International Journal of Cancer,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 20, 2024
Abstract
Fibroblasts
are
important
components
in
the
tumor
microenvironment
and
can
affect
progression
metastasis.
However,
roles
of
genetic
variants
fibroblast‐related
genes
(FRGs)
prognosis
non–small‐cell
lung
cancer
(NSCLC)
patients
have
not
been
reported.
Therefore,
we
investigated
associations
between
26,544
single
nucleotide
polymorphisms
(SNPs)
291
FRGs
survival
NSCLC
from
Prostate,
Lung,
Colorectal,
Ovarian
(PLCO)
Cancer
Screening
Trial.
In
Cox
regression
multivariable
analysis,
found
that
661
SNPs
were
associated
with
overall
(OS).
Then
validated
these
another
independent
replication
dataset
984
Harvard
Lung
Susceptibility
(HLCS)
Study.
Finally,
identified
two
(i.e.,
FER
rs7716388
A>G
SULF1
rs11785839
G>C)
remained
significantly
hazards
ratios
(HRs)
0.87
(95%
confidence
interval
[CI]
=
0.77–0.98,
p
0.018)
0.88
CI
0.79–0.99,
0.033),
respectively.
Combined
analysis
for
showed
number
protective
alleles
was
better
OS
disease‐specific
survival.
Expression
quantitative
trait
loci
indicated
G
allele
up‐regulation
mRNA
expression
levels
tissue.
Our
results
functional
may
be
prognostic
biomarkers
patients,
possible
mechanism
through
modulating
their
corresponding
genes.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9463 - 9463
Published: Aug. 30, 2024
Colorectal
cancer
(CRC)
represents
a
significant
global
health
burden,
with
high
incidence
and
mortality
rates
worldwide.
Recent
progress
in
research
highlights
the
distinct
clinical
molecular
characteristics
of
colon
versus
rectal
cancers,
underscoring
tumor
location's
importance
treatment
approaches.
This
article
provides
comprehensive
review
our
current
understanding
CRC
epidemiology,
risk
factors,
pathogenesis,
management
strategies.
We
also
present
intricate
cellular
architecture
colonic
crypts
their
roles
intestinal
homeostasis.
carcinogenesis
multistep
processes
are
described,
covering
conventional
adenoma-carcinoma
sequence,
alternative
serrated
pathways,
influential
Vogelstein
model,
which
proposes
sequential
Non-coding RNA Research,
Journal Year:
2024,
Volume and Issue:
9(3), P. 678 - 686
Published: Feb. 23, 2024
Brain
metastases
represent
a
formidable
challenge
in
cancer
management,
impacting
significant
number
of
patients
and
contributing
significantly
to
cancer-related
mortality.
Conventional
diagnostic
methods
frequently
fall
short,
underscoring
the
imperative
for
non-invasive
alternatives.
Non-coding
RNAs
(ncRNAs),
specifically
microRNAs
(miRNAs)
long
non-coding
(lncRNAs),
present
promising
avenues
exploration.
These
ncRNAs
exert
influence
over
prognosis
treatment
resistance
brain
metastases,
offering
valuable
insights
into
underlying
mechanisms
potential
therapeutic
targets.
Dysregulated
have
been
identified
originating
from
various
primary
cancers,
unveiling
opportunities
intervention
prevention.
The
analysis
ncRNA
expression
bodily
fluids,
such
as
serum
cerebrospinal
fluid,
provides
noninvasive
means
differentiate
tumors.
NcRNAs,
particularly
miRNAs,
assume
pivotal
role
orchestrating
immune
response
within
microenvironment.
MiRNAs
exhibit
promise
diagnosing
effectively
distinguishing
between
normal
cells,
pinpointing
tissue
origin
metastatic
manipulation
miRNAs
holds
substantial
treatment,
prospect
reducing
toxicity
enhancing
efficacy.
Given
limited
options
threat
patients,
RNAs,
especially
emerge
beacons
hope,
serving
both
tools
Further
clinical
studies
are
validate
specificity
sensitivity
ncRNAs,
potentially
reshaping
approaches
tackle
this
elevate
outcomes
affected
patients.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(6), P. 1709 - 1709
Published: June 14, 2023
Chemotherapy
resistance
is
still
a
serious
problem
in
the
treatment
of
most
cancers.
Many
cellular
and
molecular
mechanisms
contribute
to
both
inherent
acquired
drug
resistance.
They
include
use
unaffected
growth-signaling
pathways,
changes
tumor
microenvironment,
active
transport
medicines
out
cell.
The
antioxidant
capacity
polyphenols
their
potential
inhibit
activation
procarcinogens,
cancer
cell
proliferation,
metastasis,
angiogenesis,
as
well
promote
inhibition
or
downregulation
efflux
transporters,
have
been
linked
reduced
risk
epidemiological
studies.
Polyphenols
also
ability
alter
immunological
responses
inflammatory
cascades,
trigger
apoptosis
cells.
discovery
relationship
between
abnormal
growth
signaling
metabolic
dysfunction
cells
highlights
importance
further
investigating
effects
dietary
polyphenols,
including
boost
efficacy
chemotherapy
avoid
multidrug
(MDR).
