Frontiers in Cellular and Infection Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: April 28, 2025
Arthropod-borne
viruses,
or
arboviruses,
are
currently
considered
a
global
health
threat
responsible
for
potentially
severe
human
diseases.
The
increased
population
density,
changes
in
land
use
and
climate
change
some
of
the
factors
that
contributing
to
spread
these
infections
over
last
years.
pathogenesis
diseases
mechanisms
interaction
with
host,
especially
those
leading
development
forms,
yet
be
fully
understood.
In
recent
years
extracellular
vesicles
(EVs)
have
emerged
as
important
players
inter-cellular
host-pathogen
arising
lot
interest
also
field
vector-borne
viruses.
this
context,
EVs
seem
play
dual
role,
by
either
promoting,
thus
facilitating,
preventing
infection.
Many
studies
showing
how
viruses
can
hijack
vesiculation
machinery
escape
host
immune
response
exploit
sustain
their
replication
propagation,
even
though
shed
cells
essential
promote
antiviral
responses.
manuscript
we
reviewed
current
knowledge
regarding
association
between
paying
particular
attention
possible
role
disease
transmission
dissemination,
well
potential
novel
tools
clinical
applications,
spanning
from
biomarkers
utility
therapeutic
options.
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Oct. 6, 2023
Abstract
Pancreatic
cancer
(PC)
is
one
of
the
most
common
malignancies.
Surgical
resection
a
potential
curative
approach
for
PC,
but
patients
are
unsuitable
operations
when
at
time
diagnosis.
Even
with
surgery,
some
may
still
experience
tumour
metastasis
during
operation
or
shortly
after
as
precise
prognosis
evaluation
not
always
possible.
If
miss
opportunity
surgery
and
resort
to
chemotherapy,
they
face
challenging
issue
chemotherapy
resistance.
In
recent
years,
liquid
biopsy
has
shown
promising
prospects
in
disease
diagnosis,
treatment
monitoring,
assessment.
As
noninvasive
detection
method,
offers
advantages
over
traditional
diagnostic
procedures,
such
tissue
biopsy,
terms
both
cost-effectiveness
convenience.
The
information
provided
by
helps
clinical
practitioners
understand
molecular
mechanisms
underlying
occurrence
development,
enabling
formulation
more
personalized
decisions
each
patient.
This
review
introduces
biomarkers
methods
including
circulating
cells
(CTCs),
DNA
(ctDNA),
noncoding
RNAs
(ncRNAs),
extracellular
vesicles
(EVs)
exosomes.
Additionally,
we
summarize
applications
early
response,
resistance
assessment,
prognostic
PC.
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2024,
Volume and Issue:
43(1)
Published: April 1, 2024
Abstract
Lung
cancer
stands
as
the
most
prevalent
form
of
globally,
posing
a
significant
threat
to
human
well-being.
Due
lack
effective
and
accurate
early
diagnostic
methods,
many
patients
are
diagnosed
with
advanced
lung
cancer.
Although
surgical
resection
is
still
potential
means
eradicating
cancer,
usually
miss
best
chance
for
treatment,
even
after
may
experience
tumor
recurrence.
Additionally,
chemotherapy,
mainstay
treatment
has
be
chemo-resistant,
resulting
in
poor
clinical
outcomes.
The
emergence
liquid
biopsies
garnered
considerable
attention
owing
their
noninvasive
nature
ability
continuous
sampling.
Technological
advancements
have
propelled
circulating
cells
(CTCs),
DNA
(ctDNA),
extracellular
vesicles
(EVs),
metabolites,
tumor-educated
platelets
(TEPs),
tumor-associated
antigens
(TAA)
forefront
key
biopsy
biomarkers,
demonstrating
intriguing
encouraging
results
diagnosis
prognostic
evaluation
This
review
provides
an
overview
molecular
biomarkers
assays
utilized
encompassing
CTCs,
ctDNA,
non-coding
RNA
(ncRNA),
EVs,
TAAs
TEPs.
Furthermore,
we
expound
on
practical
applications
biopsies,
including
diagnosis,
response
monitoring,
evaluation,
recurrence
monitoring
context
Nano Convergence,
Journal Year:
2024,
Volume and Issue:
11(1)
Published: May 29, 2024
Abstract
Liquid
biopsy
has
emerged
as
a
promising
non-invasive
strategy
for
cancer
diagnosis,
enabling
the
detection
of
various
circulating
biomarkers,
including
tumor
cells
(CTCs),
nucleic
acids
(ctNAs),
tumor-derived
small
extracellular
vesicles
(sEVs),
and
proteins.
Surface-enhanced
Raman
scattering
(SERS)
biosensors
have
revolutionized
liquid
by
offering
sensitive
specific
methodologies
these
biomarkers.
