The Impact of Alcohol Consumption Duration and Types on Colorectal Cancer: Insights from a Cross-Sectional Study in Medan, Indonesia DOI Open Access

Irma Yanti Rangkuti

Journal of Asian Multicultural Research for Medical and Health Science Study, Journal Year: 2024, Volume and Issue: 5(1), P. 1 - 6

Published: Feb. 10, 2024

Colorectal cancer is the third most common type of in world, Indonesia it fourth highest position. Nearly 1 million deaths a year were due to colorectal cancer. Alcohol increases risk developing This study aims analyze differences duration alcohol consumption people with and without relationship between incidence The research was carried out at Digestive Surgery Polyclinic, H. Adam Malik Hospital, Medan. Using primary secondary data involving 31 subjects. Subjects aged 30-80 years, 21 men, 10 women, 80.6% suffered from 28 (90.3%) consumed A most. mean sufferers those 14.76 ± 3.33 years 11.00 3.688 years. There difference cancer, not related

Language: Английский

Young-onset colorectal cancer DOI
Manon C.W. Spaander, Ann G. Zauber, Sapna Syngal

et al.

Nature Reviews Disease Primers, Journal Year: 2023, Volume and Issue: 9(1)

Published: April 27, 2023

Language: Английский

Citations

143
Dietary-Lifestyle Patterns and Colorectal Cancer Risk: Global Cancer Update Programme (CUP Global) Systematic Literature Review DOI Creative Commons
Anne H. Y. Chu, Kehuan Lin, Helen Croker

et al.

American Journal of Clinical Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

6
Epidemiology and biology of early onset colorectal cancer. DOI

Anand Venugopal,

John M. Carethers

PubMed, Journal Year: 2022, Volume and Issue: 21, P. 162 - 182

Published: Jan. 1, 2022

Colorectal cancer (CRC) is the third leading cause of cancer-related mortality in men or women United States. Average-risk screening that begins at age 50 years has reduced incidence and CRC those over age, whereas under (early onset colorectal (eoCRC)) recently dramatically increased. In this review, we summarize recent literature including risk factors for eoCRC, differences clinicopathologic presentation outcomes emerging evidence regarding molecular pathways are altered eoCRC compared to later (loCRC). Epidemiologic studies show predominance distal colon rectum, association with several modifiable factors, diabetes, obesity, diet, sedentary time, alcohol consumption smoking. Data potential prior antibiotic exposure microbiome alterations direct carcinogen still emerging. Aggressive features may be due delay diagnosis more aggressive tumor biology. EoCRC similar loCRC when matched stage, but overall greater higher frequency advanced disease a younger presentation, life-years lost. There only few evaluations date, findings increase TP53 CTNNB1 somatic mutation decrease APC, KRAS BRAF mutation, loCRC. Other include LINE-1 hypomethylation, absence microsatellite instability (MSI-H), presence chromosomal (CIN) stability (MACS). These now have not yet identified specific signature defining eoCRC. Further research evaluating genetic as well environmental triggers eoCRCs should provide clearer understanding inform targeted pre-symptomatic at-risk individuals.

Language: Английский

Citations

55
Mass spectrometry‐based extracellular vesicle micromolecule detection in cancer biomarker discovery: An overview of metabolomics and lipidomics DOI Creative Commons
Liyi Bai,

Fanqin Bu,

Xiangji Li

et al.

View, Journal Year: 2023, Volume and Issue: 4(5)

Published: May 1, 2023

Abstract Extracellular vesicles (EVs) become one of the most important sources cancer biomarkers during past decade due to their wide distribution in body fluids and physiological stability. Previous studies mainly focused on nucleic acids proteins, while lipids metabolites were largely neglected. Noticeably, many those micromolecules exhibited a high abundance EVs. Revealing metabolomics lipidomics EVs would provide more comprehensive information for biomarker discovery. With rapid development mass spectrometry (MS) facilities, MS‐based micromolecule detection has an emerging technique studies. Increasing evidence demonstrated presence EV‐associated different types samples (e.g., cell, urine, serum, stool), which promising performance diagnosis, prognosis, prediction treatment responses. This review aims summarize advances profiling discovery, with emphasis metabolomic lipidomic analytical techniques. Challenges this field, including minimum sample quantity, normalization methods, compound identifications, are also discussed along possible solutions.

