Cancer Immunology Immunotherapy, Journal Year: 2023, Volume and Issue: 72(6), P. 1673 - 1683
Published: Jan. 9, 2023
Language: Английский
Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)
Published: March 18, 2022
Abstract Research on tumor immunotherapy has made tremendous progress in the past decades, with numerous studies entering clinical evaluation. The cancer vaccine is considered a promising therapeutic strategy of solid tumors. Cancer stimulates anti-tumor immunity antigens, which could be delivered form whole cells, peptides, nucleic acids, etc . Ideal vaccines overcome immune suppression tumors and induce both humoral cellular immunity. In this review, we introduced working mechanism summarized four platforms for development. We also highlighted research vaccines, especially focusing their application efficacy, might hopefully facilitate future design vaccine.
Language: Английский
Citations
495
Journal of Translational Medicine, Journal Year: 2022, Volume and Issue: 20(1)
Published: March 14, 2022
Abstract Nanocarriers as drug/biomolecule delivery systems have been significantly developed during recent decades. Given the stability, reasonable efficiency, and safety of nanocarriers, there are several barriers in fulfillment successful clinical application these systems. These challenges encouraged drug researchers to establish innovative nanocarriers with longer circulation time, high compatibility. Exosomes extracellular nanometer-sized vesicles released through various cells. serve possessing great potential overcome some obstacles encountered gene due their natural affinity recipient cells inherent capability shuttle genes, lipids, proteins, RNAs between So far, has a lot valuable research on by exosomes, but RNA delivery, especially mRNA, is very limited. Since mRNA-based vaccines therapies recently gained particular prominence diseases, it essential find suitable system large size destructive nature nucleic acids. That's why we're going take look at unique features exosomes isolation loading methods, embrace this idea that exosome-mediated would be introduced efficient strategy disease treatment within near future. Graphical
Language: Английский
Citations
111
Biomarker Research, Journal Year: 2022, Volume and Issue: 10(1)
Published: May 12, 2022
Abstract Exosomes, ranging in size from 30 to 150 nm as identified initially via electron microscopy 1946, are one of the extracellular vesicles (EVs) produced by many cells and have been subject studies; initially, they were considered cell wastes with belief that exosomes maintain homeostasis. Nowadays, it has found EVs secreted different play a vital role cellular communication usually both physiological pathological conditions. Due presence markers ligands on surface exosomes, paracrine, endocrine autocrine effects some cases. Immune cells, like other can secrete interact surrounding these vesicles. system cells-derived (IEXs) induce responses, such increasing decreasing transcription various genes regulating cytokine production. This review deliberate function innate acquired immune derived their pathogenesis diseases, therapeutic appliances.
Language: Английский
Citations
100
Cancer Gene Therapy, Journal Year: 2023, Volume and Issue: 30(8), P. 1051 - 1065
Published: April 27, 2023
Language: Английский
Citations
48
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: Jan. 2, 2024
Abstract Background Immune escape, a process by which tumor cells evade immune surveillance, remains challenge for cancer therapy. Tumor produce extracellular vesicles (EVs) that participate in escape transferring bioactive molecules between cells. The main body of the abstract EVs refer to heterogeneous intercellular communication. from usually carry antigens and have been considered source induce anti-tumor immunity. However, evidence also suggests these can accelerate carrying heat shock proteins (HSPs), programmed death-ligand 1 (PD-L1), etc. cells, suppressing function exhausting pool. are progressively being evaluated therapeutic implementation therapies. EVs-based immunotherapies involve inhibiting generation, using natural EVs, harnessing engineering EVs. All approaches associated with advantages disadvantages. heterogeneity diverse physicochemical properties challenges their clinical applications. Short conclusion Although criminal; they be useful overcoming escape. This review discusses latest knowledge on population sheds light tumor-derived It describes focus engineered followed hinder translation essential addressed future investigations.
