The state of lipid metabolism on the background of the use of ω -3 fatty acids in high-altitude conditions DOI Creative Commons

Asrankulova Gulbarchyn Alisherovna,

Makhmudova Zhyldyz Akmatovna,

Boronova Zyinat Samidinovna

et al.

E3S Web of Conferences, Journal Year: 2025, Volume and Issue: 608, P. 03004 - 03004

Published: Jan. 1, 2025

A study of the effect high altitude (Tuya-Ashu Pass, 3200 m above sea level and Bishkek, 720 level) on rat metabolism demonstrated significant changes in lipid profile oxidative stress levels after three days exposure to low oxygen availability. There was a increase total cholesterol triglyceride levels, indicating disturbances may be indicative hyperlipidemia. Low density lipoproteins (LDL) increased significantly, while (HDL) decreased which is likely associated with worsening cardiovascular health an risk atherosclerosis. Malondialdehyde (MDA) increased, as result adaptation conditions. Increased activity superoxide dismutase (SOD) catalase enzymes confirms that rats’ bodies are trying adapt by activating free radical defense mechanisms. Oral administration ω-3 fatty acids at dose 300 mg/kg animal body weight once day for 30 leads decrease atherogenic low-density lipoproteins, malondialdehyde, anti-atherogenic high-density catalase.

Language: Английский

Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement DOI Creative Commons

Rumiana Tenchov,

Janet M. Sasso, Xinmei Wang

et al.

ACS Chemical Neuroscience, Journal Year: 2023, Volume and Issue: 15(1), P. 1 - 30

Published: Dec. 14, 2023

Aging is a dynamic, time-dependent process that characterized by gradual accumulation of cell damage. Continual functional decline in the intrinsic ability living organisms to accurately regulate homeostasis leads increased susceptibility and vulnerability diseases. Many efforts have been put forth understand prevent effects aging. Thus, major cellular molecular hallmarks aging identified, their relationships age-related diseases malfunctions explored. Here, we use data from CAS Content Collection analyze publication landscape recent aging-related research. We review advances knowledge delineate trends research advancements on factors attributes across time geography. also current concepts related molecular, cellular, organismic level, age-associated diseases, with attention brain health, as well biochemical processes associated Major outlined, correlations features are hope this will be helpful for apprehending field mechanisms progression, an effort further solve remaining challenges fulfill its potential.

Language: Английский

Citations

60
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK DOI
Yajuan Li, Daniel Muñoz-Mayorga,

Yuhang Nie

et al.

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(6), P. 1351 - 1370.e8

Published: April 23, 2024

Language: Английский

Citations

36
3D reconstruction of murine mitochondria reveals changes in structure during aging linked to the MICOS complex DOI Creative Commons
Zer Vue, Edgar Garza‐Lopez, Kit Neikirk

et al.

Aging Cell, Journal Year: 2023, Volume and Issue: 22(12)

Published: Nov. 13, 2023

Abstract During aging, muscle gradually undergoes sarcopenia, the loss of function associated with mass, strength, endurance, and oxidative capacity. However, 3D structural alterations mitochondria aging in skeletal cardiac tissues are not well described. Although mitochondrial is decreased capacity, genes responsible for morphological changes during poorly characterized. We measured morphology aged murine gastrocnemius, soleus, using serial block‐face scanning electron microscopy reconstructions. also used reverse transcriptase‐quantitative PCR, transmission quantification, Seahorse analysis, metabolomics lipidomics to measure after contact site cristae organizing system (MICOS) complex genes, Chchd3 , Chchd6 Mitofilin . identified significant size tissues. found that both age‐related MICOS knockouts mice altered morphology. Given critical role maintaining cellular metabolism, we characterized metabolomes lipidomes young mouse tissues, which showed profound consistent membrane integrity, supporting our observations a relationship between aging. Thus, it important understand mechanisms underlie tissue‐dependent phenotypic occur evolutionary conservation these Drosophila mammals.