Language: Английский

Citations

29
The research progress in the interaction between Candida albicans and cancers DOI Creative Commons

Dalang Yu,

Zhiping Liu

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 28, 2022

Candida albicans is an opportunistic pathogenic fungus, which tends to infect the host with defective immune function including cancer patients. A growing number of studies have shown that C. infection increases susceptibility such as oral, gastric, and colorectal cancer. Cancer anti-cancer treatment may also affect colonization albicans. promote development by damaging mucosal epithelium, inducing production carcinogens, triggering chronic inflammation Th17 cell-mediated response. In this article, we aim elaborate interaction between cancers summarize potential molecular mechanisms, so provide theoretical basis for prevention, diagnosis cancers.

Language: Английский

Citations

31
Cancer risk based on alcohol consumption levels: a comprehensive systematic review and meta-analysis DOI Creative Commons
Seunghee Jun, Hyunjin Park, Ui Jeong Kim

et al.

Epidemiology and Health, Journal Year: 2023, Volume and Issue: 45, P. e2023092 - e2023092

Published: Oct. 16, 2023

OBJECTIVES: Alcohol consumption is a well-established risk factor for cancer. Despite extensive research into the relationship between alcohol and cancer risk, effect of light on remains topic debate. To contribute to this discourse, we conducted comprehensive systematic review meta-analysis.METHODS: Our aimed investigate associations different levels several types. We focused analyzing prospective using data from 139 cohort studies. Among them, 106 studies were included in meta-analysis after quantitative synthesis.RESULTS: analysis did not find significant association all-cause (relative 1.02; 95% confidence interval, 0.99 1.04), but observed dose-response relationship. Light was significantly associated with higher risks esophageal, colorectal, breast cancers. moderate drinking elevated laryngeal, Heavy also found stomach, liver, pancreas, prostate cancers, thereby increasing almost all types Additionally, females generally had lower compared males.CONCLUSIONS: findings highlight that extend beyond heavy include as well. These suggest there no safe level risk. results underscore importance public health interventions addressing mitigate risks.

Language: Английский

Citations

19
Birth Cohort Colorectal Cancer (CRC): Implications for Research and Practice DOI Creative Commons
Samir Gupta, Folasade P. May,

Sonia S. Kupfer

et al.

Clinical Gastroenterology and Hepatology, Journal Year: 2023, Volume and Issue: 22(3), P. 455 - 469.e7

Published: Dec. 9, 2023

Colorectal cancer (CRC) epidemiology is changing due to a birth cohort effect, first recognized by increasing incidence of early onset CRC (EOCRC, age < 50 years). In this paper, we define "birth CRC" as the observed phenomenon, among individuals born 1960 and later, risk across successive cohorts, rising EOCRC incidence, 50-54 years, flattening prior decreasing 55-74 years. We demonstrate associated with unique features, including rectal (greater than colon) distant local) stage diagnosis, all racial/ethnic groups. review potential factors, etiologies, mechanisms for CRC, using starting point describing importance viewing these through lens cohort. also outline implications epidemiologic translational research, well current clinical practice. postulate that recognition an entity - extending beyond can advance understanding mechanisms, address public health consequences epidemiology.

Language: Английский

Citations

16
Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned DOI Creative Commons
Michelle C. Turner,

Vincent Cogliano,

Kathryn Z. Guyton

et al.

Environmental Health Perspectives, Journal Year: 2023, Volume and Issue: 131(10)

Published: Oct. 1, 2023

The International Agency for Research on Cancer (IARC) Monographs program assembles expert working groups who publish a critical review and evaluation of data agents interest. These comprehensive reviews provide unique opportunity to identify research needs address classification uncertainties. A multidisciplinary workshop held in 2009 identified gaps 20 priority occupational chemicals, metals, dusts, physical agents, with the goal stimulating advances epidemiological studies cancer carcinogen mechanisms. Overarching issues were also described.

Language: Английский

Citations

14
Colon cancer transcriptome DOI

Khatere Mokhtari,

Maryam Peymani, Mohsen Rashidi

et al.

Progress in Biophysics and Molecular Biology, Journal Year: 2023, Volume and Issue: 180-181, P. 49 - 82

Published: April 13, 2023

Language: Английский

Citations

12
Modulation of Intestinal Signal Transduction Pathways: Implications on Gut Health and Disease DOI

Muskan Verma,

Manika Garg,

Pawan Yadav

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177531 - 177531

Published: March 1, 2025

Language: Английский

Citations

0