Language: Английский
Citations
30
Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 10
Published: Jan. 3, 2024
Extracellular vesicles (EVs) are membrane-enclosed particles secreted by a variety of cell types. These encapsulate diverse range molecules, including proteins, nucleic acids, lipids, metabolites, and even organelles derived from their parental cells. While EVs have emerged as crucial mediators intercellular communication, they also hold immense potential both biomarkers therapeutic agents for numerous diseases. A thorough understanding EV biogenesis is the development EV-based diagnostic developments since composition can reflect health disease status donor cell. Moreover, when taken up target cells, exert profound effects on gene expression, signaling pathways, cellular behavior, which makes these biomolecules enticing targets interventions. Yet, despite decades research, intricate processes underlying cells subsequent uptake recipient remain poorly understood. In this review, we aim to summarize current insights advancements in mechanisms EVs. By shedding light fundamental governing delivery, review underscores basic mechanistic research pave way developing novel strategies applications.
Language: Английский
Citations
30
ACS Omega, Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 5, 2024
In the realm of cancer immunotherapy, a profound evolution has ushered in sophisticated strategies that encompass both traditional vaccines and emerging viral vaccines. This comprehensive Review offers an in-depth exploration methodologies, clinical applications, success stories, future prospects these approaches. Traditional have undergone significant advancements utilizing diverse modalities such as proteins, peptides, dendritic cells. More recent innovations focused on physiological mechanisms enabling human body to recognize combat precancerous malignant cells, introducing specific markers like peptide-based anticancer targeting tumor-associated antigens. Moreover, vaccines, leveraging engineered viruses stimulate immune responses against antigens, exhibit substantial promise inducing robust enduring immunity. Integration with complementary therapeutic methods, including monoclonal antibodies, adjuvants, radiation therapy, not only improved survival rates but also deepened our understanding virulence. Recent strides vaccine design, encompassing oncolytic viruses, virus-like particles, vectors, mark frontier innovation. While advances hold immense potential, critical challenges must be addressed, for evasion, potential off-target effects, optimization genomes. landscape noteworthy take spotlight from use immunomodulatory agents enhancement innate adaptive collaboration. The emergence proteolysis-targeting chimeras (PROTACs) precision tools therapy is particularly exciting. With focus various cancers, melanoma formidable solid tumors, this critically assesses types mechanisms, barriers efficacy, safety profiles, immune-related adverse events, providing nuanced perspective underlying involving cytotoxic T natural killer underscores transformative cutting-edge technologies studies, molecular sequencing, artificial intelligence advancing field These expedite progress emphasize multidimensional rapidly evolving nature research, affirming its significance broader context therapy.
Language: Английский
Citations
19
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 17, 2025
Since their inception in the early 1960s, development and use of nanoscale materials have progressed tremendously, roles diverse fields ranging from human health to energy electronics are undeniable. The application nanotechnology inventions has revolutionized many aspects everyday life including various medical applications specifically drug delivery systems, maximizing therapeutic efficacy contained drugs by means bioavailability enhancement or minimization adverse effects. In this review, we utilize CAS Content Collection, a vast repository scientific information extracted journal patent publications, analyze trends nanoscience research relevant an effort provide comprehensive detailed picture field. We examine publication landscape area insights into current knowledge advances developments. review major classes nanosized routes, targeted diseases. outline most discussed concepts assess advantages nanocarriers. objective is broad overview evolving regarding challenges, evaluate growth opportunities. merit stems extensive, wide-ranging coverage up-to-date information, allowing unmatched breadth analysis in-depth insights.
Language: Английский
Citations
4
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: Feb. 14, 2025
Extracellular vesicles (EVs), nanoscale secreted by cells, have attracted considerable attention in recent years due to their role tumor immunomodulation. These facilitate intercellular communication transporting proteins, nucleic acids, and other biologically active substances, they exhibit a dual development immune evasion mechanisms. Specifically, EVs can assist cells evading surveillance attack impairing cell function or modulating immunosuppressive pathways, thereby promoting progression metastasis. Conversely, also transport release immunomodulatory factors that stimulate the activation regulation of system, enhancing body's capacity combat malignant diseases. This functionality presents promising avenues targets for immunotherapy. By examining biological characteristics influence on immunity, novel therapeutic strategies be developed improve efficacy relevance cancer treatment. review delineates complex immunomodulation explores potential implications approaches, aiming establish theoretical foundation provide practical insights advancement future EVs-based immunotherapy strategies.
Language: Английский
Citations
3
Autoimmunity Reviews, Journal Year: 2022, Volume and Issue: 22(3), P. 103260 - 103260
Published: Dec. 21, 2022
Language: Английский
Citations
64