This
review
comprehensively
examines
application
SERS-based
identification
analysis
biomarkers
CTCs,
ctNAs,
sEVs
proteins
in
diagnosis.
The
discussion
encompasses
diverse
range
SERS
biosensor
platforms,
label-free
assay,
magnetic
bead-based
microfluidic
device-based
system,
paper-based
each
demonstrating
unique
capabilities
enhancing
sensitivity
specificity
critically
assesses
strengths,
limitations,
future
directions
Journal of Extracellular Vesicles,
Journal Year:
2024,
Volume and Issue:
13(10)
Published: Sept. 27, 2024
Abstract
This
systematic
review
examines
the
landscape
of
extracellular
vesicle
(EV)‐related
clinical
trials
to
elucidate
field's
trends
in
applications
and
EV‐related
methodologies,
with
an
additional
focus
on
acknowledgement
EV
subpopulations.
By
analysing
data
from
public
reporting
repositories,
we
catalogued
471
date,
indications
for
over
200
diseases.
Diagnostics
companion
diagnostics
represented
bulk
cancer
being
most
frequent
application.
therapeutics
mainly
utilized
mesenchymal
stromal
cell
(MSC)
EVs
were
frequently
used
treatment
respiratory
illnesses.
Ultracentrifugation
RNA‐sequencing
common
isolation
characterization
techniques;
however,
methodology
each
was
not
reported
study
records.
Most
relied
isolates,
only
11%
utilizing
subpopulations
their
experimental
design.
While
this
may
be
connected
a
lack
available
techniques
suitable
implementation,
it
also
highlights
opportunity
use
improve
translational
efforts.
As
academic
research
identifies
more
chemically
distinct
technologies
enrichment,
forecast
refined
near
future.
emphasizes
need
meticulous
methodological
consideration
enhance
success
EV‐based
interventions,
pointing
towards
paradigm
shift
personalized
medicine.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2730 - 2730
Published: Feb. 27, 2024
Extracellular
vesicles
(EVs),
a
diverse
group
of
cell-derived
exocytosed
particles,
are
pivotal
in
mediating
intercellular
communication
due
to
their
ability
selectively
transfer
biomolecules
specific
cell
types.
EVs,
composed
proteins,
nucleic
acids,
and
lipids,
taken
up
by
cells
affect
variety
signaling
cascades.
Research
the
field
has
primarily
focused
on
stem
with
particular
focus
mesenchymal
cells,
for
potential
therapeutic
benefits.
Recently,
tissue-specific
EVs
or
type-specific
extracellular
(CTS-EVs),
have
garnered
attention
unique
biogenesis
molecular
composition
because
they
enable
highly
targeted
cell-specific
communication.
Various
studies
outlined
roles
that
CTS-EVs
play
physiological
function
maintenance
homeostasis,
including
immune
modulation,
tissue
regeneration,
organ
development.
These
properties
also
exploited
disease
propagation,
such
as
cancer,
neurological
disorders,
infectious
diseases,
autoimmune
conditions,
more.
The
insights
gained
from
analyzing
different
biological
not
only
enhance
our
understanding
pathogenesis
but
open
new
avenues
innovative
diagnostic
biomarkers
targets
wide
spectrum
medical
conditions.
This
review
comprehensively
outlines
current
CTS-EV
origins,
within
normal
physiology,
implications
diseased
states.
Genes,
Journal Year:
2024,
Volume and Issue:
15(4), P. 501 - 501
Published: April 17, 2024
Glioblastoma,
the
most
aggressive
and
common
malignant
primary
brain
tumour,
is
characterized
by
infiltrative
growth,
abundant
vascularization,
clinical
evolution.
Patients
with
glioblastoma
often
face
poor
prognoses,
a
median
survival
of
approximately
15
months.
Technological
progress
subsequent
improvement
in
understanding
pathophysiology
these
tumours
have
not
translated
into
significant
achievements
therapies
or
outcomes
for
patients.
Progress
molecular
profiling
has
yielded
new
omics
data
more
refined
classification
glioblastoma.
Several
typical
genetic
epigenetic
alterations
include
mutations
genes
regulating
receptor
tyrosine
kinase
(RTK)/rat
sarcoma
(RAS)/phosphoinositide
3-kinase
(PI3K),
p53,
retinoblastoma
protein
(RB)
signalling,
as
well
mutation
isocitrate
dehydrogenase
(IDH),
methylation
O6-methylguanine-DNA
methyltransferase
(MGMT),
amplification
epidermal
growth
factor
vIII,
codeletion
1p/19q.
Certain
microRNAs,
such
miR-10b
miR-21,
also
been
identified
prognostic
biomarkers.
Effective
treatment
options
are
limited.