Language: Английский

Citations

31
The Roles of Lipid Metabolism in the Pathogenesis of Chronic Diseases in the Elderly DOI Open Access
Rui Song,

Mengxiao Hu,

Xiyu Qin

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3433 - 3433

Published: Aug. 3, 2023

Lipid metabolism plays crucial roles in cellular processes such as hormone synthesis, energy production, and fat storage. Older adults are at risk of the dysregulation lipid metabolism, which is associated with progressive declines physiological function various organs. With advancing age, digestion absorption commonly change, thereby resulting decreased nutrient uptake. However, elderly population, accumulation excess becomes more pronounced due to a decline body's capacity utilize lipids effectively. This characterized by enhanced adipocyte synthesis reduced breakdown, along diminished peripheral tissue utilization capacity. Excessive body, manifests hyperlipidemia accumulated visceral fat, linked several chronic lipid-related diseases, including cardiovascular disease, type 2 diabetes, obesity, nonalcoholic fatty liver disease. review provides summary altered during aging, digestion, absorption, anabolism, catabolism, well their associations age-related aids developing nutritional interventions for older prevent or alleviate diseases.

Language: Английский

Citations

27
Ovarian aging: energy metabolism of oocytes DOI Creative Commons
Shenglan Bao, Tailang Yin,

Su Liu

et al.

Journal of Ovarian Research, Journal Year: 2024, Volume and Issue: 17(1)

Published: May 31, 2024

Abstract In women who are getting older, the quantity and quality of their follicles or oocytes decline. This is characterized by decreased ovarian reserve function (DOR), fewer remaining oocytes, lower oocytes. As more choose to delay childbirth, decline in fertility associated with age has become a significant concern for modern women. The oocyte key indicator aging. Many studies suggest that age-related changes energy metabolism may impact quality. Changes affect adenosine 5'-triphosphate (ATP) production, but how related products proteins influence remains largely unknown. review focuses on aging its potential quality, as well therapeutic strategies partially metabolism. research aims enhance our understanding metabolism, identification biomarkers treatment methods.

Language: Английский

Citations

14
A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement DOI Creative Commons
Mengmeng Jiang, Zhuozhao Zheng, Xuan Wang

et al.

Life Medicine, Journal Year: 2024, Volume and Issue: 3(1)

Published: Jan. 29, 2024

In human aging, liver aging per se not only increases susceptibility to diseases but also vulnerability of other organs given its central role in regulating metabolism. Total function tends be well maintained the healthy elderly, so is generally difficult identify early. response this critical challenge, Aging Biomarker Consortium China has formulated an expert consensus on biomarkers by synthesizing latest scientific literature, comprising insights from both scientists and clinicians. This provides a comprehensive assessment associated with presents systematic framework characterize these into three dimensions: functional, imaging, humoral. For functional domain, we highlight cholesterol metabolism liver-related coagulation function. imaging note that hepatic steatosis blood flow can serve as measurable for aging. Finally, humoral pinpoint hepatokines enzymatic alterations worthy attention. The aim establish foundation assessing extent early signs aging-related diseases, thereby improving health life expectancy elderly population.

Language: Английский

Citations

13
Relationship between fatty acid intake and aging: a Mendelian randomization study DOI Creative Commons
Yuhua Chen, Lian Yang, Kui Wang

et al.

