be
attributed
to
insidious
onset,
unknown
pathophysiology,
poor
prognosis
of
disease.
It
therefore
essential
identify
develop
more
effective
safer
treatments
for
Tumor
immunotherapy
new
fourth
pillar
anti-tumor
therapy
after
chemotherapy.
Significant
progress
made
use
wide
variety
tumors
years;
breakthrough
also
been
review
describes
immune
checkpoint
inhibitors,
vaccines,
adoptive
cell
oncolytic
virus,
matrix-depletion
therapies
At
same
time,
some
potential
biomarkers
combinations
are
discussed.
The
molecular
mechanisms
various
immunotherapies
have
elucidated,
their
clinical
applications
highlighted.
current
challenges
associated
proposed
strategies
hold
promise
overcoming
these
limitations
discussed,
aim
offering
insights
into