Here,
it
summarized
what
known
regarding
effectiveness
natural
polyphenolic
compounds
counteracting
that
might
develop
drugs
result
variety
different
mechanisms.
Frontiers in Cell and Developmental Biology,
Journal Year:
2023,
Volume and Issue:
11
Published: Oct. 3, 2023
Successful
clinical
methods
for
tumor
elimination
include
a
combination
of
surgical
resection,
radiotherapy,
and
chemotherapy.
Radiotherapy
is
one
the
crucial
components
cancer
treatment
regimens
which
allow
to
extend
patient
life
expectancy.
Current
cutting-edge
radiotherapy
research
focused
on
identification
that
should
increase
cell
sensitivity
radiation
activate
anti-cancer
immunity
mechanisms.
Radiation
activates
various
cells
microenvironment
(TME)
impacts
growth,
angiogenesis,
immunity.
was
shown
regulate
signaling
functions
TME
immune
vasculature
components,
including
tumor-associated
macrophages,
dendritic
cells,
endothelial
cancer-associated
fibroblasts
(CAFs),
natural
killers,
other
T
subsets.
Dual
effects
radiation,
metastasis-promoting
activation
oxidative
stress,
have
been
detected,
suggesting
triggers
heterogeneous
targets.
In
this
review,
we
critically
discuss
angiogenesis
during
used
strengthen
novel
immunotherapy.
Intracellular,
genetic,
epigenetic
mechanisms
manipulations
responses
stress
by
are
accented.
findings
indicate
be
considered
as
supporting
instrument
immunotherapy
limit
cancer-promoting
TME.
To
cancer-free
survival
rates,
it
recommended
combine
personalized
therapy
with
TME-targeting
drugs,
checkpoint
inhibitors.
Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: June 7, 2024
Abstract
Cellular
communication
(CC)
influences
tumor
development
by
mediating
intercellular
junctions
between
cells.
However,
the
role
and
underlying
mechanisms
of
CC
in
malignant
transformation
remain
unknown.
Here,
we
investigated
spatiotemporal
heterogeneity
molecular
expression
during
transformation.
It
was
found
that
although
both
tight
(TJs)
gap
(GJs)
were
involved
maintaining
microenvironment
(TME),
they
exhibited
opposite
characteristics.
Mechanistically,
for
epithelial
cells
(parenchymal
component),
TJ
molecules
consistently
decreased
normal-cancer
is
a
potential
oncogenic
factor.
For
fibroblasts
(mesenchymal
GJs
increased
In
addition,
profiles
TJs
used
to
stratify
colorectal
cancer
(CRC)
patients,
where
subtypes
characterized
high
GJ
levels
low
enhanced
mesenchymal
signals.
Importantly,
propose
leiomodin
1
(LMOD1)
biphasic,
with
features
GJs.
LMOD1
not
only
promotes
activation
cancer-associated
(CAFs)
but
also
inhibits
Epithelial–mesenchymal
transition
(EMT)
program
conclusion,
these
findings
demonstrate
provide
new
insights
into
further
understanding
TME
heterogeneity.
Graphical
Frontiers in Molecular Biosciences,
Journal Year:
2024,
Volume and Issue:
11
Published: May 28, 2024
The
interaction
between
the
tumor
microenvironment
(TME)
and
cancer
cells
is
a
complex
mutually
beneficial
system
that
leads
to
rapid
proliferation,
metastasis,
resistance
therapy.
It
now
recognized
are
not
isolated,
progression
governed
among
others,
by
many
components
of
TME.
reciprocal
cross-talk
their
can
be
indirect
through
secretion
extracellular
matrix
(ECM)
proteins
paracrine
signaling
exosomes,
cytokines,
growth
factors,
or
direct
cell-to-cell
contact
mediated
cell
surface
receptors
adhesion
molecules.
Among
TME
components,
cancer-associated
fibroblasts
(CAFs)
unique
interest.
As
one
most
abundant
TME,
CAFs
play
key
roles
in
reorganization
matrix,
facilitating
metastasis
chemotherapy
evasion.
Both
have
been
described
for
modulating
progression.
In
this
review,
we
focus
on
recent
advances
understanding
role
driving
development
metastasis.
We
also
summarize
findings
resistance.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(15), P. 8253 - 8253
Published: July 28, 2024
The
effects
of
low-dose
radiation
exposure
remain
a
controversial
topic
in
biology.
This
study
compares
early
(0.5,
4,
24,
48,
and
72
h)
late
(5,
10,
15
cell
passages)
post-irradiation
changes
γH2AX,
53BP1,
pATM,
p-p53
(Ser-15)
foci,
proliferation,
autophagy,
senescence
primary
fibroblasts
exposed
to
100
2000
mGy
X-ray
radiation.
results
show
that
significantly
increased
pATM
foci
only
at
0.5
4
h
post
irradiation.
There
were
no
or
up
passages
irradiation
the
low
dose.