Surgery,
radiotherapy,
alkylating
agent
chemotherapy
remain
pillars
treatment.
Only
promoter
gene
MGMT
predicts
benefit
from
temozolomide
it
guides
choice
first-line
elderly
targeted
strategies
based
on
tumour-intrinsic
dominant
signalling
pathways
antigenic
tumour
profiles
under
investigation
trials.
This
review
explores
potential
biomarkers
that
could
be
deployed
analytical
tools
diagnosis
prognostication
Recent
advancements
treating
discussed,
along
liquid
biopsies
to
advance
personalized
medicine
field
glioblastoma,
highlighting
challenges
promises
future.
Journal of Hematology & Oncology,
Journal Year:
2025,
Volume and Issue:
18(1)
Published: Jan. 13, 2025
The
tumor
microenvironment
(TME)
is
integral
to
cancer
progression,
impacting
metastasis
and
treatment
response.
It
consists
of
diverse
cell
types,
extracellular
matrix
components,
signaling
molecules
that
interact
promote
growth
therapeutic
resistance.
Elucidating
the
intricate
interactions
between
cells
TME
crucial
in
understanding
progression
challenges.
A
critical
process
induced
by
epithelial-mesenchymal
transition
(EMT),
wherein
epithelial
acquire
mesenchymal
traits,
which
enhance
their
motility
invasiveness
progression.
By
targeting
various
components
TME,
novel
investigational
strategies
aim
disrupt
TME's
contribution
EMT,
thereby
improving
efficacy,
addressing
resistance,
offering
a
nuanced
approach
therapy.
This
review
scrutinizes
key
players
emphasizing
avenues
therapeutically
components.
Moreover,
article
discusses
implications
for
resistance
mechanisms
highlights
current
toward
modulation
along
with
potential
caveats.
Biomaterials Research,
Journal Year:
2023,
Volume and Issue:
27(1)
Published: Feb. 9, 2023
Cancer
is
a
complex
illness
that
presents
significant
challenges
in
its
understanding
and
treatment.
The
classic
definition,
"a
group
of
diseases
characterized
by
the
uncontrolled
growth
spread
abnormal
cells
body,"
fails
to
convey
intricate
interaction
between
many
entities
involved
cancer.
Recent
advancements
field
cancer
research
have
shed
light
on
role
played
individual
tumor
microenvironment
as
whole
development
progression.
This
breakthrough
enables
utilization
components
biological
tools,
opening
new
possibilities.
article
delves
deeply
into
concept
"tumor-derived
systems",
an
umbrella
term
for
tools
sourced
from
aid
combatting
it.
It
includes
cell
membrane-coated
nanoparticles
(for
theranostics),
extracellular
vesicles
diagnosis/therapy),
lysates
vaccine
development),
engineered
cells/organoids
research).
review
seeks
offer
complete
overview
tumor-derived
materials
are
utilized
research,
well
their
current
stages
implementation.
aimed
primarily
at
researchers
working
interface
biology
biomedical
engineering,
it
provides
vital
insights
this
fast-growing
topic.
Neuro-Oncology,
Journal Year:
2024,
Volume and Issue:
26(7), P. 1280 - 1291
Published: April 2, 2024
Abstract
Background
Extracellular
vesicles
(EVs)
obtained
by
noninvasive
liquid
biopsy
from
patient
blood
can
serve
as
biomarkers.
Here,
we
investigated
the
potential
of
circulating
plasma
EVs
to
an
indicator
in
diagnosis,
prognosis,
and
treatment
response
glioblastoma
patients.
Methods
Plasma
samples
were
collected
patients
at
multiple
timepoints
before
after
surgery.
EV
concentrations
measured
nanoparticle
tracking
analysis
imaging
flow
cytometry.
Tumor
burden
edema
quantified
3D
reconstruction.
tumors
further
monitored
glioma-bearing
mice.
Results
Glioblastoma
displayed
a
5.5-fold
increase
compared
healthy
donors
(P
<
.0001).
Patients
with
higher
levels
had
significantly
shorter
overall
survival
progression-free
than
lower
levels,
concentration
was
independent
prognostic
parameter
for
survival.
correlated
extent
peritumoral
fluid-attenuated
inversion
recovery
hyperintensity
but
not
size
contrast-enhancing
tumor,
similar
findings
Postoperatively,
decreased
rapidly
back
normal
magnitude
decline
associated
tumor
resection.
remained
low
during
stable
disease,
increased
again
upon
recurrence.
In
some
patients,
resurgence
preceded
magnetic
resonance
detectability
relapse.
Conclusions
Our
suggest
that
leakiness
blood-brain
barrier
may
primarily
be
responsible
high
Elevated
reflect
presence,
their
quantification
thus
valuable
assessing
disease
activity.
