Tumor Microenvironment In Head And Neck Cancer: Insights From Spheroids DOI Creative Commons

Anshu Rao,

Uddalak Das,

Amey Ghodeswar

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Abstract The study of head and neck cancer (HNC) has been significantly enhanced by the development 3D spheroid models, which closely replicate in vivo tumor microenvironment (TME) preserving cellular heterogeneity, hypoxic regions, tumor-specific cell interactions. Traditional 2D models lack capacity to capture these critical characteristics, are essential for understanding biology therapeutic responses. This review summarizes recent advancements HNC research, with a focus on their applications drug testing, TME simulation, development. We discuss role spheroids modeling key aspects such as resistance, hypoxia, stem behavior, epithelial-mesenchymal transition (EMT). Despite challenges, including variability scalability limitations, hold significant promise advancing precision medicine HNC. also explore use evaluating strategies, chemotherapy, molecular-targeted therapies, immunotherapy. Furthermore, we conduct bibliometric analysis assess research trends identify emerging topics within field HNSCC modeling. ability predict patient-specific responses treatment is highlighted, underscoring potential personalized medicine. By examining processes that drive progression therapy evaluate how effectively speculate future could further enhance relevance treatme

Language: Английский

A Self-Cascade Penetrating Brain Tumor Immunotherapy Mediated by Near-Infrared II Cell Membrane-Disrupting Nanoflakes via Detained Dendritic Cells DOI Creative Commons

Bhanu Nirosha Yalamandala,

Yu-Jen Chen,

Ya‐Hui Lin

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(28), P. 18712 - 18728

Published: July 2, 2024

Immunotherapy can potentially suppress the highly aggressive glioblastoma (GBM) by promoting T lymphocyte infiltration. Nevertheless, immune privilege phenomenon, coupled with generally low immunogenicity of vaccines, frequently hampers presence lymphocytes within brain tumors, particularly in tumors. In this study, membrane-disrupted polymer-wrapped CuS nanoflakes that penetrate delivery to deep tumors via releasing cell-cell interactions, facilitating near-infrared II (NIR II) photothermal therapy, and detaining dendritic cells for a self-cascading immunotherapy are developed. By convection-enhanced delivery, amphiphilic polymer micelles (poly(methoxypoly(ethylene glycol)-benzoic imine-octadecane, mPEG-b-C18) enhances tumor permeability resides Under low-power NIR irradiation (0.8 W/cm2), intense heat generated well-distributed actuates thermolytic efficacy, cell apoptosis subsequent antigen release. Then, positively charged after hydrolysis benzoic-imine bond serves as an depot, autologous tumor-associated antigens presenting them cells, ensuring sustained stimulation. This penetrative amplifies response postoperative but also survival outcomes through effective immunotherapy.

Language: Английский

Citations

13
Natural killer cell-mediated immune surveillance in cancer: Role of tumor microenvironment DOI
Mohamed J. Saadh,

Irodakhon Rasulova,

Mohammed N. A. Khalil

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 254, P. 155120 - 155120

Published: Jan. 11, 2024

Language: Английский

Citations

11
Nanozymes with biomimetically designed properties for cancer treatment DOI Creative Commons
Ke Xu, Yujie Cui, Bin Guan

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(16), P. 7786 - 7824

Published: Jan. 1, 2024

The therapeutic efficacy of nanozymes, which have wide applications in cancer treatment, can be enhanced by various biomimetic design strategies, from structural and process mimicry to advanced functional biomimicry.

Language: Английский

Citations

11
Metabolic crossroads: unravelling immune cell dynamics in gastrointestinal cancer drug resistance DOI Open Access

C. Raman Suri,

Babita Pande,

Lakkakula Suhasini Sahithi

et al.

Cancer Drug Resistance, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Metabolic reprogramming within the tumor microenvironment (TME) plays a critical role in driving drug resistance gastrointestinal cancers (GI), particularly through pathways of fatty acid oxidation and glycolysis. Cancer cells often rewire their metabolism to sustain growth reshape TME, creating conditions such as nutrient depletion, hypoxia, acidity that impair antitumor immune responses. Immune TME also undergo metabolic alterations, frequently adopting immunosuppressive phenotypes promote progression reduce efficacy therapies. The competition for essential nutrients, glucose, between cancer compromises functions effector cells, T cells. Additionally, by-products like lactate kynurenine further suppress activity populations, including regulatory M2 macrophages. Targeting glycolysis presents new opportunities overcome improve therapeutic outcomes GI cancers. Modulating these key has potential reinvigorate exhausted shift toward phenotypes, enhance effectiveness immunotherapies other treatments. Future strategies will require continued research into metabolism, development novel inhibitors, clinical trials evaluating combination Identifying validating biomarkers be crucial patient stratification treatment monitoring. Insights may have broader implications across multiple types, offering avenues improving treatment.