Aging, Journal Year: 2024, Volume and Issue: 16(6), P. 5711 - 5739

Published: March 26, 2024

Background: Observational studies have previously shown a possible link between fatty acids and aging-related diseases, raising questions about its health implications. However, the causal relationship two remains uncertain. Methods: Univariable multivariable Mendelian randomization (MR) was used to analyze five types of acids—polyunsaturated acid (PUFA), monounsaturated (MUFA), saturated (SFA), Omega-6 (Omega-6 FA), Omega-3 (Omega-3 FA) three markers aging: telomere length (TL), frailty index (FI), facial aging (FclAg). The primary approach for analysis involved utilizing inverse variance weighted (IVW) method, with additional supplementary methods employed. Results: Univariate MR revealed that MUFA, PUFA, SFA, were positively associated TL (MUFA OR: 1.019, 95% CI: 1.006-1.033; PUFA 1.014, 1.002-1.026; SFA 1.016, 1.002-1.031; FAs OR=1.031, 1.006-1.058). also higher FI (OR: 1.033, 1.009-1.057). In multivariate analysis, after adjusting mutual influences among acids, MUFA independently 1.1508, CI = 1.0724-1.2350; 1.1670, 1.0497-1.2973, while negatively correlated 0.8005, 0.7045-0.9096). Conclusions: Our research presents compelling evidence association certain indicators process. particular, may play role in slowing down process, SFAs contribute accelerated aging. These findings could significant implications dietary recommendations aimed at promoting healthy

Language: Английский

Citations

9
Metabolomics of Breast Cancer: A Review DOI Creative Commons
Ramadevi Subramani, Seeta Poudel, Kenneth Smith

et al.

Metabolites, Journal Year: 2022, Volume and Issue: 12(7), P. 643 - 643

Published: July 13, 2022

Breast cancer is the most commonly diagnosed in women worldwide. Major advances have been made towards breast prevention and treatment. Unfortunately, incidence of still increasing globally. Metabolomics field science which studies all metabolites a cell, tissue, system, or organism. can provide information on dynamic changes occurring during development progression. The identified using cutting-edge metabolomics techniques will result identification biomarkers for early detection, diagnosis, treatment cancers. This review briefly introduces metabolic with particular focus cancer.

Language: Английский

Citations

37
Exploring the Possible Link between the Gut Microbiome and Fat Deposition in Pigs DOI Creative Commons
Guangmin Zhao, Yun Xiang, Xiaoli Wang

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 13

Published: Jan. 22, 2022

Excessive lipid accumulation and high oxidative stress have become a serious health economic problem in the pig industry. Fatness characteristics are crucial production since they closely related to meat quality. The gut microbiome is well acknowledged as key element fat deposition. But link between microbiota pigs remains elusive. To examine whether there pigs’ microbiome, lipogenic properties, stress, we selected 5 high-fat low-fat from 60 250-day-old Jinhua present study collected colon content, serum sample, liver abdominal segments each for metagenomic analysis, assay, RT-qPCR respectively. backfat thickness content of longissimus dorsi muscle were considerably higher than ( P < 0.05 ). An obvious difference GSH-Px MDA high- was observed. After found gene expression ACC1 SREBP1 FAS, PPARγ, LPL significantly P < 0.05 Additionally, sequencing revealed that had abundance Archaeal species with methanogenesis functions, leading more-efficient deposition, while abundances butyrate-producing bacteria improved formation SCFAs, especially butyrate, thus alleviating deposition pigs. Furthermore, total 17 CAZyme families identified give significant enrichments different phenotypes This would provide detailed understanding how influences pigs, hint improving growth performance fatness traits by manipulating microbiome.

Language: Английский

Citations

34
Spermidine – an old molecule with a new age-defying immune function DOI Creative Commons
Kenji Chamoto, Baihao Zhang, Masaki Tajima

et al.

Trends in Cell Biology, Journal Year: 2023, Volume and Issue: 34(5), P. 363 - 370

Published: Sept. 16, 2023

Polyamines – putrescine, spermidine, and spermine are widely distributed aliphatic compounds known to regulate important biological processes in prokaryotic eukaryotic cells. Therefore, spermidine insufficiency is associated with various physio-pathological processes, such as aging cancers. Recent advances immuno-metabolism immunotherapy shed new light on the role of immune cell regulation anticancer responses. Here, we review novel works demonstrating that produced by collective metabolic pathways gut bacteria, bacteria–host co-metabolism, host cells, including activated We highlight effectiveness enhancing antitumor responses aged animals otherwise nonresponsive checkpoint therapy propose supplementation could be used enhance efficacy anti-PD-1 treatment.

Language: Английский

Citations

21