Relevance of Conventional Herbal Remedies in the Prevention and Treatment of Malignant Tumors: Looking Toward the Future DOI
Priyanka Bajpai, Phool Chandra

Current Cancer Therapy Reviews, Journal Year: 2024, Volume and Issue: 21(1), P. 54 - 75

Published: Jan. 17, 2024

: The second most prevalent cause of fatalities globally is malignant tumors. avoidance and therapy cancer proliferation still have many prospects for betterment despite enormous advancements. Chemotherapy can occasionally a lot unfavorable adverse reactions. Novel agents from botanicals, especially the use therapeutic ingredients, may decrease negative consequences. There are currently several products plants used fighting cancer. However, numerous plant chemicals not yet been examined in people but show extremely encouraging invitro anti-cancer properties. Further research required to determine whether these beneficial treating human cancers. present work has focused on various traditional herbal remedies phytochemicals that exhibited promising anticancer impact. desirable activity be due novel isolated sources. investigations address natural ingredients treatment chemoprevention now being clinical settings and/or undergoing studies. Potential concentrating naturally drugs create an entirely avenue fight against could significantly boost chance survival patients.

Language: Английский

Preparation and characterization of Sorafenib nano-emulsion: impact on pharmacokinetics and toxicity; an in vitro and in vivo study DOI Creative Commons
Dalia Zaafar, Heba M. A. Khalil,

Gehad E. Elkhouly

et al.

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(11), P. 3089 - 3111

Published: March 2, 2024

Abstract Hepatocellular carcinoma (HCC) ranks as the third leading cause of cancer-related deaths worldwide. Current treatment strategies include surgical resection, liver transplantation, liver-directed therapy, and systemic therapy. Sorafenib (Sor) is first drug authorized by US Food Drug Administration (FDA) for HCC treatment. Nevertheless, conventional oral administration Sor presents several limitations: poor solubility, low bioavailability, resistance development, off-target tissue accumulation, to numerous adverse effects. Nano-emulsion, a nano-delivery system, viable carrier poorly water-soluble drugs. It aims enhance target organ reduce exposure, thus improving therapeutic outcomes while minimizing side This study formulated nano-emulsion (Sor NanoEm) using homogenization technique. The resultant was characterized particle size (121.75 ± 12 nm), polydispersity index (PDI; 0.310), zeta potential (-12.33 1.34 mV), viscosity (34,776 3276 CPs), pH (4.38 0.3). Transmission Electron Microscopy exhibited spherical nano-droplets with no aggregation signs indicating stability. Furthermore, encapsulation within sustained its release, potentially reducing frequency doses. Cytotoxicity assessments on HepG2 cell line revealed that NanoEm had significantly (P < 0.05) more potent cytotoxic effect compared suspension. Subsequent tests highlighted superior pharmacokinetic parameters reduced dosage requirements in mice. an enhanced safety profile, particularly behavior, brain, liver, suspended form. These findings underscore pharmacological toxicological attributes suggesting utility Graphical abstract

Language: Английский

Citations

11
Translational Insights into Molecular Mechanisms of Chemical Hepatocarcinogenesis for Improved Human Risk Assessment DOI Open Access

Tamer A. Addissouky

Advances in Clinical Toxicology, Journal Year: 2024, Volume and Issue: 9(1), P. 1 - 8

Published: Jan. 1, 2024

Background: Hepatocellular carcinoma (HCC) is a prevalent liver cancer with major risk factors being hepatitis viral infections, alcohol, non-alcoholic fatty disease, and aflatoxin exposure. Both genotoxic non-genotoxic agents can induce HCC through mechanisms involving DNA damage, oxidative stress, chronic inflammation, disrupted signaling pathways like MAPK/ERK, PI3K/AKT, WNT/β-catenin PPARα. While rodent assays are utilized to detect potential chemical hepatocarcinogens, species differences in PPARα CAR/PXR activation impact human assessment. Purpose: This analysis provides an updated, critical examination of concordance hepatic carcinogenesis inform safety assessment tumor findings. Main Body: Rodent including 2-year bioassays, transgenic models, short-term studies tumors lifetime exposure or early biomarkers. However, rodent-specific activation, along hepatitis, highlight key interspecies differences. Determining mode action relevance requires evaluating mechanistic validity pivotal events leading across species. Non-genotoxic compounds eliciting activate PPARα, CAR/PXR, other triggering increased cell replication; but downstream may differ liver. Understanding applicability these humans as well incorporating into experimental models for accurate Conclusion: In summary, elucidating conserved versus divergent molecular between rodents essential appropriately interpreting findings safeguarding health science-based frameworks regulatory decision-making processes around hazards.

Language: Английский

Citations

11
Spermidine synthase promotes liver cancer progression in a paracrine manner by altering the macrophage immunometabolic state DOI

Sihang Yu,

Yuanxin Zhao, Qingqing Liu

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 155, P. 108135 - 108135

Published: Jan. 7, 2025

Language: Английский

Citations

1
Antimony-induced hippocampal neuronal impairment through ferroptosis activation from NCOA4-mediated ferritinophagy DOI

Shali Yu,

Zhiqiang Qin, Yuqing Chen

et al.