Language: Английский

Citations

1
Unveiling the Immune Microenvironment’s Role in Breast Cancer: A Glimpse into Promising Frontiers DOI Open Access

Amalia Kotsifaki,

Nektarios Alevizopoulos,

Vassiliki Dimopoulou

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15332 - 15332

Published: Oct. 18, 2023

Breast cancer (BC), one of the most widespread and devastating diseases affecting women worldwide, presents a significant public health challenge. This review explores emerging frontiers research focused on deciphering intricate interplay between BC cells immune microenvironment. Understanding role system in is critical as it holds promise for novel therapeutic approaches precision medicine strategies. delves into current literature regarding microenvironment's contribution to initiation, progression, metastasis. It examines complex mechanisms by which interact with various cell populations, including tumor-infiltrating lymphocytes (TILs) tumor-associated macrophages (TAMs). Furthermore, this highlights impact immune-related factors, such cytokines checkpoint molecules. Additionally, comprehensive analysis sheds light potential biomarkers associated response BC, enabling early diagnosis prognostic assessment. The implications targeting microenvironment are also explored, encompassing immunotherapeutic strategies combination therapies enhance treatment efficacy. significance lies its pave way interventions, providing clinicians researchers essential knowledge design targeted personalized regimens patients.

Language: Английский

Citations

22
Assessing the causal relationship between 731 immunophenotypes and the risk of lung cancer: a bidirectional mendelian randomization study DOI Creative Commons
Ming Xu, Chengkai Li,

Liyan Xiang

et al.

BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)

Published: Feb. 26, 2024

Previous studies have observed a link between immunophenotypes and lung cancer, both of which are closely associated with genetic factors. However, the causal relationship them remains unclear. Bidirectional Mendelian randomization (MR) was performed on publicly available genome-wide association study (GWAS) summary statistics to analyze relationships 731 cancer. Sensitivity analyses were conducted verify robustness, heterogeneity, potential horizontal pleiotropy our findings. Following Bonferroni adjustment, CD14- CD16+ monocyte (OR = 0.930, 95%CI 0.900-0.960, P 8.648 × 10- 6, PBonferroni 0.006) CD27 CD24+ CD27+ B cells 1.036, 1.020-1.053, 1.595 10 - 5, 0.012) identified as having role in cancer via inverse variance weighted (IVW) method. At more relaxed threshold, IgD+ cell 1.035, 1.017-1.053, 8.666 0.063) switched memory 1.037, 1.018-1.056, 1.154 4, 0.084) further identified. No statistically significant effects found. The elevated level monocytes protective factor against Conversely, risk factor. class-switched factors for This research enhanced comprehension interplay immune responses risk. Additionally, these findings offer valuable perspectives development immunologically oriented therapeutic strategies.

Language: Английский

Citations

7
Bioprinting of Cells, Organoids and Organs-on-a-Chip Together with Hydrogels Improves Structural and Mechanical Cues DOI Creative Commons
Claudia Tanja Mierke

Cells, Journal Year: 2024, Volume and Issue: 13(19), P. 1638 - 1638

Published: Oct. 1, 2024

The 3D bioprinting technique has made enormous progress in tissue engineering, regenerative medicine and research into diseases such as cancer. Apart from individual cells, a collection of organoids, can be printed combination with various hydrogels. It hypothesized that will even become promising tool for mechanobiological analyses organoids their matrix environments highly defined precisely structured environments, which the mechanical properties cell environment individually adjusted. Mechanical obstacles or bead markers integrated bioprinted samples to analyze deformations forces within these constructs, perform biophysical analysis complex systems, are still not standard techniques. review highlights advances 4D printing technologies integrating cues so next step detailed key future directions organoid generation development disease model regeneration drug testing perspective. Finally, hydrogels, pure natural synthetic hydrogels mixtures, organoid–cell co-cultures, organ-on-a-chip systems organoid-organ-on-a chip combinations introduces use assembloids determine mutual interactions different types cell–matrix interferences specific biological environments.

Language: Английский

Citations

6
Immunotherapy in the Treatment of Cancer: Today and Tomorrow DOI

Gökçen Ömeroğlu Şi̇mşek

Current Molecular Biology Reports, Journal Year: 2024, Volume and Issue: unknown

Published: May 20, 2024

Language: Английский

Citations

4
Exploring Immune Checkpoint Inhibitors: Focus on PD-1/PD-L1 Axis and Beyond DOI
Durre Aden, Samreen Zaheer, Niti Sureka

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 269, P. 155864 - 155864

Published: March 1, 2025

Language: Английский

Citations

0
Current advancement of immune function paradox of tumour-infiltrating cells and their immunotherapeutic targets: a mini-review DOI

VEENA V. TOM,

A. De la Fuente Hernández José, Sumit Mallick

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

Citations

0