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111415 - 111415

Published: Feb. 1, 2025

Language: Английский

Citations

1
Transcription Factor MAZ Potentiates the Upregulated NEIL3-mediated Aerobic Glycolysis, thereby Promoting Angiogenesis in Hepatocellular Carcinoma DOI

Fabiao Zhang,

Binfeng Wang, Wenlong Zhang

et al.

Current Cancer Drug Targets, Journal Year: 2024, Volume and Issue: 24(12), P. 1235 - 1249

Published: Feb. 13, 2024

Hepatocellular carcinoma (HCC) is characterized by high vascularity and notable abnormality of blood vessels, where angiogenesis a key process in tumorigenesis metastasis. The main functions Nei Like DNA Glycosylase 3 (NEIL3) include alcoholization repair, immune response regulation, nervous system development function, damage signal transduction. However, the underlying mechanism expression NEIL3 progression HCC whether absence or silencing inhibits cancer remain unclear. Therefore, deeper understanding mechanisms which increased promotes needed.

Language: Английский

Citations

6
Juan-tong-yin potentially impacts endometriosis pathophysiology by enhancing autophagy of endometrial stromal cells via unfolded protein reaction-triggered endoplasmic reticulum stress DOI

Fengyun Meng,

Jing Li, Kun Dong

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 325, P. 117859 - 117859

Published: Feb. 3, 2024

Language: Английский

Citations

5
Identification of Erzhu Jiedu Recipe and its molecular mechanism underlying inhibited human hepatoma cells by UHPLC-Q-Exactive Orbitrap HRMS and network pharmacology DOI
Fangyuan Wang, Jingyin Mai, Haoyi Wang

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 325, P. 117893 - 117893

Published: Feb. 7, 2024

Language: Английский

Citations

5
Polygonatum sibiricum Saponin Prevents Immune Dysfunction and Strengthens Intestinal Mucosal Barrier Function in Cyclophosphamide-Induced Immunosuppressed BALB/c Mice DOI Creative Commons

Dongyun Zhao,

Huanhuan Liu, Chunhong Yan

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(6), P. 934 - 934

Published: March 19, 2024

The aim of this study was to explore the immunomodulatory effect Polygonatum sibiricum saponin (PS) in a cyclophosphamide-induced (Cy) immunosuppression mice model. Oral administration PS by gavage effectively alleviated weight loss caused Cy and increased index immune organs. promoted proliferation splenic lymphocytes T cell subsets (CD3+, CD355+, CD4+/CD8+) relieved xylene-induced inflammatory response Cy-induced increase serum hemolysin. Moreover, levels lactate dehydrogenase acid phosphatase. elevated level cytokines immunoglobulins (TNF-α, IFN-γ, IL-4, IL-6, IL-β, SIgA, IgG) expression mRNA IL-10, TNF-α, IL-6 spleen. Increased tight junction protein (ZO-1, Mucin2, Occludin) IL-6/MyD88/TLR4 small intestine showed that exhibited restorative on intestinal mucosal injury cyclophosphamide. prevented decline leukocytes, red blood cells, lymphocytes, hemoglobin concentrations, neutrophils, providing evidence for alleviating hematopoietic disorders. In addition, SOD NO levels, reduced MDA improved oxidative damage liver. These findings demonstrate has potential be developed as supplemental agent chemotherapeutic agents.

Language: Английский

Citations

4
Aqueous extract of Epimedium sagittatum (Sieb. et Zucc.) Maxim. induces liver injury in mice via pyroptosis DOI
Lei Song, Dongyu Wang,

Yuxia Zhai

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 329, P. 118164 - 118164

Published: April 7, 2024

Language: Английский

Citations

4
Research Progress on Effects of Ginsenoside Rg2 and Rh1 on Nervous System and Related Mechanisms DOI Creative Commons
Silu Liu, Weijia Chen, Yan Zhao

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(23), P. 7935 - 7935

Published: Dec. 4, 2023

Neurological-related disorders are diseases that affect the body’s neurons or peripheral nerve tissue, such as Parkinson’s disease (PD) and Alzheimer’s (AD). The development of neurological can cause serious harm to quality life functioning patient. use traditional therapeutic agents dopamine-promoting drugs, anticholinergic cholinesterase inhibitors, NMDA receptor antagonists is often accompanied by a series side effects drug resistance, cardiac arrhythmia, liver function abnormalities, blurred vision. Therefore, there an urgent need find with high safety profile few effects. Herbal medicines rich in active ingredients natural macromolecules. Ginsenoside main ingredient ginseng, which has variety pharmacological considered have potential value treatment human diseases. Modern studies shown ginsenosides Rg2 Rh1 strong activities nervous system, protective on cells, improved resistance neuronal injury, modulation neural activity, cerebral ischemia/reperfusion improvement brain damage after eclampsia hemorrhage, memory cognitive deficits, AD vascular dementia, alleviation anxiety, pain, inhibition ionic-like behavior. In this article, we searched research literature field diseases, summarized latest progress two ginsenosides, reviewed mechanisms Rh1, provided new way thinking for ginseng anti-neurological drugs.

Language: Английский

Citations

11